Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-Raf proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 1 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.4215 | 0.4237 |
Brugia malayi | Raf kinase | 0.0253 | 0.9621 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0122 | 0.4215 | 0.4215 |
Echinococcus granulosus | carboxylesterase 5A | 0.0122 | 0.4215 | 0.4215 |
Echinococcus multilocularis | acetylcholinesterase | 0.0122 | 0.4215 | 0.4215 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0122 | 0.4215 | 0.4215 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0122 | 0.4215 | 0.4381 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0122 | 0.4215 | 0.4381 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0148 | 0.5299 | 0.5327 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.4215 | 0.4237 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.9947 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0122 | 0.4215 | 0.4237 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0122 | 0.4215 | 0.4215 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0122 | 0.4215 | 0.4215 |
Loa Loa (eye worm) | carboxylesterase | 0.0122 | 0.4215 | 0.4237 |
Echinococcus granulosus | acetylcholinesterase | 0.0122 | 0.4215 | 0.4215 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.25 nM | BindingDB_Patents: Raf/Mek Amplified Luminescence Proximity Homogeneous Assay. Raf/Mek amplified luminescence proximity homogeneous assay. | ChEMBL. | No reference |
IC50 (binding) | = 0.25 nM | Raf/Mek Amplified Luminescence Proximity Homogeneous Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.