Detailed information for compound 1982439

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 584.568 | Formula: C28H28F4N8O2
  • H donors: 2 H acceptors: 5 LogP: 4.62 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1C(F)(F)F)NC(=O)c1ccc(c(c1)Nc1ncnc2c1nc(nc2)N1CCC(CC1)N(C)C)F
  • InChi: 1S/C28H28F4N8O2/c1-39(2)18-8-10-40(11-9-18)27-33-14-22-24(38-27)25(35-15-34-22)37-21-12-16(4-6-20(21)29)26(41)36-17-5-7-23(42-3)19(13-17)28(30,31)32/h4-7,12-15,18H,8-11H2,1-3H3,(H,36,41)(H,34,35,37)
  • InChiKey: WAYHIFGJCQJJHM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Brugia malayi Peptidase family M1 containing protein 0.0097 0.0451 0.0992
Toxoplasma gondii histone deacetylase HDAC5 0.0066 0.0282 0.3336
Schistosoma mansoni hypothetical protein 0.005 0.0192 0.0192
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0051 0.0245
Mycobacterium ulcerans aminopeptidase N PepN 0.0097 0.0451 0.4415
Onchocerca volvulus 0.0062 0.0259 0.2855
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0015 0.0015
Onchocerca volvulus 0.0097 0.0451 0.5037
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0097 0.0451 0.3143
Schistosoma mansoni alpha-1 adrenergic receptor 0.0062 0.0259 0.0259
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0051 0.0539
Brugia malayi Dopamine receptor protein 2 0.0062 0.0259 0.0569
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0259 0.0259
Schistosoma mansoni microtubule-associated protein tau 0.0543 0.2927 0.2927
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0012 0.0012
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0166 0.0833 0.5907
Echinococcus multilocularis serotonin receptor 0.032 0.1692 0.1692
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0308 0.2102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0095 0.0095
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0095 0.0209
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0097 0.0451 0.2728
Echinococcus granulosus adam 17 protease 0.0126 0.0613 0.0613
Brugia malayi G-protein coupled receptor 0.0062 0.0259 0.0569
Echinococcus granulosus fmrfamide receptor 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.009 0.0417 0.2516
Brugia malayi chromobox protein homolog 3 0.004 0.0135 0.0297
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0017 0.0008 0.0008
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0062 0.0259 0.0259
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.0417 0.2891
Loa Loa (eye worm) hypothetical protein 0.0175 0.0885 0.0885
Schistosoma mansoni metabotropic glutamate receptor 0.0086 0.0392 0.0392
Echinococcus granulosus hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.07 0.07
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0045 0.0166 0.0166
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Loa Loa (eye worm) phosphofructokinase 0.009 0.0417 0.0417
Echinococcus granulosus alpha 1A adrenergic receptor 0.0062 0.0259 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0889 0.6309
Brugia malayi GnHR receptor homolog 0.0347 0.184 0.4042
Echinococcus granulosus GPCR family 3 C terminal 0.0029 0.0074 0.0074
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0201 0.1027 0.1027
Echinococcus multilocularis adam 0.002 0.0026 0.0026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0012 0.0012
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0097 0.0451 0.2728
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0259 0.0259
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0259 0.0259
Echinococcus granulosus 7TM GPCR rhodopsin 0.0062 0.0259 0.0259
Schistosoma mansoni amine GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0035 0.011 0.011
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Leishmania major histone deacetylase, putative 0.0166 0.0833 0.5045
Brugia malayi hypothetical protein 0.0097 0.0451 0.0992
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0097 0.0451 0.3143
Echinococcus multilocularis glutamate receptor 2 0.0017 0.0008 0.0008
Brugia malayi Matrixin family protein 0.0035 0.011 0.0243
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0133 0.0796
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0015 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0411 0.8237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Brugia malayi Receptor family ligand binding region containing protein 0.0045 0.0166 0.0365
Onchocerca volvulus Matrix metalloproteinase homolog 0.0078 0.0348 0.3859
Onchocerca volvulus 0.0031 0.0088 0.0912
Plasmodium falciparum histone deacetylase 2 0.0128 0.0623 0.7461
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.0074
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0097 0.0451 0.5382
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0062 0.0259 0.0259
Trypanosoma brucei Aminopeptidase M1, putative 0.0097 0.0451 0.2728
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0097 0.0451 0.2728
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.0259 0.0259
Brugia malayi histone deacetylase 1 (HD1) 0.0166 0.0833 0.1831
Loa Loa (eye worm) TATA binding protein associated factor 0.0097 0.0451 0.0451
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0006
Echinococcus granulosus histone deacetylase 7 0.0128 0.0623 0.0623
Plasmodium vivax glutathione reductase, putative 0.0039 0.0133 0.153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) histone deacetylase 11 0.0066 0.0282 0.0282
Brugia malayi Serotonin receptor 0.0062 0.0259 0.0569
Brugia malayi hypothetical protein 0.0837 0.4552 1
Brugia malayi Matrixin family protein 0.0035 0.011 0.0243
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0097 0.0451 0.2728
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Brugia malayi Bromodomain containing protein 0.0078 0.0347 0.0762
Echinococcus multilocularis allatostatin A receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Echinococcus granulosus aminopeptidase N 0.0097 0.0451 0.0451
Schistosoma mansoni aminopeptidase A (M01 family) 0.0097 0.0451 0.0451
Plasmodium falciparum glutathione reductase 0.0039 0.0133 0.153
Loa Loa (eye worm) hypothetical protein 0.069 0.3738 0.3738
Schistosoma mansoni histone deacetylase hda2 0.0066 0.0282 0.0282
Brugia malayi Receptor family ligand binding region containing protein 0.0018 0.0015 0.0032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0097 0.0451 0.0451
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0153 0.0764 0.0764
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0097 0.0451 0.5382
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1399 1
Onchocerca volvulus 0.0062 0.0259 0.2855
Loa Loa (eye worm) matrix metalloproteinase 0.0035 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0062 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0002
Trypanosoma brucei histone deacetylase 4 0.0128 0.0623 0.3771
Onchocerca volvulus Histone deacetylase 10 homolog 0.0066 0.0282 0.3117
Loa Loa (eye worm) TYRA-2 protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0097 0.0451 0.0451
Schistosoma mansoni hypothetical protein 0.0424 0.2265 0.2265
Echinococcus granulosus microtubule associated protein 2 0.0543 0.2927 0.2927
Loa Loa (eye worm) hypothetical protein 0.0166 0.0833 0.0833
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0072 0.0314 0.0314
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.009 0.0417 0.2516
Schistosoma mansoni opsin-like receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.139 0.7616 0.7616
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0259 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0097 0.0451 0.0451
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0095 0.0095
Echinococcus granulosus peptide allatostatin:somatostatin 0.0062 0.0259 0.0259
Toxoplasma gondii histone deacetylase HDAC1 0.0128 0.0623 0.7461
Brugia malayi TATA binding protein associated factor 0.0097 0.0451 0.0992
Echinococcus granulosus neuropeptide receptor A26 0.0062 0.0259 0.0259
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0051 0.0245
Schistosoma mansoni tyrosine kinase 0.0018 0.0015 0.0015
Echinococcus granulosus somatostatin receptor 0.0062 0.0259 0.0259
Brugia malayi Tachykinin-like peptides receptor 99D 0.0062 0.0259 0.0569
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.016 0.0801 0.176
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.165 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0051 0.0539
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0006 0.0006
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0032 0.0032
Trypanosoma cruzi histone deacetylase, putative 0.0128 0.0623 0.3771
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0823 0.4478 0.4478
Schistosoma mansoni bromodomain containing protein 0.0066 0.0281 0.0281
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Leishmania major extracellular receptor, putative 0.0017 0.0008 0.0035
Schistosoma mansoni histone deacetylase 0.0166 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0062 0.0257 0.0257
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0062 0.0259 0.0569
Echinococcus multilocularis GPCR, family 2 0.0032 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Schistosoma mansoni growth hormone secretagogue receptor 0.0062 0.0259 0.0259
Mycobacterium ulcerans aminopeptidase N PepN 0.0097 0.0451 0.4415
Brugia malayi Melatonin receptor type 1A 0.0062 0.0259 0.0569
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0062 0.0259 0.2855
Brugia malayi hypothetical protein 0.0017 0.0007 0.0016
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0043 0.0153 0.0336
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0259 0.0259
Echinococcus granulosus g-protein coupled receptor 0.0062 0.0259 0.0259
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.165 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0015 0.0015
Brugia malayi Peptidase family M1 containing protein 0.0097 0.0451 0.0992
Onchocerca volvulus 0.0097 0.0451 0.5037
Echinococcus granulosus histone deacetylase 8 0.0066 0.0282 0.0282
Schistosoma mansoni protein kinase 0.0018 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0072 0.0314 0.0314
Schistosoma mansoni cpg binding protein 0.0033 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0062 0.0259 0.0259
Plasmodium vivax histone deacetylase, putative 0.0128 0.0623 0.7461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.07 0.07
Echinococcus multilocularis g-protein coupled receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Giardia lamblia Histone deacetylase 0.0166 0.0833 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0213 0.1281
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0097 0.0451 0.0451
Brugia malayi isocitrate dehydrogenase 0.0016 0.0006 0.0014
Schistosoma mansoni hypothetical protein 0.0032 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0135 0.0856
Echinococcus granulosus histone deacetylase 0.0128 0.0623 0.0623
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0017 0.0008 0.0008
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0058 0.0338
Loa Loa (eye worm) raf kinase 0.026 0.1358 0.1358
Echinococcus granulosus neuropeptide receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis dro:myosuppressin receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.07 0.07
Toxoplasma gondii hypothetical protein 0.005 0.0195 0.2286
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0136 0.0136
Echinococcus multilocularis adam 17 protease 0.0114 0.055 0.055
Loa Loa (eye worm) glutamate receptor 0.0176 0.0893 0.0893
Loa Loa (eye worm) RGC/RGC protein kinase 0.0018 0.0015 0.0015
Onchocerca volvulus 0.0062 0.0259 0.2855
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0006 0.0014
Onchocerca volvulus 0.0062 0.0259 0.2855
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0062 0.0259 0.0259
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0017 0.0008 0.0008
Onchocerca volvulus 0.0062 0.0259 0.2855
Loa Loa (eye worm) histone deacetylase 7A 0.0128 0.0623 0.0623
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0062 0.0259 0.0259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0482 0.106
Echinococcus multilocularis microtubule associated protein 2 0.0543 0.2927 0.2927
Echinococcus multilocularis G-protein coupled receptor, putative 0.0062 0.0259 0.0259
Echinococcus granulosus 6 phosphofructokinase 0.009 0.0417 0.0417
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Brugia malayi Hemopexin family protein 0.005 0.0192 0.0421
Plasmodium vivax histone deacetylase, putative 0.0066 0.0282 0.3336
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0097 0.0451 0.2728
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0012 0.0012
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0259 0.0259
Echinococcus granulosus nmda type glutamate receptor 0.0017 0.0008 0.0008
Brugia malayi Peptidase family M1 containing protein 0.0097 0.0451 0.0992
Echinococcus granulosus sex peptide receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0145
Trichomonas vaginalis histone deacetylase, putative 0.0166 0.0833 0.5907
Brugia malayi histone deacetylase 11 0.0066 0.0282 0.062
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Toxoplasma gondii aminopeptidase N protein 0.0097 0.0451 0.5382
Schistosoma mansoni biogenic amine (5HT) receptor 0.032 0.1692 0.1692
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0015
Schistosoma mansoni biogenic amine receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.07 0.07
Brugia malayi hypothetical protein 0.0097 0.0451 0.0992
Schistosoma mansoni hypothetical protein 0.0029 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0026 0.0058 0.0058
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0097 0.0451 0.2728
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0467 0.5593
Brugia malayi putative neuropeptide receptor 0.0062 0.0259 0.0569
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0118 0.0118
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0259 0.0259
Echinococcus granulosus metabotropic glutamate receptor 2 0.0148 0.0734 0.0734
Schistosoma mansoni neuropeptide receptor 0.0062 0.0259 0.0259
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.009 0.0417 0.8405
Loa Loa (eye worm) hypothetical protein 0.0045 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0062 0.0259 0.0259
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0058 0.0618
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.1399 0.1399
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.2265 0.2265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.07 0.07
Echinococcus multilocularis orexin receptor type 2 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0035 0.011 0.011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0411 0.492
Onchocerca volvulus 0.005 0.0192 0.2091
Loa Loa (eye worm) hypothetical protein 0.0066 0.0282 0.0282
Echinococcus granulosus biogenic amine 5HT receptor 0.032 0.1692 0.1692
Trypanosoma cruzi extracellular receptor, putative 0.0017 0.0008 0.0035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0261 0.0261
Brugia malayi Dopamine receptor 0.0062 0.0259 0.0569
Mycobacterium tuberculosis Probable reductase 0.0089 0.0411 0.492
Echinococcus multilocularis neuropeptide receptor A26 0.0062 0.0259 0.0259
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) 6-phosphofructokinase 0.009 0.0417 0.0417
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0889 1
Echinococcus granulosus histone deacetylase 6 0.0128 0.0623 0.0623
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0017 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0132 0.0132
Onchocerca volvulus Phospholipase A2 homolog 0.0153 0.0764 0.8582
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0088
Echinococcus granulosus G protein coupled receptor 139 0.0062 0.0259 0.0259
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0017 0.0008 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0467 0.5593
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.016 0.0957
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0006
Echinococcus multilocularis sex peptide receptor 0.0062 0.0259 0.0259
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0135 0.1451
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Brugia malayi Bromodomain containing protein 0.0039 0.0131 0.0288
Loa Loa (eye worm) matrixin family protein 0.013 0.0634 0.0634
Onchocerca volvulus 0.0018 0.0015 0.008
Toxoplasma gondii aminopeptidase N, putative 0.0097 0.0451 0.5382
Entamoeba histolytica phosphofructokinase, putative 0.009 0.0417 0.4953
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0118 0.0118
Leishmania major ATP-dependent phosphofructokinase 0.009 0.0417 0.2516
Brugia malayi Matrixin family protein 0.013 0.0634 0.1393
Brugia malayi Serotonin/octopamine receptor family protein 7 0.069 0.3738 0.8212
Schistosoma mansoni adenoreceptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Echinococcus granulosus histone deacetylase 6 0.0128 0.0623 0.0623
Leishmania major trypanothione reductase 0.0039 0.0133 0.0796
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0411 0.492
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Echinococcus granulosus tachykinin peptides receptor 99D 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Schistosoma mansoni myosin xvIII 0.0062 0.0259 0.0259
Plasmodium vivax histone deacetylase 1, putative 0.0166 0.0833 1
Echinococcus multilocularis histone deacetylase 6 0.0128 0.0623 0.0623
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0097 0.0451 0.2728
Trichomonas vaginalis histone deacetylase, putative 0.0166 0.0833 0.5907
Toxoplasma gondii 6-phosphofructokinase 0.0024 0.0051 0.0539
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0133 0.153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0024 0.0051 0.5
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0017 0.0008 0.0008
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis histone deacetylase 8 0.0066 0.0282 0.0282
Onchocerca volvulus Poor gastrulation protein homolog 0.0029 0.0074 0.0757
Brugia malayi Phospholipase A2 family protein 0.0153 0.0764 0.1678
Loa Loa (eye worm) leukotriene A4 hydrolase 0.182 1 1
Brugia malayi sulfakinin receptor protein 0.0175 0.0885 0.1944
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.0028
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0095 0.0209
Echinococcus granulosus neuropeptide receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Onchocerca volvulus 0.0062 0.0259 0.2855
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0259 0.0259
Onchocerca volvulus 0.003 0.0081 0.0829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.07 0.07
Trypanosoma brucei aminopeptidase, putative 0.0097 0.0451 0.2728
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0114 0.055 0.055
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0018 0.0015 0.008
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0259 0.0259
Schistosoma mansoni histamine h1 receptor 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) matrixin family protein 0.0078 0.0348 0.0348
Echinococcus granulosus 7tm_1 domain containing protein 0.0062 0.0259 0.0259
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0062 0.0259 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.007 0.0303 0.0303
Echinococcus multilocularis chromobox protein 1 0.0071 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0411 0.492
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0166 0.0833 0.5907
Echinococcus granulosus glutamate receptor 2 0.0017 0.0008 0.0008
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0006 0.0006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0062 0.0259 0.0259
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Echinococcus multilocularis leukotriene A 4 hydrolase 0.182 1 1
Brugia malayi neuropeptide F receptor 0.0062 0.0259 0.0569
Echinococcus granulosus chromobox protein 1 0.0071 0.0308 0.0308
Trypanosoma brucei Aminopeptidase M1, putative 0.0097 0.0451 0.2728
Schistosoma mansoni neuropeptide receptor 0.0062 0.0259 0.0259
Trypanosoma brucei histone deacetylase 3 0.0128 0.0623 0.3771
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.009 0.0417 0.4985
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Schistosoma mansoni biogenic amine receptor 0.0062 0.0259 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.1366 0.1366
Schistosoma mansoni amine GPCR 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.0259 0.0259
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0017 0.0008 0.0008
Trypanosoma cruzi histone deacetylase, putative 0.0066 0.0282 0.1702
Entamoeba histolytica phosphofructokinase, putative 0.009 0.0417 0.4953
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0259 0.0259
Onchocerca volvulus Matrilysin homolog 0.0035 0.011 0.1167
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1399 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0259 0.0259
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0259 0.0259
Brugia malayi ORL1-like opioid receptor 0.0062 0.0259 0.0569
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Brugia malayi G protein-coupled receptor 0.0062 0.0259 0.0569
Brugia malayi putative neuropeptide receptor NPR1 0.0062 0.0259 0.0569
Echinococcus multilocularis somatostatin receptor 0.0062 0.0259 0.0259
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0062 0.0259 0.0569
Loa Loa (eye worm) hypothetical protein 0.008 0.0358 0.0358
Echinococcus multilocularis serotonin receptor 0.032 0.1692 0.1692
Mycobacterium ulcerans 6-phosphofructokinase 0.009 0.0417 0.3898
Echinococcus granulosus receptor type guanylyl cyclase 0.0018 0.0015 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0467 0.5593
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0006 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1399 1
Onchocerca volvulus 0.0097 0.0451 0.5037
Echinococcus multilocularis aminopeptidase N 0.0097 0.0451 0.0451
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0941 0.6688
Schistosoma mansoni hypothetical protein 0.0032 0.0095 0.0095
Brugia malayi map kinase activated protein kinase protein 2 0.018 0.0911 0.2002
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0071 0.0391
Brugia malayi histone deacetylase 3 (HD3) 0.0166 0.0833 0.1831
Loa Loa (eye worm) RGC/RGC protein kinase 0.0018 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0045 0.0166 0.0166
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0308 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1399 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0257 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0482 0.0482
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0097 0.0451 0.2728
Schistosoma mansoni zinc finger protein 0.0016 0.0002 0.0002
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0097 0.0451 0.0451
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0889 0.6309
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.1399 0.3073
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Brugia malayi CXXC zinc finger family protein 0.003 0.0081 0.0177
Trypanosoma brucei trypanothione reductase 0.0039 0.0133 0.0796
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0102 0.0482 0.0482
Toxoplasma gondii histone deacetylase HDAC4 0.0066 0.0282 0.3336
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.009 0.0417 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0217 0.1119 0.1119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.07 0.07
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0259 0.0259
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0097 0.0451 0.5382
Loa Loa (eye worm) hypothetical protein 0.032 0.1692 0.1692
Schistosoma mansoni hypothetical protein 0.0032 0.0095 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.07 0.07
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0097 0.0451 0.2728
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0259 0.0259
Schistosoma mansoni amine GPCR 0.0062 0.0259 0.0259
Brugia malayi 6-phosphofructokinase 0.009 0.0417 0.0915
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1399 1
Brugia malayi Heterochromatin protein 1 0.0071 0.0308 0.0676
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Trypanosoma cruzi histone deacetylase 1, putative 0.0166 0.0833 0.5045
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0062 0.0259 0.0569
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Echinococcus multilocularis G protein coupled receptor 139 0.0062 0.0259 0.0259
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) RGC/RGC protein kinase 0.0018 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0062 0.0259 0.0259
Trypanosoma cruzi histone deacetylase, putative 0.0128 0.0623 0.3771
Echinococcus multilocularis histone deacetylase 3 0.0166 0.0833 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0135 0.0856
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.016 0.0957
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Entamoeba histolytica phosphofructokinase, putative 0.009 0.0417 0.4953
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0259 0.0259
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0051 0.0245
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0062 0.0259 0.0259
Echinococcus multilocularis cpg binding protein 0.0033 0.0101 0.0101
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Onchocerca volvulus Matrilysin homolog 0.0123 0.0595 0.6668
Trypanosoma brucei histone deacetylase 2 0.0066 0.0282 0.1702
Brugia malayi G protein-coupled receptor F59B2.13 0.0062 0.0259 0.0569
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0051 0.0539
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0152 0.0976
Brugia malayi glutathione reductase 0.0039 0.0133 0.0292
Brugia malayi RE15519p 0.0062 0.0259 0.0569
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0148 0.0734 0.0734
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0017 0.0008 0.0008
Echinococcus granulosus histone deacetylase 1 0.0166 0.0833 0.0833
Onchocerca volvulus Neuropeptide F receptor homolog 0.0062 0.0259 0.2855
Onchocerca volvulus 0.0062 0.0259 0.2855
Brugia malayi hypothetical protein 0.0017 0.0008 0.0017
Trichomonas vaginalis histone deacetylase, putative 0.0166 0.0833 0.5907
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0051 0.0245
Toxoplasma gondii aminopeptidase n, putative 0.0097 0.0451 0.5382
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0736 0.4458
Mycobacterium ulcerans hypothetical protein 0.0165 0.0829 1
Echinococcus granulosus dro:myosuppressin receptor 0.0062 0.0259 0.0259
Toxoplasma gondii histone deacetylase HDAC3 0.0166 0.0833 1
Plasmodium vivax histone deacetylase 2, putative 0.0128 0.0623 0.7461
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0062 0.0259 0.0259
Trypanosoma brucei histone deacetylase, putative 0.0128 0.0623 0.3771
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0062 0.0259 0.0259
Echinococcus multilocularis histone deacetylase 1 0.0166 0.0833 0.0833
Echinococcus granulosus GPCR family 2 0.0032 0.0095 0.0095
Echinococcus granulosus dnaJ subfamily B 0.0424 0.2265 0.2265
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0024 0.0051 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0006 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0259 0.0259
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Brugia malayi AKH receptor 0.0062 0.0259 0.0569
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.182 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Brugia malayi neuropeptide F receptor 0.0062 0.0259 0.0569
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0024 0.0051 0.0539
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0026 0.0058 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0015 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0467 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.018 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.0153
Echinococcus multilocularis receptor type guanylyl cyclase 0.0018 0.0015 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0095 0.0095
Loa Loa (eye worm) melatonin receptor type 1A 0.0062 0.0259 0.0259
Echinococcus multilocularis neuropeptide s receptor 0.0062 0.0259 0.0259
Toxoplasma gondii thioredoxin reductase 0.0039 0.0133 0.153
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0172 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Brugia malayi Histone deacetylase 1 0.0166 0.0833 0.1831
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0062 0.0259 0.0259
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0058 0.0618
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Echinococcus granulosus chromobox protein 1 0.0071 0.0308 0.0308
Echinococcus granulosus neuropeptide s receptor 0.0062 0.0259 0.0259
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0097 0.0451 0.5382
Loa Loa (eye worm) histone deacetylase 1 0.0166 0.0833 0.0833
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Onchocerca volvulus 0.0062 0.0259 0.2855
Schistosoma mansoni amine GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0259 0.0259
Trypanosoma cruzi histone deacetylase, putative 0.0066 0.0282 0.1702
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.032 0.1692 0.1692
Schistosoma mansoni chromobox protein 0.0071 0.0308 0.0308
Brugia malayi Serotonin receptor 0.0062 0.0259 0.0569
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0051 0.0245
Trypanosoma cruzi Aminopeptidase M1, putative 0.0097 0.0451 0.2728
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0135
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0736 0.4458
Schistosoma mansoni hypothetical protein 0.007 0.0303 0.0303
Brugia malayi phosphofructokinase 0.009 0.0417 0.0915
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0172 0.0871 0.0871
Brugia malayi 6-phosphofructokinase 0.009 0.0417 0.0915
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0133 0.1538
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0259 0.0259
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0081 0.0081
Brugia malayi hypothetical protein 0.0026 0.0058 0.0126
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Schistosoma mansoni 6-phosphofructokinase 0.009 0.0417 0.0417
Trypanosoma cruzi aminopeptidase, putative 0.0097 0.0451 0.2728
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Brugia malayi hypothetical protein 0.002 0.0026 0.0057
Brugia malayi larval opioid receptor 0.0062 0.0259 0.0569
Schistosoma mansoni opsin-like receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0217 0.1119 0.1119
Echinococcus granulosus g protein coupled receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0097 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Brugia malayi Thioredoxin reductase 0.0039 0.0133 0.0292
Echinococcus granulosus cpg binding protein 0.0033 0.0101 0.0101
Echinococcus granulosus serotonin receptor 0.0062 0.0259 0.0259
Echinococcus granulosus g protein coupled receptor 0.0062 0.0259 0.0259
Schistosoma mansoni histone deacetylase hda2 0.0128 0.0623 0.0623
Schistosoma mansoni hypothetical protein 0.0021 0.0032 0.0032
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0411 0.492
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.1399 1
Entamoeba histolytica histone deacetylase, putative 0.0166 0.0833 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0058 0.0618
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0051 0.0245
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Brugia malayi Matrixin family protein 0.0035 0.011 0.0243
Echinococcus granulosus histone deacetylase 3 0.0166 0.0833 0.0833
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0081
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0136 0.0136
Schistosoma mansoni glutamate receptor NMDA 0.0017 0.0008 0.0008
Brugia malayi hypothetical protein 0.0175 0.0885 0.1944
Brugia malayi Raf kinase 0.0253 0.1315 0.2889
Echinococcus multilocularis histone deacetylase 0.0128 0.0623 0.0623
Brugia malayi Histone deacetylase family protein 0.0128 0.0623 0.1369
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0889 0.6309
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0072 0.0314 0.0314
Echinococcus multilocularis raf serine:threonine protein kinase 0.0262 0.1366 0.1366
Loa Loa (eye worm) aminopeptidase N 0.0097 0.0451 0.0451
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0017 0.0008 0.0008
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0097 0.0451 0.0451
Echinococcus granulosus histone deacetylase 6 0.0128 0.0623 0.0623
Schistosoma mansoni opsin-like receptor 0.0062 0.0259 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0889 0.6309
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Schistosoma mansoni histone deacetylase 1 2 3 0.0066 0.0282 0.0282
Entamoeba histolytica aminopeptidase, putative 0.0097 0.0451 0.5376
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0148 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.165 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.069 0.3738 0.3738
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0062 0.0259 0.0569
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.07 0.1538
Trypanosoma cruzi histone deacetylase, putative 0.0128 0.0623 0.3771
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0095
Echinococcus multilocularis chromobox protein 1 0.0071 0.0308 0.0308
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0829 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Echinococcus multilocularis tyrosine kinase 0.0018 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.016 0.0957
Echinococcus granulosus neuropeptide FF receptor 2 0.0062 0.0259 0.0259
Plasmodium falciparum histone deacetylase 1 0.0166 0.0833 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0024 0.0051 0.0526
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0242 0.2843
Echinococcus multilocularis neuropeptide FF receptor 2 0.0062 0.0259 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0911 0.0911
Echinococcus granulosus raf serine:threonine protein kinase 0.0262 0.1366 0.1366
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0259 0.0259
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0259 0.0259
Leishmania major histone deacetylase, putative 0.0128 0.0623 0.3771
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0054 0.0215 0.0215
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0152 0.164
Brugia malayi Guanylyl cyclase protein 23 0.0018 0.0015 0.0032
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0259 0.0259
Schistosoma mansoni 6-phosphofructokinase 0.009 0.0417 0.0417
Schistosoma mansoni amine GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Schistosoma mansoni tyrosine kinase 0.0018 0.0015 0.0015
Leishmania major histone deacetylase, putative 0.0166 0.0833 0.5045
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0259 0.0259
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Trichomonas vaginalis histone deacetylase, putative 0.0166 0.0833 0.5907
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0058 0.0338
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0062 0.0259 0.0259
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.069 0.3738 0.3738
Echinococcus multilocularis histone deacetylase 6 0.0128 0.0623 0.0623
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0259 0.0259
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0736 0.4458
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0015 0.0015
Brugia malayi Histone deacetylase family protein 0.0128 0.0623 0.1369
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0045 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0241 0.1249 0.1249
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0058 0.0618
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0259 0.0259
Toxoplasma gondii phosphofructokinase PFKII 0.0024 0.0051 0.0539
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Onchocerca volvulus 0.0062 0.0259 0.2855
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.165 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Schistosoma mansoni metabotropic glutamate receptor 0.0148 0.0734 0.0734
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0062 0.0259 0.0259
Echinococcus granulosus zinc finger protein 0.0022 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0062 0.0259 0.0259
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0017 0.0008 0.0008
Loa Loa (eye worm) glutamate receptor 0.0069 0.03 0.03
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.008 0.0358 0.0358
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0024 0.0051 0.0245
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0266 0.0266
Schistosoma mansoni zinc finger protein 0.0022 0.0035 0.0035
Brugia malayi follicle stimulating hormone receptor 0.0062 0.0259 0.0569
Onchocerca volvulus 0.0062 0.0259 0.2855
Leishmania major histone deacetylase, putative 0.0128 0.0623 0.3771
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0062 0.0259 0.0259
Trypanosoma brucei histone deacetylase 1 0.0166 0.0833 0.5045
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0062 0.0259 0.0259
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0152 0.0976
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0054 0.0215 0.0215
Echinococcus granulosus metabotropic glutamate receptor 5 0.0217 0.1119 0.1119
Brugia malayi Dopamine receptor protein 1 0.0062 0.0259 0.0569
Schistosoma mansoni biogenic amine receptor 0.0062 0.0259 0.0259
Trichomonas vaginalis histone deacetylase, putative 0.0166 0.0833 0.5907
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0308 0.2102
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0133 0.0133
Trypanosoma cruzi aminopeptidase, putative 0.0097 0.0451 0.2728
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.0417 0.2891
Echinococcus multilocularis zinc finger protein 0.0022 0.0035 0.0035
Onchocerca volvulus 0.0035 0.011 0.1167
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0062 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Echinococcus multilocularis nmda type glutamate receptor 0.0017 0.0008 0.0008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0006 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0062 0.0259 0.0259
Plasmodium falciparum histone deacetylase, putative 0.0128 0.0623 0.7461
Echinococcus granulosus glutamate receptor 2 0.0017 0.0008 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0006 0.0006
Onchocerca volvulus Phospholipase A2 homolog 0.0153 0.0764 0.8582
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.0417 0.2891
Echinococcus multilocularis 6 phosphofructokinase 0.009 0.0417 0.0417
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0054 0.0215 0.0473
Brugia malayi G-protein coupled receptor 0.0062 0.0259 0.0569
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0153 0.0764 0.0764
Brugia malayi metabotropic glutamate receptor type 2 0.0086 0.0392 0.0861
Echinococcus granulosus MAP kinase activated protein kinase 2 0.018 0.0911 0.0911
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0482 0.106
Echinococcus granulosus adam 0.002 0.0026 0.0026
Echinococcus multilocularis GPCR, family 3, C terminal 0.0029 0.0074 0.0074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0259 0.0259
Brugia malayi hypothetical protein 0.0062 0.0259 0.0569
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0941 0.6688
Echinococcus granulosus g protein coupled receptor 0.0062 0.0259 0.0259
Schistosoma mansoni cpg binding protein 0.0033 0.0101 0.0101
Echinococcus multilocularis histone deacetylase 6 0.0128 0.0623 0.0623
Schistosoma mansoni histone deacetylase 4 5 0.0128 0.0623 0.0623
Schistosoma mansoni chromobox protein 0.0071 0.0308 0.0308
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0058 0.0338
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0097 0.0451 0.2728
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0303 0.0666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0261 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0889 0.6309
Schistosoma mansoni neuropeptide f receptor 76f 0.0062 0.0259 0.0259
Schistosoma mansoni neuropeptide receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0062 0.0259 0.0259
Plasmodium falciparum thioredoxin reductase 0.0039 0.0133 0.153
Brugia malayi PHD-finger family protein 0.0027 0.0065 0.0143
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0889 0.6309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0054 0.0215 0.0215
Echinococcus granulosus orexin receptor type 2 0.0062 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0032 0.0095 0.0095
Echinococcus multilocularis histone deacetylase 7 0.0128 0.0623 0.0623
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.016 0.0957
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0889 0.6309
Echinococcus granulosus atrial natriuretic peptide receptor 0.0017 0.0008 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0259 0.0259
Schistosoma mansoni histone deacetylase 4 5 0.0128 0.0623 0.0623
Echinococcus granulosus allatostatin A receptor 0.0062 0.0259 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0259 0.0259
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0017 0.0008 0.0008
Schistosoma mansoni histone deacetylase 0.0166 0.0833 0.0833
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0012 0.0012
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0051 0.0539
Loa Loa (eye worm) histone deacetylase 3 0.0166 0.0833 0.0833
Loa Loa (eye worm) glutathione reductase 0.0039 0.0133 0.0133
Trypanosoma cruzi histone deacetylase 1, putative 0.0166 0.0833 0.5045
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0259 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0071 0.0391
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.0028
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0411 0.492
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0166 0.0833 0.5907
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0097 0.0451 0.3143
Brugia malayi Matrixin family protein 0.0035 0.011 0.0243
Echinococcus multilocularis glutamate receptor 2 0.0017 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0026 0.0058 0.0338
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.018 0.0911 0.0911
Brugia malayi Metabotropic glutamate receptor precursor. 0.0176 0.0893 0.1962
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Trichomonas vaginalis histone deacetylase, putative 0.0166 0.0833 0.5907
Loa Loa (eye worm) histone deacetylase 0.0128 0.0623 0.0623
Loa Loa (eye worm) peptidase family M1 containing protein 0.0097 0.0451 0.0451
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0062 0.0259 0.0259
Loa Loa (eye worm) 6-phosphofructokinase 0.009 0.0417 0.0417
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0043 0.0153 0.178
Toxoplasma gondii histone deacetylase HDAC2 0.0166 0.0833 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0029 0.0074 0.0163
Echinococcus granulosus tyrosine kinase 0.0018 0.0015 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.0417 0.2891
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0259 0.0259
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0029 0.0074 0.0757
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0097 0.0451 0.0451

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 nM BindingDB_Patents: kinase Assay. The final concentration of DMSO is 5%. 10 µL of the B-Raf (V600E)-kinase solution are pipetted in (containing 0.5 ng B-Raf (V600E)-kinase in 20 mM Tris-HCl pH 7.5, 0.1 mM EDTA, 0.1 mM EGTA, 0.286 mM sodium orthovanadate, 10% glycerol, 1 mg/mL bovine serum albumin, 1 mM dithiothreitol) and the mixture is incubated for 24 h at RT under with shaking. The kinase reaction is started by the addition of 20 µL ATP solution [final concentration: 250 µM ATP, 30 mM Tris-HCl pH 7.5, 0.02% Brij, 0.2 mM sodium orthovanadate, 10 mM magnesium acetate, 0.1 mM EGTA, phosphatase cocktail (Sigma, # P2850, dilution recommended by the manufacturer), 0.1 mM EGTA] and 10 µL MEK1 solution [containing 50 ng biotinylated MEK1 (prepared from purified MEK1 according to standard procedure, e.g. with EZ-Link Sulpho-NHS-LC-Biotin reagent, Pierce, #21335) and carried out for 60 min at RT with constant shaking. ChEMBL. No reference
IC50 (binding) = 3 nM kinase Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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