TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.757 | Formula: C20H12ClF3O
H donors: 1 H acceptors: 1 LogP: 5.63 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1c1ccc2c(c1)C(O)(c1c2cccc1)C(F)(F)F
InChi: 1S/C20H12ClF3O/c21-18-8-4-2-5-13(18)12-9-10-15-14-6-1-3-7-16(14)19(25,17(15)11-12)20(22,23)24/h1-11,25H
InChiKey: OVEZLYUBLWCYNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	pyruvate dehydrogenase kinase, isozyme 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma mansoni	pyruvate dehydrogenase	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma japonicum	[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial precursor, putative	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma mansoni	pyruvate dehydrogenase	Get druggable targets OG5_127409	All targets in OG5_127409
Brugia malayi	kinase, mitochondrial precursor	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma brucei	developmentally regulated phosphoprotein	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma congolense	developmentally regulated phosphoprotein, putative	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania major	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma japonicum	ko:K00898 pyruvate dehydrogenase kinase [EC2.7.11.2], putative	Get druggable targets OG5_127409	All targets in OG5_127409
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma brucei gambiense	developmentally regulated phosphoprotein	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania donovani	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	Get druggable targets OG5_127409	All targets in OG5_127409
Candida albicans	similar to S. pombe SPAC644.11c predicted pyruvate dehydrogenase kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma mansoni	pyruvate dehydrogenase	Get druggable targets OG5_127409	All targets in OG5_127409
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania mexicana	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania braziliensis	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	pyruvate dehydrogenase kinase, isozyme 2	343 aa	321 aa	22.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.002	0.0156	0.0117
Brugia malayi	Nuclear hormone receptor-like 1	0.0043	0.0483	0.0483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0256	0.0448
Echinococcus multilocularis	para nitrobenzyl esterase	0.0118	0.1573	0.1541
Brugia malayi	Carboxylesterase family protein	0.0118	0.1573	0.1573
Loa Loa (eye worm)	acetylcholinesterase 1	0.0698	1	1
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.005	0.059	0.2888
Brugia malayi	beta-lactamase family protein	0.0031	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Loa Loa (eye worm)	carboxylesterase	0.0118	0.1573	0.1541
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0081	0.104	0.104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0206	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0315	0.0277
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0118	0.1573	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0483	0.0446
Echinococcus multilocularis	musashi	0.0044	0.0497	0.046
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0031	0.0315	0.0315
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0081	0.104	0.1005
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0126	0.1691	0.1658
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0081	0.104	0.1005
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0315	0.2831
Brugia malayi	Muscleblind-like protein	0.0147	0.1997	0.1997
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0038	0.0417	0.0379
Loa Loa (eye worm)	beta-lactamase	0.0031	0.0315	0.0277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0256	0.0448
Brugia malayi	nuclear hormone receptor	0.0081	0.104	0.104
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0043	0.0483	0.0446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0179	0.031
Onchocerca volvulus		0.0118	0.1573	0.2507
Echinococcus multilocularis	Smad4	0.0013	0.0056	0.0017
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0038	0.0417	0.0417
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0279	0.0241
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0038	0.0417	0.0386
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0081	0.104	0.104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0284	0.0496
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0081	0.104	0.1005
Echinococcus multilocularis	microtubule associated protein 2	0.0679	0.9732	0.9731
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.0591	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Brugia malayi	intermediate filament protein	0.0044	0.0497	0.0497
Echinococcus granulosus	beta LACTamase domain containing family member	0.0031	0.0315	0.0277
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0081	0.104	0.104
Schistosoma mansoni	nuclear receptor	0.0038	0.0417	0.0417
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0122	0.1639	0.1607
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0081	0.104	0.104
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0118	0.1573	0.1573
Brugia malayi	nuclear hormone receptor	0.0038	0.0417	0.0417
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0256	0.0448
Brugia malayi	Pre-SET motif family protein	0.0351	0.4956	0.4956
Schistosoma mansoni	smad	0.0013	0.0056	0.0056
Echinococcus granulosus	acetylcholinesterase	0.0698	1	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0034	0.0354	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0081	0.104	0.1005
Brugia malayi	hypothetical protein	0.0118	0.1573	0.1573
Loa Loa (eye worm)	hypothetical protein	0.002	0.0156	0.0117
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0081	0.104	0.104
Echinococcus multilocularis	lamin	0.0044	0.0497	0.046
Schistosoma mansoni	Smad4	0.0013	0.0056	0.0056
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0038	0.0417	0.0379
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0284	0.0496
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0081	0.104	0.1005
Onchocerca volvulus		0.0038	0.0417	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1949	0.1917
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0144	0.1949	0.1917
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0043	0.0483	0.0446
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0021	0.0167	0.0129
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.0417	0.0417
Onchocerca volvulus		0.0083	0.1071	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0081	0.104	0.1005
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0027	0.0256	0.1011
Brugia malayi	nuclear receptor NHR-88	0.0038	0.0417	0.0417
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0039	0.0063
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0078	0.0992	0.0957
Entamoeba histolytica	hypothetical protein	0.0035	0.0375	0.5382
Schistosoma mansoni	gliotactin	0.0118	0.1573	0.1573
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.005	0.0591	0.0554
Onchocerca volvulus		0.0118	0.1573	0.2507
Echinococcus multilocularis	ecdysone induced protein 78C	0.0081	0.104	0.1005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0284	0.0496
Schistosoma mansoni	smad1 5 8 and	0.0013	0.0056	0.0056
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0038	0.0417	0.0379
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0256	0.0448
Schistosoma mansoni	retinoic acid receptor RXR	0.0081	0.104	0.104
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1997	0.1966
Brugia malayi	hypothetical protein	0.0035	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0315	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1638	0.1605
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0375	0.0337
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0038	0.0417	0.0379
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0175	0.0304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0148	0.0256
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0148	0.0256
Schistosoma mansoni	hypothetical protein	0.0039	0.0423	0.0423
Echinococcus multilocularis	lysine specific demethylase 5A	0.0029	0.0279	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1573	0.1541
Loa Loa (eye worm)	phosphatidylinositol 3	0.0037	0.0393	0.0356
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0043	0.0483	0.0483
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0698	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Echinococcus granulosus	neuroligin	0.0118	0.1573	0.1541
Loa Loa (eye worm)	acetyltransferase	0.0126	0.1691	0.1658
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0284	0.0496
Schistosoma mansoni	BC026374 protein (S09 family)	0.0118	0.1573	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1071	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Schistosoma mansoni	hypothetical protein	0.0084	0.1075	0.1075
Loa Loa (eye worm)	Smad1	0.0013	0.0056	0.0017
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0206	0.0168
Schistosoma mansoni	hypothetical protein	0.0035	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0698	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0081	0.104	0.104
Schistosoma mansoni	jumonji domain containing protein	0.0062	0.076	0.076
Onchocerca volvulus		0.005	0.0591	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1573	0.1541
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0029	0.0284	0.1286
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0078	0.0992	0.0957
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.005	0.0591	0.0554
Schistosoma mansoni	hypothetical protein	0.0024	0.0206	0.0206
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.0591	0.0591
Brugia malayi	nuclear receptor NHR-88	0.0081	0.104	0.104
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.005	0.0591	0.7695
Brugia malayi	hypothetical protein	0.0038	0.0417	0.0417
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0118	0.1573	0.1573
Loa Loa (eye worm)	carboxylesterase	0.0118	0.1573	0.1541
Echinococcus granulosus	nuclear receptor nhr 48	0.0038	0.0417	0.0379
Brugia malayi	Carboxylesterase family protein	0.0118	0.1573	0.1573
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0081	0.104	0.104
Brugia malayi	conserved hypotetical protein	0.0038	0.0417	0.0417
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0081	0.104	0.1005
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0081	0.104	0.1005
Mycobacterium leprae	Probable lipase LipE	0.0031	0.0315	0.5
Echinococcus granulosus	muscleblind protein	0.0147	0.1997	0.1966
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0037	0.0393	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0081	0.104	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0483	0.0446
Brugia malayi	Latrophilin receptor protein 2	0.0039	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0148	0.0256
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0144	0.1949	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0144	0.1949	0.1917
Brugia malayi	nuclear receptor RXR	0.0038	0.0417	0.0417
Toxoplasma gondii	ABC1 family protein	0.0031	0.0315	0.2179
Brugia malayi	Carboxylesterase family protein	0.0118	0.1573	0.1573
Onchocerca volvulus		0.0031	0.0315	0.02
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0081	0.104	0.104
Brugia malayi	Steroid receptor seven-up type 2	0.0081	0.104	0.104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0039	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Entamoeba histolytica	hypothetical protein	0.0035	0.0375	0.5382
Schistosoma mansoni	cellular tumor antigen P53	0.0083	0.1071	0.1071
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0081	0.104	0.1005
Brugia malayi	latrophilin 2 splice variant baaae	0.0084	0.1075	0.1075
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0013	0.0056	0.0056
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0038	0.0417	0.0417
Schistosoma mansoni	smad1 5 8 and	0.0013	0.0056	0.0056
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.005	0.059	0.2888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0218	0.0379
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0037	0.0393	0.1854
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0393	0.0689
Schistosoma mansoni	microtubule-associated protein tau	0.0679	0.9732	0.9732
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0122	0.1638	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0497	0.046
Brugia malayi	hypothetical protein	0.0043	0.0483	0.0483
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0118	0.1573	0.5136
Loa Loa (eye worm)	carboxylesterase	0.0698	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0081	0.104	0.104
Schistosoma mansoni	lamin	0.0044	0.0497	0.0497
Echinococcus granulosus	PHD finger protein rhinoceros	0.0024	0.0206	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0423	0.0385
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0081	0.104	0.1529
Brugia malayi	MH2 domain containing protein	0.0198	0.2736	0.2736
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0017	0.0112	0.0384
Echinococcus multilocularis	muscleblind protein	0.0147	0.1997	0.1966
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0039	0.0063
Echinococcus granulosus	carboxylesterase 5A	0.0698	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0081	0.104	0.1529
Onchocerca volvulus		0.0118	0.1573	0.2507
Echinococcus granulosus	lamin dm0	0.0044	0.0497	0.046
Trypanosoma cruzi	target of rapamycin kinase 3	0.0029	0.0284	0.1286
Brugia malayi	cytoplasmic intermediate filament protein	0.0023	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0375	0.0337
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0038	0.0417	0.0379
Echinococcus granulosus	FTZ F1 alpha	0.0081	0.104	0.1005
Loa Loa (eye worm)	intermediate filament protein	0.0044	0.0497	0.046
Echinococcus multilocularis	carboxylesterase 5A	0.0698	1	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0037	0.0398	0.0699
Loa Loa (eye worm)	nuclear hormone receptor	0.0038	0.0417	0.0379
Onchocerca volvulus		0.0399	0.566	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0038	0.0417	0.0417
Echinococcus granulosus	ecdysone induced protein 78C	0.0081	0.104	0.1005
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0037	0.0393	0.1854
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.0591	0.0591
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0038	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0039	0.0039
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0081	0.104	0.104
Echinococcus multilocularis	GPCR, family 2	0.0039	0.0423	0.0385
Brugia malayi	Nuclear hormone receptor-like 1	0.0043	0.0483	0.0483
Brugia malayi	nuclear hormone receptor family member odr-7	0.0038	0.0417	0.0417
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0031	0.0315	0.0315
Schistosoma mansoni	coup transcription factor	0.0081	0.104	0.104
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.1997	0.1966
Schistosoma mansoni	smad1 5 8 and	0.0013	0.0056	0.0056
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0081	0.104	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Schistosoma mansoni	intermediate filament proteins	0.0044	0.0497	0.0497
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0351	0.4956	0.4937
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0021	0.0167	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0256	0.0448
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0012	0.0039	0.0039
Schistosoma mansoni	nuclear receptor	0.0038	0.0417	0.0417
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0081	0.104	0.104
Echinococcus multilocularis	peregrin	0.0027	0.0251	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1573	0.1541
Schistosoma mansoni	zinc finger protein	0.0038	0.0417	0.0417
Brugia malayi	jmjC domain containing protein	0.0029	0.0279	0.0279
Brugia malayi	Carboxylesterase family protein	0.0118	0.1573	0.1573
Loa Loa (eye worm)	MH2 domain-containing protein	0.0013	0.0056	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0081	0.104	0.1005
Brugia malayi	jmjC domain containing protein	0.0078	0.0992	0.0992
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0037	0.0393	0.0356
Echinococcus granulosus	Smad4	0.0013	0.0056	0.0017
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0013	0.0056	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0081	0.104	0.1005
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0144	0.1949	1
Plasmodium vivax	SET domain protein, putative	0.005	0.0591	1
Brugia malayi	nuclear receptor RXR	0.0043	0.0483	0.0483
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0038	0.0417	0.0379
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0037	0.0393	0.1854
Loa Loa (eye worm)	hypothetical protein	0.005	0.0591	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1997	0.1966
Onchocerca volvulus		0.0038	0.0417	0.0386
Brugia malayi	Bromodomain containing protein	0.0027	0.0251	0.0251
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.005	0.059	0.2888
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0118	0.1573	0.5136
Entamoeba histolytica	hypothetical protein	0.0035	0.0375	0.5382
Brugia malayi	kinase, mitochondrial precursor	0.0144	0.1949	0.1949
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0037	0.0398	0.3848
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0167	0.0129
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0037	0.0398	0.5001
Schistosoma mansoni	thyroid hormone receptor	0.0081	0.104	0.104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0039	0.0063
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.02	0.2765	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0081	0.104	0.1005
Brugia malayi	orphan nuclear receptor NR2E1	0.0038	0.0417	0.0417
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0044	0.0497	0.046
Echinococcus granulosus	microtubule associated protein 2	0.0679	0.9732	0.9731
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0147	0.0255
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0081	0.104	0.104
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0024	0.0206	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0081	0.104	0.104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0179	0.031
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0417	0.0379
Echinococcus multilocularis	jumonji domain containing protein	0.0033	0.0341	0.0304
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0039	0.0423	0.0385
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0037	0.0393	0.0356
Brugia malayi	hypothetical protein	0.0043	0.0483	0.0483
Leishmania major	hypothetical protein, conserved	0.0031	0.0315	0.1445
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0029	0.0279	0.0279
Loa Loa (eye worm)	transcription factor SMAD2	0.0198	0.2736	0.2708
Brugia malayi	PHD-finger family protein	0.0024	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0315	0.0277
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0039	0.0423	0.0385
Trichomonas vaginalis	penicillin-binding protein, putative	0.0031	0.0315	0.0551
Echinococcus multilocularis	tumor protein p63	0.0569	0.8134	0.8127
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0039	0.0423	0.0423
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0031	0.0315	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1573	0.1541
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0037	0.0393	0.0393
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.005	0.059	0.768
Brugia malayi	steroid hormone receptor	0.0081	0.104	0.104
Onchocerca volvulus		0.0044	0.0497	0.0534
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0122	0.1638	0.1638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0175	0.0304
Schistosoma mansoni	acetylcholinesterase	0.0118	0.1573	0.1573
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0029	0.0284	0.1286
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0485	0.0448
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0118	0.1573	0.1541
Echinococcus multilocularis	acetylcholinesterase	0.0698	1	1
Echinococcus multilocularis	lamin dm0	0.0044	0.0497	0.046
Echinococcus granulosus	para nitrobenzyl esterase	0.0118	0.1573	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0315	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.0168
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0315	0.1445
Echinococcus granulosus	smad	0.0013	0.0056	0.0017
Brugia malayi	MH1 domain containing protein	0.0013	0.0056	0.0056
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0118	0.1573	0.1573
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0058	0.0707	1
Brugia malayi	Smad1	0.0013	0.0056	0.0056
Mycobacterium ulcerans	carboxylesterase, LipT	0.0118	0.1573	1
Brugia malayi	tailless protein	0.0038	0.0417	0.0417
Trichomonas vaginalis	spcc417.12 protein, putative	0.0118	0.1573	0.2776
Brugia malayi	MH1 domain containing protein	0.0013	0.0056	0.0056
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0015	0.0081	0.0223
Loa Loa (eye worm)	steroid hormone receptor	0.0081	0.104	0.1005
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0038	0.0417	0.0379
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0013	0.0056	0.0017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0081	0.104	0.1005
Echinococcus granulosus	BC026374 protein S09 family	0.0118	0.1573	0.1541
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0031	0.0315	0.0277
Loa Loa (eye worm)	MH1 domain-containing protein	0.0013	0.0056	0.0017
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0038	0.0417	0.0379
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0043	0.0483	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Echinococcus granulosus	lysine specific demethylase 5A	0.0029	0.0279	0.0241
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0081	0.104	0.1005
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0483	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0081	0.104	0.1005
Brugia malayi	hypothetical protein	0.0038	0.0417	0.0417
Echinococcus granulosus	histone lysine methyltransferase setb	0.005	0.0591	0.0554
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0037	0.0398	0.0699
Brugia malayi	MH2 domain containing protein	0.0013	0.0056	0.0056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0147	0.0255
Brugia malayi	Nuclear hormone receptor-like 1	0.0081	0.104	0.104
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.005	0.0591	0.0591
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0038	0.0417	0.0417
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0081	0.104	0.104
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0081	0.104	0.104
Giardia lamblia	Histone acetyltransferase GCN5	0.0034	0.0354	0.7899
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1075	0.104
Echinococcus multilocularis	acetylcholinesterase	0.0698	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0315	0.0551
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0037	0.0393	0.1854
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0039	0.0063
Onchocerca volvulus		0.0044	0.0497	0.0534
Echinococcus granulosus	thyroid hormone receptor alpha	0.0038	0.0417	0.0379
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0179	0.031
Brugia malayi	Nuclear hormone receptor E75	0.0038	0.0417	0.0417
Brugia malayi	Carboxylesterase family protein	0.0698	1	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0126	0.1691	0.1691
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0126	0.1691	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0453	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1573	0.1541
Brugia malayi	beta-lactamase	0.0031	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0315	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Onchocerca volvulus		0.0118	0.1573	0.2507
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0039	0.0423	0.0385
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0256	0.0448
Loa Loa (eye worm)	DR-78	0.0038	0.0417	0.0379
Schistosoma mansoni	RAR-like nuclear receptor	0.0081	0.104	0.104
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0118	0.1573	0.1573
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0148	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0315	0.0277
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0118	0.1573	0.5136
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0081	0.104	0.104
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0417	0.0379
Giardia lamblia	GTOR	0.0037	0.0393	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0136	0.1833	0.1833
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0024	0.0206	0.0206
Echinococcus granulosus	tumor protein p63	0.0569	0.8134	0.8127
Brugia malayi	ecdysone receptor	0.0038	0.0417	0.0417
Onchocerca volvulus		0.0081	0.104	0.1529
Brugia malayi	nuclear receptor NHR-67	0.0038	0.0417	0.0417
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0038	0.0417	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1573	0.1541
Schistosoma mansoni	thyroid hormone receptor	0.0081	0.104	0.104
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0081	0.104	0.104
Echinococcus granulosus	mothers against decapentaplegic 5	0.0013	0.0056	0.0017
Brugia malayi	Intermediate filament tail domain containing protein	0.0044	0.0497	0.0497
Trichomonas vaginalis	set domain proteins, putative	0.0399	0.566	1
Loa Loa (eye worm)	hypothetical protein	0.0698	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0081	0.104	0.1529
Echinococcus granulosus	lamin	0.0044	0.0497	0.046
Schistosoma mansoni	pyruvate dehydrogenase	0.0136	0.1833	0.1833
Echinococcus granulosus	acetylcholinesterase	0.0698	1	1
Echinococcus granulosus	peregrin	0.0027	0.0251	0.0213
Brugia malayi	MH2 domain containing protein	0.0013	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0483	0.0446
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0037	0.0393	1
Trypanosoma brucei	hypothetical protein, conserved	0.0031	0.0315	0.1445
Loa Loa (eye worm)	jmjC domain-containing protein	0.0049	0.0574	0.0537
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0048	0.0564	0.0527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0315	0.0551
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0144	0.1949	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0038	0.0417	0.0379
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0031	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Brugia malayi	photoreceptor-specific nuclear receptor	0.0081	0.104	0.104
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0037	0.0398	0.3848
Onchocerca volvulus		0.0031	0.0315	0.02
Schistosoma mansoni	nuclear hormone receptor	0.0081	0.104	0.104
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0043	0.0483	0.0446
Echinococcus multilocularis	neuroligin	0.0118	0.1573	0.1541
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0315	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0379
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0023	0.0201	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1573	0.1541
Loa Loa (eye worm)	MH2 domain-containing protein	0.0198	0.2736	0.2708
Schistosoma mansoni	lamin	0.0044	0.0497	0.0497
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0013	0.0056	0.0017
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0315	0.0551
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0081	0.104	0.104
Echinococcus granulosus	GPCR family 2	0.0039	0.0423	0.0385
Entamoeba histolytica	hypothetical protein	0.0035	0.0375	0.5382
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0037	0.0398	0.0361
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0081	0.104	0.104
Schistosoma mansoni	pyruvate dehydrogenase	0.0144	0.1949	0.1949
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0039	0.0423	0.0385
Onchocerca volvulus		0.0031	0.0315	0.02
Brugia malayi	beta-lactamase family protein	0.0031	0.0315	0.0315
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0081	0.104	0.1005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0122	0.1638	0.1638
Schistosoma mansoni	hypothetical protein	0.0039	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0256	0.0448
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0081	0.104	0.1005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0147	0.0255
Echinococcus granulosus	jumonji domain containing protein	0.0033	0.0341	0.0304
Brugia malayi	Nuclear hormone receptor E75	0.0038	0.0417	0.0417
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0037	0.0393	0.1854
Brugia malayi	ecdysteroid receptor	0.0081	0.104	0.104
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0144	0.1949	0.1917
Brugia malayi	Pre-SET motif family protein	0.005	0.0591	0.0591
Schistosoma mansoni	hypothetical protein	0.0039	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0393	0.0689
Echinococcus multilocularis	FTZ F1 alpha	0.0081	0.104	0.1005
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0081	0.104	0.1005
Echinococcus multilocularis	smad	0.0013	0.0056	0.0017
Echinococcus multilocularis	nuclear receptor nhr 48	0.0038	0.0417	0.0379
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0029	0.0279	0.0279
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0118	0.1573	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0483	0.0446
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0315	0.1445
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0284	0.0496
Schistosoma mansoni	hypothetical protein	0.0039	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0393	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0081	0.104	0.1005
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0081	0.104	0.1005
Echinococcus granulosus	intermediate filament protein	0.0044	0.0497	0.046
Mycobacterium leprae	conserved hypothetical protein	0.0031	0.0315	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0031	0.0315	0.0551
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0037	0.0393	0.0393
Onchocerca volvulus		0.0118	0.1573	0.2507
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0037	0.0393	0.1854
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0118	0.1573	0.2776
Trichomonas vaginalis	esterase, putative	0.0031	0.0315	0.0551
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.0417	0.0417
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0081	0.104	0.104
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0039	0.0423	0.0385

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6838 nM	BindingDB_Patents: Inhibition Assay. The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the residual PDH activity. For expression of hPDHK2 activity, Escherichia coli strain BL21(DE3) cells (Novagen) were transformed with the pET17b vector containing modified hPDHK2 cDNA. Escherichia coli were grown to an optical density 0.6 (600 nmol/L) at 30C. Protein expression was induced by the addition of 500 umol/L isopropyl-beta-thiogalactopyranoside. Escherichia coli were cultured at 30 C. for 5 hr and harvested by centrifugation. Resuspension of the Escherichia coli paste was disrupted by a microfluidizer. FLAG-Tagged protein was separated using FLAG affinity gel (Sigma). The gel was washed with 20 mmol/L N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid-sodium hydroxide (HEPES-NaOH), 500 mmol/L sodium chloride, 1% ethylene glycol, and 0.1% Pluronic F-68 (pH 8.0), and the binding protein was eluted with 20 mmol/L HEPES.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3671732

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1980081