Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase 1 | 0.0148 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0148 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.0114 | 0.619 | 0.619 |
Brugia malayi | Histone deacetylase 1 | 0.0148 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0148 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0148 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0148 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0114 | 0.619 | 0.619 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.8202 | 0.8202 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0114 | 0.619 | 0.619 |
Plasmodium vivax | histone deacetylase, putative | 0.0114 | 0.619 | 0.619 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.8202 | 0.8202 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.8202 | 0.8202 |
Loa Loa (eye worm) | histone deacetylase | 0.0114 | 0.619 | 0.619 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0148 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0148 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0148 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0148 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.8202 | 0.8202 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0126 | 0.7547 | 0.7547 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0114 | 0.619 | 0.619 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0114 | 0.619 | 0.619 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.8202 | 0.8202 |
Giardia lamblia | Histone deacetylase | 0.0148 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0148 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.8202 | 0.8202 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0148 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0114 | 0.619 | 0.619 |
Trypanosoma brucei | histone deacetylase 1 | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 0.8202 | 0.8202 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0114 | 0.619 | 0.619 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0148 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0114 | 0.619 | 0.619 |
Echinococcus granulosus | histone deacetylase 6 | 0.0114 | 0.619 | 0.619 |
Plasmodium falciparum | histone deacetylase 1 | 0.0148 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0114 | 0.619 | 0.619 |
Trypanosoma brucei | histone deacetylase, putative | 0.0114 | 0.619 | 0.619 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0148 | 1 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0114 | 0.619 | 0.619 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0114 | 0.619 | 0.619 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 0.8202 | 0.8202 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0895 | 0.0895 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0148 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 0.8202 | 0.8202 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 0.8202 | 0.8202 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0114 | 0.619 | 0.619 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0114 | 0.619 | 0.619 |
Echinococcus granulosus | histone deacetylase | 0.0114 | 0.619 | 0.619 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0114 | 0.619 | 0.619 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0148 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0148 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0148 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0148 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0148 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0126 | 0.7547 | 0.7547 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 0.8202 | 0.8202 |
Schistosoma mansoni | histone deacetylase | 0.0148 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0114 | 0.619 | 0.619 |
Echinococcus granulosus | histone deacetylase 3 | 0.0148 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0126 | 0.7547 | 0.7547 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.8202 | 0.8202 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0148 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0148 | 1 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0114 | 0.619 | 0.619 |
Leishmania major | histone deacetylase, putative | 0.0148 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0148 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0114 | 0.619 | 0.619 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0114 | 0.619 | 0.619 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0059 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 0.8202 | 0.8202 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0148 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.8 | Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments | ChEMBL. | 12139452 |
Log Ki (binding) | = 8.8 | Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments | ChEMBL. | 12139452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.