Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotrophic tyrosine kinase, receptor, type 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.1064 | 0.1064 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.1064 | 0.1064 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.1064 | 0.1064 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.4503 | 0.4503 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.7465 | 0.7465 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.4859 | 0.4859 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.6693 | 0.6693 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.6693 | 0.6693 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.1064 | 0.1064 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.1064 | 0.1064 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.1064 | 0.1064 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.6693 | 0.6693 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.6693 | 0.6693 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.4859 | 0.4859 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.4503 | 0.4503 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4503 | 0.4503 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.6693 | 0.6693 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.4859 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.4859 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.6693 | 0.6693 |
Brugia malayi | hypothetical protein | 0.0042 | 0.4859 | 0.4859 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.7465 | 0.7465 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.4859 | 0.4859 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.4859 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.6693 | 0.6693 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.1064 | 0.1064 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.6693 | 0.6693 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.4859 | 0.4859 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.4859 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.7465 | 0.7465 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.1064 | 0.1064 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.7465 | 0.7465 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.6693 | 0.6693 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 716 nM | BindingDB_Patents: Enzyme Assay. Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sourced from Invitrogen (see table below). This activity-assay measures the phosphorylation of tyrosine residues within a substrate from the HTRF kit which has been validated by Cisbio for a variety of tyrosine kinases including the TRK receptors. Assay details: Target:TRKA; Invitrogen Cat# PV3144; Amino acids:aa 441-796; FAC enzyme:4nM; FAC ATP:40uM; Assay Reaction Time:35min. | ChEMBL. | No reference |
IC50 (binding) | = 716 nM | Enzyme Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.