Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ribonuclease H1 | 0.0011 | 0.0025 | 0.0004 |
Echinococcus multilocularis | allatostatin A receptor | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | amine GPCR | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.1261 | 0.5281 | 0.5269 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | neuropeptide Y receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | neuropeptide receptor | 0.1261 | 0.5281 | 0.5271 |
Trypanosoma brucei | beta tubulin | 0.2383 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.1261 | 0.5281 | 0.5269 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | neuropeptides capa receptor | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.1261 | 0.5281 | 0.5271 |
Brugia malayi | putative neuropeptide receptor | 0.1261 | 0.5281 | 0.5276 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.2383 | 1 | 1 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | beta-tubulin | 0.2383 | 1 | 1 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.1261 | 0.5281 | 0.5276 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1261 | 0.5281 | 0.5269 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Trypanosoma brucei | beta tubulin | 0.2383 | 1 | 1 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.1261 | 0.5281 | 0.5269 |
Echinococcus multilocularis | fmrfamide receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | allatostatin A receptor | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.1261 | 0.5281 | 0.5271 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | opsin-like receptor | 0.1261 | 0.5281 | 0.5269 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.1261 | 0.5281 | 0.5271 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | GnHR receptor homolog | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | g-protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | g-protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | tubulin subunit beta | 0.2383 | 1 | 1 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0012 | 0.0029 | 0.0029 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | sex peptide receptor | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.2383 | 1 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.1261 | 0.5281 | 0.5271 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.001 | 0.0021 | 0.0021 |
Brugia malayi | RE15519p | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | neuropeptide receptor | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.1261 | 0.5281 | 0.5269 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | tubulin subunit beta | 0.2383 | 1 | 1 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.1261 | 0.5281 | 0.5269 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0012 | 0.0029 | 0.0029 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus granulosus | fmrfamide receptor | 0.1261 | 0.5281 | 0.5271 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Loa Loa (eye worm) | BEN-1 protein | 0.2383 | 1 | 1 |
Schistosoma mansoni | histamine h1 receptor | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0008 | 0.001 | 0.001 |
Giardia lamblia | Ribonuclease H | 0.0011 | 0.0025 | 0.0025 |
Schistosoma mansoni | neuropeptide receptor | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | amine GPCR | 0.1261 | 0.5281 | 0.5269 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Schistosoma mansoni | tubulin subunit beta | 0.2383 | 1 | 1 |
Echinococcus multilocularis | fmrfamide receptor | 0.1261 | 0.5281 | 0.5271 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Giardia lamblia | Beta tubulin | 0.2383 | 1 | 1 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Echinococcus granulosus | tubulin subunit beta | 0.2383 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | ribonuclease H1 | 0.0011 | 0.0025 | 0.0004 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.1261 | 0.5281 | 0.5269 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.2383 | 1 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | neuropeptide F receptor | 0.1261 | 0.5281 | 0.5276 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0009 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | g protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Brugia malayi | RNase H family protein | 0.0011 | 0.0025 | 0.0014 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0011 | 0.0025 | 0.0004 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.1261 | 0.5281 | 0.5269 |
Brugia malayi | sulfakinin receptor protein | 0.1261 | 0.5281 | 0.5276 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Brugia malayi | Dopamine receptor | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | neuropeptide receptor | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Entamoeba histolytica | tubulin family protein | 0.2383 | 1 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0012 | 0.0029 | 0.0029 |
Brugia malayi | larval opioid receptor | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.2383 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.001 | 0.0021 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma brucei | unspecified product | 0.0009 | 0.0014 | 0.0014 |
Echinococcus multilocularis | g protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | opsin-like receptor | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.1261 | 0.5281 | 0.5269 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | neuropeptide s receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | g protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | amine GPCR | 0.1261 | 0.5281 | 0.5269 |
Echinococcus granulosus | neuropeptides capa receptor | 0.1261 | 0.5281 | 0.5271 |
Trypanosoma brucei | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1261 | 0.5281 | 0.5271 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.2383 | 1 | 1 |
Echinococcus granulosus | neuropeptide Y receptor | 0.1261 | 0.5281 | 0.5271 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.2383 | 1 | 1 |
Brugia malayi | G protein-coupled receptor | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | hypothetical protein | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma brucei | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.1261 | 0.5281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | neuropeptide receptor | 0.1261 | 0.5281 | 0.5269 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Schistosoma mansoni | tubulin subunit beta | 0.2383 | 1 | 1 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Schistosoma mansoni | biogenic amine receptor | 0.1261 | 0.5281 | 0.5269 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0011 | 0.0025 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Entamoeba histolytica | tubulin family protein | 0.2383 | 1 | 0.5 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Toxoplasma gondii | beta tubulin | 0.2383 | 1 | 1 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | g protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | biogenic amine receptor | 0.1261 | 0.5281 | 0.5269 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.1261 | 0.5281 | 0.5269 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Loa Loa (eye worm) | neuropeptide F receptor | 0.1261 | 0.5281 | 0.5276 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Echinococcus multilocularis | orexin receptor type 2 | 0.1261 | 0.5281 | 0.5271 |
Plasmodium vivax | tubulin beta chain, putative | 0.2383 | 1 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.1261 | 0.5281 | 1 |
Echinococcus multilocularis | somatostatin receptor | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | hypothetical protein | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.1261 | 0.5281 | 0.5269 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | orexin receptor type 2 | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.1261 | 0.5281 | 0.5269 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.1261 | 0.5281 | 0.5271 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0046 | 0.0173 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | serotonin receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1261 | 0.5281 | 0.5271 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0011 | 0.0025 | 0.5 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.001 | 0.0021 | 0.0021 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.1261 | 0.5281 | 0.5271 |
Brugia malayi | Dopamine receptor protein 2 | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | serotonin receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.2383 | 1 | 1 |
Brugia malayi | ORL1-like opioid receptor | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0011 | 0.0025 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | TYRA-2 protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1261 | 0.5281 | 0.5271 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0008 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Toxoplasma gondii | beta-1 tubulin, putative | 0.2383 | 1 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.1261 | 0.5281 | 0.5271 |
Giardia lamblia | Beta tubulin | 0.2383 | 1 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.1261 | 0.5281 | 0.5269 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | neuropeptide s receptor | 0.1261 | 0.5281 | 0.5271 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | neuropeptide receptor | 0.1261 | 0.5281 | 0.5269 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | amine GPCR | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | adenoreceptor | 0.1261 | 0.5281 | 0.5269 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0012 | 0.0029 | 0.0029 |
Echinococcus granulosus | sex peptide receptor | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | tubulin beta chain | 0.2383 | 1 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0046 | 0.0173 | 0.0148 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.1261 | 0.5281 | 0.5271 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Echinococcus multilocularis | neuropeptide receptor | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1261 | 0.5281 | 0.5269 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Brugia malayi | RNase H family protein | 0.0011 | 0.0025 | 0.0014 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.2383 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.1261 | 0.5281 | 0.5276 |
Trypanosoma brucei | unspecified product | 0.0012 | 0.0029 | 0.0029 |
Brugia malayi | beta-tubulin, identical | 0.2383 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.2383 | 1 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0153 | 0.0129 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1261 | 0.5281 | 0.5271 |
Brugia malayi | Serotonin receptor | 0.1261 | 0.5281 | 0.5276 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 1 | 0.1261 | 0.5281 | 0.5276 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Echinococcus granulosus | somatostatin receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | AKH receptor | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | tubulin subunit beta | 0.2383 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.2383 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | neuropeptide receptor | 0.1261 | 0.5281 | 0.5271 |
Trypanosoma brucei | ribonuclease H1 | 0.0011 | 0.0025 | 0.0025 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.1261 | 0.5281 | 0.5276 |
Mycobacterium ulcerans | DNA polymerase IV | 0.001 | 0.0021 | 0.5 |
Brugia malayi | Serotonin receptor | 0.1261 | 0.5281 | 0.5276 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Brugia malayi | Melatonin receptor type 1A | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 | |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.1261 | 0.5281 | 0.5269 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Loa Loa (eye worm) | BEN-1 protein | 0.2383 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.2383 | 1 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | biogenic amine receptor | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma cruzi | beta tubulin, putative | 0.2383 | 1 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0146 | 0.0591 | 0.0591 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.1261 | 0.5281 | 0.5269 |
Brugia malayi | RNase H family protein | 0.0011 | 0.0025 | 0.0014 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Leishmania major | ribonuclease H1, putative | 0.0011 | 0.0025 | 0.0025 |
Echinococcus multilocularis | beta tubulin | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.1261 | 0.5281 | 0.5276 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.2383 | 1 | 1 |
Echinococcus granulosus | g protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | serotonin receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.2383 | 1 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.1261 | 0.5281 | 0.5271 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.1261 | 0.5281 | 0.5269 |
Plasmodium falciparum | tubulin beta chain | 0.2383 | 1 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.1261 | 0.5281 | 0.5271 |
Echinococcus granulosus | g protein coupled receptor | 0.1261 | 0.5281 | 0.5271 |
Giardia lamblia | Beta tubulin | 0.2383 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.1261 | 0.5281 | 0.5276 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | tubulin subunit beta | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.1261 | 0.5281 | 0.5269 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.1261 | 0.5281 | 0.5271 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.001 | 0.0021 | 0.0021 |
Schistosoma mansoni | amine GPCR | 0.1261 | 0.5281 | 0.5269 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0011 | 0.0025 | 0.0004 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1261 | 0.5281 | 0.5269 |
Schistosoma mansoni | myosin xvIII | 0.1261 | 0.5281 | 0.5269 |
Brugia malayi | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.2383 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1261 | 0.5281 | 0.5276 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.1261 | 0.5281 | 0.5271 |
Leishmania major | beta tubulin | 0.2383 | 1 | 1 |
Onchocerca volvulus | 0.1261 | 0.5281 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 74350 nM | BindingDB_Patents: Alphascreen Assay. The AlphaScreen assay was performed according to the manufacturer's protocol (Perkin Elmer, Benelux). Reactions were performed in 25 ul final volume in 384-well Optiwell microtiter plates (Perkin Elmer). The reaction buffer contained 25 mM Tris-HCl (pH 7.4), 150 mM NaCl, 1 mM MgCl2, 0.01% (v/v) Tween-20 and 0.1% (w/v) bovine serum albumin. His6-tagged integrase (300 nM final concentration) was incubated with the compounds for 30 min at 4C. The compounds were added at varying concentrations spanning a wide range from 0.1 up to 100 uM. Afterwards 100 nM flag-LEDGF/p75 was added and incubation was prolonged for an additional hour at 4C. Subsequently 5 ul of Ni-chelate-coated acceptor beads and 5 ul anti-flag donor beads were added to a final concentration of 20 ug/ml of both beads. Proteins and beads were incubated for 1 h at 30C. in order to allow association to occur. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.