Detailed information for compound 1986072

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 527.41 | Formula: C25H27BrN4O4
  • H donors: 1 H acceptors: 4 LogP: 2.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1ccc(nc1)COc1cnn(c(=O)c1)CC(=O)c1ccc(cc1C)CN1CCC(C1)(C)O
  • InChi: 1S/C25H27BrN4O4/c1-17-9-18(13-29-8-7-25(2,33)16-29)3-6-22(17)23(31)14-30-24(32)10-21(12-28-30)34-15-20-5-4-19(26)11-27-20/h3-6,9-12,33H,7-8,13-16H2,1-2H3
  • InChiKey: WCJMNHMPTCQAEU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0016 0.0035 0.0122
Brugia malayi follicle stimulating hormone receptor 0.019 0.143 0.3993
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0035 0.0034
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0197 0.1132
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0101 0.0566
Loa Loa (eye worm) hypothetical protein 0.0138 0.1015 0.1283
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0098 0.0689 0.0688
Trypanosoma cruzi trypanothione reductase, putative 0.0067 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0009
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0053 0.0331 0.7455
Entamoeba histolytica Flap nuclease, putative 0.002 0.0069 0.019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0035 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0851 0.6722 0.6722
Schistosoma mansoni transient receptor potential channel 0.0101 0.0715 0.0714
Brugia malayi Peptidase family M1 containing protein 0.0053 0.0331 0.0924
Schistosoma mansoni smad1 5 8 and 0.0015 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0086 0.0598 0.0756
Onchocerca volvulus 0.0058 0.0371 0.1325
Echinococcus granulosus acetylcholinesterase 0.007 0.0467 0.0466
Echinococcus granulosus neuroglian 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0113 0.0813 0.1027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0035 0.0034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0031 0.0155 0.0154
Brugia malayi TATA binding protein associated factor 0.0053 0.0331 0.0924
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.002 0.0069 0.1342
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0031 0.0155 0.0154
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0037 0.0589
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0037 0.0104
Schistosoma mansoni cpg binding protein 0.005 0.0306 0.0305
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0091 0.052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.0225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Schistosoma mansoni microtubule-associated protein tau 0.126 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0126 0.0918 0.2563
Brugia malayi MH2 domain containing protein 0.022 0.1667 0.4653
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0035 0.0098
Brugia malayi Carboxylesterase family protein 0.0012 0.0001 0.0003
Echinococcus granulosus cpg binding protein 0.005 0.0306 0.0305
Brugia malayi Thioredoxin reductase 0.0067 0.044 0.1228
Brugia malayi Carboxylesterase family protein 0.007 0.0467 0.1304
Brugia malayi steroid hormone receptor 0.0016 0.0035 0.0098
Echinococcus granulosus netrin receptor unc 5 0.0018 0.0053 0.0052
Trypanosoma brucei trypanothione reductase 0.0067 0.044 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0053 0.0331 0.7061
Echinococcus multilocularis zinc finger protein 0.002 0.0063 0.0062
Loa Loa (eye worm) TK/INSR protein kinase 0.0285 0.2187 0.2767
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0333 0.751
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0068 0.0387
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0091 0.5
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0091 0.113
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.1002 0.5784
Schistosoma mansoni transient receptor potential channel 0.0067 0.0446 0.0446
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0037 0.0289
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0037 0.0589
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0998 0.79 0.79
Brugia malayi nuclear receptor NHR-88 0.0016 0.0035 0.0098
Schistosoma mansoni hypothetical protein 0.0285 0.2191 0.219
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0035 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0035 0.0034
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0053 0.0331 0.1906
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0035 0.0098
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0081 0.1603
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0091 0.0584
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0091 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0037 0.021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.0033 0.0174 0.0219
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Echinococcus granulosus flap endonuclease 1 0.002 0.0069 0.0068
Trypanosoma cruzi Aminopeptidase M1, putative 0.0053 0.0331 0.7455
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0226 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.018 0.0179
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.002 0.0069 0.1342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.0237
Echinococcus multilocularis jun protein 0.0074 0.0498 0.0498
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0701 0.5518 0.5517
Schistosoma mansoni transient receptor potential channel 0.0068 0.0447 0.0446
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0035 0.0034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0089 0.0622 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0091 0.0254
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0715 0.0714
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0285 0.2187 0.2186
Brugia malayi MH1 domain containing protein 0.0015 0.0026 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.003 0.0165
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0447 0.0446
Schistosoma mansoni tyrosine kinase 0.0223 0.1693 0.1692
Loa Loa (eye worm) Smad1 0.0015 0.0026 0.0032
Echinococcus granulosus GPCR family 2 0.004 0.0226 0.0225
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0169 0.1259 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0053 0.0331 0.033
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0037 0.0104
Schistosoma mansoni netrin receptor unc5 0.0018 0.0053 0.0052
Toxoplasma gondii aminopeptidase N protein 0.0053 0.0331 0.4728
Echinococcus granulosus epidermal growth factor receptor 0.0332 0.2569 0.2568
Loa Loa (eye worm) hypothetical protein 0.0039 0.0217 0.0274
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0053 0.0331 0.7061
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0715 0.0714
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0081 0.0302
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0054 0.034 0.0339
Brugia malayi Heterochromatin protein 1 0.006 0.0388 0.1084
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0091 0.1848
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.0217 0.0216
Echinococcus granulosus smad 0.0015 0.0026 0.0025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0091 0.009
Schistosoma mansoni aminopeptidase A (M01 family) 0.0053 0.0331 0.033
Brugia malayi hypothetical protein 0.0459 0.3581 1
Echinococcus granulosus insulin receptor 0.0285 0.2187 0.2186
Brugia malayi chromobox protein homolog 3 0.0034 0.0176 0.0493
Trichomonas vaginalis chromobox protein, putative 0.006 0.0388 0.2237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0115 0.0824 0.0823
Brugia malayi PHD-finger family protein 0.0024 0.0099 0.0278
Plasmodium falciparum glutathione reductase 0.0023 0.0091 0.0584
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0035 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0035 0.0098
Loa Loa (eye worm) hypothetical protein 0.004 0.0226 0.0285
Echinococcus multilocularis epidermal growth factor receptor 0.0332 0.2569 0.2568
Brugia malayi hypothetical protein 0.0053 0.0331 0.0924
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0024 0.0023
Echinococcus multilocularis Ankyrin 0.0013 0.0008 0.0008
Loa Loa (eye worm) glutathione reductase 0.0067 0.044 0.0555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0824 0.0823
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Brugia malayi Death domain containing protein 0.0013 0.0008 0.0021
Leishmania major DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0053 0.0333 0.0931
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0059
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0043 0.015
Echinococcus granulosus mothers against decapentaplegic 5 0.0015 0.0026 0.0025
Schistosoma mansoni nephrin 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0126 0.0918 0.1161
Echinococcus granulosus Smad4 0.0015 0.0026 0.0025
Plasmodium vivax thioredoxin reductase, putative 0.0067 0.044 1
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0037 0.0589
Loa Loa (eye worm) hypothetical protein 0.003 0.015 0.0189
Trypanosoma brucei aminopeptidase, putative 0.0053 0.0331 0.7455
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0053 0.0331 0.7061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Brugia malayi CHD4 protein 0.0014 0.0019 0.0054
Loa Loa (eye worm) hypothetical protein 0.0101 0.0715 0.0903
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0176 0.0628
Echinococcus multilocularis smad 0.0015 0.0026 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0387
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0053 0.0331 0.1906
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.0672 0.0671
Loa Loa (eye worm) TATA binding protein associated factor 0.0053 0.0331 0.0418
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0019 0.0018
Echinococcus granulosus aminopeptidase N 0.0053 0.0331 0.033
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0206 0.0205
Schistosoma mansoni tyrosine kinase 0.0285 0.2187 0.2186
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0176 0.1014
Echinococcus multilocularis acetylcholinesterase 0.007 0.0467 0.0466
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0035 0.0034
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0013 0.0008 0.0007
Echinococcus granulosus dnaJ subfamily B 0.0651 0.5116 0.5116
Leishmania major flap endonuclease-1 (FEN-1), putative 0.002 0.0069 0.1342
Schistosoma mansoni hypothetical protein 0.006 0.0388 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0219 0.0218
Echinococcus multilocularis neuropeptide s receptor 0.0851 0.6722 0.6722
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0019 0.0018
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0053 0.0331 0.033
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0053 0.0331 0.033
Toxoplasma gondii thioredoxin reductase 0.0067 0.044 0.6695
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.0225
Brugia malayi Calcitonin receptor-like protein seb-1 0.0126 0.0918 0.2563
Echinococcus multilocularis serotonin receptor 0.0071 0.0474 0.0473
Trypanosoma brucei unspecified product 0.0016 0.0037 0.0589
Loa Loa (eye worm) hypothetical protein 0.0061 0.0396 0.05
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0035 0.0034
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0037 0.0589
Brugia malayi Phospholipase A2 family protein 0.0297 0.2283 0.6374
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0035 0.0098
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0035 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.1002 0.5784
Schistosoma mansoni hypothetical protein 0.0651 0.5116 0.5116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0333 0.751
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0053 0.0331 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.1002 0.5784
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.014 0.0804
Onchocerca volvulus 0.0026 0.0118 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0101 0.01
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0998 0.79 0.79
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.0219 0.0218
Brugia malayi Carboxylesterase family protein 0.0012 0.0001 0.0003
Echinococcus multilocularis netrin receptor unc 5 0.0018 0.0053 0.0052
Echinococcus granulosus leukotriene A 4 hydrolase 0.0998 0.79 0.79
Plasmodium falciparum thioredoxin reductase 0.0067 0.044 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0226 0.0632
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0209 0.1577 0.4403
Echinococcus multilocularis serotonin receptor 0.0071 0.0474 0.0473
Schistosoma mansoni zinc finger protein 0.002 0.0063 0.0062
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0053 0.0331 0.7455
Brugia malayi Latrophilin receptor protein 2 0.004 0.0226 0.0632
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0101 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0115 0.0824 0.1042
Loa Loa (eye worm) hypothetical protein 0.0072 0.0482 0.0609
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0035 0.0122
Echinococcus multilocularis neuroglian 0.0012 0.0003 0.0002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0054 0.034 0.0339
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0035 0.0034
Schistosoma mansoni tyrosine kinase 0.0015 0.0023 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0091 0.1848
Trichomonas vaginalis glucosylceramidase, putative 0.0144 0.1061 0.6124
Trichomonas vaginalis flap endonuclease-1, putative 0.002 0.0069 0.0395
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0026 0.0032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0091 0.5
Schistosoma mansoni DNA polymerase eta 0.0016 0.0037 0.0036
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0183 0.0182
Brugia malayi Bromodomain containing protein 0.0067 0.0446 0.1246
Brugia malayi ecdysteroid receptor 0.0016 0.0035 0.0098
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0081 0.1603
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) bromodomain containing protein 0.0015 0.0028 0.0035
Trypanosoma brucei Aminopeptidase M1, putative 0.0053 0.0331 0.7455
Schistosoma mansoni chromobox protein 0.006 0.0388 0.0387
Onchocerca volvulus Phospholipase A2 homolog 0.0297 0.2283 0.8164
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0035 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0035 0.0098
Echinococcus multilocularis dnaJ subfamily B 0.0651 0.5116 0.5116
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0091 0.113
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Mycobacterium tuberculosis Probable reductase 0.0152 0.1123 0.8921
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0005 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0005 0.0004
Schistosoma mansoni cpg binding protein 0.0046 0.0272 0.0271
Schistosoma mansoni tyrosine kinase 0.0332 0.2569 0.2568
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0206 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Echinococcus granulosus dna polymerase eta 0.0016 0.0037 0.0036
Echinococcus multilocularis carboxylesterase 5A 0.007 0.0467 0.0466
Echinococcus granulosus nuclear factor of activated T cells 5 0.0065 0.0426 0.0425
Schistosoma mansoni smad 0.0015 0.0026 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0226 0.0225
Brugia malayi Peptidase family M1 containing protein 0.0053 0.0331 0.0924
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0086 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0035 0.0098
Echinococcus multilocularis thioredoxin glutathione reductase 0.0067 0.0443 0.0442
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0446 0.0446
Onchocerca volvulus 0.0053 0.0331 0.118
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0197 0.0701
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0042 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0035 0.0034
Echinococcus multilocularis dna polymerase eta 0.0016 0.0037 0.0036
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0015 0.0026 0.0025
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0111 0.0798 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0035 0.0034
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0053 0.0331 0.7455
Loa Loa (eye worm) thioredoxin reductase 0.0067 0.044 0.0555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Loa Loa (eye worm) hypothetical protein 0.0361 0.2796 0.3538
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0053 0.0333 0.0421
Brugia malayi MH2 domain containing protein 0.0015 0.0026 0.0073
Echinococcus multilocularis roundabout 2 0.0018 0.0048 0.0047
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Schistosoma mansoni tyrosine kinase 0.0218 0.1656 0.1655
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0053 0.0333 0.751
Echinococcus granulosus thioredoxin glutathione reductase 0.0067 0.0443 0.0442
Entamoeba histolytica aminopeptidase, putative 0.0053 0.0331 0.1732
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0053 0.0331 0.7455
Schistosoma mansoni hypothetical protein 0.0013 0.0012 0.0011
Schistosoma mansoni zinc finger protein 0.0013 0.0012 0.0011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0004 0.0003
Schistosoma mansoni smad1 5 8 and 0.0015 0.0026 0.0025
Echinococcus granulosus carboxylesterase 5A 0.007 0.0467 0.0466
Trypanosoma cruzi aminopeptidase, putative 0.0053 0.0331 0.7455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0038 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0081 0.0302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Schistosoma mansoni vesicular amine transporter 0.0013 0.001 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0152 0.1123 0.8921
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0035 0.0098
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0035 0.0034
Brugia malayi hypothetical protein 0.0058 0.0371 0.1037
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0013 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0098 0.0558
Echinococcus multilocularis aminopeptidase N 0.0053 0.0331 0.033
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0065 0.0426 0.0425
Echinococcus granulosus zinc finger protein 0.002 0.0063 0.0062
Loa Loa (eye worm) heterochromatin protein 1 0.006 0.0388 0.049
Onchocerca volvulus 0.0053 0.0331 0.118
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0091 0.0391
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0053 0.0331 0.7455
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0035 0.0098
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0074 0.0498 0.0498
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0053 0.0331 0.7455
Brugia malayi nuclear hormone receptor 0.0016 0.0035 0.0098
Loa Loa (eye worm) follicle stimulating hormone receptor 0.019 0.143 0.1809
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0091 0.1848
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0019 0.0018
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0998 0.79 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0035 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0226 0.0225
Schistosoma mansoni hypothetical protein 0.0086 0.0598 0.0597
Echinococcus multilocularis flap endonuclease 1 0.002 0.0069 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0126 0.0918 0.1161
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.003 0.0165
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0053 0.0331 0.7455
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0053 0.0331 0.7455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0219 0.0218
Echinococcus multilocularis cpg binding protein 0.005 0.0306 0.0305
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0152 0.1123 0.8921
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0035 0.0098
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0037 0.0036
Echinococcus granulosus Ankyrin 0.0013 0.0008 0.0008
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0053 0.0333 0.0332
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0387
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0035 0.0122
Echinococcus granulosus roundabout 2 0.0018 0.0048 0.0047
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0013 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0223 0.1693 0.1692
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0035 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0091 0.1848
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0053 0.0147
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0042 0.0117
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0013 0.0012 0.0011
Plasmodium vivax SET domain protein, putative 0.0024 0.0101 0.0845
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0091 0.1848
Giardia lamblia Fructose-bisphosphate aldolase 0.0228 0.1732 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Brugia malayi Pre-SET motif family protein 0.0024 0.0101 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0447 0.0446
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0228 0.1732 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0053 0.0333 0.0332
Onchocerca volvulus Glucosylceramidase homolog 0.0137 0.1002 0.3583
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0035 0.0043
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0037 0.0455
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0004 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0035 0.0043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0071 0.0474 0.0473
Loa Loa (eye worm) CXXC zinc finger family protein 0.0046 0.0272 0.0343
Loa Loa (eye worm) hypothetical protein 0.0062 0.0404 0.051
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Echinococcus granulosus biogenic amine 5HT receptor 0.0071 0.0474 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0144 0.1061 0.6124
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0035 0.0034
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0091 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.1002 0.5784
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0037 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.1577 0.9101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0035 0.0043
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0015 0.0024 0.0023
Echinococcus granulosus twitchin 0.0012 0.0003 0.0002
Treponema pallidum fructose-bisphosphate aldolase 0.0228 0.1732 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0015 0.0024 0.0023
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0074 0.0498 0.0498
Echinococcus granulosus jun protein 0.0074 0.0498 0.0498
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0091 0.1848
Schistosoma mansoni smad1 5 8 and 0.0015 0.0026 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.1577 0.9101
Loa Loa (eye worm) peptidase family M1 containing protein 0.0053 0.0331 0.0418
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0005 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0091 0.0584
Echinococcus multilocularis chromobox protein 1 0.006 0.0388 0.0387
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0037 0.0455
Loa Loa (eye worm) hypothetical protein 0.0053 0.0331 0.0418
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0053 0.0331 0.1906
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0152 0.1123 0.8921
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0228 0.1732 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0013 0.0008 0.0007
Schistosoma mansoni chromobox protein 0.006 0.0388 0.0387
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0163 0.1215 0.1536
Brugia malayi latrophilin 2 splice variant baaae 0.0086 0.0598 0.167
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0083 0.0082
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0223 0.1693 0.1692
Mycobacterium ulcerans aminopeptidase N PepN 0.0053 0.0331 0.4138
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0276
Echinococcus granulosus epidermal growth factor receptor 0.0223 0.1693 0.1692
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0824 0.0823
Loa Loa (eye worm) hypothetical protein 0.0297 0.2283 0.2889
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0068 0.0387
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0037 0.0589
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0035 0.0098
Brugia malayi hypothetical protein 0.0022 0.0081 0.0225
Schistosoma mansoni Smad4 0.0015 0.0026 0.0025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0004 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0186 0.1394 0.8047
Brugia malayi Protein kinase domain containing protein 0.0013 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.059
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0467 0.0466
Brugia malayi Protein kinase domain containing protein 0.0285 0.2187 0.6105
Loa Loa (eye worm) transcription factor SMAD2 0.022 0.1667 0.2109
Loa Loa (eye worm) hypothetical protein 0.0071 0.0474 0.0598
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0053 0.0333 0.1746
Schistosoma mansoni jun-related protein 0.006 0.0388 0.0387
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0333 0.751
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0285 0.2187 0.2186
Echinococcus multilocularis epidermal growth factor receptor 0.0223 0.1693 0.1692
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0026 0.0025
Brugia malayi MH2 domain containing protein 0.0015 0.0026 0.0073
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0053 0.0331 0.7455
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0035 0.0034
Brugia malayi Transient-receptor-potential like protein 0.0039 0.0217 0.0607
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0035 0.0098
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0715 0.0714
Echinococcus multilocularis acetylcholinesterase 0.007 0.0467 0.0466
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0037 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0851 0.6722 0.6722
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0037 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.1002 0.5784
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0005 0.0004
Plasmodium falciparum thioredoxin reductase 0.0023 0.0091 0.0584
Onchocerca volvulus 0.0046 0.0272 0.097
Echinococcus multilocularis mothers against decapentaplegic 5 0.0015 0.0026 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0035 0.0034
Echinococcus granulosus transcription factor Dp 1 0.0031 0.0153 0.0152
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0091 0.0716
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0148
Echinococcus multilocularis geminin 0.0285 0.2191 0.219
Giardia lamblia Flap structure-specific endonuclease 0.002 0.0069 0.019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0037 0.0036
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0152 0.1123 0.7052
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.014 0.0804
Loa Loa (eye worm) hypothetical protein 0.0071 0.0474 0.0598
Echinococcus granulosus neuropeptide s receptor 0.0851 0.6722 0.6722
Echinococcus granulosus dna polymerase kappa 0.0016 0.0037 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0035 0.0034
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0026 0.0025
Loa Loa (eye worm) acetylcholinesterase 1 0.007 0.0467 0.059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0115 0.0824 0.2301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0273 0.2095 0.5849
Loa Loa (eye worm) hypothetical protein 0.0297 0.2283 0.2889
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0183 0.0182
Leishmania major hypothetical protein, conserved 0.0022 0.0081 0.1603
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Loa Loa (eye worm) flap endonuclease-1 0.002 0.0069 0.0087
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0083 0.0082
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0152 0.1123 0.8921
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0101
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0169 0.1259 1
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0049 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0081 0.1603
Onchocerca volvulus 0.0186 0.1395 0.4988
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Brugia malayi MH1 domain containing protein 0.0015 0.0026 0.0073
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0015 0.0026 0.0025
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0037 0.021
Loa Loa (eye worm) carboxylesterase 0.007 0.0467 0.059
Onchocerca volvulus Tyrosine kinase homolog 0.0264 0.2024 0.7237
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0035 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0091 0.1848
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0035 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0081 0.0302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0115 0.0824 0.0823
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0226 0.0225
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0091 0.1848
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0387
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0004 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0037 0.0589
Loa Loa (eye worm) hypothetical protein 0.0039 0.0222 0.028
Echinococcus multilocularis microtubule associated protein 2 0.126 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0091 0.0584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0035 0.0043
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0083 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.0219 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0035 0.0098
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.1577 0.9101
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0091 0.113
Schistosoma mansoni flap endonuclease-1 0.0018 0.0054 0.0053
Brugia malayi bZIP transcription factor family protein 0.0074 0.0498 0.1392
Onchocerca volvulus 0.0361 0.2796 1
Brugia malayi Carboxylesterase family protein 0.0012 0.0001 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0035 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0098 0.0558
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0091 0.0318
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0209 0.1577 0.1995
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0387
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0091 0.0584
Mycobacterium ulcerans aminopeptidase N PepN 0.0053 0.0331 0.4138
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.1577 0.9101
Schistosoma mansoni cpg binding protein 0.005 0.0306 0.0305
Brugia malayi Flap endonuclease-1 0.002 0.0069 0.0194
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0043
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0035 0.0183 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0035 0.0098
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0446 0.0446
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0005 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0015 0.0024 0.0023
Schistosoma mansoni tyrosine kinase 0.0218 0.1656 0.1655
Echinococcus multilocularis Smad4 0.0015 0.0026 0.0025
Echinococcus multilocularis transcription factor Dp 1 0.0031 0.0153 0.0152
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0091 0.052
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0035 0.0183 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0824 0.0823
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0226 0.0285
Toxoplasma gondii aminopeptidase N, putative 0.0053 0.0331 0.4728
Schistosoma mansoni tyrosine kinase 0.0218 0.1656 0.1655
Trypanosoma cruzi aminopeptidase, putative 0.0053 0.0331 0.7455
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0005 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0035 0.0034
Brugia malayi hypothetical protein 0.0014 0.0019 0.0053
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0035 0.0043
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0053 0.0331 0.7455
Brugia malayi Furin-like cysteine rich region family protein 0.0332 0.2569 0.7172
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0035 0.0034
Brugia malayi Smad1 0.0015 0.0026 0.0073
Echinococcus multilocularis chromobox protein 1 0.006 0.0388 0.0387
Schistosoma mansoni ankyrin 23/unc44 0.0013 0.0008 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0035 0.0034
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.0672 0.0671
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0035 0.0034
Echinococcus granulosus geminin 0.0285 0.2191 0.219
Loa Loa (eye worm) aminopeptidase N 0.0053 0.0331 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0035 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.1002 0.5784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0035 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Onchocerca volvulus 0.0053 0.0331 0.118
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0035 0.0034
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0035 0.0034
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0273 0.2095 0.2651
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0037 0.0036
Brugia malayi Uncoordinated protein 44 0.0013 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0172 0.0216
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Onchocerca volvulus Phospholipase A2 homolog 0.0297 0.2283 0.8164
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0053 0.0333 0.0332
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.013
Echinococcus granulosus chromobox protein 1 0.006 0.0388 0.0387
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0067 0.044 0.3488
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0081 0.0202
Schistosoma mansoni bromodomain containing protein 0.0057 0.0365 0.0364
Leishmania major trypanothione reductase 0.0067 0.044 1
Schistosoma mansoni tyrosine kinase 0.0285 0.2187 0.2186
Loa Loa (eye worm) MH2 domain-containing protein 0.022 0.1667 0.2109
Toxoplasma gondii aminopeptidase n, putative 0.0053 0.0331 0.4728
Brugia malayi hypothetical protein 0.0361 0.2796 0.7807
Loa Loa (eye worm) hypothetical protein 0.0053 0.0331 0.0418
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Brugia malayi hypothetical protein 0.0053 0.0331 0.0924
Schistosoma mansoni hypothetical protein 0.0285 0.2191 0.219
Trichomonas vaginalis chromobox protein, putative 0.006 0.0388 0.2237
Plasmodium vivax glutathione reductase, putative 0.0067 0.044 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0228 0.1732 1
Brugia malayi Carboxylesterase family protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0152 0.1123 0.8921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0115 0.0824 0.0823
Echinococcus granulosus chromobox protein 1 0.006 0.0388 0.0387
Brugia malayi hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) TK/EGFR protein kinase 0.0332 0.2569 0.3251
Brugia malayi glutathione reductase 0.0067 0.044 0.1228
Echinococcus multilocularis insulin receptor 0.0285 0.2187 0.2186
Brugia malayi Peptidase family M1 containing protein 0.0053 0.0331 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Leishmania major DNA polymerase eta, putative 0.0016 0.0037 0.0589
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0169 0.1259 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.0387
Brugia malayi CXXC zinc finger family protein 0.0046 0.0272 0.076
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0091 0.1848
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0091 0.0391
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0035 0.0034
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0059
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0019 0.0023
Onchocerca volvulus 0.0255 0.1952 0.698
Echinococcus multilocularis GPCR, family 2 0.004 0.0226 0.0225
Loa Loa (eye worm) hypothetical protein 0.0053 0.0331 0.0418
Plasmodium falciparum glutathione reductase 0.0067 0.044 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0035 0.0098
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0111 0.0798 0.6338
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0053 0.0331 0.7061
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0331 0.033
Schistosoma mansoni cell adhesion molecule 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0222
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0091 0.1848
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.0217 0.0216
Echinococcus granulosus acetylcholinesterase 0.007 0.0467 0.0466
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0035 0.0043
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Brugia malayi Carboxylesterase family protein 0.007 0.0467 0.1304
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0176 0.1014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0091 0.5
Loa Loa (eye worm) histone methyltransferase 0.0015 0.0026 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.1577 0.9101
Echinococcus granulosus TGF beta signal transducer SmadC 0.0015 0.0026 0.0025
Brugia malayi Bromodomain containing protein 0.0033 0.0171 0.0478
Brugia malayi Pre-SET motif family protein 0.0163 0.1215 0.3391
Trypanosoma brucei Aminopeptidase M1, putative 0.0053 0.0331 0.7455
Brugia malayi Protein kinase domain containing protein 0.0118 0.0849 0.2371
Echinococcus multilocularis 0.01 0.071 0.0709
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.1577 0.9101
Trichomonas vaginalis glucosylceramidase, putative 0.0137 0.1002 0.5784
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0589
Echinococcus granulosus death domain containing protein 0.0013 0.0008 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0026 0.0032
Schistosoma mansoni coup transcription factor 0.0016 0.0035 0.0034
Onchocerca volvulus 0.0034 0.018 0.0639
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0197 0.1132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0115 0.0824 0.0823
Mycobacterium tuberculosis Probable oxidoreductase 0.0169 0.1259 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0035 0.0034

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18 nM BindingDB_Patents: Binding Assay. Membranes from CHO/Galpha16 cells stably transfected with human hMCH-1R are resuspended using a syringe (needle 0.6x25 mm) and diluted in test buffer (50 mM HEPES, 10 mM MgCl2, 2 mM EGTA, pH 7.00; 0.1% bovine serum albumin (protease-free), 0.021% bacitracin, 1 ug/ml aprotinin, 1 ug/ml leupeptin and 1 uM phosphoramidone) to a concentration of 5 to 15 ug/ml. 200 microliters of this membrane fraction (contains 1 to 3 ug of protein) are incubated for 60 minutes at ambient temperature with 100 pM of 125I-tyrosyl melanin concentrating hormone (125I-MCH commercially obtainable from NEN) and increasing concentrations of the test compound in a final volume of 250 microliters. After the incubation the reaction is filtered using a cell harvester through 0.5% PEI treated fibreglass filters (GF/B, Unifilter Packard). The membrane-bound radioactivity retained on the filter is then determined after the addition of scintillator substance (Packard Microscint 20). ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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