Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotrophic tyrosine kinase, receptor, type 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.4951 | 0.4159 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4087 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3679 | 0.3972 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0947 | 0.1188 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.4951 | 0.6206 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.3258 | 0.4427 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.007 | 0.736 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.4951 | 0.6206 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.9262 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.3667 | 0.2673 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0435 | 0.0592 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0947 | 0.1287 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.4951 | 0.5346 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0618 | 0.0774 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0106 | 0.0114 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0435 | 0.0592 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.4951 | 0.6206 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0947 | 0.1287 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.3258 | 0.4427 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0618 | 0.0667 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.4951 | 0.6727 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.4951 | 0.6727 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0435 | 0.0546 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.4951 | 0.6727 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.4951 | 0.6727 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.007 | 0.736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.4417 | 0.4769 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.7978 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 451 nM | BindingDB_Patents: Enzyme Assay. Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sourced from Invitrogen (see table below). This activity-assay measures the phosphorylation of tyrosine residues within a substrate from the HTRF kit which has been validated by Cisbio for a variety of tyrosine kinases including the TRK receptors. Assay details: Target:TRKA; Invitrogen Cat# PV3144; Amino acids:aa 441-796; FAC enzyme:4nM; FAC ATP:40uM; Assay Reaction Time:35min. | ChEMBL. | No reference |
IC50 (binding) | = 451 nM | Enzyme Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.