Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotrophic tyrosine kinase, receptor, type 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.3568 | 0.5122 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.6965 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3568 | 0.3423 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.3568 | 0.3423 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.6965 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3568 | 0.3423 |
Brugia malayi | Smad1 | 0.001 | 0.022 | 0.0316 |
Echinococcus multilocularis | geminin | 0.0198 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.022 | 0.0316 |
Brugia malayi | RNA binding protein | 0.0074 | 0.3568 | 0.5122 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.022 | 0.0316 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.3568 | 0.5122 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.6965 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.022 | 0.0316 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.3568 | 0.5122 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.022 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.3568 | 0.5122 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.022 | 0.0316 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.3568 | 0.5122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3568 | 0.3423 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3568 | 0.3423 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.022 | 0.0316 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.022 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.3568 | 0.3423 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.3568 | 0.3423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 354 nM | BindingDB_Patents: Enzyme Assay. Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sourced from Invitrogen (see table below). This activity-assay measures the phosphorylation of tyrosine residues within a substrate from the HTRF kit which has been validated by Cisbio for a variety of tyrosine kinases including the TRK receptors. Assay details: Target:TRKA; Invitrogen Cat# PV3144; Amino acids:aa 441-796; FAC enzyme:4nM; FAC ATP:40uM; Assay Reaction Time:35min. | ChEMBL. | No reference |
IC50 (binding) | = 354 nM | Enzyme Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.