Detailed information for compound 2000365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 607.527 | Formula: C32H32Cl2N4O4
  • H donors: 2 H acceptors: 4 LogP: 5.45 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCC(=O)NCc1ccc(c(c1)c1nc2c(n1C(C)C)C(N(C2=O)c1cc(Cl)ccc1C)c1ccc(cc1C)Cl)OC
  • InChi: 1S/C32H32Cl2N4O4/c1-17(2)37-30-28(36-31(37)24-13-20(7-11-26(24)42-5)15-35-27(40)16-39)32(41)38(25-14-22(34)8-6-18(25)3)29(30)23-10-9-21(33)12-19(23)4/h6-14,17,29,39H,15-16H2,1-5H3,(H,35,40)
  • InChiKey: ZBFNQGJLOPNHTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MDM2 proto-oncogene, E3 ubiquitin protein ligase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutathione reductase 0.0025 0.0067 0.0179
Loa Loa (eye worm) hypothetical protein 0.0022 0.0051 0.0136
Loa Loa (eye worm) RNA binding protein 0.0067 0.0294 0.078
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0067 0.0194
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0057 0.0238 0.8342
Echinococcus granulosus biogenic amine 5HT receptor 0.03 0.1537 0.4475
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0294 0.0855
Echinococcus multilocularis peregrin 0.0025 0.0067 0.0067
Echinococcus granulosus poly (ADP ribose) polymerase 0.0028 0.0086 0.025
Brugia malayi brahma associated protein 60 kDa 0.0013 0.0003 0.0009
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0056 0.0235 0.0625
Schistosoma mansoni poly [ADP-ribose] polymerase 0.005 0.0202 0.0589
Loa Loa (eye worm) nuclear factor I 0.0027 0.0079 0.0209
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0003 0.0003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0016 0.0046
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0042 0.0156 0.0455
Brugia malayi MH2 domain containing protein 0.0717 0.3764 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0032 0.0107 0.1445
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0195 0.0569
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0168 0.0833 0.2425
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0057 0.0238 0.8342
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0042 0.0156 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0063 0.0272 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0482
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0091 0.0422 0.3971
Echinococcus granulosus poly (ADP ribose) polymerase 0.0014 0.001 0.003
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0168 0.0833 0.0833
Echinococcus granulosus jumonji domain containing protein 0.0034 0.0119 0.0345
Brugia malayi hypothetical protein 0.0076 0.0339 0.0902
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0016 0.0042
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0032 0.0107 0.0311
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0203 0.1016 0.3492
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0534 0.2785 0.8109
Brugia malayi hypothetical protein 0.0024 0.0061 0.0162
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0067 0.024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0016 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0056 0.0235 0.0625
Loa Loa (eye worm) hypothetical protein 0.03 0.1537 0.4083
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0057 0.0238 0.8342
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0033 0.0112 0.0325
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0016 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0016 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0042 0.0156 0.558
Loa Loa (eye worm) thioredoxin reductase 0.0025 0.0067 0.0179
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0051 0.0136
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0294 0.0294
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0021 0.0046 0.0046
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0042 0.0156 0.0561
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0203 0.1016 0.3648
Onchocerca volvulus Matrilysin homolog 0.0103 0.0483 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0208 0.0552
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0096 0.0447 0.9252
Plasmodium falciparum thioredoxin reductase 0.0025 0.0067 0.0242
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.005 0.0202 0.496
Loa Loa (eye worm) hypothetical protein 0.007 0.0306 0.0812
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0016 0.0046
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0116 0.0116
Echinococcus granulosus peptidase Clp S14 family 0.0027 0.008 0.0233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0177
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0016 0.0046
Echinococcus multilocularis jumonji domain containing protein 0.0034 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0482
Toxoplasma gondii thioredoxin reductase 0.0025 0.0067 0.0242
Schistosoma mansoni hypothetical protein 0.0131 0.0634 0.1846
Schistosoma mansoni Smad4 0.0049 0.0195 0.0569
Schistosoma mansoni hypothetical protein 0.0344 0.177 0.5155
Echinococcus granulosus poly (ADP ribose) polymerase 0.0014 0.001 0.003
Trypanosoma brucei trypanothione reductase 0.0025 0.0067 0.1986
Loa Loa (eye worm) Smad1 0.0049 0.0195 0.0519
Schistosoma mansoni smad1 5 8 and 0.0049 0.0195 0.0569
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0014 0.0011 0.0039
Brugia malayi MH2 domain containing protein 0.0049 0.0195 0.0519
Brugia malayi RNA binding protein 0.0067 0.0294 0.078
Brugia malayi MH1 domain containing protein 0.0027 0.0079 0.0209
Onchocerca volvulus 0.0046 0.0182 0.3718
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0063 0.0271 0.0271
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0046 0.0182 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0016 0.0042
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0016 0.0016
Brugia malayi Matrixin family protein 0.0046 0.0182 0.0482
Entamoeba histolytica hypothetical protein 0.0208 0.1047 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0116 0.0338
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0016 0.0016
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0027 0.008 0.0612
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.001
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0003 0.0003
Brugia malayi brahma associated protein 60 kDa 0.0013 0.0003 0.0009
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0056 0.0235 0.823
Entamoeba histolytica hypothetical protein 0.0208 0.1047 1
Loa Loa (eye worm) hypothetical protein 0.0344 0.177 0.4703
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0294 0.0855
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Schistosoma mansoni smad 0.0049 0.0195 0.0569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0297 0.0864
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0042 0.0156 0.0561
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0339 0.1219
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0534 0.2785 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0503 0.262 0.6961
Loa Loa (eye worm) hypothetical protein 0.0076 0.0339 0.0902
Brugia malayi WGR domain containing protein 0.0091 0.0422 0.1121
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0013 0.0003 0.0012
Brugia malayi hypothetical protein 0.0049 0.0196 0.052
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0339 1
Echinococcus granulosus WGR domain containing protein 0.0028 0.0086 0.025
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0016 0.0257
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Schistosoma mansoni hypothetical protein 0.0656 0.3434 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0027 0.008 0.008
Toxoplasma gondii preprocathepsin c precursor, putative 0.0534 0.2785 1
Echinococcus granulosus sodium channel protein 0.0032 0.0107 0.0311
Brugia malayi Matrixin family protein 0.0046 0.0182 0.0482
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0016 0.0046
Brugia malayi MH2 domain containing protein 0.0049 0.0195 0.0519
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0016 0.0046
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0051 0.0136
Onchocerca volvulus Matrix metalloproteinase homolog 0.0103 0.0483 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0016 0.0042
Echinococcus granulosus peregrin 0.0025 0.0067 0.0194
Loa Loa (eye worm) MH2 domain-containing protein 0.0717 0.3764 1
Schistosoma mansoni hypothetical protein 0.0159 0.0784 0.2284
Echinococcus granulosus poly (ADP ribose) polymerase 0.0014 0.001 0.003
Loa Loa (eye worm) matrix metalloproteinase 0.0046 0.0182 0.0482
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0042 0.0156 0.0561
Loa Loa (eye worm) hypothetical protein 0.0096 0.0447 0.1187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0068 0.0297 0.0788
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0063 0.0272 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0057 0.0238 0.8342
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0014 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0016 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0159 0.0784 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0016 0.0042
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0016 0.0016
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0195 0.0195
Schistosoma mansoni hypothetical protein 0.0159 0.0784 0.2284
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0159 0.0784 0.2284
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0043 0.0166 0.0484
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0013 0.0003 0.0003
Brugia malayi glutathione reductase 0.0025 0.0067 0.0179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0503 0.262 0.6961
Echinococcus granulosus tar DNA binding protein 0.0067 0.0294 0.0855
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0294 0.078
Schistosoma mansoni hypothetical protein 0.0025 0.0067 0.0194
Giardia lamblia Encystation-specific protease 0.0203 0.1016 0.3492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0297 0.0864
Mycobacterium ulcerans hydrolase 0.0056 0.0235 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0016 0.0257
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0534 0.2785 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0003 0.0012
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0095 0.0276
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0051 0.0149
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0013 0.0003 0.0012
Entamoeba histolytica hypothetical protein 0.0208 0.1047 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0159 0.0784 0.2083
Echinococcus granulosus adam 0.0024 0.0061 0.0177
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0013 0.0003 0.0012
Echinococcus multilocularis GPCR, family 2 0.0159 0.0784 0.0784
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0051 0.0149
Brugia malayi MH2 domain containing protein 0.0022 0.0051 0.0136
Loa Loa (eye worm) transcription factor SMAD2 0.0717 0.3764 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0042 0.0156 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0208 0.1047 0.1047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0016 0.0046
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0014 0.0007 0.002
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0051 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0068 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0016 0.0042
Leishmania major hypothetical protein, conserved 0.0076 0.0339 1
Echinococcus multilocularis lysine specific demethylase 5A 0.003 0.0095 0.0095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0016 0.0016
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0042 0.0156 0.0156
Echinococcus multilocularis sodium channel protein 0.0032 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0016 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0068 0.0297 0.0864
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0042 0.0156 0.0561
Echinococcus granulosus SWI:SNF matrix associated 0.0013 0.0003 0.001
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0013 0.0003 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0016 0.0042
Echinococcus granulosus snurportin 1 0.0131 0.0634 0.1846
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0063 0.0271 0.0788
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0294 0.078
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0339 0.1219
Echinococcus granulosus poly adp ribose polymerase 2 0.005 0.0202 0.0589
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0339 0.1219
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0203 0.1016 0.3648
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0016 0.0042
Toxoplasma gondii cathepsin CPC1 0.0534 0.2785 1
Schistosoma mansoni transcription factor LCR-F1 0.0208 0.1047 0.3049
Echinococcus multilocularis snurportin 1 0.0131 0.0634 0.0634
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0033 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0208 0.1047 0.3049
Toxoplasma gondii hypothetical protein 0.0014 0.0011 0.0039
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0294 0.078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0159 0.0784 0.2083
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.005 0.0202 0.496
Schistosoma mansoni Smad4 0.0022 0.0051 0.0149
Brugia malayi steroid hormone receptor 0.0015 0.0016 0.0042
Mycobacterium tuberculosis Probable reductase 0.0057 0.0238 0.8342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0016 0.0042
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0534 0.2785 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0057 0.0238 0.8702
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0016 0.0042
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0016 0.0046
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0095 0.0276
Echinococcus granulosus geminin 0.0656 0.3434 1
Schistosoma mansoni brg-1 associated factor 0.0013 0.0003 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0095 0.0251
Schistosoma mansoni hypothetical protein 0.0656 0.3434 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Loa Loa (eye worm) reprolysin 0.0014 0.0007 0.0018
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0067 0.0194
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0482
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0195 0.0569
Echinococcus multilocularis SWI:SNF matrix associated 0.0013 0.0003 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0016 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0016 0.0042
Onchocerca volvulus 0.0015 0.0016 0.0257
Entamoeba histolytica hypothetical protein 0.0208 0.1047 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0016 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0016 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0159 0.0784 0.0784
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0014 0.0011 0.0039
Brugia malayi SWIB/MDM2 domain containing protein 0.0013 0.0003 0.0009
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0067 0.0177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0068 0.0297 0.0864
Loa Loa (eye worm) hypothetical protein 0.0503 0.262 0.6961
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0016 0.0046
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0042 0.0156 1
Brugia malayi TAR-binding protein 0.0067 0.0294 0.078
Brugia malayi latrophilin 2 splice variant baaae 0.0344 0.177 0.4703
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0294 0.0855
Schistosoma mansoni Smad4 0.0022 0.0051 0.0149
Brugia malayi Matrixin family protein 0.0112 0.0532 0.1413
Loa Loa (eye worm) hypothetical protein 0.03 0.1537 0.4083
Loa Loa (eye worm) hypothetical protein 0.0056 0.0232 0.0617
Schistosoma mansoni smad1 5 8 and 0.0049 0.0195 0.0569
Loa Loa (eye worm) disintegrin family protein 0.0036 0.0128 0.034
Schistosoma mansoni biogenic amine (5HT) receptor 0.03 0.1537 0.4475
Onchocerca volvulus Alhambra homolog 0.0025 0.0067 0.1322
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0051 0.0051
Loa Loa (eye worm) matrixin family protein 0.0103 0.0483 0.1282
Schistosoma mansoni smad 0.0022 0.0051 0.0149
Brugia malayi nuclear hormone receptor 0.0015 0.0016 0.0042
Echinococcus multilocularis serotonin receptor 0.03 0.1537 0.1537
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0131 0.0634 0.1684
Mycobacterium leprae PROBABLE HYDROLASE 0.0056 0.0235 0.8613
Schistosoma mansoni dihydroceramide desaturase 0.005 0.0201 0.0584
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0091 0.0422 0.1229
Brugia malayi Thioredoxin reductase 0.0025 0.0067 0.0179
Brugia malayi RNA, U transporter 1 0.0035 0.0121 0.0321
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0195 0.0569
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0503 0.262 0.6961
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0024 0.0061 0.0177
Loa Loa (eye worm) matrixin family protein 0.0112 0.0532 0.1413
Echinococcus granulosus adam 17 protease 0.0014 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0161 0.0429
Loa Loa (eye worm) hypothetical protein 0.0033 0.0112 0.0296
Brugia malayi Bromodomain containing protein 0.0025 0.0067 0.0177
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.005 0.0202 0.0202
Brugia malayi jmjC domain containing protein 0.003 0.0095 0.0251
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0339 0.1219
Echinococcus multilocularis disintegrin and metalloproteinase 0.005 0.0201 0.0201
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0013 0.0003 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0195 0.0519
Schistosoma mansoni hypothetical protein 0.0034 0.0116 0.0338
Brugia malayi WGR domain containing protein 0.005 0.0202 0.0537
Brugia malayi follicle stimulating hormone receptor 0.0225 0.1137 0.3021
Echinococcus multilocularis thioredoxin glutathione reductase 0.0025 0.0067 0.0067
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0016 0.0016
Toxoplasma gondii cathepsin CPC2 0.0203 0.1016 0.3648
Echinococcus granulosus GPCR family 2 0.0159 0.0784 0.2284
Loa Loa (eye worm) brahma associated protein 0.0013 0.0003 0.0009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0159 0.0784 0.2284
Echinococcus granulosus disintegrin and metalloproteinase 0.005 0.0201 0.0584
Echinococcus multilocularis adam 0.0024 0.0061 0.0061
Brugia malayi ecdysteroid receptor 0.0015 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0156 0.0415
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0279 0.0812
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0209
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0016 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0016 0.0042
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0203 0.1016 0.3492
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0081 0.0368 0.1071
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0339 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0016 0.0046
Brugia malayi MH1 domain containing protein 0.0049 0.0195 0.0519
Brugia malayi Disintegrin family protein 0.005 0.0201 0.0533
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0339 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0025 0.0067 0.0196
Schistosoma mansoni hypothetical protein 0.0159 0.0784 0.2284
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0016 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0016 0.0046
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0067 0.024
Schistosoma mansoni hypothetical protein 0.0066 0.0285 0.0829
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0095 0.0441 0.1584
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0091 0.0422 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0016 0.0042
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0022 0.0051 0.0994
Mycobacterium tuberculosis Probable oxidoreductase 0.0063 0.0272 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0016 0.0042
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0534 0.2785 1
Brugia malayi hypothetical protein 0.0208 0.1047 0.2782
Schistosoma mansoni hypothetical protein 0.0159 0.0784 0.2284
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0331 0.1703 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0063 0.0272 1
Brugia malayi jmjC domain containing protein 0.0081 0.0368 0.0977
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0095 0.0276
Brugia malayi Hemopexin family protein 0.0066 0.0285 0.0757
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0016 0.0046
Brugia malayi N-terminal motif family protein 0.0096 0.0447 0.1187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0068 0.0297 0.0297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0208 0.1047 0.3049
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0016 0.0257
Mycobacterium tuberculosis Probable dehydrogenase 0.0057 0.0238 0.8342
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0067 0.024
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0294 0.0855
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0016 0.0046
Brugia malayi Matrixin family protein 0.0046 0.0182 0.0482
Echinococcus multilocularis Smad4 0.0049 0.0195 0.0195
Plasmodium vivax thioredoxin reductase, putative 0.0025 0.0067 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0016 0.0042
Plasmodium falciparum phd finger protein, putative 0.0025 0.0067 0.024
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0042 0.0156 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0294 0.0855
Schistosoma mansoni smad1 5 8 and 0.0049 0.0195 0.0569
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0081 0.0368 0.0368
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0016 0.0046
Plasmodium falciparum glutathione reductase 0.0025 0.0067 0.0242
Brugia malayi Matrixin family protein 0.0046 0.0182 0.0482
Brugia malayi nuclear receptor NHR-88 0.0015 0.0016 0.0042
Echinococcus granulosus Smad4 0.0049 0.0195 0.0569
Onchocerca volvulus Matrilysin homolog 0.0046 0.0182 0.3718
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0027 0.008 0.2647
Brugia malayi MH1 domain containing protein 0.0027 0.0079 0.0209
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0013 0.0003 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0016 0.0042
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0036 0.0127 0.0336
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0016 0.0042
Brugia malayi PHD-finger family protein 0.0025 0.0067 0.0177
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0534 0.2785 1
Schistosoma mansoni coup transcription factor 0.0015 0.0016 0.0046
Loa Loa (eye worm) nuclear hormone receptor 0.0055 0.0228 0.0605
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.1137 0.3021
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0195 0.0195
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0195 0.0519
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0027 0.008 0.0612
Brugia malayi Probable ClpP-like protease 0.0042 0.0156 0.0415
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0049 0.0195 0.0569
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Plasmodium vivax glutathione reductase, putative 0.0025 0.0067 0.0242
Onchocerca volvulus 0.0066 0.0285 0.5873
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0067 0.0067
Echinococcus multilocularis geminin 0.0656 0.3434 0.3434
Echinococcus granulosus poly ADP ribose polymerase 1 0.0091 0.0422 0.1229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Schistosoma mansoni peptidase Clp (S14 family) 0.0042 0.0156 0.0455
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0068 0.0297 0.0864
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0016 0.0046
Echinococcus granulosus smad 0.0049 0.0195 0.0569
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.0063 0.0271 0.0719
Brugia malayi Smad1 0.0049 0.0195 0.0519
Brugia malayi MH1 domain containing protein 0.0049 0.0195 0.0519
Trypanosoma brucei poly(adp-ribose) polymerase 0.005 0.0202 0.5961
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0013 0.0003 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0016 0.0016
Echinococcus multilocularis serotonin receptor 0.03 0.1537 0.1537
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0014 0.0007 0.002
Echinococcus multilocularis smad 0.0049 0.0195 0.0195
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0014 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0016 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0159 0.0784 0.2083
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.0537
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0068 0.0297 0.0788
Brugia malayi Latrophilin receptor protein 2 0.0159 0.0784 0.2083

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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