TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.558 | Formula: C29H28N4O3
H donors: 2 H acceptors: 3 LogP: 5.12 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccnc1Oc1ccc(cc1)Nc1ccccn1)NC1CCC[C@@H]1OCc1ccccc1
InChi: 1S/C29H28N4O3/c34-28(33-25-11-6-12-26(25)35-20-21-8-2-1-3-9-21)24-10-7-19-31-29(24)36-23-16-14-22(15-17-23)32-27-13-4-5-18-30-27/h1-5,7-10,13-19,25-26H,6,11-12,20H2,(H,30,32)(H,33,34)/t25?,26-/m0/s1
InChiKey: LUHUGXXXALTRNC-AMVUTOCUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	Get druggable targets OG5_135363	All targets in OG5_135363
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	672 aa	30.2 %
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	688 aa	29.1 %
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	656 aa	30.9 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	24.1 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	683 aa	27.5 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	693 aa	25.3 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	679 aa	26.7 %
Leishmania donovani	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	653 aa	23.0 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	25.7 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.1 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	699 aa	25.5 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.4 %
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	23.5 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	30.5 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	655 aa	24.1 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	28.9 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	23.5 %
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	24.7 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	30.5 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	711 aa	26.2 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	716 aa	26.0 %
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	712 aa	25.0 %
Drosophila melanogaster	Phosphodiesterase 6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	684 aa	32.2 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	29.1 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	22.7 %
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	29.0 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.8 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	26.5 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.2 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.033	0.9418	0.9418
Brugia malayi	RNA, U transporter 1	0.0088	0.2012	0.1997
Echinococcus granulosus	geminin	0.0321	0.9143	0.9707
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0502	0.0513
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2067	0.2194
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0582	0.0582
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2067	0.2178
Toxoplasma gondii	hypothetical protein	0.0023	0.0042	0.0899
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0023	0.0042	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0091	0.2885
Schistosoma mansoni	hypothetical protein	0.0321	0.9143	0.9708
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3098	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0269	0.0269
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0024	0.0051	0.0033
Brugia malayi	MH1 domain containing protein	0.0024	0.0051	0.0032
Schistosoma mansoni	hypothetical protein	0.008	0.1758	0.1867
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0024	0.0051	0.0054
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0033	0.0319	0.0339
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.1281	0.1343
Schistosoma mansoni	Smad4	0.0024	0.0051	0.0054
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0042	0.0749
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0033	0.0319	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0091	0.2885
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0091	0.2885
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0503	0.0534
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0063	0.0046
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.008	0.1758	0.185
Loa Loa (eye worm)	Smad1	0.0024	0.0051	0.0051
Brugia malayi	Latrophilin receptor protein 2	0.008	0.1758	0.1742
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0091	0.2404
Plasmodium falciparum	importin beta, putative	0.0031	0.0269	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2067	0.2178
Brugia malayi	hypothetical protein	0.0039	0.0503	0.0485
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus granulosus	tar DNA binding protein	0.0123	0.3098	0.3276
Loa Loa (eye worm)	transcription factor SMAD2	0.0349	1	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.1758	0.1758
Leishmania major	importin beta-1 subunit, putative	0.0025	0.009	0.2363
Brugia malayi	Bromodomain containing protein	0.008	0.1783	0.1767
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0024	0.0051	0.0033
Echinococcus granulosus	GPCR family 2	0.008	0.1758	0.185
Schistosoma mansoni	hypothetical protein	0.0321	0.9143	0.9708
Brugia malayi	latrophilin 2 splice variant baaae	0.0172	0.4584	0.4573
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0051	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0251	0.7019	0.7019
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0319	1
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0503	0.0534
Entamoeba histolytica	hypothetical protein	0.0025	0.009	0.1464
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0659	0.0659
Schistosoma mansoni	hypothetical protein	0.008	0.1758	0.1867
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.009	0.2363
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.0042	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0042	0.0749
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.7171	0.7171
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0091	0.2404
Schistosoma mansoni	hypothetical protein	0.008	0.1758	0.1867
Brugia malayi	MH2 domain containing protein	0.0024	0.0051	0.0032
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.008	0.1758	0.185
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0024	0.0051	0.0033
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3098	0.3289
Echinococcus multilocularis	tar DNA binding protein	0.0123	0.3098	0.3276
Loa Loa (eye worm)	latrophilin receptor protein 2	0.008	0.1758	0.1758
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.2067	0.2051
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0503	0.0515
Toxoplasma gondii	GAF domain-containing protein	0.0023	0.0042	0.0899
Echinococcus multilocularis	geminin	0.0321	0.9143	0.9707
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0503	0.0515
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0033	0.0319	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0033	0.0319	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.4584	0.4584
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Brugia malayi	hypothetical protein	0.0025	0.0091	0.0072
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0289	0.8166	0.8163
Brugia malayi	MH2 domain containing protein	0.0024	0.0051	0.0032
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0024	0.0051	0.0051
Brugia malayi	RNA binding protein	0.0123	0.3098	0.3085
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0502	0.0513
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0042	0.0749
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Brugia malayi	TAR-binding protein	0.0123	0.3098	0.3085
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.0042	0.0899
Brugia malayi	PHD-finger family protein	0.0027	0.014	0.0121
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0091	0.2885
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0091	0.0091
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.1281	0.1343
Entamoeba histolytica	hypothetical protein	0.0039	0.0503	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1643	0.1643
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0033	0.0319	0.03
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0091	0.2404
Loa Loa (eye worm)	MH1 domain-containing protein	0.0024	0.0051	0.0051
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0019	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2067	0.2178
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3098	0.3289
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0269	0.0266
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0024	0.0051	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0042	0.0749
Schistosoma mansoni	hypothetical protein	0.0172	0.4584	0.4867
Loa Loa (eye worm)	MH2 domain-containing protein	0.0349	1	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0269	0.8332
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0033	0.0319	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0251	0.7019	0.7013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2067	0.2194
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0019	0.0019
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.008	0.1758	0.185
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0033	0.0319	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0269	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.009	0.2363
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0033	0.0319	1
Brugia malayi	Smad1	0.0024	0.0051	0.0032
Loa Loa (eye worm)	hypothetical protein	0.028	0.7889	0.7889
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.0042	0.5
Toxoplasma gondii	hypothetical protein	0.0023	0.0042	0.0899
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.009	0.2363
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus granulosus	snurportin 1	0.033	0.9418	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0503	1
Echinococcus multilocularis	GPCR, family 2	0.008	0.1758	0.185
Schistosoma mansoni	hypothetical protein	0.008	0.1758	0.1867
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0123	0.3098	0.3098
Brugia malayi	MH1 domain containing protein	0.0024	0.0051	0.0032
Loa Loa (eye worm)	RNA binding protein	0.0123	0.3098	0.3098
Entamoeba histolytica	hypothetical protein	0.0039	0.0503	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0023	0.0042	0.5
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0051	0.0054
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0033	0.0319	0.0319
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0289	0.8166	0.8668
Brugia malayi	RNA recognition motif domain containing protein	0.0123	0.3098	0.3085
Schistosoma mansoni	ran	0.0023	0.0019	0.002
Leishmania major	hypothetical protein, conserved	0.0025	0.0091	0.2404
Schistosoma mansoni	smad	0.0024	0.0051	0.0054
Schistosoma mansoni	ran	0.0023	0.0019	0.002
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3098	0.3289
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0319	0.0319
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus granulosus	smad	0.0024	0.0051	0.0033
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.008	0.1758	0.1742
Brugia malayi	Importin beta-1 subunit	0.0031	0.0269	0.025
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Schistosoma mansoni	bromodomain containing protein	0.0068	0.1399	0.1485
Loa Loa (eye worm)	TAR-binding protein	0.0123	0.3098	0.3098
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.009	0.2363
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0033	0.0319	0.0339
Schistosoma mansoni	importin beta-1	0.0031	0.0269	0.0286
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0269	0.8332
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2067	0.2178
Echinococcus multilocularis	Smad4	0.0024	0.0051	0.0033
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0289	0.8166	0.8668
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0269	0.0266
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.3098	0.3289
Schistosoma mansoni	hypothetical protein	0.033	0.9418	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0251	0.7019	0.7019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2067	0.2194
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0033	0.0319	0.0319
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0319	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.008	0.1758	0.185
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0319	1
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0051	0.0054
Echinococcus multilocularis	smad	0.0024	0.0051	0.0033
Brugia malayi	Bromodomain containing protein	0.0041	0.0579	0.0561
Toxoplasma gondii	hypothetical protein	0.0023	0.0042	0.0899
Echinococcus multilocularis	snurportin 1	0.033	0.9418	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0063	0.0067
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0269	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0503	1
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.0042	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.2067	0.2067
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0023	0.0042	0.5
Echinococcus granulosus	Smad4	0.0024	0.0051	0.0033
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0063	0.0046
Plasmodium falciparum	GAF domain-related protein, putative	0.0023	0.0042	0.0899
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0251	0.7019	0.7013

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1923 nM	BindingDB_Patents: Enzyme Inhibition Assay. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 µL of serial diluted PDE10A (BPS Bioscience, San Diego, Calif.) or tissue homogenate was incubated with equal volumes of diluted fluorescein labeled cAMP or cGMP for 60 min in 384-well polystyrene assay plates (Corning, Corning, N.Y.) at room temperature. After incubation, the reaction was stopped by adding 60 µL of diluted binding reagents and was incubated for 3 hours to overnight at room temperature. The plates were read on an Envision (Perkin Elmer, Waltham, Mass.) for time resolved fluorescence resonance energy transfer.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3665289

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2000901