Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | No references |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | No references |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Schistosoma mansoni | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Schistosoma mansoni | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Trypanosoma brucei | beta tubulin | 0.0192 | 0.5409 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0192 | 0.5409 | 0.5409 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0192 | 0.5409 | 1 |
Giardia lamblia | Beta tubulin | 0.0192 | 0.5409 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0192 | 0.5409 | 0.5409 |
Toxoplasma gondii | beta-tubulin, putative | 0.0192 | 0.5409 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0192 | 0.5409 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Plasmodium falciparum | tubulin beta chain | 0.0192 | 0.5409 | 1 |
Toxoplasma gondii | beta tubulin | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Trypanosoma brucei | beta tubulin | 0.0192 | 0.5409 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0192 | 0.5409 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0192 | 0.5409 | 0.5409 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0192 | 0.5409 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 1 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0192 | 0.5409 | 0.5409 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0192 | 0.5409 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 1 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0192 | 0.5409 | 0.5409 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Giardia lamblia | Beta tubulin | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 1 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0192 | 0.5409 | 1 |
Echinococcus granulosus | beta tubulin | 0.0192 | 0.5409 | 0.5409 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0192 | 0.5409 | 0.5409 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0192 | 0.5409 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0192 | 0.5409 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Trypanosoma brucei | beta tubulin | 0.0192 | 0.5409 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Onchocerca volvulus | 0.0292 | 1 | 0.5 | |
Echinococcus multilocularis | beta tubulin | 0.0192 | 0.5409 | 0.5409 |
Trypanosoma cruzi | beta tubulin, putative | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0192 | 0.5409 | 0.5409 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Schistosoma mansoni | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Loa Loa (eye worm) | beta-tubulin | 0.0192 | 0.5409 | 0.5409 |
Echinococcus multilocularis | beta tubulin | 0.0192 | 0.5409 | 0.5409 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0192 | 0.5409 | 0.5409 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0192 | 0.5409 | 0.5409 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0192 | 0.5409 | 0.5409 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0192 | 0.5409 | 0.5409 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0192 | 0.5409 | 0.5409 |
Leishmania major | beta tubulin | 0.0192 | 0.5409 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0192 | 0.5409 | 0.5409 |
Echinococcus granulosus | beta tubulin | 0.0192 | 0.5409 | 0.5409 |
Plasmodium vivax | tubulin beta chain, putative | 0.0192 | 0.5409 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0192 | 0.5409 | 0.5409 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 33 nM | Binding Assay | BINDINGDB. | No reference |
Ki (binding) | = 39 nM | Binding Assay | BINDINGDB. | No reference |
Ki (binding) | = 73 nM | Binding Assay | BINDINGDB. | No reference |
Ki (binding) | = 93 nM | BindingDB_Patents: Binding Assay. In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express each of the three human transporters. cDNAs containing the complete coding regions of each transporter were amplified by PCR from human brain libraries. The cDNAs contained in pCRII vectors were sequenced to verify their identity and then subcloned into an Epstein-Barr virus based expression plasmid (Shen et al., Gene 156:235-239 (1995), which is hereby incorporated by reference in its entirety). This plasmid containing the coding sequence for one of the human transporters was transfected into HEK93E cells. Successful transfection was verified by the ability of known reuptake blockers to inhibit the uptake of tritiated NE, DA or 5HT.For binding, cells were homogenized, centrifuged, and then resuspended in incubation buffer (5 mM Tris, 120 mM NaCl, 5 mM KCl, pH 7.4). Then, the appropriate radioligand was added. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.