Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 3 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0049 | 0.1385 | 0.1385 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Schistosoma mansoni | gliotactin | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | carboxylesterase | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0049 | 0.1385 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | carboxylesterase | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0291 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0291 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0049 | 0.1385 | 0.1385 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Onchocerca volvulus | 0.0049 | 0.1385 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.1385 | 0.1385 |
Schistosoma mansoni | acetylcholinesterase | 0.0049 | 0.1385 | 0.1385 |
Echinococcus multilocularis | acetylcholinesterase | 0.0291 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0291 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0049 | 0.1385 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.001 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.1385 | 0.1385 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0291 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0291 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0291 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0049 | 0.1385 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.1385 | 0.1385 |
Echinococcus granulosus | neuroligin | 0.0049 | 0.1385 | 0.1385 |
Onchocerca volvulus | 0.0049 | 0.1385 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0049 | 0.1385 | 0.1385 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Echinococcus multilocularis | neuroligin | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.1385 | 0.1385 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0049 | 0.1385 | 0.1385 |
Onchocerca volvulus | 0.0049 | 0.1385 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0049 | 0.1385 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.1385 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.1385 | 0.1385 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0049 | 0.1385 | 0.5 |
Onchocerca volvulus | 0.0049 | 0.1385 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0049 | 0.1385 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0049 | 0.1385 | 0.1385 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0049 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1385 | 0.1385 |
Brugia malayi | Carboxylesterase family protein | 0.0291 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.032625 nM | Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.1413 nM | BindingDB_Patents: Inhibition Assay. The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. | ChEMBL. | No reference |
Ki (binding) | = 0.01631 nM | Inhibition Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.