TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.396 | Formula: C19H14FN3O3S
H donors: 1 H acceptors: 4 LogP: 3.42 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cc(ccc1Oc1ccccc1C)S(=O)(=O)Nc1ccc(cn1)F
InChi: 1S/C19H14FN3O3S/c1-13-4-2-3-5-17(13)26-18-8-7-16(10-14(18)11-21)27(24,25)23-19-9-6-15(20)12-22-19/h2-10,12H,1H3,(H,22,23)
InChiKey: MOLAGKBOOWDZDV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 22 (organic anion/urate transporter), member 12	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	major facilitator superfamily protein	solute carrier family 22 (organic anion/urate transporter), member 12	519 aa	541 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0122	0.0891	0.5348
Onchocerca volvulus		0.0066	0.0264	0.1206
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0049	0.0082	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0082	0.0082
Brugia malayi	hypothetical protein	0.0049	0.0082	0.0294
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0056	0.0159	0.0348
Echinococcus granulosus	nAChR subunit	0.0066	0.0264	0.0276
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0044	0.002	0.007
Echinococcus multilocularis	ankyrin repeat protein	0.0452	0.4566	0.4774
Echinococcus multilocularis	neuroligin	0.0049	0.0082	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0082	0.0082
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0056	0.0159	0.0159
Onchocerca volvulus		0.0122	0.0891	0.5348
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0162	0.0355
Loa Loa (eye worm)	carboxylesterase	0.0049	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Brugia malayi	hypothetical protein	0.0056	0.0159	0.0571
Schistosoma mansoni	nAChR subunit	0.0122	0.0891	0.1951
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0091	0.0541	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0122	0.0891	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Onchocerca volvulus		0.0122	0.0891	0.5348
Echinococcus multilocularis	nAChR subunit	0.0066	0.0264	0.0276
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0162	0.0355
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0185	0.1595	0.1595
Echinococcus multilocularis	acetylcholinesterase	0.0292	0.2784	0.2911
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0122	0.0891	0.0932
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0056	0.0159	0.0571
Brugia malayi	Cation transporter family protein	0.0122	0.0891	0.32
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0049	0.0082	0.0085
Onchocerca volvulus		0.0056	0.0159	0.0511
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0122	0.0891	0.1951
Brugia malayi	Cation transporter family protein	0.0122	0.0891	0.32
Loa Loa (eye worm)	GABA receptor subunit	0.0066	0.0264	0.0264
Loa Loa (eye worm)	TAR-binding protein	0.0057	0.0162	0.0162
Echinococcus multilocularis	para nitrobenzyl esterase	0.0049	0.0082	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0292	0.2784	0.2784
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0122	0.0891	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0044	0.002	0.007
Loa Loa (eye worm)	transcription factor SMAD2	0.0226	0.2052	0.2052
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0044	0.002	0.002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0049	0.0082	0.0179
Onchocerca volvulus		0.0122	0.0891	0.5348
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0091	0.0541	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus granulosus	ankyrin repeat protein	0.0452	0.4566	0.4774
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0122	0.0891	0.0891
Loa Loa (eye worm)	MH2 domain-containing protein	0.0226	0.2052	0.2052
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0122	0.0891	0.1951
Schistosoma mansoni	nAChR subunit	0.0056	0.0159	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0541	0.0541
Brugia malayi	RNA recognition motif domain containing protein	0.0057	0.0162	0.0583
Onchocerca volvulus	Putative nachr subunit	0.0185	0.1595	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0091	0.0541	0.0566
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0292	0.2784	0.6097
Echinococcus granulosus	tar DNA binding protein	0.0057	0.0162	0.017
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0185	0.1595	0.1668
Schistosoma mansoni	nAChR subunit	0.0122	0.0891	0.1951
Brugia malayi	hypothetical protein	0.0056	0.0159	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0185	0.1595	0.1668
Entamoeba histolytica	hypothetical protein	0.0066	0.0264	0.5
Brugia malayi	hypothetical protein	0.0056	0.0159	0.0571
Echinococcus granulosus	para nitrobenzyl esterase	0.0049	0.0082	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Echinococcus granulosus	geminin	0.03	0.2874	0.3005
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0056	0.0159	0.0166
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0056	0.0159	0.0571
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0066	0.0264	0.0579
Brugia malayi	excitatory GABA receptor EXP-1A	0.0122	0.0891	0.32
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0122	0.0891	0.1951
Echinococcus granulosus	transient receptor potential cation channel	0.047	0.4771	0.4989
Schistosoma mansoni	acetylcholinesterase	0.0049	0.0082	0.0179
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0122	0.0891	0.0932
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0162	0.0355
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0122	0.0891	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0049	0.0082	0.5
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0122	0.0891	0.0932
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0122	0.0891	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Schistosoma mansoni	hypothetical protein	0.03	0.2874	0.6294
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0056	0.0159	0.0571
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0185	0.1595	0.1668
Brugia malayi	TAR-binding protein	0.0057	0.0162	0.0583
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0122	0.0891	0.0932
Schistosoma mansoni	voltage-gated cation channel	0.0091	0.0541	0.1185
Echinococcus granulosus	nAChR subunit	0.0122	0.0891	0.0932
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0122	0.0891	0.32
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0122	0.0891	0.1951
Onchocerca volvulus		0.0056	0.0159	0.0511
Loa Loa (eye worm)	carboxylesterase	0.0292	0.2784	0.2784
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0056	0.0159	0.0571
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0122	0.0891	0.1951
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0066	0.0264	0.0949
Echinococcus multilocularis	nAChR subunit	0.0122	0.0891	0.0932
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0122	0.0891	0.0932
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0185	0.1595	0.1668
Echinococcus multilocularis	voltage dependent calcium channel	0.0091	0.0541	0.0566
Schistosoma mansoni	nAChR subunit	0.0122	0.0891	0.1951
Onchocerca volvulus		0.0122	0.0891	0.5348
Echinococcus granulosus	voltage dependent calcium channel	0.0091	0.0541	0.0566
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0122	0.0891	0.0891
Brugia malayi	Carboxylesterase family protein	0.0049	0.0082	0.0294
Loa Loa (eye worm)	ACC-1 protein	0.0122	0.0891	0.0891
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0122	0.0891	0.32
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0091	0.0541	0.0566
Echinococcus granulosus	neuroligin	0.0049	0.0082	0.0085
Echinococcus multilocularis	carboxylesterase 5A	0.0292	0.2784	0.2911
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0049	0.0082	0.0085
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0066	0.0264	0.0579
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0056	0.0159	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Loa Loa (eye worm)	LGC-31 protein	0.0122	0.0891	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0122	0.0891	0.0932
Echinococcus multilocularis	transient receptor potential cation channel	0.047	0.4771	0.4989
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0122	0.0891	0.0932
Schistosoma mansoni	nAChR subunit	0.0056	0.0159	0.0348
Brugia malayi	Cation transporter family protein	0.0122	0.0891	0.32
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0049	0.0082	0.5
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0091	0.0541	0.0566
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0091	0.0541	0.1185
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.09	0.9565	1
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0056	0.0159	0.0571
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0122	0.0891	0.32
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0049	0.0082	0.0179
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0122	0.0891	0.0932
Schistosoma mansoni	nAChR subunit	0.0122	0.0891	0.1951
Echinococcus granulosus	acetylcholinesterase	0.0292	0.2784	0.2911
Loa Loa (eye worm)	acetylcholine receptor protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0091	0.0541	0.0566
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0066	0.0264	0.0949
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0049	0.0082	0.0179
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0122	0.0891	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0082	0.0082
Schistosoma mansoni	neurotransmitter gated ion channel	0.0056	0.0159	0.0348
Loa Loa (eye worm)	calcium channel	0.0091	0.0541	0.0541
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0122	0.0891	0.32
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0162	0.0355
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0122	0.0891	0.0932
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0122	0.0891	0.32
Echinococcus granulosus	glycine receptor subunit beta	0.0122	0.0891	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0292	0.2784	0.2784
Schistosoma mansoni	hypothetical protein	0.03	0.2874	0.6294
Brugia malayi	MH2 domain containing protein	0.0226	0.2052	0.737
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0185	0.1595	0.5728
Onchocerca volvulus		0.0056	0.0159	0.0511
Schistosoma mansoni	nAChR subunit	0.0122	0.0891	0.1951
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0066	0.0264	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus granulosus	acetylcholinesterase	0.0292	0.2784	0.2911
Schistosoma mansoni	acetylcholine receptor-related	0.0056	0.0159	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0082	0.0082
Echinococcus granulosus	glycine receptor subunit beta	0.0122	0.0891	0.0932
Brugia malayi	RNA binding protein	0.0057	0.0162	0.0583
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0049	0.0082	0.5
Brugia malayi	hypothetical protein	0.0056	0.0159	0.0571
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0122	0.0891	0.32
Schistosoma mansoni	gliotactin	0.0049	0.0082	0.0179
Echinococcus multilocularis	tar DNA binding protein	0.0057	0.0162	0.017
Loa Loa (eye worm)	acetylcholinesterase 1	0.0292	0.2784	0.2784
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0056	0.0159	0.0166
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0091	0.0541	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Schistosoma mansoni	neurotransmitter gated ion channel	0.0066	0.0264	0.0579
Schistosoma mansoni	BC026374 protein (S09 family)	0.0049	0.0082	0.0179
Schistosoma mansoni	nAChR subunit	0.0122	0.0891	0.1951
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0122	0.0891	0.32
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0066	0.0264	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Brugia malayi	Carboxylesterase family protein	0.0292	0.2784	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0122	0.0891	0.32
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0056	0.0159	0.0159
Schistosoma mansoni	nAChR subunit	0.0122	0.0891	0.1951
Echinococcus granulosus	tm gpcr rhodopsin	0.09	0.9565	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0122	0.0891	0.0891
Brugia malayi	Carboxylesterase family protein	0.0049	0.0082	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0122	0.0891	0.32
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0122	0.0891	0.1951
Echinococcus multilocularis	glycine receptor subunit beta	0.0122	0.0891	0.0932
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0056	0.0159	0.0571
Mycobacterium ulcerans	carboxylesterase, LipT	0.0049	0.0082	0.5
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0091	0.0541	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.0162	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Brugia malayi	Carboxylesterase family protein	0.0292	0.2784	1
Loa Loa (eye worm)	ACC-1 protein	0.0122	0.0891	0.0891
Onchocerca volvulus		0.0122	0.0891	0.5348
Echinococcus multilocularis	acetylcholinesterase	0.0292	0.2784	0.2911
Brugia malayi	hypothetical protein	0.0056	0.0159	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Loa Loa (eye worm)	carboxylesterase	0.0049	0.0082	0.0082
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0049	0.0082	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0044	0.002	0.002
Echinococcus multilocularis	geminin	0.03	0.2874	0.3005
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0091	0.0541	0.0566
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0056	0.0159	0.0166
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0122	0.0891	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0122	0.0891	0.32
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0122	0.0891	0.0932
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0122	0.0891	0.32
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0185	0.1595	0.1668
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0122	0.0891	0.0932
Brugia malayi	Carboxylesterase family protein	0.0049	0.0082	0.0294
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0122	0.0891	0.32
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus multilocularis	glycine receptor subunit beta	0.0122	0.0891	0.0932
Echinococcus granulosus	carboxylesterase 5A	0.0292	0.2784	0.2911
Brugia malayi	Carboxylesterase family protein	0.0049	0.0082	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0082	0.0082
Loa Loa (eye worm)	RNA binding protein	0.0057	0.0162	0.0162
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0122	0.0891	0.32
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0452	0.4566	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0082	0.0082
Echinococcus granulosus	BC026374 protein S09 family	0.0049	0.0082	0.0085
Trichomonas vaginalis	spcc417.12 protein, putative	0.0049	0.0082	0.5
Schistosoma mansoni	neurotransmitter gated ion channel	0.0056	0.0159	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0159	0.0159
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0122	0.0891	0.32
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0264	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0185	0.1595	0.1595
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0122	0.0891	0.32
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0057	0.0162	0.0162
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0091	0.0541	0.1185
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0049	0.0082	0.5
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0891	0.0891
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0185	0.1595	0.1668
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0056	0.0159	0.0166
Onchocerca volvulus		0.0066	0.0264	0.1206

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 324 nM	BindingDB_Patents: Inhibition Assay. Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 mM Ca-gluconate, 1.2 mM KH2PO4, 1.2 mM MgSO4, 5.6 mM D-glucose, 25 mM HEPES, pH 7.4 with NaOH) in 100% DMSO to a final concentration of 1% DMSO. [14C]-Uric Uric acid working stock was made by addition of radiolabeled compound to a final concentration of 120 nM in chloride-free buffer. In all wells, the final assay concentration of solvent (DMSO) was 0.25%; the final assay concentration of [14C]-uric acid was 30 nM in chloride-free buffer and the final compound of formula (I) concentrations ranged from 0 to 10 uM. The vehicle comparator was DMSO (i.e. no inhibition of uric acid transport) and the pharmacological blockade (i.e. 100% inhibition of uric acid transport) was defined by benzbromarone at 10 uM final assay concentration.After pre-incubation, cells were washed with 50 uL of chloride-free buffer.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3683468

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1980849