Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2049 | 0.2041 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0048 | 0.1715 | 0.1707 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.001 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0229 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0059 | 0.2256 | 0.2248 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1715 | 0.1707 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0088 | 0.3538 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.001 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0048 | 0.1715 | 0.1707 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0229 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0088 | 0.3538 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0229 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.001 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0229 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0088 | 0.3538 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.0344 | 0.0334 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0229 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0019 | 0.0413 | 0.0403 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0088 | 0.3538 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.259 | 0.2582 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0413 | 0.0403 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0088 | 0.3538 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0019 | 0.0413 | 0.0403 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.0344 | 0.0334 |
Schistosoma mansoni | dihydrofolate reductase | 0.0229 | 1 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0067 | 0.259 | 0.2582 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Brugia malayi | protein kinase C II. | 0.0019 | 0.0413 | 0.0403 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0048 | 0.1715 | 0.1707 |
Echinococcus granulosus | protein kinase C gamma type | 0.0059 | 0.2256 | 0.2248 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0049 | 0.1795 | 0.1786 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0019 | 0.0413 | 0.0403 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.001 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0057 | 0.2128 | 0.212 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0088 | 0.3538 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.0344 | 0.0334 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.259 | 0.2582 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0229 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0067 | 0.259 | 0.2582 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0229 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0229 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.001 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 78.1 nM | BindingDB_Patents: Inhibition Assay. Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide (A->S, RFARKGSLRQKNV). This transfer is coupled to the oxidation of p-NADH through the activities of Pyruvate Kinase (PK) and Lactate Dehydrogenase (LDH). (3-NADH conversion to NAD+ is monitored by the decrease in absorbance at 340 nm (e=6.22 cm-1 mM-1) using a Molecular Devices SPECTRA max PLUS spectrophotometer.A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30 C. in 0.1 mL of assay buffer containing 50 mM HEPES, pH 7.4, 5 nM PKC, 23 units of pyruvate kinase, 33 units of lactate dehydrogenase, 0.15 mM peptide, 0.1 mM ATP, 1 mM DTT, 4 mM PEP, 8 mM MgCl2, 0.3 mM NADH, 60 mM CaCl2, 10 mg/mL PS, 50 ng/mL PMA, 7.5% DMSO and from about 10,000 nM to 0.169 nM compound inhibitor. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.