Detailed information for compound 201069

Basic information

Technical information
  • TDR Targets ID: 201069
  • Name: benzyl N-[(2S)-1-oxo-1-[[(5R,6S)-7-oxo-4-oxa- 1-azabicyclo[3.2.0]heptan-6-yl]amino]-3-pheny lpropan-2-yl]carbamate
  • MW: 409.435 | Formula: C22H23N3O5
  • H donors: 2 H acceptors: 3 LogP: 1.9 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](C(=O)N[C@@H]1C(=O)N2[C@@H]1OCC2)Cc1ccccc1)OCc1ccccc1
  • InChi: 1S/C22H23N3O5/c26-19(24-18-20(27)25-11-12-29-21(18)25)17(13-15-7-3-1-4-8-15)23-22(28)30-14-16-9-5-2-6-10-16/h1-10,17-18,21H,11-14H2,(H,23,28)(H,24,26)/t17-,18+,21+/m0/s1
  • InChiKey: VYRSXJDNPISAMG-WAOWUJCRSA-N  


Substructure search Similarity search

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Synonyms

  • benzyl N-[(1S)-1-benzyl-2-oxo-2-[[(5R,6S)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]ethyl]carbamate
  • N-[(1S)-1-benzyl-2-oxo-2-[[(5R,6S)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]ethyl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S)-1-oxo-1-[[(5R,6S)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]-3-phenyl-propan-2-yl]carbamate
  • N-[(1S)-1-benzyl-2-keto-2-[[(5R,6S)-7-keto-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]ethyl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S)-1-oxo-1-[[(5R,6S)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]-3-phenylpropan-2-yl]carbamate
  • phenylmethyl N-[(1S)-2-oxo-2-[[(5R,6S)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]-1-(phenylmethyl)ethyl]carbamate
  • N-[(1S)-2-oxo-2-[[(5R,6S)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]-1-(phenylmethyl)ethyl]carbamic acid phenylmethyl ester
  • N-[(1S)-1-(benzyl)-2-keto-2-[[(5R,6S)-7-keto-4-oxa-1-azabicyclo[3.2.0]heptan-6-yl]amino]ethyl]carbamic acid benzyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Rattus norvegicus Cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 279 aa 28.3 %
Onchocerca volvulus Cathepsin L   334 aa 300 aa 24.3 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 279 aa 25.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 372 aa 23.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 271 aa 26.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 336 aa 25.9 %
Plasmodium berghei berghepain-1 Cathepsin L   334 aa 353 aa 29.7 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 273 aa 26.0 %
Trypanosoma cruzi cysteine protease, putative Cathepsin L   334 aa 323 aa 30.3 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 273 aa 25.3 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin L   334 aa 296 aa 31.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 275 aa 29.1 %
Onchocerca volvulus Cathepsin L   334 aa 311 aa 40.8 %
Toxoplasma gondii cathepsin CPC1 Cathepsin L   334 aa 295 aa 28.1 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 270 aa 25.6 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin L   334 aa 311 aa 36.0 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin L   334 aa 312 aa 42.0 %
Onchocerca volvulus Cathepsin L   334 aa 325 aa 47.4 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 277 aa 26.0 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin L   334 aa 303 aa 23.4 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 309 aa 30.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 347 aa 28.8 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 298 aa 28.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 28.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 332 aa 23.5 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 278 aa 26.6 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin L   334 aa 360 aa 29.2 %
Plasmodium knowlesi knowpain-1 Cathepsin L   334 aa 373 aa 27.6 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin L   334 aa 318 aa 48.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin L   334 aa 323 aa 46.1 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 325 aa 38.1 %
Babesia bovis papain family cysteine protease containing protein Cathepsin L   334 aa 321 aa 32.7 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 274 aa 48.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 295 aa 25.4 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin L   334 aa 277 aa 24.5 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin L   334 aa 311 aa 35.0 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 38.0 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 333 aa 28.8 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 276 aa 25.4 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin L   334 aa 294 aa 23.8 %
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 273 aa 27.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 36.4 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 274 aa 48.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 319 aa 25.7 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 325 aa 29.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 341 aa 26.7 %
Onchocerca volvulus Cathepsin L homolog Cathepsin L   334 aa 322 aa 41.6 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.9 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin L   334 aa 316 aa 30.1 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 277 aa 26.0 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin L   334 aa 288 aa 26.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 25.9 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 270 aa 25.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium vivax vivapain-1 Cathepsin L   334 aa 366 aa 28.4 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin L   334 aa 300 aa 41.0 %
Neospora caninum hypothetical protein Cathepsin L   334 aa 299 aa 28.4 %
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Cathepsin L   334 aa 290 aa 27.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 276 aa 26.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 309 aa 26.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 23.4 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 337 aa 26.1 %
Echinococcus granulosus cysteine protease Cathepsin L   334 aa 323 aa 44.3 %
Plasmodium vivax unspecified product Cathepsin L   334 aa 366 aa 28.4 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 324 aa 34.6 %
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 271 aa 27.7 %
Plasmodium vivax vivapain-3 Cathepsin L   334 aa 345 aa 30.7 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 303 aa 26.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 24.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 282 aa 26.2 %
Plasmodium yoelii cathepsin c precursor Cathepsin L   334 aa 292 aa 22.6 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin L   334 aa 345 aa 35.4 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin L   334 aa 359 aa 29.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 317 aa 33.8 %
Giardia lamblia Dipeptidyl-peptidase I precursor Cathepsin L   334 aa 304 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphoglycerate mutase 0.0071 0.0059 0.0059
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0071 0.0059 0.0059
Toxoplasma gondii histone deacetylase HDAC1 0.0393 0.0831 1
Plasmodium vivax phosphoglycerate mutase, putative 0.0071 0.0059 0.0707
Schistosoma mansoni 6-phosphofructokinase 0.4211 1 1
Trypanosoma brucei histone deacetylase 1 0.0362 0.0757 0.0757
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Trichomonas vaginalis histone deacetylase, putative 0.0362 0.0757 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Onchocerca volvulus Histone deacetylase 10 homolog 0.0171 0.0299 0.027
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.003 0.003
Echinococcus multilocularis phosphoglycerate mutase 0.0071 0.0059 0.0059
Schistosoma mansoni histone deacetylase 4 5 0.0393 0.0831 0.0831
Onchocerca volvulus Protein UBASH3A homolog 0.0071 0.0059 0.0029
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0071 0.0059 0.0059
Trichomonas vaginalis histone deacetylase, putative 0.0362 0.0757 1
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.0071 0.0059 0.5
Mycobacterium leprae probable isochorismate synthase EntC 0.0071 0.0059 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.0114 0.0084
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4139 0.9829 0.9828
Leishmania major hypothetical protein, conserved 0.0071 0.0059 0.0003
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Brugia malayi Cathepsin L-like precursor 0.0086 0.0094 0.1134
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0094 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0094 0.1244
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0071 0.0059 0.0044
Echinococcus granulosus phosphoglycerate mutase 0.0071 0.0059 0.0059
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0071 0.0059 0.5
Onchocerca volvulus 0.0086 0.0094 0.0064
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0059 0.5
Echinococcus multilocularis phosphoglycerate mutase 0.0071 0.0059 0.0059
Schistosoma mansoni phosphoglycerate mutase 0.0071 0.0059 0.0059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0094 0.0094
Echinococcus multilocularis histone deacetylase 7 0.0393 0.0831 0.0831
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0059 0.5
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0059 0.5
Brugia malayi histone deacetylase 11 0.0171 0.0299 0.3602
Echinococcus granulosus histone deacetylase 6 0.0393 0.0831 0.0831
Toxoplasma gondii phosphoglycerate mutase family protein 0.0071 0.0059 0.0044
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.0094 0.0094
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0059 0.0775
Leishmania major glycerolphosphate mutase, putative 0.0071 0.0059 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Brugia malayi Cathepsin L-like precursor 0.0086 0.0094 0.1134
Onchocerca volvulus Protein UBASH3A homolog 0.0071 0.0059 0.0029
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Echinococcus multilocularis histone deacetylase 6 0.0393 0.0831 0.0831
Echinococcus granulosus histone deacetylase 7 0.0393 0.0831 0.0831
Onchocerca volvulus Protein UBASH3A homolog 0.0071 0.0059 0.0029
Giardia lamblia Histone deacetylase 0.0362 0.0757 0.121
Plasmodium vivax histone deacetylase, putative 0.0171 0.0299 0.3602
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Echinococcus multilocularis cysteine protease 0.0086 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0094 0.0094
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.0071 0.0059 0.01
Onchocerca volvulus Protein UBASH3A homolog 0.0071 0.0059 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Echinococcus granulosus histone deacetylase 3 0.0362 0.0757 0.0757
Trypanosoma brucei histone deacetylase 4 0.0393 0.0831 0.0831
Onchocerca volvulus 0.0071 0.0059 0.0029
Echinococcus multilocularis histone deacetylase 8 0.0171 0.0299 0.0299
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4211 1 1
Onchocerca volvulus 0.0086 0.0094 0.0064
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4211 1 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0071 0.0059 0.0044
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0071 0.0059 0.01
Echinococcus multilocularis histone deacetylase 3 0.0362 0.0757 0.0757
Schistosoma mansoni histone deacetylase 4 5 0.0393 0.0831 0.0831
Trypanosoma brucei glycerolphosphate mutase, putative 0.0071 0.0059 0.0059
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0094 0.1244
Leishmania major hypothetical protein, unknown function 0.0071 0.0059 0.0003
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.0055 0.0055
Giardia lamblia Hypothetical protein 0.2485 0.5856 1
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0059
Trypanosoma cruzi histone deacetylase, putative 0.0393 0.0831 0.0831
Brugia malayi UBASH3A protein homolog 0.0071 0.0059 0.0707
Mycobacterium leprae Possible phosphoglycerate mutase 0.0071 0.0059 0.5
Plasmodium falciparum histone deacetylase, putative 0.0393 0.0831 1
Plasmodium vivax histone deacetylase 1, putative 0.0362 0.0757 0.9114
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0071 0.0059 0.5
Plasmodium falciparum phosphoglucomutase-2 0.0071 0.0059 0.0707
Plasmodium vivax vivapain-2 0.0086 0.0094 0.1134
Brugia malayi Cathepsin L-like precursor 0.0086 0.0094 0.1134
Echinococcus granulosus phosphoglycerate mutase 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0362 0.0757 0.0729
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.0322 0.3877
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0055 0.0055
Echinococcus granulosus cathepsin b 0.0181 0.0322 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Entamoeba histolytica cysteine protease, putative 0.0086 0.0094 0.0161
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.0322 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.0322 0.0322
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.0071 0.0059 0.5
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0071 0.0059 0.01
Echinococcus multilocularis phosphoglycerate mutase 0.0071 0.0059 0.0059
Leishmania major phosphoglycerate mutase, putative 0.0071 0.0059 0.0003
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0071 0.0059 0.0059
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Plasmodium vivax histone deacetylase, putative 0.0393 0.0831 1
Loa Loa (eye worm) cysteine protease 0.0086 0.0094 0.0064
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.0094 0.0094
Loa Loa (eye worm) histone deacetylase 11 0.0171 0.0299 0.027
Echinococcus granulosus phosphoglycerate mutase 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0029
Echinococcus granulosus histone deacetylase 1 0.0362 0.0757 0.0757
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.0055 0.0055
Entamoeba histolytica histone deacetylase, putative 0.0362 0.0757 0.1293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Brugia malayi Histone deacetylase family protein 0.0393 0.0831 1
Trichomonas vaginalis histone deacetylase, putative 0.0362 0.0757 1
Echinococcus multilocularis phosphoglycerate mutase 0.0071 0.0059 0.0059
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.0071 0.0059 0.5
Onchocerca volvulus 0.0086 0.0094 0.0064
Trypanosoma brucei histone deacetylase, putative 0.0393 0.0831 0.0831
Leishmania major hypothetical protein, conserved 0.0071 0.0059 0.0003
Onchocerca volvulus 0.0086 0.0094 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0094 0.0161
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0071 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Leishmania major hypothetical protein, conserved 0.0071 0.0059 0.0003
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0071 0.0059 0.0059
Onchocerca volvulus 0.0086 0.0094 0.0064
Toxoplasma gondii histone deacetylase HDAC4 0.0171 0.0299 0.3146
Onchocerca volvulus 0.0071 0.0059 0.0029
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Loa Loa (eye worm) histone deacetylase 3 0.0362 0.0757 0.0729
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0029
Brugia malayi phosphoglycerate mutase family protein 0.0071 0.0059 0.0707
Echinococcus granulosus cathepsin l1 0.0086 0.0094 0.0094
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0094 0.0114 0.0084
Trichomonas vaginalis histone deacetylase, putative 0.0362 0.0757 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0094 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.2485 0.5856 1
Echinococcus multilocularis histone deacetylase 1 0.0362 0.0757 0.0757
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0094 0.0094
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0071 0.0059 0.0059
Schistosoma mansoni histone deacetylase hda2 0.0399 0.0846 0.0846
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0094 0.0094
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0071 0.0059 0.0775
Brugia malayi Cathepsin L-like precursor 0.0086 0.0094 0.1134
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0094 0.0094
Plasmodium vivax phosphoglucomutase-2, putative 0.0071 0.0059 0.0707
Echinococcus granulosus histone deacetylase 0.0393 0.0831 0.0831
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Brugia malayi Histone deacetylase 1 0.0362 0.0757 0.9114
Brugia malayi cathepsin L-like precursor 0.0059 0.003 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Plasmodium falciparum histone deacetylase 2 0.0393 0.0831 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0362 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0094 0.0114 0.0084
Plasmodium vivax histone deacetylase 2, putative 0.0393 0.0831 1
Plasmodium vivax vivapain-2 0.0086 0.0094 0.1134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0094 0.0094
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0071 0.0059 0.5
Loa Loa (eye worm) phosphoglycerate mutase 0.0071 0.0059 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4211 1 1
Toxoplasma gondii phosphoglycerate mutase 0.0071 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.0228 0.0435 0.0406
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0094 0.1134
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0071 0.0059 0.0775
Trypanosoma brucei histone deacetylase 3 0.0393 0.0831 0.0831
Echinococcus granulosus histone deacetylase 6 0.0393 0.0831 0.0831
Toxoplasma gondii hypothetical protein 0.0094 0.0114 0.076
Trypanosoma cruzi histone deacetylase, putative 0.0393 0.0831 0.0831
Echinococcus granulosus cathepsin l1 0.0059 0.003 0.003
Leishmania major phosphoglycerate mutase protein, putative 0.0071 0.0059 0.0003
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0071 0.0059 0.0059
Echinococcus multilocularis histone deacetylase 0.0393 0.0831 0.0831
Brugia malayi histone deacetylase 1 (HD1) 0.0362 0.0757 0.9114
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.003 0.0361
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0071 0.0059 0.0059
Echinococcus multilocularis cathepsin b 0.0181 0.0322 0.0322
Echinococcus granulosus histone deacetylase 6 0.0399 0.0846 0.0846
Onchocerca volvulus Cathepsin F homolog 0.0086 0.0094 0.0064
Schistosoma mansoni histone deacetylase 0.0362 0.0757 0.0757
Echinococcus multilocularis phosphoglycerate mutase 0.0071 0.0059 0.0059
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0071 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Leishmania major histone deacetylase, putative 0.0393 0.0831 0.078
Loa Loa (eye worm) hypothetical protein 0.4139 0.9829 0.9829
Schistosoma mansoni phosphoglycerate mutase 0.0071 0.0059 0.0059
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0071 0.0059 0.0059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0094 0.0094
Echinococcus multilocularis cysteine protease 0.0086 0.0094 0.0094
Toxoplasma gondii histone deacetylase HDAC5 0.0171 0.0299 0.3146
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1797 0.4203 0.4203
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0071 0.0059 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0055 0.073
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0059 0.0775
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Loa Loa (eye worm) histone deacetylase 7A 0.0393 0.0831 0.0803
Brugia malayi Cathepsin L-like precursor 0.0059 0.003 0.0361
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.003 0.0051
Leishmania major histone deacetylase, putative 0.0393 0.0831 0.078
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.0094 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.4211 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0029
Brugia malayi phosphoglycerate mutase family protein 0.0071 0.0059 0.0707
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Plasmodium falciparum histone deacetylase 1 0.0362 0.0757 0.9114
Brugia malayi Histone deacetylase family protein 0.0393 0.0831 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4139 0.9829 0.9829
Loa Loa (eye worm) histone deacetylase 1 0.0362 0.0757 0.0729
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0059
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0071 0.0059 0.0775
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1797 0.4203 0.4203
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0362 0.0757 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.0094 0.1134
Leishmania major histone deacetylase, putative 0.0362 0.0757 0.0706
Toxoplasma gondii histone deacetylase HDAC3 0.0362 0.0757 0.9051
Loa Loa (eye worm) hypothetical protein 0.0221 0.042 0.0391
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.4211 1 1
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0071 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0094 0.0094
Echinococcus granulosus histone deacetylase 8 0.0171 0.0299 0.0299
Trypanosoma brucei phosphoglycerate mutase, putative 0.0071 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0059
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0071 0.0059 0.0059
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.0299 0.0299
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Schistosoma mansoni histone deacetylase 1 2 3 0.0171 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0059
Giardia lamblia Hypothetical protein 0.2485 0.5856 1
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0094 0.0064
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.0322 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0059
Trypanosoma cruzi histone deacetylase 1, putative 0.0362 0.0757 0.0757
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Onchocerca volvulus 0.4211 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Loa Loa (eye worm) hypothetical protein 0.2414 0.5685 0.5672
Toxoplasma gondii phosphoglycerate mutase family protein 0.0071 0.0059 0.0044
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0059 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.003 0.0396
Mycobacterium tuberculosis Conserved protein 0.0071 0.0059 0.5
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0071 0.0059 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0094 0.1244
Brugia malayi histone deacetylase 3 (HD3) 0.0362 0.0757 0.9114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.003 0.003
Mycobacterium ulcerans hypothetical protein 0.2485 0.5856 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.0094 0.1134
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0071 0.0059 0.0775
Loa Loa (eye worm) ctsf protein 0.0086 0.0094 0.0064
Trypanosoma brucei histone deacetylase 2 0.0171 0.0299 0.0299
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.0322 0.0322
Leishmania major histone deacetylase, putative 0.0362 0.0757 0.0706
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.1797 0.4203 0.4171
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0071 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.003 0.0396
Trypanosoma cruzi histone deacetylase, putative 0.0393 0.0831 0.0831
Treponema pallidum phosphoglyceromutase 0.0071 0.0059 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0094 0.0094
Echinococcus multilocularis phosphoglycerate mutase 0.0071 0.0059 0.0059
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0094 0.0064
Loa Loa (eye worm) hypothetical protein 0.0094 0.0114 0.0084
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.4139 0.9829 0.9829
Toxoplasma gondii cathepsin CPL 0.0086 0.0094 0.0502
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Echinococcus granulosus cathepsin b 0.0181 0.0322 0.0322
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0171 0.0299 0.027
Schistosoma mansoni histone deacetylase hda2 0.0171 0.0299 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0094 0.0094
Trypanosoma cruzi histone deacetylase, putative 0.0171 0.0299 0.0299
Mycobacterium tuberculosis Conserved protein 0.0071 0.0059 0.5
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0181 0.0322 0.0293
Loa Loa (eye worm) fibroinase 0.0086 0.0094 0.0064
Leishmania major cysteine peptidase A (CPA) 0.0086 0.0094 0.0039
Echinococcus granulosus phosphoglycerate mutase 0.0071 0.0059 0.0059
Loa Loa (eye worm) cathepsin B 0.007 0.0055 0.0025
Trichomonas vaginalis histone deacetylase, putative 0.0362 0.0757 1
Loa Loa (eye worm) histone deacetylase 0.0393 0.0831 0.0803
Leishmania major phosphoglycerate mutase family member 5, putative 0.0071 0.0059 0.0003
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.1797 0.4203 0.4203
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.0094 0.0064
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Loa Loa (eye worm) hypothetical protein 0.0086 0.0094 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.2485 0.5856 1
Trichomonas vaginalis histone deacetylase, putative 0.0362 0.0757 1
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0071 0.0059 0.0059
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4211 1 1
Onchocerca volvulus 0.0071 0.0059 0.0029
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0071 0.0059 0.5
Schistosoma mansoni histone deacetylase 0.0362 0.0757 0.0757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0094 0.1244
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0071 0.0059 0.0059
Echinococcus multilocularis cathepsin b 0.0181 0.0322 0.0322
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4139 0.9829 0.9829
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0094 0.0094
Plasmodium falciparum phosphoglycerate mutase, putative 0.0071 0.0059 0.0707
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.0094 0.1134
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.0071 0.0059 0.5
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0362 0.0757 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0071 0.0059 0.0044
Brugia malayi Cathepsin L-like precursor 0.0059 0.003 0.0361
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0071 0.0059 0.0059
Echinococcus multilocularis histone deacetylase 6 0.0393 0.0831 0.0831
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0362 0.0757 1
Leishmania major cathepsin L-like protease 0.0086 0.0094 0.0039
Onchocerca volvulus 0.0086 0.0094 0.0064
Onchocerca volvulus 0.0086 0.0094 0.0064
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0071 0.0059 0.5
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0029
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0071 0.0059 0.5
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0071 0.0059 0.0003
Echinococcus multilocularis histone deacetylase 6 0.0399 0.0846 0.0846
Toxoplasma gondii histone deacetylase HDAC2 0.0362 0.0757 0.9051
Brugia malayi Cathepsin L-like precursor 0.0086 0.0094 0.1134

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.085 uM In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC ChEMBL. 12419373
IC50 (binding) = 0.085 uM In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC ChEMBL. 12419373
IC50 (binding) = 0.43 uM In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC ChEMBL. 12419373
IC50 (binding) = 0.43 uM In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC ChEMBL. 12419373
IC50 (binding) = 1.63 uM In vitro Inhibitory activity of the compound was determined against Cathepsin K cysteine protease by using Cbz-Phe-Arg-AMC ChEMBL. 12419373
IC50 (binding) = 1.63 uM In vitro Inhibitory activity of the compound was determined against Cathepsin K cysteine protease by using Cbz-Phe-Arg-AMC ChEMBL. 12419373
IC50 (binding) = 1.76 uM In vitro Inhibitory activity of the compound was determined against Cathepsin B cysteine protease by using Cbz-Phe-Arg-AMC ChEMBL. 12419373
IC50 (binding) = 1.76 uM In vitro Inhibitory activity of the compound was determined against Cathepsin B cysteine protease by using Cbz-Phe-Arg-AMC ChEMBL. 12419373

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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