Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | interleukin 6 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.8 nM | Fluorescence Polarization Ligand Binding Assay | BINDINGDB. | No reference |
IC50 (binding) | = 9.12 nM | BindingDB_Patents: Fluorescence Polarization Ligand Binding Assay. The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-length glucocorticoid (GR) protein. Reagents for this assay are purchased from Invitrogen in a test kit. A fluorescent labeled GR ligand is used as a fluorescent tracer and test compounds compete with the fluorescent tracer for GR binding. The change in polarization value in the presence of test compounds is due to binding of test compounds to GR and is used to determine IC50 and relative binding affinity of test compounds for GR. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.