Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.0106 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0106 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0106 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0149 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0106 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0106 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0106 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0149 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0106 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0106 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta mean survival time (functional) | = 7.2 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 8.3 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 8.8 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 7.2 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 8.3 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
Delta mean survival time (functional) | = 8.8 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 2 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 4 | Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 2 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 4 | Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.