Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 2600 nM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8230134 |
IC50 (binding) | > 2600 nM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 8230134 |
IC50 (binding) | > 2600 nM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8230134 |
IC50 (binding) | > 2600 nM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 8230134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.