Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-Raf proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0037 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0053 | 0.0917 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.0376 | 0.0376 |
Brugia malayi | Raf kinase | 0.0253 | 0.794 | 0.786 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0917 | 0.0563 |
Loa Loa (eye worm) | carboxylesterase | 0.0311 | 1 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0262 | 0.8261 | 0.8085 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0917 | 0.0563 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0053 | 0.0917 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0917 | 0.0917 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0311 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0037 | 0.0376 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0053 | 0.0917 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.0917 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0148 | 0.4281 | 0.4281 |
Echinococcus granulosus | acetylcholinesterase | 0.0311 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0917 | 0.0917 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 0.8261 | 0.8085 |
Onchocerca volvulus | 0.0053 | 0.0917 | 0.5 | |
Onchocerca volvulus | 0.0053 | 0.0917 | 0.5 | |
Onchocerca volvulus | 0.0053 | 0.0917 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.0376 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0311 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0917 | 0.0563 |
Loa Loa (eye worm) | carboxylesterase | 0.0053 | 0.0917 | 0.0917 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0917 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0053 | 0.0917 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0311 | 1 | 1 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0262 | 0.8261 | 0.8085 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0917 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0917 | 0.0917 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.0376 | 0.5 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.8216 | 0.8216 |
Brugia malayi | Carboxylesterase family protein | 0.0053 | 0.0917 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0917 | 0.0917 |
Onchocerca volvulus | 0.0053 | 0.0917 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0053 | 0.0917 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0037 | 0.0376 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0917 | 0.0917 |
Echinococcus granulosus | carboxylesterase 5A | 0.0311 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0053 | 0.0917 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 204 nM | BindingDB_Patents: Raf/Mek Amplified Luminescence Proximity Homogeneous Assay. Raf/Mek amplified luminescence proximity homogeneous assay. | ChEMBL. | No reference |
IC50 (binding) | = 204 nM | Raf/Mek Amplified Luminescence Proximity Homogeneous Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.