Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cricetulus griseus | Prokineticin receptor 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | allatostatin A receptor | Prokineticin receptor 2 | 391 aa | 340 aa | 22.9 % |
Onchocerca volvulus | Prokineticin receptor 2 | 391 aa | 330 aa | 20.9 % | |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Prokineticin receptor 2 | 391 aa | 379 aa | 21.6 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Prokineticin receptor 2 | 391 aa | 379 aa | 22.2 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Prokineticin receptor 2 | 391 aa | 375 aa | 24.0 % |
Echinococcus multilocularis | neuropeptide receptor | Prokineticin receptor 2 | 391 aa | 357 aa | 24.6 % |
Onchocerca volvulus | Prokineticin receptor 2 | 391 aa | 321 aa | 27.7 % | |
Echinococcus granulosus | allatostatin A receptor | Prokineticin receptor 2 | 391 aa | 372 aa | 23.1 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Prokineticin receptor 2 | 391 aa | 406 aa | 21.9 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Prokineticin receptor 2 | 391 aa | 376 aa | 22.6 % |
Echinococcus multilocularis | neuropeptide receptor | Prokineticin receptor 2 | 391 aa | 329 aa | 30.1 % |
Echinococcus granulosus | neuropeptide receptor | Prokineticin receptor 2 | 391 aa | 322 aa | 31.1 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Prokineticin receptor 2 | 391 aa | 329 aa | 28.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1614 | 0.1614 |
Echinococcus multilocularis | acetylcholinesterase | 0.0936 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0252 | 0.1614 | 0.1614 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0252 | 0.1614 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1614 | 0.1614 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0158 | 0.0467 | 0.0467 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0936 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0158 | 0.0467 | 0.0467 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0158 | 0.0467 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0158 | 0.0467 | 0.0467 |
Echinococcus granulosus | acetylcholinesterase | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0407 | 0.3514 | 0.3514 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0407 | 0.3514 | 0.3514 |
Brugia malayi | Carboxylesterase family protein | 0.0158 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.0873 | 0.0873 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.3514 | 0.3514 |
Echinococcus granulosus | serotonin transporter | 0.0252 | 0.1614 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1614 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0633 | 0.0633 |
Brugia malayi | Carboxylesterase family protein | 0.0158 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | carboxylesterase | 0.0936 | 1 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0363 | 0.2978 | 0.2634 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0158 | 0.0467 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0252 | 0.1614 | 0.1614 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0158 | 0.0467 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0158 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | carboxylesterase | 0.0158 | 0.0467 | 0.0467 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.012 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0407 | 0.3514 | 0.3197 |
Schistosoma mansoni | hypothetical protein | 0.0407 | 0.3514 | 0.3197 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0252 | 0.1614 | 0.1204 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Echinococcus granulosus | carboxylesterase 5A | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0936 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0158 | 0.0467 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0158 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0252 | 0.1614 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0158 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Echinococcus granulosus | acetylcholinesterase | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Brugia malayi | Carboxylesterase family protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0158 | 0.0467 | 0.0467 |
Brugia malayi | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Echinococcus multilocularis | acetylcholinesterase | 0.0936 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0252 | 0.1614 | 0.1614 |
Plasmodium falciparum | choline kinase | 0.012 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0158 | 0.0467 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0252 | 0.1614 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0158 | 0.0467 | 0.0467 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0252 | 0.1614 | 0.1204 |
Plasmodium vivax | choline kinase, putative | 0.012 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0158 | 0.0467 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0158 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0158 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | serotonin transporter b | 0.0252 | 0.1614 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0467 | 0.0467 |
Echinococcus multilocularis | neuroligin | 0.0158 | 0.0467 | 0.0467 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0936 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 183 nM | BindingDB_Patents: Calcium Mobilization Assay. An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65, 582-588, 2004). Chinese hamster ovary (CHO) cells stably expressing photoprotein aequorin and recombinant PKR1 or PKR2 were tested by this method. Briefly, the cells were charged in Opti-MEM (Invitrogen) containing 8 µM of coelenterazine cp at 37° C. for 2 hours. Cells were detached by brief typsinization and maintained in Hank's Balanced Salt Solution (HBSS) plus 10 mM HEPES (pH7.5) and 0.1% BSA at about 5×105 cells/ml. Luminescence measurements were made using a Berthold luminometer. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.