Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0147 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0147 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0147 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0147 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0147 | 1 | 1 |
Giardia lamblia | Kinase, AGC AKT | 0.0101 | 0.34 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0147 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0147 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0147 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0118 | 0.5824 | 0.5824 |
Brugia malayi | nuclear receptor NHR-88 | 0.0147 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0147 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0147 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0147 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0147 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0147 | 1 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0101 | 0.34 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0147 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0147 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0147 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0147 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0147 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0147 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0147 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0147 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0147 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0147 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0147 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0147 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0147 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0147 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0147 | 1 | 0.5 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0118 | 0.5824 | 0.5824 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0147 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0147 | 1 | 1 |
Onchocerca volvulus | 0.0147 | 1 | 0.5 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0147 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0147 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0147 | 1 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0101 | 0.34 | 0.34 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0118 | 0.5824 | 0.5824 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0147 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0147 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0118 | 0.5824 | 0.5824 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 205 nM | BindingDB_Patents: Kinase Glo Assay. Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology, which uses a luciferin-luciferase based ATP detection reagent to quantify residual ATP. The assay is performed using 0.75 nM His-RSK2, 0.75 uM ATP and 1.0 uM S6 Kinase/RSK Substrate Peptide 1 (Upstate, catalog #12-124), in assay buffer consisting of 25 mM HEPES, pH 7.5, 10 mM MgCl2, 5 mM MnCl2, 50 mM KCl, 0.2% BSA, 0.01% CHAPS, 100 uM Na3VO4, 0.5 mM DTT, and 1% DMSO. Solutions of test compounds at various concentrations are prepared by 1:3 fold serial dilution of a 1 mM solution of compound in DMSO. The DMSO solutions are further diluted with assay buffer to a final concentration of DMSO of 5%.The assay is performed in a 384 well, white, non-binding plate (Corning, catalogue #3574). Solutions of test compounds (10 uL) are transferred to a dry assay plate, followed by addition of 20 uL kinase. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.