TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.56 | Formula: C26H36O6
H donors: 4 H acceptors: 5 LogP: 8.16 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1c(OCCCCCCCCCCc2cccc(c2O)O)ccc(c1O)C(=O)O
InChi: 1S/C26H36O6/c1-2-12-20-23(17-16-21(25(20)29)26(30)31)32-18-10-8-6-4-3-5-7-9-13-19-14-11-15-22(27)24(19)28/h11,14-17,27-29H,2-10,12-13,18H2,1H3,(H,30,31)
InChiKey: KBPZHHDBBBMAFS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Arachidonate 5-lipoxygenase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Echinococcus multilocularis	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing	Get druggable targets OG5_127482	All targets in OG5_127482
Echinococcus granulosus	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative	Get druggable targets OG5_127482	All targets in OG5_127482

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Brugia malayi	cathepsin L-like cysteine proteinase	0.0097	0.0369	0.0369
Giardia lamblia	Cathepsin B precursor	0.0421	0.3348	1
Onchocerca volvulus		0.0267	0.1928	0.6358
Trypanosoma cruzi	cruzipain precursor, putative	0.0383	0.2991	0.2931
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0369	0.0874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Brugia malayi	Cathepsin L-like precursor	0.0267	0.1928	0.1928
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0097	0.0369	0.0977
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0097	0.0369	0.0369
Echinococcus granulosus	tissue type plasminogen activator	0.0066	0.0086	0.0086
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0097	0.0369	0.0369
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0238	0.1663	0.4933
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0213	0.1432	0.1432
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0097	0.0369	0.0369
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0097	0.0369	0.0977
Loa Loa (eye worm)	trypsin family protein	0.0065	0.0072	0.0072
Schistosoma mansoni	cathepsin B (C01 family)	0.0097	0.0369	0.0369
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0267	0.1928	0.1859
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0017	0.0017
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0097	0.0369	0.0977
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2991	0.2991
Plasmodium vivax	vivapain-1	0.0213	0.1432	0.4635
Trypanosoma cruzi	cysteine peptidase, putative	0.0116	0.0541	0.046
Brugia malayi	eukaryotic initiation factor 4A	0.0238	0.1663	0.1663
Brugia malayi	Papain family cysteine protease containing protein	0.0213	0.1432	0.1432
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Onchocerca volvulus		0.0229	0.1579	0.5164
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Echinococcus multilocularis	cathepsin b	0.1146	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0213	0.1432	0.4635
Entamoeba histolytica	cysteine proteinase 2	0.0213	0.1432	0.4054
Plasmodium vivax	vivapain-2	0.0383	0.2991	1
Brugia malayi	fibroinase precursor	0.0097	0.0369	0.0369
Echinococcus granulosus	transmembrane protease serine 3	0.0065	0.0072	0.0072
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2991	1
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0238	0.1663	0.4836
Echinococcus multilocularis	calpain family protein 1, d	0.0091	0.031	0.031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0213	0.1432	0.1432
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.5599	0.5599
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0238	0.1663	0.1663
Entamoeba histolytica	cysteine proteinase, putative	0.0267	0.1928	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Trypanosoma cruzi	major cysteine proteinase, putative	0.0097	0.0369	0.0286
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0238	0.1663	0.1663
Echinococcus multilocularis	cysteine protease	0.0383	0.2991	0.2991
Brugia malayi	Papain family cysteine protease containing protein	0.0213	0.1432	0.1432
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0017	0.0017
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0238	0.1663	0.1663
Loa Loa (eye worm)	cathepsin B	0.0421	0.3348	0.3348
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2991	0.2931
Echinococcus multilocularis	cathepsin L	0.0097	0.0369	0.0369
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0421	0.3348	0.3348
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0369	0.0874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.1928	0.565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Trypanosoma cruzi	cysteine peptidase, putative	0.0213	0.1432	0.1358
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1928	0.1928
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0383	0.2991	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0541	0.0541
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0017	0.0017
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0123	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0066	0.0086	0.0086
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0129	0.066	0.066
Loa Loa (eye worm)	calpain family protein 1	0.0123	0.0608	0.0608
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2991	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0369	0.0874
Plasmodium vivax	vivapain-3	0.0213	0.1432	0.4635
Echinococcus granulosus	cathepsin l1	0.0383	0.2991	0.2991
Entamoeba histolytica	cysteine proteinase, putative	0.0213	0.1432	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0097	0.0369	0.0977
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2991	0.2991
Mycobacterium ulcerans	hypothetical protein	0.0065	0.0072	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0267	0.1928	0.1928
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0383	0.2991	0.2991
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0369	0.0369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0541	0.0541
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0097	0.0369	0.0977
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0116	0.0541	0.0541
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0369	0.0874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0369	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1014	0.1014
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2991	0.2991
Echinococcus granulosus	cathepsin L cysteine protease	0.0213	0.1432	0.1432
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1146	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0213	0.1432	0.413
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0369	0.0874
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.1324	0.1324
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0097	0.0369	0.0977
Echinococcus granulosus	glycoprotein Antigen 5	0.0065	0.0072	0.0072
Onchocerca volvulus		0.0383	0.2991	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0383	0.2991	0.2991
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0238	0.1663	0.1203
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0072	0.0072
Echinococcus multilocularis	Mastin	0.0065	0.0072	0.0072
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0099	0.0387	0.0387
Onchocerca volvulus		0.0097	0.0369	0.1017
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Leishmania major	eukaryotic initiation factor 4a, putative	0.0238	0.1663	0.4941
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0097	0.0369	0.0369
Echinococcus multilocularis	cysteine protease	0.0383	0.2991	0.2991
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Loa Loa (eye worm)	cysteine protease	0.0383	0.2991	0.2991
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0099	0.0387	0.0387
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0017	0.0017
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0065	0.0072	0.0072
Loa Loa (eye worm)	calpain family protein 1	0.0091	0.031	0.031
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0065	0.0072	0.0072
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0238	0.1663	0.4941
Plasmodium falciparum	serine repeat antigen 2	0.0097	0.0369	0.0977
Toxoplasma gondii	cathepsin CPC1	0.0097	0.0369	0.1058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Echinococcus granulosus	cathepsin L	0.0213	0.1432	0.1432
Brugia malayi	Kringle domain containing protein	0.0066	0.0086	0.0086
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0421	0.3348	0.3291
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0142	0.0786	0.0786
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Trypanosoma cruzi	major cysteine proteinase, putative	0.0097	0.0369	0.0286
Echinococcus granulosus	calpain A	0.0129	0.066	0.066
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.1146	1	1
Echinococcus granulosus	cathepsin L	0.0097	0.0369	0.0369
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1928	0.1928
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.1579	0.4581
Loa Loa (eye worm)	ctsf protein	0.0383	0.2991	0.2991
Giardia lamblia	Cathepsin B precursor	0.0421	0.3348	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0167	0.1014	0.1014
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.5599	0.5599
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0072	0.0072
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0129	0.066	0.066
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0167	0.1014	0.1014
Schistosoma mansoni	lipoxygenase	0.0142	0.0786	0.0786
Leishmania major	eukaryotic initiation factor 4a, putative	0.0238	0.1663	0.4941
Brugia malayi	Trypsin family protein	0.0065	0.0072	0.0072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0238	0.1663	0.1663
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0142	0.0786	0.0786
Schistosoma mansoni	cathepsin s	0.0116	0.0541	0.0541
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0238	0.1663	0.1663
Echinococcus multilocularis	calpain A	0.0129	0.066	0.066
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0421	0.3348	1
Plasmodium falciparum	serine repeat antigen 3	0.0097	0.0369	0.0977
Entamoeba histolytica	cysteine proteinase, putative	0.0213	0.1432	0.4054
Echinococcus multilocularis	cathepsin b	0.1146	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2991	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2991	0.2931
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1146	1	1
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Brugia malayi	Pre-SET motif family protein	0.0201	0.1324	0.1324
Onchocerca volvulus		0.0383	0.2991	1
Brugia malayi	Cathepsin L-like precursor	0.0267	0.1928	0.1928
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0065	0.0072	0.0072
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0065	0.0072	0.0072
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Onchocerca volvulus		0.0383	0.2991	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0383	0.2991	0.2991
Onchocerca volvulus		0.0066	0.0086	0.0045
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2991	0.2991
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0369	0.0369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0267	0.1928	0.565
Leishmania major	hypothetical protein, conserved	0.0066	0.0086	0.0206
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Onchocerca volvulus		0.0383	0.2991	1
Loa Loa (eye worm)	hypothetical protein	0.05	0.4073	0.4073
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1146	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0369	0.0369
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0066	0.0084	0.0084
Brugia malayi	Papain family cysteine protease containing protein	0.0383	0.2991	0.2991
Entamoeba histolytica	cysteine proteinase, putative	0.0213	0.1432	0.4054
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0369	0.0369
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2991	0.2991
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0369	0.0369
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2991	0.2991
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0238	0.1663	0.5428
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0369	0.0369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Onchocerca volvulus		0.0383	0.2991	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0097	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0267	0.1928	0.1928
Brugia malayi	cathepsin F-like cysteine proteinase	0.0116	0.0541	0.0541
Brugia malayi	hypothetical protein	0.0065	0.0072	0.0072
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0072	0.0072
Brugia malayi	Trypsin-like protease protein 5	0.0065	0.0072	0.0072
Brugia malayi	Probable ATP-dependent helicase DHX35	0.05	0.4073	0.4073
Brugia malayi	calpain family protein 1	0.0123	0.0608	0.0608
Plasmodium falciparum	serine repeat antigen 5	0.0097	0.0369	0.0977
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0097	0.0369	0.0977
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0238	0.1663	0.1663
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0097	0.0369	0.0874
Schistosoma mansoni	hypothetical protein	0.0065	0.0072	0.0072
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Toxoplasma gondii	kringle domain-containing protein	0.0066	0.0086	0.0206
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0421	0.3348	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Echinococcus granulosus	cysteine protease	0.0213	0.1432	0.1432
Echinococcus multilocularis	glycoprotein Antigen 5	0.0065	0.0072	0.0072
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2991	0.2991
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0369	0.0874
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0238	0.1663	1
Entamoeba histolytica	cysteine proteinase, putative	0.0213	0.1432	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0369	0.0874
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0072	0.0072
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1146	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0369	0.0369
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0099	0.0387	0.0387
Echinococcus multilocularis	enteropeptidase	0.0065	0.0072	0.0072
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0097	0.0369	0.0369
Entamoeba histolytica	cysteine protease, putative	0.0383	0.2991	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0541	0.0541
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0369	0.0874
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0213	0.1432	0.1358
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0383	0.2991	0.2991
Loa Loa (eye worm)	DEAH box polypeptide 35	0.05	0.4073	0.4073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0213	0.1432	0.413
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0097	0.0369	0.0874
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0097	0.0369	0.0977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0097	0.0369	0.0874
Plasmodium falciparum	serine repeat antigen 7	0.0097	0.0369	0.0977
Trypanosoma cruzi	cysteine protease, putative	0.0213	0.1432	0.1358
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2991	0.2991
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.0369	0.0874
Echinococcus granulosus	Mastin	0.0065	0.0072	0.0072
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0099	0.0387	0.0387
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2991	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2991	0.2931
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0099	0.0387	0.0387
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1146	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0383	0.2991	1
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0129	0.066	0.066
Brugia malayi	Trypsin family protein	0.0065	0.0072	0.0072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0097	0.0369	0.0874
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0238	0.1663	0.1591
Loa Loa (eye worm)	TK/ROR protein kinase	0.0066	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0369	0.0874
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.0369	0.0874
Plasmodium falciparum	serine repeat antigen 6	0.0097	0.0369	0.0977
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0097	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0084	0.0084
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0129	0.066	0.066
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0238	0.1663	0.1591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0369	0.0874
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0369	0.0369
Echinococcus granulosus	cathepsin b	0.1146	1	1
Brugia malayi	Trypsin family protein	0.0167	0.1014	0.1014
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2991	0.2991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0369	0.0874
Brugia malayi	cathepsin L-like precursor	0.0267	0.1928	0.1928
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0097	0.0369	0.0977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0238	0.1663	0.4836
Onchocerca volvulus		0.0383	0.2991	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0072	0.0072
Echinococcus granulosus	cathepsin l1	0.0267	0.1928	0.1928
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0116	0.0541	0.0541
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2991	0.2991
Echinococcus multilocularis	transmembrane protease serine 3	0.0065	0.0072	0.0072
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.5599	0.5599
Toxoplasma gondii	cathepsin CPL	0.0383	0.2991	0.8928
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0086	0.0086
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0065	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0369	0.0874
Onchocerca volvulus		0.0103	0.042	0.1191
Plasmodium vivax	unspecified product	0.0097	0.0369	0.0977
Brugia malayi	Melibiase family protein	0.0066	0.0084	0.0084
Toxoplasma gondii	melibiase subfamily protein	0.0099	0.0387	0.1111
Loa Loa (eye worm)	hypothetical protein	0.0109	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0072	0.0072
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0369	0.0369
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Plasmodium vivax	serine-repeat antigen (SERA)	0.0097	0.0369	0.0977
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0238	0.1663	0.4836
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0072	0.0072
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0097	0.0369	0.0977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2991	0.8906
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0097	0.0369	0.1058
Leishmania major	cysteine peptidase A (CPA)	0.0383	0.2991	0.8928
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0065	0.0072	0.0072
Plasmodium falciparum	serine repeat antigen 4	0.0097	0.0369	0.0977
Leishmania major	cathepsin L-like protease	0.0383	0.2991	0.8928
Trypanosoma cruzi	cysteine proteinase, putative	0.0213	0.1432	0.1358
Plasmodium falciparum	serine repeat antigen 8	0.0097	0.0369	0.0977
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0066	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0072	0.0072
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0238	0.1663	0.4342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Giardia lamblia	Cathepsin B precursor	0.0421	0.3348	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0213	0.1432	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0097	0.0369	0.0369
Toxoplasma gondii	cathepsin CPC2	0.0097	0.0369	0.1058
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0097	0.0369	0.0977
Plasmodium falciparum	serine repeat antigen 1	0.0097	0.0369	0.0977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2991	0.2991
Onchocerca volvulus		0.0383	0.2991	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0072	0.0072
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0383	0.2991	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2991	0.8906
Schistosoma mansoni	cercarial elastase (S01 family)	0.0065	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0182	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2991	0.8906
Echinococcus granulosus	enteropeptidase	0.0065	0.0072	0.0072
Plasmodium vivax	serine-repeat antigen (SERA)	0.0097	0.0369	0.0977
Plasmodium vivax	RNA helicase-1, putative	0.0238	0.1663	0.5428
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1014	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0383	0.2991	0.2991
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0369	0.0369
Schistosoma mansoni	cathepsin C	0.0097	0.0369	0.0369
Plasmodium vivax	unspecified product	0.0116	0.0541	0.1568
Brugia malayi	Trypsin family protein	0.0065	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0213	0.1432	0.1432
Brugia malayi	calpain family protein 1	0.0123	0.0608	0.0608
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0213	0.1432	0.1358
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0099	0.0387	0.0387
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0421	0.3348	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0097	0.0369	0.0369
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2991	0.2931
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2991	0.8137
Treponema pallidum	ATP-dependent RNA helicase	0.0238	0.1663	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0097	0.0369	0.1017
Plasmodium vivax	vivapain-2	0.0383	0.2991	1
Echinococcus multilocularis	cathepsin L	0.0213	0.1432	0.1432
Brugia malayi	cathepsin F-like cysteine proteinase	0.0097	0.0369	0.0369
Echinococcus multilocularis	tissue type plasminogen activator	0.0066	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2991	0.8906
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0369	0.0369
Brugia malayi	Cathepsin L-like precursor	0.0116	0.0541	0.0541
Onchocerca volvulus		0.0077	0.0182	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1663	0.1663
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0369	0.0369
Plasmodium falciparum	serine repeat antigen 9	0.0097	0.0369	0.0977
Echinococcus granulosus	cathepsin b	0.1146	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0097	0.0369	0.0977
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0097	0.0369	0.0369
Loa Loa (eye worm)	fibroinase	0.0383	0.2991	0.2991
Schistosoma mansoni	lipoxygenase	0.01	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0091	0.031	0.031
Toxoplasma gondii	cathepsin B	0.0421	0.3348	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0086
Schistosoma mansoni	cathepsin F (C01 family)	0.0267	0.1928	0.1928
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Brugia malayi	cathepsin L precursor	0.0097	0.0369	0.0369
Onchocerca volvulus		0.0167	0.1014	0.3227
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0099	0.0387	0.0387
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0238	0.1663	0.5449
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0097	0.0369	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0072	0.0072
Trypanosoma cruzi	cruzipain precursor, putative	0.0116	0.0541	0.046
Plasmodium vivax	unspecified product	0.0213	0.1432	0.4635
Entamoeba histolytica	cysteine protease, putative	0.0213	0.1432	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0383	0.2991	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2991	0.2991
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0369	0.0369
Schistosoma mansoni	cathepsin S (C01 family)	0.0097	0.0369	0.0369

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.02 uM	Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells	ChEMBL.	No reference
IC50 (binding)	= 0.02 uM	Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells	ChEMBL.	No reference
IC50 (functional)	= 0.4 uM	Inhibitory activity against peroxidation of rat cardiac membrane liposomes	ChEMBL.	No reference
Inhibition (functional)	0 %	In vivo inhibitory activity against acetic acid-induced colitis of rat at 10 mg/kg upon peroral administration; Not tested	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL114013

Bibliographic References

No literature references available for this target.

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Detailed information for compound 200928