Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone deacetylase | 0.0022 | 0.1563 | 0.1563 |
Entamoeba histolytica | histone deacetylase, putative | 0.0077 | 1 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2748 | 0.2748 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 1 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 1 | 1 |
Schistosoma mansoni | lamin | 0.003 | 0.2748 | 0.2748 |
Leishmania major | histone deacetylase, putative | 0.0077 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0022 | 0.1563 | 0.1563 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0022 | 0.1563 | 0.1563 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.4423 | 0.4423 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.2748 | 1 | |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0022 | 0.1563 | 0.1563 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.2748 | 0.2748 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0022 | 0.1563 | 0.1563 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.003 | 0.2748 | 0.2748 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.2748 | 0.2748 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0022 | 0.1563 | 0.1563 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.031 | 0.031 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0022 | 0.1563 | 0.1563 |
Echinococcus multilocularis | lamin | 0.003 | 0.2748 | 0.2748 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.36 | 0.36 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2665 | 0.2665 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0022 | 0.1563 | 0.1563 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0022 | 0.1563 | 0.1563 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.4423 | 0.4423 |
Schistosoma mansoni | lamin | 0.003 | 0.2748 | 0.2748 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0022 | 0.1563 | 0.1563 |
Onchocerca volvulus | 0.003 | 0.2748 | 1 | |
Echinococcus granulosus | lamin | 0.003 | 0.2748 | 0.2748 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0393 | 0.0393 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.2748 | 0.2748 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0022 | 0.1563 | 0.1563 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0635 | 0.0635 |
Trypanosoma brucei | histone deacetylase 1 | 0.0077 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.2748 | 0.2748 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0393 | 0.0393 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.2748 | 0.2748 |
Giardia lamblia | Histone deacetylase | 0.0077 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.2748 | 0.2748 |
Echinococcus granulosus | histone deacetylase 6 | 0.0022 | 0.1563 | 0.1563 |
Echinococcus granulosus | histone deacetylase 7 | 0.0022 | 0.1563 | 0.1563 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.2748 | 0.2748 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0022 | 0.1563 | 0.1563 |
Brugia malayi | Histone deacetylase family protein | 0.0022 | 0.1563 | 0.1563 |
Brugia malayi | intermediate filament protein | 0.003 | 0.2748 | 0.2748 |
Brugia malayi | Histone deacetylase family protein | 0.0022 | 0.1563 | 0.1563 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0022 | 0.1563 | 0.1563 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.4423 | 0.4423 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.4995 | 0.4995 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0635 | 0.0635 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.4995 | 0.4995 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0022 | 0.1563 | 0.1563 |
Echinococcus granulosus | histone deacetylase 8 | 0.0022 | 0.1563 | 0.1563 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.4423 | 0.4423 |
Echinococcus granulosus | histone deacetylase 6 | 0.0022 | 0.1563 | 0.1563 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1563 | 0.1563 |
Echinococcus granulosus | histone deacetylase | 0.0022 | 0.1563 | 0.1563 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0022 | 0.1563 | 0.1563 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0022 | 0.1563 | 0.1563 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 42 nM | BindingDB_Patents: Flag Assay. Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme source for this assay was an epitope-tagged human HDAC1 complex immuno-purified from stably expressing mammalian cells. The substrate consisted of a commercial product containing an acetylated lysine side chain (BIOMOL Research Laboratories, Inc., Plymouth Meeting, Pa.). Upon deacetylation of the substrate by incubation with the purified HDAC1 complex, a fluorophore is produced that is directly proportional to the level of deacetylation. Using a substrate concentration at the Km for the enzyme preparation, the deacetylation assay was performed in the presence of increasing concentrations of novel compounds to semi-quantitatively determine the concentration of compound required for 50% inhibition (IC50) of the deacetylation reaction. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.