TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.48 | Formula: C22H26N6O4
H donors: 1 H acceptors: 6 LogP: 2.17 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CO[C@H]2[C@@H]1N(CC2)C(=O)[C@H](C1CCCCC1)NC(=O)c1cccc(c1)n1cnnn1
InChi: 1S/C22H26N6O4/c29-17-12-32-18-9-10-27(20(17)18)22(31)19(14-5-2-1-3-6-14)24-21(30)15-7-4-8-16(11-15)28-13-23-25-26-28/h4,7-8,11,13-14,18-20H,1-3,5-6,9-10,12H2,(H,24,30)/t18-,19+,20-/m1/s1
InChiKey: VHBCENDEKXXWEY-HSALFYBXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin V	Starlite/ChEMBL	No references
Homo sapiens	cathepsin S	Starlite/ChEMBL	No references
Homo sapiens	cathepsin L	Starlite/ChEMBL	No references
Homo sapiens	cathepsin K	Starlite/ChEMBL	No references
Homo sapiens	cathepsin B	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0113	0.2605	0.4772
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1045	0.2187
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.0303	0.0427
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0113	0.2605	0.2677
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0079	0.1588	0.528
Loa Loa (eye worm)	acyl carrier protein	0.0039	0.0395	0.024
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2605	0.3807
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Loa Loa (eye worm)	hypothetical protein	0.0142	0.3461	0.3621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Giardia lamblia	Cathepsin B precursor	0.0075	0.1466	0.5
Plasmodium vivax	unspecified product	0.0036	0.0303	0.0519
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0089	0.1909	0.6357
Loa Loa (eye worm)	fatty acid synthase	0.0083	0.1719	0.17
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.2605	0.2471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1045	0.4013
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0061	0.1045	0.3575
Echinococcus multilocularis	cathepsin b	0.0186	0.478	0.4685
Brugia malayi	Cathepsin L-like precursor	0.0077	0.1541	0.2246
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.2605	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	0.478	0.4685
Echinococcus granulosus	snurportin 1	0.0335	0.9246	0.9232
Loa Loa (eye worm)	fibroinase	0.0113	0.2605	0.2677
Entamoeba histolytica	hypothetical protein	0.0039	0.0409	0.1572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.1541	0.5918
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.2605	0.2471
Trypanosoma cruzi	cruzipain precursor, putative	0.0113	0.2605	0.5449
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0075	0.1466	0.3067
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.478	0.4685
Plasmodium vivax	vivapain-2	0.0113	0.2605	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0409	0.1572
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2605	0.3807
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Onchocerca volvulus		0.0113	0.2605	0.4772
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1045	0.1517
Schistosoma mansoni	hypothetical protein	0.0039	0.0409	0.0236
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0089	0.1909	0.6337
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0084	0.1753	0.581
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0082	0.1676	0.5576
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1045	0.4013
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0043	0.051	0.137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0068	0.1262	0.4155
Echinococcus granulosus	cathepsin l1	0.0077	0.1541	0.1389
Mycobacterium ulcerans	polyketide synthase Pks9	0.0056	0.0902	0.2981
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0048	0.0668	0.2199
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0089	0.1909	0.6357
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0113	0.2605	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0055	0.087	0.2854
Plasmodium vivax	vivapain-2	0.0113	0.2605	1
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Echinococcus multilocularis	cysteine protease	0.0113	0.2605	0.2471
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1045	0.3575
Schistosoma mansoni	hypothetical protein	0.0361	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	0.478	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0409	0.0236
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0084	0.1753	0.5834
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Entamoeba histolytica	cysteine proteinase 1, putative	0.0061	0.1045	0.4013
Onchocerca volvulus		0.0113	0.2605	0.4772
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Echinococcus granulosus	cysteine protease	0.0061	0.1045	0.0884
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0056	0.0902	0.2941
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1541	0.1504
Brugia malayi	Importin beta-1 subunit	0.0031	0.0177	0.0242
Onchocerca volvulus		0.0147	0.3613	0.93
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0648	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0113	0.2605	0.2677
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0084	0.1753	0.2556
Plasmodium vivax	vivapain-3	0.0061	0.1045	0.3575
Loa Loa (eye worm)	hypothetical protein	0.0186	0.478	0.5075
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2605	0.5449
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.016	0.4002	0.586
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0113	0.2605	0.2471
Loa Loa (eye worm)	transcription factor SMAD2	0.0254	0.6821	0.7326
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0056	0.0902	0.2981
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0036	0.0303	0.0427
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.2605	0.4772
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1045	0.1517
Echinococcus granulosus	cathepsin l1	0.0113	0.2605	0.2471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.2605	1
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1045	0.0884
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0084	0.1753	0.5834
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0068	0.1262	0.4188
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0077	0.1541	0.2246
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1541	0.1504
Brugia malayi	MH2 domain containing protein	0.0254	0.6821	1
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Onchocerca volvulus	Cathepsin F homolog	0.0113	0.2605	0.4772
Trypanosoma cruzi	cruzipain precursor, putative	0.0036	0.0303	0.0634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1045	0.0884
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2605	0.3807
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0084	0.1753	0.5834
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2605	0.5449
Trypanosoma cruzi	cysteine protease, putative	0.0061	0.1045	0.2187
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Toxoplasma gondii	cathepsin B	0.0075	0.1466	0.5308
Echinococcus multilocularis	cysteine protease	0.0113	0.2605	0.2471
Loa Loa (eye worm)	ctsf protein	0.0113	0.2605	0.2677
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0089	0.1909	0.6357
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0084	0.1753	0.5834
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Plasmodium vivax	unspecified product	0.0061	0.1045	0.3575
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0335	0.9246	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1045	0.4013
Brugia malayi	cathepsin B-like cysteine proteinase	0.0186	0.478	0.7002
Echinococcus granulosus	cathepsin b	0.0186	0.478	0.4685
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0126	0.2995	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1045	0.0884
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Brugia malayi	Cathepsin L-like precursor	0.0077	0.1541	0.2246
Toxoplasma gondii	type I fatty acid synthase, putative	0.006	0.1029	0.3507
Onchocerca volvulus	Fatty acid synthase homolog	0.0152	0.3769	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1541	0.1504
Brugia malayi	cathepsin L-like precursor	0.0077	0.1541	0.2246
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0079	0.1588	0.1555
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0113	0.2605	1
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2605	0.3807
Mycobacterium ulcerans	polyketide synthase	0.0089	0.1909	0.6357
Mycobacterium ulcerans	polyketide synthase Pks13	0.0126	0.2995	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Onchocerca volvulus		0.0113	0.2605	0.4772
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0089	0.1909	0.6357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0409	0.1572
Echinococcus granulosus	cathepsin L	0.0061	0.1045	0.0884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Toxoplasma gondii	type I fatty acid synthase, putative	0.0089	0.1909	0.7133
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0075	0.1466	0.5627
Brugia malayi	RNA, U transporter 1	0.0089	0.1905	0.278
Schistosoma mansoni	hypothetical protein	0.0361	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0075	0.1466	0.5308
Onchocerca volvulus		0.0113	0.2605	0.4772
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.007	0.1334	0.4398
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2605	0.3807
Mycobacterium ulcerans	thioesterase	0.007	0.1334	0.443
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.1541	0.5918
Mycobacterium ulcerans	thioesterase TesA	0.007	0.1334	0.443
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0075	0.1466	0.5627
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0029	0.0104	0.0306
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0126	0.2995	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0069	0.1295	0.4299
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1045	0.4013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Onchocerca volvulus		0.0113	0.2605	0.4772
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0084	0.1753	0.5834
Giardia lamblia	Cathepsin B precursor	0.0075	0.1466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0303	0.0139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.1045	0.2187
Entamoeba histolytica	hypothetical protein	0.0039	0.0409	0.1572
Entamoeba histolytica	cysteine proteinase 2	0.0061	0.1045	0.4013
Echinococcus multilocularis	cathepsin b	0.0186	0.478	0.4685
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0089	0.1909	0.6337
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Leishmania major	cysteine peptidase A (CPA)	0.0113	0.2605	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0303	0.0634
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.478	0.4685
Echinococcus multilocularis	geminin	0.0361	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1045	0.4013
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0113	0.2605	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0303	0.0139
Brugia malayi	hypothetical protein	0.0039	0.0409	0.0583
Schistosoma mansoni	cathepsin s	0.0036	0.0303	0.0128
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0084	0.1753	0.5834
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0089	0.1909	0.6337
Echinococcus multilocularis	cathepsin L	0.0061	0.1045	0.0884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Entamoeba histolytica	cysteine proteinase, putative	0.0077	0.1541	0.5918
Brugia malayi	AMP-binding enzyme family protein	0.0079	0.1588	0.2313
Entamoeba histolytica	cysteine protease, putative	0.0113	0.2605	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0061	0.1045	0.3461
Schistosoma mansoni	hypothetical protein	0.0335	0.9246	0.9232
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.478	0.4685
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.2605	0.2471
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Giardia lamblia	Cathepsin B precursor	0.0075	0.1466	0.5
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0084	0.1753	0.581
Echinococcus granulosus	cathepsin b	0.0186	0.478	0.4685
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2605	0.3807
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0068	0.1262	0.4188
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0409	0.0236
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0082	0.1676	0.5576
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1045	0.4013
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0113	0.2605	0.2471
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.2605	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1045	0.3575
Mycobacterium leprae	Polyketide synthase Pks13	0.0126	0.2995	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0075	0.1466	0.1312
Loa Loa (eye worm)	MH2 domain-containing protein	0.0254	0.6821	0.7326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1045	0.4013
Echinococcus granulosus	cathepsin L cysteine protease	0.0061	0.1045	0.0884
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.2605	0.2471
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0077	0.1541	0.3225
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0303	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Brugia malayi	Papain family cysteine protease containing protein	0.0113	0.2605	0.3807
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0409	0.0236
Echinococcus multilocularis	snurportin 1	0.0335	0.9246	0.9232
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0061	0.1045	0.2187
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.2605	0.4772
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.2605	0.2471
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2605	0.5449
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0113	0.2605	0.2677
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0026	0.0029	0.0056
Mycobacterium ulcerans	fatty acid synthase Fas	0.0026	0.0029	0.0056
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.2605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2605	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0089	0.1909	0.6357
Loa Loa (eye worm)	cathepsin B	0.0075	0.1466	0.1421
Onchocerca volvulus		0.0113	0.2605	0.4772
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0034	0.0256	0.0817
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	0.1541	0.1389
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2605	1
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0084	0.1753	0.5834
Mycobacterium tuberculosis	Probable thioesterase TesA	0.007	0.1334	0.443
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0303	0.0427
Plasmodium vivax	vivapain-1	0.0061	0.1045	0.3575
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2605	0.5449
Loa Loa (eye worm)	cysteine protease	0.0113	0.2605	0.2677
Onchocerca volvulus		0.0079	0.1588	0.0207
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1045	0.2187
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.2605	0.2471
Leishmania major	cathepsin L-like protease	0.0113	0.2605	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0303	0.0139
Mycobacterium ulcerans	polyketide synthase	0.0084	0.1753	0.5834
Toxoplasma gondii	cathepsin CPL	0.0113	0.2605	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 560 nM	In Vitro Inhibition Assay	BINDINGDB.	No reference
Ki (binding)	= 5000 nM	BindingDB_Patents: In Vitro Inhibition Assay. In vitro inhibition assay using cathepsin.	ChEMBL.	No reference
Ki (binding)	> 6500 nM	In Vitro Inhibition Assay	BINDINGDB.	No reference
Ki (binding)	> 10000 nM	In Vitro Inhibition Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3648403

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1991334