Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0077 | 0.0231 | 0.1241 |
Echinococcus granulosus | transcription factor btf3 | 0.0042 | 0.003 | 0.0159 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0613 | 0.3368 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 0.1196 | 0.1113 |
Mycobacterium leprae | Isocitrate lyase | 0.0463 | 0.2486 | 0.3321 |
Brugia malayi | jmjC domain containing protein | 0.014 | 0.0601 | 0.3226 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0053 | 0.0094 | 0.0094 |
Brugia malayi | beta-NAC-like protein | 0.0042 | 0.003 | 0.0159 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.0105 | 0.0561 |
Leishmania major | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.0279 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0356 | 0.1864 | 0.1864 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0126 | 0.0519 | 0.0418 |
Giardia lamblia | DNA topoisomerase II | 0.0333 | 0.1727 | 1 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.1279 | 0.726 | 0.7234 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.0105 | 0.0311 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.1747 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.014 | 0.0601 | 0.3226 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0987 | 0.5552 | 0.5505 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.1285 | 0.7298 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0356 | 0.1864 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0181 | 0.0842 | 0.0756 |
Echinococcus multilocularis | transcription factor btf3 | 0.0042 | 0.003 | 0.0159 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0053 | 0.0094 | 0.0503 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0613 | 0.3368 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.014 | 0.0601 | 0.0502 |
Brugia malayi | glutathione reductase | 0.0055 | 0.0105 | 0.0561 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0077 | 0.0231 | 0.1241 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.014 | 0.0601 | 0.3226 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.0105 | 0.0561 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.014 | 0.0601 | 0.3226 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.0105 | 0.0561 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.0987 | 0.5552 | 0.7577 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.014 | 0.0601 | 0.3226 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0242 | 0.1196 | 0.1103 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0053 | 0.0094 | 0.0503 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0042 | 0.003 | 0.003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.0231 | 0.1241 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0053 | 0.0094 | 0.0279 |
Loa Loa (eye worm) | TAR-binding protein | 0.0077 | 0.0231 | 0.1241 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0053 | 0.0094 | 0.0094 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0987 | 0.5552 | 0.5505 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0833 | 0.4652 | 0.6328 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0126 | 0.0519 | 0.0418 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0053 | 0.0094 | 0.0503 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.0105 | 0.0561 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0077 | 0.0231 | 0.1241 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.1747 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0206 | 0.0985 | 0.5284 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0747 | 0.4151 | 0.4089 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0747 | 0.4151 | 0.4096 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.1279 | 0.726 | 0.7234 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.0105 | 0.0105 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.003 | 0.0088 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0356 | 0.1864 | 0.1864 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0303 | 0.1551 | 0.4606 |
Leishmania major | basic transcription factor 3a, putative | 0.0042 | 0.003 | 0.0088 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0987 | 0.5552 | 0.5505 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.0105 | 0.0311 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0053 | 0.0094 | 0.0094 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0257 | 0.1286 | 0.1655 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0053 | 0.0094 | 0.0279 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0126 | 0.0519 | 0.0418 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 0.0985 | 0.5284 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.035 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) | 0.1285 | 0.7298 | 0.727 |
Mycobacterium ulcerans | error-prone DNA polymerase | 0.1279 | 0.726 | 0.7234 |
Mycobacterium tuberculosis | Probable reductase | 0.0126 | 0.0519 | 0.0418 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0356 | 0.1864 | 0.1864 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.0231 | 0.1241 |
Leishmania major | DNA topoisomerase ii | 0.0303 | 0.1551 | 0.4606 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.1747 | 1 | 1 |
Leishmania major | DNA topoisomerase 1A | 0.0053 | 0.0094 | 0.0279 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0053 | 0.0094 | 0.0503 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0053 | 0.0094 | 0.0279 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.1747 | 1 | 1 |
Leishmania major | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.0279 |
Echinococcus multilocularis | tar DNA binding protein | 0.0077 | 0.0231 | 0.1241 |
Chlamydia trachomatis | DNA polymerase III subunit alpha | 0.1279 | 0.726 | 0.7234 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0053 | 0.0094 | 0.035 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0356 | 0.1864 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.0105 | 0.0105 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.0279 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.0231 | 0.1241 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0303 | 0.1551 | 0.4606 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 0.0985 | 0.5284 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.0231 | 0.1241 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0747 | 0.4151 | 0.4096 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.049 | 0.263 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.014 | 0.0601 | 0.0502 |
Loa Loa (eye worm) | ICD-1 protein | 0.0042 | 0.003 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0842 | 0.452 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.0105 | 0.0105 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.0279 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0747 | 0.4151 | 0.4151 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0053 | 0.0094 | 0.0094 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0126 | 0.0519 | 0.059 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0356 | 0.1864 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0356 | 0.1864 | 1 |
Brugia malayi | GRF zinc finger family protein | 0.0053 | 0.0094 | 0.0503 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.014 | 0.0601 | 0.0502 |
Schistosoma mansoni | DNA topoisomerase II | 0.0356 | 0.1864 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0356 | 0.1864 | 1 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0842 | 0.452 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0303 | 0.1551 | 0.4606 |
Brugia malayi | DNA topoisomerase III | 0.0053 | 0.0094 | 0.0503 |
Echinococcus granulosus | tar DNA binding protein | 0.0077 | 0.0231 | 0.1241 |
Schistosoma mansoni | transcription factor btf3 | 0.0042 | 0.003 | 0.0159 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.1279 | 0.726 | 0.7234 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0432 | 0.2307 | 0.2307 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0613 | 0.3368 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.014 | 0.0601 | 0.3226 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0053 | 0.0094 | 0.0503 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0747 | 0.4151 | 0.4096 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0356 | 0.1864 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.014 | 0.0601 | 0.0704 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.1285 | 0.7298 | 0.727 |
Toxoplasma gondii | NAC domain-containing protein | 0.0042 | 0.003 | 0.003 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.003 | 0.0088 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.1747 | 1 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0042 | 0.003 | 0.0088 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.014 | 0.0601 | 0.3226 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.014 | 0.0601 | 0.3226 |
Leishmania major | trypanothione reductase | 0.0055 | 0.0105 | 0.0311 |
Echinococcus multilocularis | geminin | 0.0206 | 0.0985 | 0.5284 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0747 | 0.4151 | 0.4096 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.049 | 0.263 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0356 | 0.1864 | 1 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.035 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.1747 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0356 | 0.1864 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0613 | 0.3368 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0747 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0053 | 0.0094 | 0.0503 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.014 | 0.0601 | 0.3226 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.0105 | 0.0105 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0987 | 0.5552 | 0.551 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.0279 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.049 | 0.2647 | 0.2577 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0053 | 0.0094 | 0.0503 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0126 | 0.0519 | 0.0418 |
Brugia malayi | jmjC domain containing protein | 0.014 | 0.0601 | 0.3226 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0303 | 0.1551 | 0.4606 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0987 | 0.5552 | 0.551 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.0231 | 0.1241 |
Brugia malayi | TAR-binding protein | 0.0077 | 0.0231 | 0.1241 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0356 | 0.1864 | 1 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0053 | 0.0094 | 0.0279 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0356 | 0.1864 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0053 | 0.0094 | 0.0503 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | RNA binding protein | 0.0077 | 0.0231 | 0.1241 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0053 | 0.0094 | 0.035 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0356 | 0.1864 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.0105 | 0.0561 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0042 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0126 | 0.0519 | 0.0418 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0053 | 0.0094 | 0.0503 |
Plasmodium falciparum | DNA gyrase subunit A | 0.1747 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50000 nM | BindingDB_Patents: In Vitro Kinase Enzyme Assay. In vitro kinase enzyme assay using Jak3, Jak2, Jak1, and Tyk2. | ChEMBL. | No reference |
IC50 (binding) | > 50000 nM | In Vitro Kinase Enzyme Assay | BINDINGDB. | No reference |
IC50 (binding) | > 50000 nM | In Vitro Kinase Enzyme Assay | BINDINGDB. | No reference |
IC50 (binding) | > 50000 nM | In Vitro Kinase Enzyme Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.