TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 483.006 | Formula: C23H19ClN4O2S2
H donors: 2 H acceptors: 4 LogP: 4.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)C1=CCNCC1)c1cccc2c1ccc(c2)S(=O)(=O)Nc1ncns1
InChi: 1S/C23H19ClN4O2S2/c24-17-4-6-21(22(13-17)15-8-10-25-11-9-15)20-3-1-2-16-12-18(5-7-19(16)20)32(29,30)28-23-26-14-27-31-23/h1-8,12-14,25H,9-11H2,(H,26,27,28)
InChiKey: OCYJVPZHZLJYEH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.4443	0.5452
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.4443	0.4382
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.4443	0.5452
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.4443	0.4382
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.4443	0.5452
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Brugia malayi	Melatonin receptor type 1A	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.4443	1
Brugia malayi	ORL1-like opioid receptor	0.0028	0.4443	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.4443	0.4382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.4443	0.5452
Schistosoma mansoni	histamine h1 receptor	0.0028	0.4443	0.4382
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.4443	0.5452
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.4443	0.4382
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.4443	0.5452
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.4443	0.4382
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	AKH receptor	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	sodium channel protein	0.0045	0.7621	1
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	amine GPCR	0.0028	0.4443	0.4382
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.4443	0.4382
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.4443	0.5452
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0525	1
Schistosoma mansoni	hypothetical protein	0.0028	0.4443	0.4382
Trichomonas vaginalis	helicase, putative	0.0006	0.0525	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Onchocerca volvulus		0.0028	0.4443	1
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.4443	0.5452
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.4443	0.5452
Echinococcus granulosus	g protein coupled receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.4443	0.5452
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	neuropeptide receptor	0.0028	0.4443	0.4382
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.4443	0.5452
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.4443	0.5452
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0939	0.0436
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.4443	1
Brugia malayi	RE15519p	0.0028	0.4443	1
Schistosoma mansoni	myosin xvIII	0.0028	0.4443	0.4382
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.4443	0.5452
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.4443	1
Echinococcus multilocularis	serotonin receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.4443	0.5452
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Brugia malayi	Dopamine receptor protein 2	0.0028	0.4443	1
Onchocerca volvulus		0.0028	0.4443	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0045	0.7621	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.4443	0.5452
Echinococcus granulosus	allatostatin A receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.4443	1
Schistosoma mansoni	amine GPCR	0.0028	0.4443	0.4382
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.4443	1
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.4443	0.5452
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0525	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.4443	0.4382
Echinococcus granulosus	hypothetical protein	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.4443	0.5452
Brugia malayi	G protein-coupled receptor	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.4393	0.9856
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.4443	0.5452
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Echinococcus granulosus	g protein coupled receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Brugia malayi	G-protein coupled receptor	0.0028	0.4443	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.4443	0.4382
Brugia malayi	neuropeptide F receptor	0.0028	0.4443	1
Brugia malayi	Dopamine receptor	0.0028	0.4443	1
Schistosoma mansoni	cpg binding protein	0.0029	0.4678	0.4619
Onchocerca volvulus		0.0028	0.4443	1
Schistosoma mansoni	opsin-like receptor	0.0028	0.4443	0.4382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Onchocerca volvulus		0.0028	0.4443	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.4443	0.5452
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.4443	0.4382
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Echinococcus granulosus	serotonin receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.4443	0.5452
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.4443	0.5452
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Brugia malayi	G-protein coupled receptor	0.0028	0.4443	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.4443	0.4382
Echinococcus multilocularis	cpg binding protein	0.0029	0.4678	0.5788
Echinococcus granulosus	g protein coupled receptor	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Brugia malayi	Dopamine receptor protein 1	0.0028	0.4443	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.4393	0.9857
Brugia malayi	sulfakinin receptor protein	0.0028	0.4443	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.4443	0.5452
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.4443	0.4382
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.4443	0.5452
Schistosoma mansoni	opsin-like receptor	0.0028	0.4443	0.4382
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.4443	0.4382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Onchocerca volvulus		0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.4443	0.5452
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0525	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.4443	0.5452
Echinococcus multilocularis	sex peptide receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.4443	0.5452
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0634	0.0531
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.4443	0.5452
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	somatostatin receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.4443	0.5452
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.4443	0.5452
Schistosoma mansoni	biogenic amine receptor	0.0028	0.4443	0.4382
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.4443	1
Schistosoma mansoni	biogenic amine receptor	0.0028	0.4443	0.4382
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0045	0.7621	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.4443	1
Schistosoma mansoni	neuropeptide receptor	0.0028	0.4443	0.4382
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0525	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.4443	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.4443	1
Brugia malayi	Serotonin receptor	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	serotonin receptor	0.0028	0.4443	0.5452
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.4443	0.5452
Echinococcus granulosus	fmrfamide receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.4443	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.4443	0.4382
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.4443	0.5452
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.4443	0.4382
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0525	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.4443	1
Echinococcus multilocularis	somatostatin receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	opsin-like receptor	0.0028	0.4443	0.4382
Schistosoma mansoni	hypothetical protein	0.0028	0.4443	0.4382
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0052	0.8867	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.4443	0.5452
Brugia malayi	GnHR receptor homolog	0.0028	0.4443	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.4443	0.5452
Schistosoma mansoni	amine GPCR	0.0028	0.4443	0.4382
Schistosoma mansoni	amine GPCR	0.0028	0.4443	0.4382
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.4443	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.4443	0.5452
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0525	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.4443	0.4382
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0525	1
Schistosoma mansoni	biogenic amine receptor	0.0028	0.4443	0.4382
Brugia malayi	neuropeptide F receptor	0.0028	0.4443	1
Echinococcus granulosus	cpg binding protein	0.0029	0.4678	0.5788
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0939	0.0436
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.4443	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0525	1
Onchocerca volvulus		0.0028	0.4443	1
Schistosoma mansoni	cpg binding protein	0.0028	0.4393	0.4331
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	putative neuropeptide receptor	0.0028	0.4443	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.4443	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.4443	0.4382
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.4443	0.5452
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.4443	0.5452
Brugia malayi	larval opioid receptor	0.0028	0.4443	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.4443	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.4443	0.4382
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	cpg binding protein	0.0029	0.4678	0.4619
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.4443	1
Schistosoma mansoni	amine GPCR	0.0028	0.4443	0.4382
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.4443	0.4382
Echinococcus multilocularis	sodium channel protein	0.0045	0.7621	1
Echinococcus granulosus	orexin receptor type 2	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Echinococcus granulosus	neuropeptide receptor	0.0028	0.4443	0.5452
Echinococcus granulosus	sex peptide receptor	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.4443	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.4443	0.5452
Echinococcus granulosus	neuropeptide receptor	0.0028	0.4443	0.5452
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.4443	0.5452
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.4443	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.4443	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.4443	0.4382
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0525	1
Schistosoma mansoni	neuropeptide receptor	0.0028	0.4443	0.4382
Schistosoma mansoni	hypothetical protein	0.0028	0.4443	0.4382
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.4443	0.4382
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.4443	0.5452
Brugia malayi	Serotonin receptor	0.0028	0.4443	1
Schistosoma mansoni	neuropeptide receptor	0.0028	0.4443	0.4382
Brugia malayi	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.4443	0.4382
Onchocerca volvulus		0.0028	0.4443	1
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.4443	0.5452
Onchocerca volvulus		0.0028	0.4443	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.4443	0.5452
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.4443	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4443	1
Schistosoma mansoni	hypothetical protein	0.0028	0.4443	0.4382
Schistosoma mansoni	adenoreceptor	0.0028	0.4443	0.4382

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 20 nM	BindingDB_Patents: In Vitro Assay. 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrophysiology system in accordance with the manufacturer's specifications (Molecular Devices, LLC, Sunnyvale, Calif.). Sodium channel currents were measured in response to a train of depolarizations that induced successively greater inactivation.Cells were held at -110 mV for three seconds (Nav 1.7) or half a second (Nav 1.5) from a holding voltage of -15 mV, then put through a series of 26 pulses of 150 msec duration to -20 mV at a frequency of 5 Hz. Cells were then left unclamped for a period of 3 to 8 minutes while a single concentration of test compound was added. Cells were then reclamped and put through the same voltage protocol. Current at the end of the 26th pulse to -20 mV was subtracted from the peak current evoked by the 26th pulse to -20 mV to correct for leak current.	ChEMBL.	No reference
IC50 (binding)	> 30000 nM	BindingDB_Patents: In Vitro PX Assay. 293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system according the manufacturer's specifications (Molecular Devices, LLC, Sunnyvale, Calif.). Cells were held at a holding potential of -50 mV to inactivate sodium channels. To elicit sodium currents the voltage was changed to -120 mV to recover a portion of the channels, followed by delivery of test pulses of 20 msec duration to 0 mV, at 0.1 Hz. A single concentration of test compound was applied to cells for a duration of 5 minutes. Peak sodium current was measured at the end of the compound addition period to determine percent inhibition.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3682637

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1984799