TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.432 | Formula: C23H17FN8O2
H donors: 1 H acceptors: 6 LogP: 2.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(nc1)[C@H]1COC(=O)N1c1ccn2c(n1)c(cn2)c1ccc(c(c1)F)c1n[nH]cn1
InChi: 1S/C23H17FN8O2/c1-13-2-5-18(25-9-13)19-11-34-23(33)32(19)20-6-7-31-22(29-20)16(10-28-31)14-3-4-15(17(24)8-14)21-26-12-27-30-21/h2-10,12,19H,11H2,1H3,(H,26,27,30)/t19-/m1/s1
InChiKey: NICNFSMAEZFMOR-LJQANCHMSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.1557	0.1557
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0045	0.7452	0.7452
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0045	0.7452	0.7452
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.3945	0.3945
Brugia malayi	nuclear receptor RXR	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3078	0.3078
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3078	0.3078
Echinococcus granulosus	FTZ F1 alpha	0.0045	0.7452	0.7452
Brugia malayi	orphan nuclear receptor NR2E1	0.0021	0.085	0.085
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.7452	0.7452
Brugia malayi	steroid hormone receptor	0.0045	0.7452	0.7452
Loa Loa (eye worm)	nuclear hormone receptor	0.0021	0.085	0.085
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6145	0.6145
Echinococcus granulosus	thyroid hormone receptor alpha	0.0021	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1557	0.1557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3066	0.3066
Giardia lamblia	GTOR	0.0054	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0045	0.7452	0.7452
Brugia malayi	nuclear receptor RXR	0.0024	0.1557	0.1557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3078	0.3078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.3855	0.3855
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0045	0.7452	1
Brugia malayi	hypothetical protein	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3066	0.3066
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0021	0.085	0.085
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.1557	0.1557
Schistosoma mansoni	nuclear receptor nhr-48	0.0021	0.085	0.085
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0045	0.7452	0.7452
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.085	0.085
Echinococcus multilocularis	ecdysone induced protein 78C	0.0045	0.7452	0.7452
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.207	0.207
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.3855	0.3855
Onchocerca volvulus	Bile acid receptor homolog	0.0045	0.7452	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0021	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6145	0.6145
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.6934	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.3945	0.3945
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.085	0.085
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	1	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0045	0.7452	0.7452
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0045	0.7452	0.7452
Loa Loa (eye worm)	DR-78	0.0021	0.085	0.085
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0045	0.7452	0.7452
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0045	0.7452	0.7452
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.085	0.085
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.7452	0.7452
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.5047	0.5047
Echinococcus granulosus	nuclear receptor nhr 48	0.0021	0.085	0.085
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.7452	0.7452
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.6145	0.5
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.6934	0.6934
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0045	0.7452	0.7452
Brugia malayi	nuclear hormone receptor	0.0045	0.7452	0.7452
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Brugia malayi	nuclear hormone receptor family member odr-7	0.0021	0.085	0.085
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.7452	0.7452
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.085	0.085
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0021	0.085	0.085
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0045	0.7452	0.7452
Brugia malayi	nuclear hormone receptor	0.0021	0.085	0.085
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.085	0.085
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0021	0.085	0.085
Brugia malayi	conserved hypotetical protein	0.0021	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Onchocerca volvulus	Protein ultraspiracle homolog	0.0045	0.7452	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.7452	0.7452
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.7452	0.7452
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.1557	0.1557
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1557	0.1557
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.1557	0.1557
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.3945	0.3945
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	1	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.7452	0.7452
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1557	0.1557
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.7452	0.7452
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Brugia malayi	tailless protein	0.0021	0.085	0.085
Schistosoma mansoni	nuclear receptor	0.0021	0.085	0.085
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.085	0.085
Brugia malayi	hypothetical protein	0.0024	0.1557	0.1557
Schistosoma mansoni	coup transcription factor	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.6922	0.6922
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.6922	0.6922
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	1	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0045	0.7452	0.7452
Brugia malayi	photoreceptor-specific nuclear receptor	0.0045	0.7452	0.7452
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6145	0.6145
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0045	0.7452	0.7452
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.7452	0.7452
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0045	0.7452	0.7452
Brugia malayi	Steroid receptor seven-up type 2	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.6922	0.6922
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6145	0.6145
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0045	0.7452	0.7452
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0021	0.085	0.085
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0045	0.7452	0.7452
Schistosoma mansoni	zinc finger protein	0.0021	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Schistosoma mansoni	RAR-like nuclear receptor	0.0045	0.7452	0.7452
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1557	0.1557
Brugia malayi	hypothetical protein	0.0021	0.085	0.085
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0045	0.7452	0.7452
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.6934	0.6934
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3066	0.3066
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.7452	0.7452
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0021	0.085	0.085
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6145	0.6145
Brugia malayi	hypothetical protein	0.0024	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6145	0.6145
Echinococcus multilocularis	nuclear receptor nhr 48	0.0021	0.085	0.085
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0021	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.78	0.78
Brugia malayi	ecdysteroid receptor	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.6922	0.6922
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.085	0.085
Onchocerca volvulus		0.0045	0.7452	1
Brugia malayi	nuclear receptor NHR-88	0.0021	0.085	0.085
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0045	0.7452	0.7452
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6145	0.6145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0045	0.7452	0.7452
Brugia malayi	ecdysone receptor	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.6922	0.6922
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Schistosoma mansoni	nuclear receptor	0.0021	0.085	0.085
Loa Loa (eye worm)	steroid hormone receptor	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	1	1
Brugia malayi	nuclear receptor NHR-88	0.0045	0.7452	0.7452
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.7452	0.7452
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	1	1
Brugia malayi	nuclear receptor NHR-67	0.0021	0.085	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.4722	0.4722
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.7452	0.7452
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1557	0.1557
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.085	0.085
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.1204	0.1204
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0021	0.085	0.085
Loa Loa (eye worm)	hypothetical protein	0.0045	0.7452	0.7452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3078	0.3078
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0045	0.7452	0.7452
Loa Loa (eye worm)	hypothetical protein	0.0021	0.085	0.085
Echinococcus granulosus	ecdysone induced protein 78C	0.0045	0.7452	0.7452
Schistosoma mansoni	retinoic acid receptor RXR	0.0045	0.7452	0.7452

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9.3 nM	BindingDB_Patents: Kinase Assay. The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled phosphate from [gamma-33P]ATP to the protein substrate 4E-BP1. Compounds were first prepared at 50x the top dose of 10,000 nM and serially diluted 3-fold in DMSO to give ten dose dilution series. Assays were conducted in 96-well polypropylene U-bottom plates in 40 uL (final volume) assay mixtures that contained 50 mM K+HEPES, pH 7.5, 1 mM EGTA, 0.005% Tween-20, 10 mM MnCl2, 2.5 mM DTT, 2% DMSO (final concentration with compound), 10 uM [gamma-33P]ATP (50 uCi/mL), 5 uM 4E-BP1 and 5 nM mTOR, which was added last to initiate the assay. Each plate contained appropriate high (uninhibited) and low (prequenched) controls as well as a reference compound. Incubations were carried out at 22 C. for 45 minutes, after which the reaction was stopped by the addition of 100 uL aliquots of 25% TCA.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1983217