Detailed information for compound 200499

Basic information

Technical information
  • TDR Targets ID: 200499
  • Name: 4-[(Z)-1-(5,5,8,8-tetramethyl-6,7-dihydronaph thalen-2-yl)prop-1-enyl]benzoic acid
  • MW: 348.478 | Formula: C24H28O2
  • H donors: 1 H acceptors: 2 LogP: 7.47 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C(\c1ccc2c(c1)C(C)(C)CCC2(C)C)/c1ccc(cc1)C(=O)O
  • InChi: 1S/C24H28O2/c1-6-19(16-7-9-17(10-8-16)22(25)26)18-11-12-20-21(15-18)24(4,5)14-13-23(20,2)3/h6-12,15H,13-14H2,1-5H3,(H,25,26)/b19-6-
  • InChiKey: ADPKGIMONMWKST-SWNXQHNESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(Z)-1-(1,1,4,4-tetramethyltetralin-6-yl)prop-1-enyl]benzoic acid
  • 4-[(Z)-1-(1,1,4,4-tetramethyl-6-tetralinyl)prop-1-enyl]benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens retinoid X receptor, beta Starlite/ChEMBL References
Homo sapiens retinoid X receptor, gamma Starlite/ChEMBL References
Homo sapiens retinoid X receptor, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus granulosus retinoic acid receptor rxr beta a Get druggable targets OG5_130073 All targets in OG5_130073
Schistosoma japonicum ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative Get druggable targets OG5_130073 All targets in OG5_130073
Schistosoma mansoni retinoic acid receptor RXR Get druggable targets OG5_130073 All targets in OG5_130073
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor retinoid X receptor, alpha 435 aa 352 aa 23.9 %
Brugia malayi ecdysteroid receptor retinoid X receptor, gamma 340 aa 338 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus granulosus somatostatin receptor 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Onchocerca volvulus Bile acid receptor homolog 0.007 0.026 0.046
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0101 0.0473 0.0814
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0101 0.0473 0.0836
Echinococcus granulosus 7tm_1 domain containing protein 0.0101 0.0473 0.0473
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0101 0.0473 0.0509
Schistosoma mansoni hypothetical protein 0.0065 0.0222 0.0382
Echinococcus granulosus neuropeptide receptor A26 0.0101 0.0473 0.0473
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0095 0.0432 0.0744
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0028 0.0048
Echinococcus multilocularis sex peptide receptor 0.0101 0.0473 0.0509
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Onchocerca volvulus 0.0101 0.0473 0.0836
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.0473 0.0814
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0101 0.0473 0.0509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.026 0.0448
Echinococcus multilocularis fmrfamide receptor 0.0101 0.0473 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.026 0.0381
Schistosoma mansoni biogenic amine receptor 0.0101 0.0473 0.0814
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.026 0.028
Schistosoma mansoni voltage-gated potassium channel 0.0079 0.0324 0.0558
Schistosoma mansoni biogenic amine receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.026 0.0448
Loa Loa (eye worm) TYRA-2 protein 0.0101 0.0473 0.0814
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0101 0.0473 0.0509
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0861 0.5808 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.026 0.0381
Brugia malayi G protein-coupled receptor F59B2.13 0.0101 0.0473 0.0693
Brugia malayi G-protein coupled receptor 0.0101 0.0473 0.0693
Echinococcus granulosus sex peptide receptor 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0802 0.5396 0.9291
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.005 0.0118 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0118 0.0203
Schistosoma mansoni hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0473 0.0473
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0101 0.0473 0.0473
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0028 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.026 0.0448
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.026 0.0381
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.026 0.028
Echinococcus multilocularis g-protein coupled receptor 0.0101 0.0473 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.026 0.0381
Onchocerca volvulus 0.0101 0.0473 0.0836
Brugia malayi RNA recognition motif domain containing protein 0.012 0.0612 0.0896
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0101 0.0473 0.0509
Brugia malayi follicle stimulating hormone receptor 0.0101 0.0473 0.0693
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0507 0.3322 0.3322
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0101 0.0473 0.0814
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.0473 0.0473
Brugia malayi neuropeptide F receptor 0.0101 0.0473 0.0693
Echinococcus multilocularis allatostatin A receptor 0.0101 0.0473 0.0509
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.026 0.028
Brugia malayi putative neuropeptide receptor NPR1 0.0101 0.0473 0.0693
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.026 0.026
Schistosoma mansoni tar DNA-binding protein 0.012 0.0612 0.1053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Schistosoma mansoni nuclear hormone receptor 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0406 0.2615 0.4502
Brugia malayi jmjC domain containing protein 0.005 0.0118 0.0172
Schistosoma mansoni hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.026 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.026 0.0381
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Brugia malayi Dopamine receptor protein 2 0.0101 0.0473 0.0693
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0048
Echinococcus granulosus allatostatin A receptor 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Echinococcus granulosus neuropeptide FF receptor 2 0.0101 0.0473 0.0473
Brugia malayi Serotonin receptor 0.1006 0.6824 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0101 0.0473 0.0473
Brugia malayi Dopamine receptor protein 1 0.0101 0.0473 0.0693
Echinococcus granulosus lysine specific demethylase 5A 0.005 0.0118 0.0118
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.005 0.0118 0.0127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.026 0.028
Onchocerca volvulus 0.0101 0.0473 0.0836
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0063 0.021 0.0361
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0473 0.0814
Onchocerca volvulus 0.0101 0.0473 0.0836
Schistosoma mansoni neuropeptide receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Brugia malayi nuclear receptor RXR 0.0037 0.0028 0.0041
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0473 0.0509
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.026 0.0381
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.0473 0.0814
Schistosoma mansoni hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.026 0.026
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0101 0.0473 0.0814
Onchocerca volvulus 0.0101 0.0473 0.0836
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0048
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0101 0.0473 0.0693
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0473 0.0509
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0473 0.0473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0028 0.0048
Brugia malayi Tachykinin-like peptides receptor 99D 0.0101 0.0473 0.0693
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0244 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.026 0.0381
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.0473 0.0814
Echinococcus multilocularis neuropeptide receptor 0.0101 0.0473 0.0509
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.026 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.026 0.0381
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.0473 0.0473
Echinococcus granulosus orexin receptor type 2 0.0101 0.0473 0.0473
Brugia malayi nuclear receptor NHR-88 0.007 0.026 0.0381
Schistosoma mansoni thyroid hormone receptor 0.007 0.026 0.0448
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.026 0.028
Brugia malayi G protein-coupled receptor 0.0101 0.0473 0.0693
Echinococcus multilocularis orexin receptor type 2 0.0101 0.0473 0.0509
Loa Loa (eye worm) hypothetical protein 0.0065 0.0222 0.0382
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Echinococcus granulosus peptide allatostatin:somatostatin 0.0101 0.0473 0.0473
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.026 0.0381
Echinococcus multilocularis neuropeptide s receptor 0.0101 0.0473 0.0509
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Brugia malayi Calcitonin receptor-like protein seb-1 0.0095 0.0432 0.0633
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.0473 0.0509
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0406 0.2615 0.4502
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0095 0.0432 0.0633
Echinococcus granulosus neuropeptide receptor 0.0101 0.0473 0.0473
Brugia malayi putative neuropeptide receptor 0.0101 0.0473 0.0693
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Onchocerca volvulus 0.0101 0.0473 0.0836
Schistosoma mansoni biogenic amine receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.0473 0.0814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Loa Loa (eye worm) hypothetical protein 0.0769 0.5163 0.8891
Schistosoma mansoni amine GPCR 0.0101 0.0473 0.0814
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0406 0.2615 0.3832
Schistosoma mansoni biogenic amine (5HT) receptor 0.0861 0.5808 1
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Brugia malayi hypothetical protein 0.0037 0.0028 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.026 0.028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.026 0.026
Brugia malayi RE15519p 0.0101 0.0473 0.0693
Schistosoma mansoni neuropeptide receptor 0.0101 0.0473 0.0814
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0244 0.5
Schistosoma mansoni tar DNA-binding protein 0.012 0.0612 0.1053
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.026 0.0448
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Schistosoma mansoni adenoreceptor 0.0101 0.0473 0.0814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Echinococcus multilocularis dro:myosuppressin receptor 0.0101 0.0473 0.0509
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.026 0.0381
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Brugia malayi AKH receptor 0.0101 0.0473 0.0693
Brugia malayi ORL1-like opioid receptor 0.0101 0.0473 0.0693
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Brugia malayi Steroid receptor seven-up type 2 0.007 0.026 0.0381
Schistosoma mansoni tar DNA-binding protein 0.012 0.0612 0.1053
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Schistosoma mansoni thyroid hormone receptor 0.007 0.026 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0101 0.0473 0.0509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus granulosus g-protein coupled receptor 0.0101 0.0473 0.0473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Schistosoma mansoni jumonji domain containing protein 0.005 0.0118 0.0203
Echinococcus granulosus fmrfamide receptor 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0101 0.0473 0.0814
Schistosoma mansoni myosin xvIII 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.026 0.028
Echinococcus granulosus serotonin receptor 0.0101 0.0473 0.0473
Echinococcus granulosus 7TM GPCR rhodopsin 0.0101 0.0473 0.0473
Brugia malayi hypothetical protein 0.0037 0.0028 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0079 0.0324 0.0558
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0101 0.0473 0.0509
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0473 0.0509
Loa Loa (eye worm) melatonin receptor type 1A 0.0101 0.0473 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.026 0.0448
Schistosoma mansoni neuropeptide receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0101 0.0473 0.0814
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0101 0.0473 0.0693
Brugia malayi RNA binding protein 0.012 0.0612 0.0896
Onchocerca volvulus 0.0101 0.0473 0.0836
Schistosoma mansoni jumonji/arid domain-containing protein 0.005 0.0118 0.0203
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.0473 0.0814
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.0277 0.0277
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0028 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0473 0.0473
Brugia malayi steroid hormone receptor 0.007 0.026 0.0381
Echinococcus granulosus g protein coupled receptor 0.0101 0.0473 0.0473
Echinococcus multilocularis serotonin receptor 0.0861 0.5808 0.6248
Brugia malayi Melatonin receptor type 1A 0.0101 0.0473 0.0693
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0101 0.0473 0.0814
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0473 0.0473
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni amine GPCR 0.0101 0.0473 0.0814
Onchocerca volvulus Neuropeptide F receptor homolog 0.0101 0.0473 0.0836
Brugia malayi Serotonin receptor 0.0101 0.0473 0.0693
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.0473 0.0473
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0839 0.5656 1
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.0473 0.0473
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.0473 0.0814
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0473 0.0814
Schistosoma mansoni coup transcription factor 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.0473 0.0509
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0222 0.0325
Brugia malayi GnHR receptor homolog 0.0101 0.0473 0.0693
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Onchocerca volvulus 0.0101 0.0473 0.0836
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.0473 0.0509
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.026 0.0448
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.026 0.026
Schistosoma mansoni amine GPCR 0.0101 0.0473 0.0814
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.012 0.0612 0.1053
Schistosoma mansoni amine GPCR 0.0101 0.0473 0.0814
Echinococcus multilocularis neuropeptide receptor 0.0101 0.0473 0.0509
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Echinococcus granulosus G protein coupled receptor 139 0.0101 0.0473 0.0473
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0028 0.003
Echinococcus granulosus g protein coupled receptor 0.0101 0.0473 0.0473
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0028 0.0041
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.0473 0.0509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.0473 0.0509
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.047 0.3062 0.3294
Schistosoma mansoni opsin-like receptor 0.0101 0.0473 0.0814
Echinococcus granulosus FTZ F1 alpha 0.007 0.026 0.026
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0073 0.0277 0.0477
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0101 0.0473 0.0509
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus granulosus tachykinin peptides receptor 99D 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0861 0.5808 1
Loa Loa (eye worm) TAR-binding protein 0.012 0.0612 0.1053
Echinococcus multilocularis lysine specific demethylase 5A 0.005 0.0118 0.0127
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.0473 0.0473
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0101 0.0473 0.0814
Onchocerca volvulus 0.0101 0.0473 0.0836
Echinococcus multilocularis conserved hypothetical protein 0.1358 0.9295 1
Schistosoma mansoni histamine h1 receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.026 0.0448
Echinococcus granulosus neuropeptide s receptor 0.0101 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0406 0.2615 0.4502
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.026 0.0381
Onchocerca volvulus 0.0101 0.0473 0.0836
Brugia malayi larval opioid receptor 0.0101 0.0473 0.0693
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0101 0.0473 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.026 0.0381
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0101 0.0473 0.0693
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.026 0.0381
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.0473 0.0814
Brugia malayi Dopamine receptor 0.0101 0.0473 0.0693
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0473 0.0473
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.026 0.026
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0073 0.0277 0.0406
Onchocerca volvulus 0.0101 0.0473 0.0836
Echinococcus multilocularis tar DNA binding protein 0.012 0.0612 0.0658
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.0473 0.0509
Onchocerca volvulus 0.0101 0.0473 0.0836
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Brugia malayi TAR-binding protein 0.012 0.0612 0.0896
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.026 0.046
Echinococcus multilocularis G-protein coupled receptor, putative 0.0101 0.0473 0.0509
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.0473 0.0473
Echinococcus granulosus g protein coupled receptor 0.0101 0.0473 0.0473
Schistosoma mansoni jumonji/arid domain-containing protein 0.005 0.0118 0.0203
Brugia malayi ecdysteroid receptor 0.007 0.026 0.0381
Brugia malayi G-protein coupled receptor 0.0101 0.0473 0.0693
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.0473 0.0509
Echinococcus multilocularis FTZ F1 alpha 0.007 0.026 0.028
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0101 0.0473 0.0509
Echinococcus multilocularis neuropeptide receptor A26 0.0101 0.0473 0.0509
Schistosoma mansoni opsin-like receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0101 0.0473 0.0814
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.0473 0.0814
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.026 0.0381
Brugia malayi hypothetical protein 0.0101 0.0473 0.0693
Loa Loa (eye worm) hypothetical protein 0.0037 0.0028 0.0048
Echinococcus granulosus neuropeptide receptor 0.0101 0.0473 0.0473
Loa Loa (eye worm) RNA binding protein 0.012 0.0612 0.1053
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0101 0.0473 0.0814
Echinococcus granulosus biogenic amine 5HT receptor 0.0861 0.5808 0.5808
Echinococcus multilocularis fmrfamide receptor 0.0101 0.0473 0.0509
Onchocerca volvulus 0.0101 0.0473 0.0836
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.026 0.0448
Brugia malayi jmjC domain containing protein 0.005 0.0118 0.0172
Echinococcus multilocularis somatostatin receptor 0.0101 0.0473 0.0509
Schistosoma mansoni neuropeptide receptor 0.0101 0.0473 0.0814
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0101 0.0473 0.0473
Brugia malayi neuropeptide F receptor 0.0101 0.0473 0.0693
Brugia malayi sulfakinin receptor protein 0.0101 0.0473 0.0693
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0473 0.0509
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0101 0.0473 0.0693
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.026 0.028
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0101 0.0473 0.0473
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0101 0.0473 0.0473
Onchocerca volvulus 0.0101 0.0473 0.0836
Loa Loa (eye worm) hypothetical protein 0.0095 0.0432 0.0744
Onchocerca volvulus 0.0101 0.0473 0.0836
Onchocerca volvulus 0.0101 0.0473 0.0836
Brugia malayi nuclear hormone receptor 0.007 0.026 0.0381
Schistosoma mansoni tar DNA-binding protein 0.012 0.0612 0.1053
Loa Loa (eye worm) hypothetical protein 0.007 0.026 0.0448
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.0473 0.0473
Schistosoma mansoni growth hormone secretagogue receptor 0.0101 0.0473 0.0814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Onchocerca volvulus 0.0101 0.0473 0.0836
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.026 0.0448
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.0473 0.0473
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni opsin-like receptor 0.0101 0.0473 0.0814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.0473 0.0509
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) steroid hormone receptor 0.007 0.026 0.0448
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0473 0.0473
Echinococcus multilocularis neuropeptide FF receptor 2 0.0101 0.0473 0.0509
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.0277 0.0298
Onchocerca volvulus 0.007 0.026 0.046
Schistosoma mansoni neuropeptide f receptor 76f 0.0101 0.0473 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.026 0.0381
Schistosoma mansoni retinoic acid receptor RXR 0.0507 0.3322 0.572
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Loa Loa (eye worm) hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni hypothetical protein 0.0101 0.0473 0.0814
Schistosoma mansoni alpha-1 adrenergic receptor 0.0101 0.0473 0.0814
Echinococcus granulosus dro:myosuppressin receptor 0.0101 0.0473 0.0473
Echinococcus multilocularis serotonin receptor 0.0861 0.5808 0.6248
Echinococcus granulosus tar DNA binding protein 0.012 0.0612 0.0612
Schistosoma mansoni amine GPCR 0.0101 0.0473 0.0814
Echinococcus multilocularis G protein coupled receptor 139 0.0101 0.0473 0.0509
Brugia malayi nuclear hormone receptor 0.0802 0.5396 0.7907
Schistosoma mansoni tar DNA-binding protein 0.012 0.0612 0.1053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.0473 0.0814
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.0473 0.0473
Echinococcus multilocularis g protein coupled receptor 0.0101 0.0473 0.0509

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 48 % Relative activity against Retinoic acid receptor alpha at 10e-6 M with respect to 10e-6 M of trans-RA ChEMBL. 7650690
Activity (binding) = 48 % Relative activity against Retinoic acid receptor gamma at 10e-6 M with respect to 10e-6 M of trans-RA ChEMBL. 7650690
Activity (binding) = 48 % Relative activity against Retinoic acid receptor alpha at 10e-6 M with respect to 10e-6 M of trans-RA ChEMBL. 7650690
Activity (binding) = 48 % Relative activity against Retinoic acid receptor gamma at 10e-6 M with respect to 10e-6 M of trans-RA ChEMBL. 7650690
Activity (binding) = 97 % Relative activity against Retinoic acid receptor RXR-alpha at 10e-6 M retinoid relative to 10e-6 M of 9-cis-RA. ChEMBL. 7650690
Activity (binding) = 97 % Relative activity against Retinoic acid receptor RXR-alpha at 10e-6 M retinoid relative to 10e-6 M of 9-cis-RA. ChEMBL. 7650690
Activity (binding) = 102 % Relative activity against Retinoic acid receptor beta at 10e-6 M with respect to 10e-6 M of trans-RA ChEMBL. 7650690
Activity (binding) = 102 % Relative activity against Retinoic acid receptor beta at 10e-6 M with respect to 10e-6 M of trans-RA ChEMBL. 7650690
EC50 (binding) = 55 nM Effective concentration against Retinoic acid receptor RXR-alpha ChEMBL. 7650690
EC50 (binding) = 55 nM Effective concentration against Retinoic acid receptor RXR-alpha ChEMBL. 7650690
EC50 (binding) = 160 nM Effective concentrations against Retinoic acid receptor RXR-beta ChEMBL. 7650690
EC50 (binding) = 160 nM Effective concentrations against Retinoic acid receptor RXR-beta ChEMBL. 7650690
EC50 (binding) = 370 nM Effective concentrations against Retinoic acid receptor RXR-gamma ChEMBL. 7650690
EC50 (binding) = 370 nM Effective concentrations against Retinoic acid receptor RXR-gamma ChEMBL. 7650690
EC50 (binding) = 470 nM Effective concentration against Retinoic acid receptor RXR-alpha ChEMBL. 7650690
EC50 (binding) = 470 nM Effective concentration against Retinoic acid receptor RXR-alpha ChEMBL. 7650690

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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