Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis familiaris | Transient receptor potential M8 protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1114 aa | 24.9 % |
Echinococcus multilocularis | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1108 aa | 25.5 % |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | Transient receptor potential M8 protein | 1104 aa | 1075 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.022 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.022 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.022 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.022 | 0.5 | 0.5 |
Onchocerca volvulus | 0.022 | 0.5 | 0.5 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.022 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.022 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.022 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.022 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.022 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.022 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.022 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.022 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.022 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.022 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 32.8 nM | BindingDB_Patents: FLIPR Assay. The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dye. The changes in fluorescent signal were monitored by a fluorescence plate reader, either a FLIPR (Molecular Devices) or FDSS (Hamamatsu). Increases in intracellular Ca2+ concentration were readily detected upon activation with icilin.At 24 hrs prior to assay, HEK293 cells stably expressing canine TRPM8 were seeded in culture medium in black wall, clear-base poly-D-lysine coated 384-well plates (BD Biosciences, NJ, USA) and grown overnight in 5% CO2 at 37° C. On assay day, growth media was removed and cells were loaded with Calcium 3 Dye (Molecular Devices) for 35 min at 37° C., under 5% CO2 and then for 25 min at room temperature and atmosphere. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.