TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.435 | Formula: C22H23N3O5
H donors: 2 H acceptors: 3 LogP: 1.9 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC(C(=O)NC1C(=O)N2[C@H]1OCC2)Cc1ccccc1)OCc1ccccc1
InChi: 1S/C22H23N3O5/c26-19(24-18-20(27)25-11-12-29-21(18)25)17(13-15-7-3-1-4-8-15)23-22(28)30-14-16-9-5-2-6-10-16/h1-10,17-18,21H,11-14H2,(H,23,28)(H,24,26)/t17?,18?,21-/m0/s1
InChiKey: VYRSXJDNPISAMG-NGICGMGXSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Rattus norvegicus	Cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	346 aa	26.9 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Cathepsin L	334 aa	311 aa	36.0 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	276 aa	26.8 %
Onchocerca volvulus		Cathepsin L	334 aa	321 aa	38.0 %
Brugia malayi	cathepsin B-like cysteine proteinase	Cathepsin L	334 aa	303 aa	23.4 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Cathepsin L	334 aa	359 aa	29.8 %
Plasmodium vivax	vivapain-3	Cathepsin L	334 aa	345 aa	30.7 %
Echinococcus multilocularis	cathepsin L	Cathepsin L	334 aa	274 aa	48.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	347 aa	26.5 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin L	334 aa	292 aa	22.6 %
Plasmodium vivax	vivapain-1	Cathepsin L	334 aa	366 aa	28.4 %
Schistosoma mansoni	cathepsin S (C01 family)	Cathepsin L	334 aa	311 aa	35.0 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin L	334 aa	273 aa	27.8 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Cathepsin L	334 aa	277 aa	24.5 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	27.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	346 aa	26.9 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	274 aa	24.8 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	275 aa	29.1 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	276 aa	25.4 %
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Cathepsin L	334 aa	290 aa	27.6 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	270 aa	25.6 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin L	334 aa	329 aa	39.5 %
Plasmodium knowlesi	knowpain-1	Cathepsin L	334 aa	373 aa	27.6 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	341 aa	26.7 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin L	334 aa	322 aa	41.6 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin L	334 aa	278 aa	26.6 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	282 aa	26.2 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	277 aa	26.0 %
Onchocerca volvulus		Cathepsin L	334 aa	311 aa	40.8 %
Brugia malayi	Papain family cysteine protease containing protein	Cathepsin L	334 aa	296 aa	31.8 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	274 aa	25.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	295 aa	25.4 %
Theileria parva	cysteine proteinase, putative	Cathepsin L	334 aa	337 aa	26.1 %
Babesia bovis	papain family cysteine protease containing protein	Cathepsin L	334 aa	321 aa	32.7 %
Onchocerca volvulus	Protein MCM10 homolog	Cathepsin L	334 aa	300 aa	41.0 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin L	334 aa	304 aa	33.2 %
Theileria parva	cysteine proteinase, putative	Cathepsin L	334 aa	333 aa	28.8 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	27.9 %
Echinococcus granulosus	cathepsin L	Cathepsin L	334 aa	325 aa	29.5 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin L	334 aa	273 aa	25.3 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	279 aa	28.3 %
Onchocerca volvulus		Cathepsin L	334 aa	325 aa	47.4 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	27.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	346 aa	23.4 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin L	334 aa	271 aa	27.7 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin L	334 aa	295 aa	28.1 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin L	334 aa	298 aa	28.9 %
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Cathepsin L	334 aa	273 aa	26.0 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	271 aa	26.9 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin L	334 aa	304 aa	33.9 %
Trypanosoma congolense	cysteine peptidase C (CPC)	Cathepsin L	334 aa	280 aa	28.6 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin L	334 aa	329 aa	39.5 %
Plasmodium yoelii	cysteine proteinase precursor	Cathepsin L	334 aa	360 aa	29.2 %
Dictyostelium discoideum	hypothetical protein	Cathepsin L	334 aa	324 aa	34.6 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Cathepsin L	334 aa	304 aa	28.3 %
Neospora caninum	hypothetical protein	Cathepsin L	334 aa	299 aa	28.4 %
Onchocerca volvulus		Cathepsin L	334 aa	300 aa	24.3 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Cathepsin L	334 aa	318 aa	48.4 %
Echinococcus granulosus	cathepsin L	Cathepsin L	334 aa	274 aa	48.5 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	347 aa	26.5 %
Echinococcus granulosus	cathepsin L cysteine protease	Cathepsin L	334 aa	323 aa	46.1 %
Trypanosoma cruzi	cysteine protease, putative	Cathepsin L	334 aa	323 aa	30.3 %
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Cathepsin L	334 aa	277 aa	26.0 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	317 aa	33.8 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	336 aa	25.9 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin L	334 aa	294 aa	23.8 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	270 aa	25.6 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Cathepsin L	334 aa	309 aa	26.5 %
Giardia lamblia	Cathepsin L precursor	Cathepsin L	334 aa	303 aa	26.1 %
Plasmodium berghei	berghepain-1	Cathepsin L	334 aa	353 aa	29.7 %
Theileria parva	cysteine proteinase, putative	Cathepsin L	334 aa	347 aa	28.8 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin L	334 aa	312 aa	42.0 %
Plasmodium vivax	unspecified product	Cathepsin L	334 aa	366 aa	28.4 %
Echinococcus granulosus	cysteine protease	Cathepsin L	334 aa	323 aa	44.3 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Cathepsin L	334 aa	345 aa	35.4 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Cathepsin L	334 aa	279 aa	25.8 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	332 aa	23.5 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	372 aa	23.7 %
Onchocerca volvulus		Cathepsin L	334 aa	321 aa	36.4 %
Dictyostelium discoideum	hypothetical protein	Cathepsin L	334 aa	325 aa	38.1 %
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Cathepsin L	334 aa	288 aa	26.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin L	334 aa	319 aa	25.7 %
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	Cathepsin L	334 aa	316 aa	30.1 %
Echinococcus multilocularis	cathepsin L	Cathepsin L	334 aa	309 aa	30.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	histone deacetylase 8	0.0171	0.0299	0.0299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0094	0.0094
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0071	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0071	0.0059	0.0059
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0071	0.0059	0.0059
Toxoplasma gondii	histone deacetylase HDAC3	0.0362	0.0757	0.9051
Leishmania major	histone deacetylase, putative	0.0362	0.0757	0.0706
Loa Loa (eye worm)	hypothetical protein	0.4211	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0221	0.042	0.0391
Schistosoma mansoni	hypothetical protein	0.0071	0.0059	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Onchocerca volvulus		0.4211	1	1
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Trypanosoma cruzi	histone deacetylase 1, putative	0.0362	0.0757	0.0757
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Trypanosoma cruzi	histone deacetylase, putative	0.0171	0.0299	0.0299
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0071	0.0059	0.0059
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.0322	0.0322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Schistosoma mansoni	hypothetical protein	0.0071	0.0059	0.0059
Giardia lamblia	Hypothetical protein	0.2485	0.5856	1
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.0094	0.0064
Schistosoma mansoni	histone deacetylase 1 2 3	0.0171	0.0299	0.0299
Brugia malayi	Cathepsin L-like precursor	0.0059	0.003	0.0361
Loa Loa (eye worm)	histone deacetylase 7A	0.0393	0.0831	0.0803
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.003	0.0051
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0071	0.0059	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.0055	0.073
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0059	0.0775
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0071	0.0059	0.0775
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1797	0.4203	0.4203
Brugia malayi	Histone deacetylase family protein	0.0393	0.0831	1
Schistosoma mansoni	hypothetical protein	0.0071	0.0059	0.0059
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.4139	0.9829	0.9829
Plasmodium falciparum	histone deacetylase 1	0.0362	0.0757	0.9114
Loa Loa (eye worm)	histone deacetylase 1	0.0362	0.0757	0.0729
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.0094	0.1134
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0362	0.0757	1
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.4211	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.0094	0.1134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Leishmania major	histone deacetylase, putative	0.0393	0.0831	0.078
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Brugia malayi	phosphoglycerate mutase family protein	0.0071	0.0059	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0059	0.0029
Echinococcus granulosus	histone deacetylase 6	0.0399	0.0846	0.0846
Echinococcus multilocularis	cathepsin b	0.0181	0.0322	0.0322
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0071	0.0059	0.0059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0071	0.0059	0.0059
Echinococcus multilocularis	phosphoglycerate mutase	0.0071	0.0059	0.0059
Schistosoma mansoni	histone deacetylase	0.0362	0.0757	0.0757
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.0094	0.0064
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.003	0.0361
Brugia malayi	histone deacetylase 1 (HD1)	0.0362	0.0757	0.9114
Echinococcus multilocularis	histone deacetylase	0.0393	0.0831	0.0831
Toxoplasma gondii	histone deacetylase HDAC5	0.0171	0.0299	0.3146
Echinococcus multilocularis	cysteine protease	0.0086	0.0094	0.0094
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.0094	0.0094
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1797	0.4203	0.4203
Schistosoma mansoni	phosphoglycerate mutase	0.0071	0.0059	0.0059
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0071	0.0059	0.0059
Leishmania major	histone deacetylase, putative	0.0393	0.0831	0.078
Loa Loa (eye worm)	hypothetical protein	0.4139	0.9829	0.9829
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Loa Loa (eye worm)	phosphoglycerate mutase	0.0071	0.0059	0.0029
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0071	0.0059	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.0094	0.0094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.4211	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Plasmodium falciparum	histone deacetylase 2	0.0393	0.0831	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Brugia malayi	cathepsin L-like precursor	0.0059	0.003	0.0361
Brugia malayi	Histone deacetylase 1	0.0362	0.0757	0.9114
Plasmodium vivax	vivapain-2	0.0086	0.0094	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0114	0.0084
Plasmodium vivax	histone deacetylase 2, putative	0.0393	0.0831	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0362	0.0757	0.0757
Toxoplasma gondii	hypothetical protein	0.0094	0.0114	0.076
Leishmania major	phosphoglycerate mutase protein, putative	0.0071	0.0059	0.0003
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0071	0.0059	0.0059
Echinococcus granulosus	cathepsin l1	0.0059	0.003	0.003
Trypanosoma cruzi	histone deacetylase, putative	0.0393	0.0831	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0435	0.0406
Toxoplasma gondii	phosphoglycerate mutase	0.0071	0.0059	0.0044
Trypanosoma brucei	histone deacetylase 3	0.0393	0.0831	0.0831
Echinococcus granulosus	histone deacetylase 6	0.0393	0.0831	0.0831
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0071	0.0059	0.0775
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.0094	0.1134
Echinococcus multilocularis	histone deacetylase 6	0.0393	0.0831	0.0831
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0071	0.0059	0.0059
Brugia malayi	Cathepsin L-like precursor	0.0059	0.003	0.0361
Onchocerca volvulus		0.0086	0.0094	0.0064
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0362	0.0757	1
Onchocerca volvulus		0.0086	0.0094	0.0064
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0094	0.0094
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0071	0.0059	0.0044
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0362	0.0757	1
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0071	0.0059	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.0094	0.1134
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0071	0.0059	0.0707
Toxoplasma gondii	histone deacetylase HDAC2	0.0362	0.0757	0.9051
Echinococcus multilocularis	histone deacetylase 6	0.0399	0.0846	0.0846
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0071	0.0059	0.0003
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0094	0.1134
Schistosoma mansoni	hypothetical protein	0.0071	0.0059	0.0059
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0071	0.0059	0.5
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0071	0.0059	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0059	0.0029
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0094	0.0064
Trichomonas vaginalis	histone deacetylase, putative	0.0362	0.0757	1
Loa Loa (eye worm)	histone deacetylase	0.0393	0.0831	0.0803
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.0094	0.0064
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0071	0.0059	0.0003
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1797	0.4203	0.4203
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0071	0.0059	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.4139	0.9829	0.9829
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0071	0.0059	0.0059
Echinococcus multilocularis	cathepsin b	0.0181	0.0322	0.0322
Schistosoma mansoni	histone deacetylase	0.0362	0.0757	0.0757
Trichomonas vaginalis	histone deacetylase, putative	0.0362	0.0757	1
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.2485	0.5856	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.4211	1	1
Onchocerca volvulus		0.0071	0.0059	0.0029
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0071	0.0059	0.0059
Echinococcus granulosus	cathepsin b	0.0181	0.0322	0.0322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Schistosoma mansoni	histone deacetylase hda2	0.0171	0.0299	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0299	0.027
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0071	0.0059	0.0059
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.0094	0.0064
Echinococcus multilocularis	phosphoglycerate mutase	0.0071	0.0059	0.0059
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.0094	0.0094
Toxoplasma gondii	cathepsin CPL	0.0086	0.0094	0.0502
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.4139	0.9829	0.9829
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0114	0.0084
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.0094	0.0039
Echinococcus granulosus	phosphoglycerate mutase	0.0071	0.0059	0.0059
Loa Loa (eye worm)	fibroinase	0.0086	0.0094	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0322	0.0293
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Loa Loa (eye worm)	cathepsin B	0.007	0.0055	0.0025
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0059	0.5
Trypanosoma cruzi	histone deacetylase, putative	0.0171	0.0299	0.0299
Brugia malayi	histone deacetylase 3 (HD3)	0.0362	0.0757	0.9114
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.003	0.003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0059	0.5
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0071	0.0059	0.0044
Loa Loa (eye worm)	hypothetical protein	0.2414	0.5685	0.5672
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0071	0.0059	0.0775
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0059	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.003	0.0396
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1797	0.4203	0.4171
Leishmania major	histone deacetylase, putative	0.0362	0.0757	0.0706
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0322	0.0322
Trypanosoma cruzi	histone deacetylase, putative	0.0393	0.0831	0.0831
Treponema pallidum	phosphoglyceromutase	0.0071	0.0059	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.003	0.0396
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0071	0.0059	0.0059
Loa Loa (eye worm)	ctsf protein	0.0086	0.0094	0.0064
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0071	0.0059	0.0775
Mycobacterium ulcerans	hypothetical protein	0.2485	0.5856	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0094	0.1134
Trypanosoma brucei	histone deacetylase 2	0.0171	0.0299	0.0299
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Plasmodium vivax	histone deacetylase, putative	0.0171	0.0299	0.3602
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0071	0.0059	0.01
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.0094	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Echinococcus multilocularis	cysteine protease	0.0086	0.0094	0.0094
Echinococcus multilocularis	histone deacetylase 6	0.0393	0.0831	0.0831
Echinococcus granulosus	histone deacetylase 7	0.0393	0.0831	0.0831
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Giardia lamblia	Histone deacetylase	0.0362	0.0757	0.121
Onchocerca volvulus	Protein UBASH3A homolog	0.0071	0.0059	0.0029
Onchocerca volvulus		0.0086	0.0094	0.0064
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.4211	1	1
Echinococcus multilocularis	histone deacetylase 8	0.0171	0.0299	0.0299
Trypanosoma brucei	histone deacetylase 4	0.0393	0.0831	0.0831
Onchocerca volvulus		0.0071	0.0059	0.0029
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0071	0.0059	0.0044
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.4211	1	1
Onchocerca volvulus	Protein UBASH3A homolog	0.0071	0.0059	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Echinococcus granulosus	histone deacetylase 3	0.0362	0.0757	0.0757
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0059	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0059	0.5
Echinococcus multilocularis	histone deacetylase 7	0.0393	0.0831	0.0831
Echinococcus granulosus	histone deacetylase 6	0.0393	0.0831	0.0831
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0071	0.0059	0.0044
Brugia malayi	histone deacetylase 11	0.0171	0.0299	0.3602
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.0094	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0094	0.1134
Onchocerca volvulus	Protein UBASH3A homolog	0.0071	0.0059	0.0029
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0094	0.0094
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.0094	0.0094
Leishmania major	glycerolphosphate mutase, putative	0.0071	0.0059	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0059	0.0775
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.0094	0.0161
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0071	0.0059	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.0094	0.1244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Leishmania major	hypothetical protein, conserved	0.0071	0.0059	0.0003
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.4139	0.9829	0.9828
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0114	0.0084
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0094	0.1134
Schistosoma mansoni	phosphoglycerate mutase	0.0071	0.0059	0.0059
Echinococcus multilocularis	phosphoglycerate mutase	0.0071	0.0059	0.0059
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0071	0.0059	0.5
Echinococcus granulosus	phosphoglycerate mutase	0.0071	0.0059	0.0059
Onchocerca volvulus		0.0086	0.0094	0.0064
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0071	0.0059	0.5
Echinococcus multilocularis	phosphoglycerate mutase	0.0071	0.0059	0.0059
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.003	0.003
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0171	0.0299	0.027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0071	0.0059	0.0059
Onchocerca volvulus	Protein UBASH3A homolog	0.0071	0.0059	0.0029
Schistosoma mansoni	histone deacetylase 4 5	0.0393	0.0831	0.0831
Toxoplasma gondii	histone deacetylase HDAC1	0.0393	0.0831	1
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0071	0.0059	0.0059
Echinococcus granulosus	phosphoglycerate mutase	0.0071	0.0059	0.0059
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Trichomonas vaginalis	histone deacetylase, putative	0.0362	0.0757	1
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Trypanosoma brucei	histone deacetylase 1	0.0362	0.0757	0.0757
Plasmodium vivax	phosphoglycerate mutase, putative	0.0071	0.0059	0.0707
Schistosoma mansoni	6-phosphofructokinase	0.4211	1	1
Mycobacterium leprae	probable isochorismate synthase EntC	0.0071	0.0059	0.5
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0071	0.0059	0.5
Trichomonas vaginalis	histone deacetylase, putative	0.0362	0.0757	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.0094	0.0094
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.2485	0.5856	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.0094	0.0064
Echinococcus multilocularis	histone deacetylase 1	0.0362	0.0757	0.0757
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Schistosoma mansoni	histone deacetylase hda2	0.0399	0.0846	0.0846
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0071	0.0059	0.0059
Brugia malayi	phosphoglycerate mutase family protein	0.0071	0.0059	0.0707
Echinococcus granulosus	cathepsin l1	0.0086	0.0094	0.0094
Loa Loa (eye worm)	histone deacetylase 3	0.0362	0.0757	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0059	0.0029
Trichomonas vaginalis	histone deacetylase, putative	0.0362	0.0757	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0094	0.0114	0.0084
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0071	0.0059	0.0775
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.0094	0.0094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Echinococcus granulosus	histone deacetylase	0.0393	0.0831	0.0831
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.0094	0.0094
Plasmodium vivax	phosphoglucomutase-2, putative	0.0071	0.0059	0.0707
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0094	0.1134
Leishmania major	hypothetical protein, conserved	0.0071	0.0059	0.0003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Onchocerca volvulus		0.0086	0.0094	0.0064
Trichomonas vaginalis	histone deacetylase, putative	0.0362	0.0757	1
Trypanosoma brucei	histone deacetylase, putative	0.0393	0.0831	0.0831
Onchocerca volvulus		0.0086	0.0094	0.0064
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0071	0.0059	0.5
Echinococcus multilocularis	phosphoglycerate mutase	0.0071	0.0059	0.0059
Toxoplasma gondii	histone deacetylase HDAC4	0.0171	0.0299	0.3146
Onchocerca volvulus		0.0086	0.0094	0.0064
Onchocerca volvulus		0.0071	0.0059	0.0029
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.0094	0.0161
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0071	0.0059	0.0059
Leishmania major	hypothetical protein, conserved	0.0071	0.0059	0.0003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0071	0.0059	0.0059
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0071	0.0059	0.0059
Leishmania major	phosphoglycerate mutase, putative	0.0071	0.0059	0.0003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.0094	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Echinococcus multilocularis	phosphoglycerate mutase	0.0071	0.0059	0.0059
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0071	0.0059	0.01
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0071	0.0059	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0322	0.0322
Echinococcus granulosus	histone deacetylase 1	0.0362	0.0757	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0059	0.0029
Echinococcus granulosus	phosphoglycerate mutase	0.0071	0.0059	0.0059
Brugia malayi	Histone deacetylase family protein	0.0393	0.0831	1
Entamoeba histolytica	histone deacetylase, putative	0.0362	0.0757	0.1293
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.0055	0.0055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.0094	0.1244
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.0094	0.0094
Loa Loa (eye worm)	histone deacetylase 11	0.0171	0.0299	0.027
Leishmania major	cathepsin L-like protease	0.0086	0.0094	0.0039
Loa Loa (eye worm)	cysteine protease	0.0086	0.0094	0.0064
Plasmodium vivax	histone deacetylase, putative	0.0393	0.0831	1
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0071	0.0059	0.5
Brugia malayi	UBASH3A protein homolog	0.0071	0.0059	0.0707
Trypanosoma cruzi	histone deacetylase, putative	0.0393	0.0831	0.0831
Schistosoma mansoni	hypothetical protein	0.0071	0.0059	0.0059
Giardia lamblia	Hypothetical protein	0.2485	0.5856	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.0055	0.0055
Plasmodium falciparum	phosphoglucomutase-2	0.0071	0.0059	0.0707
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0071	0.0059	0.5
Plasmodium vivax	histone deacetylase 1, putative	0.0362	0.0757	0.9114
Plasmodium falciparum	histone deacetylase, putative	0.0393	0.0831	1
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0071	0.0059	0.0059
Schistosoma mansoni	histone deacetylase 4 5	0.0393	0.0831	0.0831
Echinococcus multilocularis	histone deacetylase 3	0.0362	0.0757	0.0757
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0071	0.0059	0.01
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.0094	0.1244
Leishmania major	hypothetical protein, unknown function	0.0071	0.0059	0.0003
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0071	0.0059	0.0059
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.0055	0.0055
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.0322	0.3877
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.0322	0.0322
Entamoeba histolytica	cysteine protease, putative	0.0086	0.0094	0.0161
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.0094	0.1244
Echinococcus granulosus	cathepsin b	0.0181	0.0322	0.0322
Brugia malayi	Cathepsin L-like precursor	0.0086	0.0094	0.1134
Plasmodium vivax	vivapain-2	0.0086	0.0094	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0362	0.0757	0.0729
Echinococcus granulosus	phosphoglycerate mutase	0.0071	0.0059	0.0059

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5 nM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 5 nM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 4 uM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease	ChEMBL.	12419374
IC50 (binding)	= 4 uM	Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease	ChEMBL.	12419374

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL332025

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 200758