Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.3423 | 0.4963 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.3423 | 0.4963 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.3423 | 0.4963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3423 | 0.3423 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.6896 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.6896 | 1 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.3423 | 0.4963 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.3423 | 0.4963 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.3423 | 0.3423 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.6896 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3423 | 0.3423 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.3423 | 0.3423 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3423 | 0.3423 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3423 | 0.3423 |
Brugia malayi | RNA binding protein | 0.0074 | 0.3423 | 0.4963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3423 | 0.3423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | BindingDB_Patents: Receptor Calcium FLIPR Antagonist Assay. The assay measures intracellular changes of Ca2+ mediated by the synthetic probing agonist 3-{[2-(2-Trifluoromethyl-biphenyl-4-yl)-benzo[b]thiophen-5-ylmethyl]-amino}-propionic acid (GNF-AC-1) in the HeLa-S1P1/Galpha16 cell clone 1: HeLa (human cervix carcinoma, ATCC CCL2) cells stably expressing N-terminally myc-tagged human S1P1 receptors (GenBank accession No. NM001400; UNIPROT P21453) and promiscuous Galpha16 protein (GenBank accession number M63904, Swissprot P30679) are cultured at 37 C., 5% CO2, and 95% relative humidity. The cells are plated in 384 well black plates (10'000 cells per well). After 24 hours the cells are loaded with Fluo-4-AM (1.6 uM in HBSS and 2.5 mM probenicid) for 1 hour at 37 C. After washing, the cells are transferred to the FLIPR. The test compounds are added at different concentrations (<=100 uM) in HBSS in the presence of 0.1% BSA and changes in fluorescence are recorded (indication of agonism). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.