Detailed information for compound 1990819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 482.615 | Formula: C27H38N4O4
  • H donors: 1 H acceptors: 3 LogP: 3.05 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@H]1CN([C@H]2[C@@H]1OCC2=O)C(=O)[C@H](C1CCCC1)NC(=O)c1ccc(cc1)N1CCN(CC1)C
  • InChi: 1S/C27H38N4O4/c1-3-18-16-31(24-22(32)17-35-25(18)24)27(34)23(19-6-4-5-7-19)28-26(33)20-8-10-21(11-9-20)30-14-12-29(2)13-15-30/h8-11,18-19,23-25H,3-7,12-17H2,1-2H3,(H,28,33)/t18-,23-,24+,25+/m0/s1
  • InChiKey: NXBUCHQUCFKIDV-URPHZZJISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0027 0.1418 0.2031
Treponema pallidum NADH oxidase 0.0015 0.0524 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.2027 0.1978
Brugia malayi Cathepsin L-like precursor 0.0027 0.1418 0.1317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.6635 0.659
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1418 0.5491
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Loa Loa (eye worm) hypothetical protein 0.0018 0.0775 0.0667
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.2027 0.7638
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.2569 0.2544
Loa Loa (eye worm) hypothetical protein 0.0109 0.7345 0.7314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.6635 0.6793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0775 0.2972
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1418 0.1302
Brugia malayi CXXC zinc finger family protein 0.0062 0.3941 0.387
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0475 0.0475
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.1418 0.1317
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.2027 0.1959
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0524 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Brugia malayi glutathione reductase 0.0042 0.2507 0.2419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0775 0.0667
Plasmodium vivax vivapain-2 0.0027 0.1418 0.5308
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.7345 0.7314
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.2311 0.4471
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Entamoeba histolytica cysteine proteinase 1, putative 0.0014 0.0475 0.0919
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.6393 0.8902
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.2569 0.2665
Echinococcus granulosus cathepsin l1 0.0018 0.0775 0.067
Onchocerca volvulus 0.0027 0.1418 0.2031
Schistosoma mansoni cpg binding protein 0.0065 0.4196 0.4196
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0775 0.2756
Schistosoma mansoni apoferritin-2 0.0009 0.0133 0.0133
Mycobacterium tuberculosis Probable reductase 0.0096 0.6393 0.8902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.3941 0.387
Schistosoma mansoni cathepsin s 0.0009 0.0116 0.0116
Echinococcus multilocularis cathepsin L 0.0014 0.0475 0.0346
Brugia malayi Isocitrate dehydrogenase 0.0035 0.2027 0.1933
Plasmodium falciparum cysteine proteinase falcipain 1 0.0014 0.0475 0.1894
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0014 0.0475 0.1501
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.2027 0.1919
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.2507 1
Echinococcus multilocularis cpg binding protein 0.0065 0.4196 0.4117
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.9705 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0775 0.0775
Echinococcus multilocularis GPCR, family 2 0.0035 0.1964 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0583 0.0456
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Schistosoma mansoni hypothetical protein 0.0075 0.4854 0.4854
Plasmodium falciparum glutathione reductase 0.0015 0.0524 0.2091
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.2027 0.1919
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0524 0.1708
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.5168 0.526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.2027 0.7791
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.1964 0.1869
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0524 0.1665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Loa Loa (eye worm) hypothetical protein 0.0027 0.1418 0.1317
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.2027 0.1919
Leishmania major cysteine peptidase A (CPA) 0.0027 0.1418 0.4507
Echinococcus granulosus cathepsin L 0.0014 0.0475 0.0357
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0524 0.0396
Brugia malayi Thioredoxin reductase 0.0042 0.2507 0.2419
Schistosoma mansoni ferritin 0.0009 0.0133 0.0133
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1418 0.5445
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.2027 0.7638
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1418 0.2031
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.2027 0.1933
Schistosoma mansoni ferritin 0.0009 0.0133 0.0133
Entamoeba histolytica cysteine proteinase 2 0.0014 0.0475 0.0919
Trypanosoma cruzi cysteine proteinase, putative 0.0014 0.0475 0.1501
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1418 0.1302
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.6635 0.6596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0524 0.1708
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.2027 0.7579
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1418 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Mycobacterium tuberculosis Probable oxidoreductase 0.0107 0.7166 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.6393 0.8902
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0485 0.1838
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0107 0.7166 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1418 0.5445
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.8196 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0524 0.1708
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.2311 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.2547 0.2522
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.1418 0.5445
Brugia malayi Cathepsin L-like precursor 0.0027 0.1418 0.1317
Echinococcus granulosus cysteine protease 0.0014 0.0475 0.0357
Toxoplasma gondii cathepsin CPL 0.0027 0.1418 0.1165
Brugia malayi Cathepsin L-like precursor 0.0027 0.1418 0.1317
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.1964 0.1855
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Trypanosoma brucei trypanothione reductase 0.0042 0.2507 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.1418 0.1317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.0079 0.5168 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.1418 0.2743
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.5168 0.5168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0524 0.0243
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1418 0.1302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0524 0.1708
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.2027 0.7993
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Echinococcus multilocularis cysteine protease 0.0027 0.1418 0.1302
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0475 0.0919
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.1964 0.1912
Plasmodium vivax glutathione reductase, putative 0.0042 0.2507 0.9748
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.2027 0.7993
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0475 0.0919
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.6393 0.8902
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0485 0.1838
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1418 0.2743
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1418 0.5491
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.1418 0.1342
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0524 0.1991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0485 0.1838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Loa Loa (eye worm) cysteine protease 0.0027 0.1418 0.1317
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.2507 0.2419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0475 0.1797
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.2311 0.9218
Trichomonas vaginalis helicase, putative 0.0014 0.0485 0.1838
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0475 0.1501
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0524 1
Plasmodium vivax vivapain-2 0.0027 0.1418 0.5308
Brugia malayi Cathepsin L-like precursor 0.0027 0.1418 0.1317
Plasmodium falciparum thioredoxin reductase 0.0015 0.0524 0.2091
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.6393 0.8902
Onchocerca volvulus Cathepsin F homolog 0.0027 0.1418 0.2031
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Entamoeba histolytica hypothetical protein 0.0079 0.5168 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.1418 0.1317
Brugia malayi isocitrate dehydrogenase 0.0035 0.2027 0.1933
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0475 0.0363
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0475 0.0919
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.1418 0.1317
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0524 0.2091
Plasmodium vivax vivapain-3 0.0014 0.0475 0.1463
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0524 0.1708
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1418 0.1302
Schistosoma mansoni ferritin 0.0009 0.0133 0.0133
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0524 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.6635 0.6635
Schistosoma mansoni ferritin light chain 0.0009 0.0133 0.0133
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0524 0.0524
Schistosoma mansoni hypothetical protein 0.0035 0.1964 0.1964
Onchocerca volvulus 0.0027 0.1418 0.2031
Schistosoma mansoni hypothetical protein 0.0079 0.5168 0.5168
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.1418 0.1317
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0475 0.0363
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.6635 0.6793
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.1418 0.5656
Brugia malayi cathepsin L-like precursor 0.0018 0.0775 0.0667
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0524 0.0243
Echinococcus granulosus cathepsin L cysteine protease 0.0014 0.0475 0.0357
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.2507 0.9748
Schistosoma mansoni cpg binding protein 0.0062 0.3941 0.3941
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0855 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0583 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.6635 0.6635
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0485 0.1838
Loa Loa (eye worm) hypothetical protein 0.0035 0.1964 0.1869
Loa Loa (eye worm) acetyltransferase 0.0146 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.2569 0.2665
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0524 0.1708
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0855 0.0748
Schistosoma mansoni hypothetical protein 0.0035 0.1964 0.1964
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0475 0.0475
Onchocerca volvulus 0.0027 0.1418 0.2031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.6635 0.6635
Echinococcus granulosus GPCR family 2 0.0035 0.1964 0.1912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0107 0.7166 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Entamoeba histolytica hypothetical protein 0.0079 0.5168 1
Schistosoma mansoni ferritin light chain 0.0009 0.0133 0.0133
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.2507 0.3375
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0475 0.1797
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0524 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.6393 0.8902
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0524 0.0413
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0583 0.0456
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0775 0.0667
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0485 0.1838
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.7345 0.7314
Schistosoma mansoni hypothetical protein 0.0035 0.1964 0.1964
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0855 0.0754
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0485 0.1838
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0475 0.0919
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0475 0.0475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.2027 0.1959
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.2027 0.8085
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0524 1
Toxoplasma gondii thioredoxin reductase 0.0042 0.2507 0.2584
Echinococcus granulosus cpg binding protein 0.0065 0.4196 0.4244
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0583 0.047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0524 0.1708
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Schistosoma mansoni cpg binding protein 0.0065 0.4196 0.4196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.7345 0.7314
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1418 0.2031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.2027 0.1919
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.2547 0.2447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.2569 1
Onchocerca volvulus 0.0027 0.1418 0.2031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.2027 0.2027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0775 0.2972
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Brugia malayi Cathepsin L-like precursor 0.0018 0.0775 0.0667
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.1964 0.1869
Schistosoma mansoni apoferritin-2 0.0009 0.0133 0.0133
Onchocerca volvulus 0.0027 0.1418 0.2031
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0524 0.1665
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.1964 0.1855
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0583 0.047
Leishmania major cathepsin L-like protease 0.0027 0.1418 0.4507
Trypanosoma cruzi cysteine proteinase, putative 0.0014 0.0475 0.1501
Plasmodium vivax unspecified product 0.0014 0.0475 0.1463
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1418 0.1418
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.1418 0.5656
Brugia malayi hypothetical protein 0.0079 0.5168 0.5112
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.6393 0.8902
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Trichomonas vaginalis ferritin, putative 0.0009 0.0133 0.0459
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0524 1
Brugia malayi Latrophilin receptor protein 2 0.0035 0.1964 0.1869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0524 0.1708
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.2027 0.1919
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.2569 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0775 0.1499
Loa Loa (eye worm) hypothetical protein 0.0075 0.4854 0.4794
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0485 0.1838
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1418 0.5445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.6635 0.659
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.2569 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.1964 0.1912
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0524 0.2091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0485 0.1838
Loa Loa (eye worm) ctsf protein 0.0027 0.1418 0.1317
Leishmania major trypanothione reductase 0.0042 0.2507 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1418 0.5445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0107 0.7166 1
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.4854 0.4794
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.6635 0.6596
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.895 0.895
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0838 0.073
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Loa Loa (eye worm) hypothetical protein 0.0018 0.0775 0.0667
Trypanosoma cruzi cysteine protease, putative 0.0014 0.0475 0.1501
Plasmodium falciparum thioredoxin reductase 0.0042 0.2507 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1418 0.2743
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0245 0.0131
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0524 0.0243
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.1418 0.5656
Echinococcus multilocularis cysteine protease 0.0027 0.1418 0.1302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1418 0.5491
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0524 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1418 0.5491
Brugia malayi Cathepsin L-like precursor 0.0018 0.0775 0.0667
Plasmodium falciparum glutathione reductase 0.0042 0.2507 1
Schistosoma mansoni hypothetical protein 0.0035 0.1964 0.1964
Plasmodium vivax vivapain-1 0.0014 0.0475 0.1463
Loa Loa (eye worm) glutathione reductase 0.0042 0.2507 0.2419
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0524 0.0243
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.2027 0.2693
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0524 0.1708
Onchocerca volvulus 0.0062 0.3941 1
Onchocerca volvulus 0.0027 0.1418 0.2031
Echinococcus granulosus cathepsin l1 0.0027 0.1418 0.1342
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.1418 0.1342
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0485 0.1838
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0524 0.1991
Entamoeba histolytica hypothetical protein 0.0079 0.5168 1
Schistosoma mansoni ferritin 0.0009 0.0133 0.0133
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0524 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1418 0.4641
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.5168 0.5103
Loa Loa (eye worm) fibroinase 0.0027 0.1418 0.1317
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0245 0.0131
Entamoeba histolytica cysteine protease, putative 0.0014 0.0475 0.0919

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.4 nM BindingDB_Patents: In Vitro Inhibition Assay. In vitro cathepsin inhibition assay. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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