Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0063 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.09 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production; Imax=84% | ChEMBL. | 9871731 |
IC50 (binding) | = 0.09 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production; Imax=84% | ChEMBL. | 9871731 |
IC50 (binding) | = 0.25 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production. | ChEMBL. | 9871731 |
IC50 (binding) | = 0.25 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production. | ChEMBL. | 9871731 |
Inhibition (binding) | = -1 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = -1 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 11 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 11 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 28 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 28 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 46 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 46 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 47 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 47 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 50 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 50 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 66 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 66 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 68 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 68 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 72 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 72 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 82 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 10 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 82 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 10 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 86 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 86 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 87 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 10 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 87 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 10 ug/mL | ChEMBL. | 9871731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.