Detailed information for compound 1991074

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1058.2 | Formula: C49H71N17O10
  • H donors: 15 H acceptors: 10 LogP: -2.11 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(=O)NC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC1=O)Cc1ccccc1)CCCNC(=N)N)Cc1c[nH]c2c1cccc2)C(=O)N)NC(=O)[C@@H](NC(=O)C)CCCNC(=N)N
  • InChi: 1S/C49H71N17O10/c1-27(67)58-26-39-47(76)63-36(22-29-12-4-3-5-13-29)44(73)62-35(18-11-21-57-49(53)54)43(72)64-37(23-30-25-59-32-15-7-6-14-31(30)32)45(74)61-33(41(50)70)16-8-9-19-55-40(69)24-38(46(75)66-39)65-42(71)34(60-28(2)68)17-10-20-56-48(51)52/h3-7,12-15,25,33-39,59H,8-11,16-24,26H2,1-2H3,(H2,50,70)(H,55,69)(H,58,67)(H,60,68)(H,61,74)(H,62,73)(H,63,76)(H,64,72)(H,65,71)(H,66,75)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36+,37-,38-,39-/m0/s1
  • InChiKey: UPHFRJYMAKTAEP-WNZMCKAXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0242 0.0242
Echinococcus granulosus sodium and chloride dependent glycine 0.0072 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis dro:myosuppressin receptor 0.0091 0.0242 0.0242
Echinococcus multilocularis sodium and chloride dependent glycine 0.0072 0.0019 0.0019
Brugia malayi Dopamine receptor protein 2 0.0091 0.0242 0.0427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0072 0.0019 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0242 0.0242
Onchocerca volvulus 0.0091 0.0242 0.0595
Mycobacterium ulcerans carboxylesterase, LipT 0.007 0 0.5
Onchocerca volvulus 0.0091 0.0242 0.0595
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0072 0.0019 0.0046
Onchocerca volvulus 0.0072 0.0019 0.0046
Echinococcus granulosus tachykinin peptides receptor 99D 0.0091 0.0242 0.0242
Echinococcus multilocularis g-protein coupled receptor 0.0091 0.0242 0.0242
Onchocerca volvulus Neuropeptide F receptor homolog 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0072 0.0019 0.0046
Echinococcus granulosus G protein coupled receptor 139 0.0091 0.0242 0.0242
Brugia malayi G-protein coupled receptor 0.0091 0.0242 0.0427
Echinococcus granulosus neuropeptide FF receptor 2 0.0091 0.0242 0.0242
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0091 0.0242 0.0595
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Onchocerca volvulus 0.0091 0.0242 0.0595
Schistosoma mansoni amine GPCR 0.0091 0.0242 0.0595
Schistosoma mansoni hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0072 0.0019 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0242 0.0242
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0242 0.0242
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0072 0.0019 0.0046
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0423 0.4065 1
Brugia malayi putative neuropeptide receptor NPR1 0.0091 0.0242 0.0427
Echinococcus multilocularis acetylcholinesterase 0.0415 0.3977 0.3977
Treponema pallidum sodium- and chloride- dependent transporter 0.0423 0.4065 0.5
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0072 0.0019 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0242 0.0595
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis serotonin receptor 0.0091 0.0242 0.0242
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0091 0.0242 0.0595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Brugia malayi Carboxylesterase family protein 0.0415 0.3977 0.7022
Echinococcus granulosus somatostatin receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0091 0.0242 0.0595
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0091 0.0242 0.0427
Echinococcus granulosus fmrfamide receptor 0.0091 0.0242 0.0242
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Schistosoma mansoni sodium/chloride dependent transporter 0.0072 0.0019 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0242 0.0242
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0072 0.0019 0.0019
Onchocerca volvulus 0.0091 0.0242 0.0595
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0242 0.0242
Brugia malayi Carboxylesterase family protein 0.0415 0.3977 0.7022
Brugia malayi Serotonin receptor 0.0091 0.0242 0.0427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Schistosoma mansoni hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni amine GPCR 0.0091 0.0242 0.0595
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0242 0.0242
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0091 0.0242 0.0595
Echinococcus granulosus neuropeptide receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0242 0.0595
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0091 0.0242 0.0595
Echinococcus granulosus g protein coupled receptor 0.0091 0.0242 0.0242
Onchocerca volvulus 0.0091 0.0242 0.0595
Brugia malayi AKH receptor 0.0091 0.0242 0.0427
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0091 0.0242 0.0242
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0072 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Onchocerca volvulus 0.0091 0.0242 0.0595
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Plasmodium falciparum transporter, putative 0.0072 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni sodium/chloride dependent transporter 0.0423 0.4065 1
Schistosoma mansoni opsin-like receptor 0.0091 0.0242 0.0595
Schistosoma mansoni neuropeptide receptor 0.0091 0.0242 0.0595
Brugia malayi larval opioid receptor 0.0091 0.0242 0.0427
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0242 0.0242
Brugia malayi Tachykinin-like peptides receptor 99D 0.0091 0.0242 0.0427
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0091 0.0242 0.0595
Echinococcus granulosus neuropeptide receptor 0.0091 0.0242 0.0242
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0091 0.0242 0.0242
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0072 0.0019 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0072 0.0019 0.0046
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0072 0.0019 0.0046
Brugia malayi neuropeptide F receptor 0.0091 0.0242 0.0427
Mycobacterium tuberculosis Carboxylesterase LipT 0.007 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0091 0.0242 0.0242
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) norepinephrine transporter 0.0423 0.4065 1
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0072 0.0019 0.0046
Brugia malayi G-protein coupled receptor 0.0091 0.0242 0.0427
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.007 0 0.5
Brugia malayi neuropeptide F receptor 0.0091 0.0242 0.0427
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.0242 0.0242
Echinococcus granulosus serotonin receptor 0.0091 0.0242 0.0242
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0091 0.0242 0.0242
Echinococcus granulosus acetylcholinesterase 0.0415 0.3977 0.3977
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0072 0.0019 0.0046
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0072 0.0019 0.0046
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0072 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0423 0.4065 1
Brugia malayi follicle stimulating hormone receptor 0.0091 0.0242 0.0427
Onchocerca volvulus 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0091 0.0242 0.0595
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0072 0.0019 0.0019
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0415 0.3977 0.9784
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0091 0.0242 0.0427
Echinococcus multilocularis neuropeptide receptor A26 0.0091 0.0242 0.0242
Brugia malayi Serotonin receptor 0.0561 0.5663 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0091 0.0242 0.0595
Brugia malayi G protein-coupled receptor 0.0091 0.0242 0.0427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0072 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.0415 0.3977 0.9784
Echinococcus granulosus g-protein coupled receptor 0.0091 0.0242 0.0242
Echinococcus multilocularis somatostatin receptor 0.0091 0.0242 0.0242
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Schistosoma mansoni biogenic amine receptor 0.0091 0.0242 0.0595
Echinococcus granulosus neuropeptide receptor A26 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni amine GPCR 0.0091 0.0242 0.0595
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0091 0.0242 0.0427
Echinococcus granulosus peptide allatostatin:somatostatin 0.0091 0.0242 0.0242
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.0242 0.0595
Echinococcus multilocularis carboxylesterase 5A 0.0415 0.3977 0.3977
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0072 0.0019 0.0033
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis allatostatin A receptor 0.0091 0.0242 0.0242
Onchocerca volvulus 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0091 0.0242 0.0595
Echinococcus multilocularis sodium and chloride dependent glycine 0.0072 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis acetylcholinesterase 0.0415 0.3977 0.3977
Brugia malayi putative neuropeptide receptor 0.0091 0.0242 0.0427
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0091 0.0242 0.0595
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0937 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Echinococcus granulosus orexin receptor type 2 0.0091 0.0242 0.0242
Schistosoma mansoni sodium/chloride dependent transporter 0.0072 0.0019 0.0046
Schistosoma mansoni histamine h1 receptor 0.0091 0.0242 0.0595
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0072 0.0019 0.0033
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0072 0.0019 0.0019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0091 0.0242 0.0595
Schistosoma mansoni sodium-dependent amino acid transporter 0.0072 0.0019 0.0046
Schistosoma mansoni opsin-like receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0091 0.0242 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Echinococcus granulosus carboxylesterase 5A 0.0415 0.3977 0.3977
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0242 0.0595
Schistosoma mansoni biogenic amine receptor 0.0091 0.0242 0.0595
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0242 0.0595
Brugia malayi GnHR receptor homolog 0.0091 0.0242 0.0427
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0072 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Onchocerca volvulus 0.0072 0.0019 0.0046
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0072 0.0019 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.0242 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Onchocerca volvulus 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0091 0.0242 0.0595
Echinococcus multilocularis serotonin receptor 0.0091 0.0242 0.0242
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0072 0.0019 0.0046
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0247 0.2042 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus granulosus g protein coupled receptor 0.0091 0.0242 0.0242
Schistosoma mansoni opsin-like receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus granulosus allatostatin A receptor 0.0091 0.0242 0.0242
Echinococcus multilocularis fmrfamide receptor 0.0091 0.0242 0.0242
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0242 0.0242
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Onchocerca volvulus 0.0091 0.0242 0.0595
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.0242 0.0595
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni growth hormone secretagogue receptor 0.0091 0.0242 0.0595
Echinococcus granulosus serotonin transporter 0.0423 0.4065 0.4065
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0091 0.0242 0.0242
Trichomonas vaginalis spcc417.12 protein, putative 0.007 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Echinococcus granulosus hypothetical protein 0.0091 0.0242 0.0242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Echinococcus multilocularis orexin receptor type 2 0.0091 0.0242 0.0242
Schistosoma mansoni myosin xvIII 0.0091 0.0242 0.0595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Echinococcus granulosus sodium and chloride dependent glycine 0.0072 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni neuropeptide receptor 0.0091 0.0242 0.0595
Brugia malayi RE15519p 0.0091 0.0242 0.0427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni biogenic amine receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0423 0.4065 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Brugia malayi Dopamine receptor 0.0091 0.0242 0.0427
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0072 0.0019 0.0046
Schistosoma mansoni neuropeptide receptor 0.0091 0.0242 0.0595
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0072 0.0019 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0423 0.4065 0.7178
Loa Loa (eye worm) hypothetical protein 0.0423 0.4065 1
Loa Loa (eye worm) hypothetical protein 0.0415 0.3977 0.9784
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0091 0.0242 0.0242
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.0242 0.0242
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Loa Loa (eye worm) acetylcholinesterase 1 0.0415 0.3977 0.9784
Echinococcus granulosus dro:myosuppressin receptor 0.0091 0.0242 0.0242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Plasmodium falciparum amino acid transporter, putative 0.0072 0.0019 0.5
Plasmodium vivax amine transporter, putative 0.0072 0.0019 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Onchocerca volvulus 0.0091 0.0242 0.0595
Echinococcus multilocularis sex peptide receptor 0.0091 0.0242 0.0242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Echinococcus granulosus alpha 1A adrenergic receptor 0.0091 0.0242 0.0242
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0072 0.0019 0.0019
Echinococcus granulosus 7TM GPCR rhodopsin 0.0091 0.0242 0.0242
Schistosoma mansoni alpha-1 adrenergic receptor 0.0091 0.0242 0.0595
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus multilocularis G-protein coupled receptor, putative 0.0091 0.0242 0.0242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.0242 0.0595
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.0242 0.0242
Brugia malayi G protein-coupled receptor F59B2.13 0.0091 0.0242 0.0427
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.007 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Brugia malayi Dopamine receptor protein 1 0.0091 0.0242 0.0427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0072 0.0019 0.0033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Loa Loa (eye worm) TYRA-2 protein 0.0091 0.0242 0.0595
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0072 0.0019 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0091 0.0242 0.0242
Echinococcus granulosus sex peptide receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) serotonin transporter b 0.0423 0.4065 1
Brugia malayi sulfakinin receptor protein 0.0091 0.0242 0.0427
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.0242 0.0595
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0091 0.0242 0.0242
Echinococcus granulosus neuropeptide s receptor 0.0091 0.0242 0.0242
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0072 0.0019 0.0046
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.019 0.1383 0.3403
Echinococcus multilocularis g protein coupled receptor 0.0091 0.0242 0.0242
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0072 0.0019 0.0019
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0091 0.0242 0.0427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Onchocerca volvulus 0.0091 0.0242 0.0595
Echinococcus granulosus g protein coupled receptor 0.0091 0.0242 0.0242
Brugia malayi Melatonin receptor type 1A 0.0091 0.0242 0.0427
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0091 0.0242 0.0595
Schistosoma mansoni neuropeptide receptor 0.0091 0.0242 0.0595
Echinococcus granulosus acetylcholinesterase 0.0415 0.3977 0.3977
Schistosoma mansoni amine GPCR 0.0091 0.0242 0.0595
Echinococcus multilocularis serotonin transporter 0.0423 0.4065 0.4065
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0091 0.0242 0.0595
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0091 0.0242 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.0242 0.0242
Echinococcus granulosus 7tm_1 domain containing protein 0.0091 0.0242 0.0242
Loa Loa (eye worm) melatonin receptor type 1A 0.0091 0.0242 0.0595
Brugia malayi hypothetical protein 0.0072 0.0019 0.0033
Schistosoma mansoni neuropeptide f receptor 76f 0.0091 0.0242 0.0595
Echinococcus multilocularis G protein coupled receptor 139 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Brugia malayi hypothetical protein 0.0091 0.0242 0.0427
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.007 0 0.5
Loa Loa (eye worm) solute carrier family 6 member 4 0.0423 0.4065 1
Loa Loa (eye worm) carboxylesterase 0.0415 0.3977 0.9784
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.0242 0.0595
Schistosoma mansoni adenoreceptor 0.0091 0.0242 0.0595
Echinococcus multilocularis neuropeptide FF receptor 2 0.0091 0.0242 0.0242
Brugia malayi ORL1-like opioid receptor 0.0091 0.0242 0.0427
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0091 0.0242 0.0595
Loa Loa (eye worm) hypothetical protein 0.0091 0.0242 0.0595
Schistosoma mansoni amine GPCR 0.0091 0.0242 0.0595
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0423 0.4065 1
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.0242 0.0242
Echinococcus multilocularis neuropeptide s receptor 0.0091 0.0242 0.0242

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 88 nM Competitive Inhibition Assay BINDINGDB. No reference
Ki (binding) = 88 nM Competitive Binding Assay Using Eu-NDP-a-MSH BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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