Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine threonine protein kinase | 0.0059 | 0.8712 | 0.8707 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.1328 | 0.1293 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.001 | 0.0039 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0049 | 0.6929 | 0.8753 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.791 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0057 | 0.8217 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0059 | 0.8712 | 0.8707 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.6622 | 0.6609 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 1 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0019 | 0.1595 | 0.1562 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.6622 | 0.6609 |
Toxoplasma gondii | AGC kinase | 0.001 | 0.0039 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.1595 | 0.1562 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.6622 | 0.6609 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0039 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.6622 | 0.8363 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0039 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.1328 | 0.1293 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.1328 | 0.1293 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0019 | 0.1595 | 0.1562 |
Brugia malayi | protein kinase C II. | 0.0019 | 0.1595 | 0.1903 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0067 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0039 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0039 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0019 | 0.1595 | 0.1977 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0039 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 25.1 nM | BindingDB_Patents: Inhibition Assay. Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide (A->S, RFARKGSLRQKNV). This transfer is coupled to the oxidation of p-NADH through the activities of Pyruvate Kinase (PK) and Lactate Dehydrogenase (LDH). (3-NADH conversion to NAD+ is monitored by the decrease in absorbance at 340 nm (e=6.22 cm-1 mM-1) using a Molecular Devices SPECTRA max PLUS spectrophotometer.A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30 C. in 0.1 mL of assay buffer containing 50 mM HEPES, pH 7.4, 5 nM PKC, 23 units of pyruvate kinase, 33 units of lactate dehydrogenase, 0.15 mM peptide, 0.1 mM ATP, 1 mM DTT, 4 mM PEP, 8 mM MgCl2, 0.3 mM NADH, 60 mM CaCl2, 10 mg/mL PS, 50 ng/mL PMA, 7.5% DMSO and from about 10,000 nM to 0.169 nM compound inhibitor. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.