Detailed information for compound 201118

Basic information

Technical information
  • TDR Targets ID: 201118
  • Name: N-[(4S,7S,10R)-10-amino-4-[3-(diaminomethylid eneamino)propyl]-7-[(4-hydroxyphenyl)methyl]- 6,9,13-trioxo-2-oxa-5,8,12-triazabicyclo[12.4 .0]octadeca-1(14),15,17-trien-16-yl]-2,3-diox o-1,4-dihydroquinoxaline-6-carboxamide
  • MW: 714.728 | Formula: C34H38N10O8
  • H donors: 10 H acceptors: 9 LogP: -0.32 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=NCCC[C@H]1COc2ccc(cc2C(=O)NC[C@H](C(=O)N[C@H](C(=O)N1)Cc1ccc(cc1)O)N)NC(=O)c1ccc2c(c1)nc(c(n2)O)O)N
  • InChi: 1S/C34H38N10O8/c35-23-15-39-29(47)22-14-19(40-28(46)18-5-9-24-25(13-18)43-33(51)32(50)42-24)6-10-27(22)52-16-20(2-1-11-38-34(36)37)41-31(49)26(44-30(23)48)12-17-3-7-21(45)8-4-17/h3-10,13-14,20,23,26,45H,1-2,11-12,15-16,35H2,(H,39,47)(H,40,46)(H,41,49)(H,42,50)(H,43,51)(H,44,48)(H4,36,37,38)/t20-,23+,26-/m0/s1
  • InChiKey: ZMSGYVHIKPXOTB-CLLDFNAGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4S,7S,10R)-10-amino-4-(3-guanidinopropyl)-7-[(4-hydroxyphenyl)methyl]-6,9,13-trioxo-2-oxa-5,8,12-triazabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]-2,3-dioxo-1,4-dihydroquinoxaline-6-carboxamide
  • N-[(4S,7S,10R)-10-azanyl-4-[3-[bis(azanyl)methylideneamino]propyl]-7-[(4-hydroxyphenyl)methyl]-6,9,13-trioxo-2-oxa-5,8,12-triazabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]-2,3-dioxo-1,4-dihydroquinoxaline-6-carboxamide
  • N-[(4S,7S,10R)-10-amino-4-(3-guanidinopropyl)-7-(4-hydroxybenzyl)-6,9,13-triketo-2-oxa-5,8,12-triazabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]-2,3-diketo-1,4-dihydroquinoxaline-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0278 0.0248
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0127 0.0314
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0312 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0278 0.0236
Brugia malayi ecdysone receptor 0.0014 0.0109 0.0093
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0722 0.0997
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0278 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0278 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0278 0.0342
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0442 0.0585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0278 0.0236
Echinococcus granulosus secreted frizzled protein 0.0019 0.0166 0.0136
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0278 0.0245
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0278 0.0248
Echinococcus multilocularis cpg binding protein 0.0029 0.0263 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0278 0.0236
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0278 0.0342
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0042 0.0411 0.0373
Echinococcus multilocularis frizzled 0.0042 0.0411 0.0382
Brugia malayi hypothetical protein 0.0014 0.0109 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Schistosoma mansoni hypothetical protein 0.0384 0.4061 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0247 0.0204
Brugia malayi nuclear receptor NHR-67 0.0014 0.0109 0.0093
Brugia malayi tailless protein 0.0014 0.0109 0.0093
Schistosoma mansoni hypothetical protein 0.0023 0.0204 0.0502
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0278 0.0684
Schistosoma mansoni hypothetical protein 0.0033 0.0312 0.0768
Loa Loa (eye worm) hypothetical protein 0.0071 0.0722 0.0691
Schistosoma mansoni thyroid hormone receptor 0.003 0.0278 0.0684
Echinococcus granulosus FTZ F1 alpha 0.003 0.0278 0.0248
Echinococcus granulosus frizzled 5 0.0042 0.0411 0.0382
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0127 0.0314
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0278 0.0248
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0109 0.0079
Echinococcus granulosus frizzled 0.0042 0.0411 0.0382
Echinococcus multilocularis secreted frizzled protein 0.0019 0.0166 0.0136
Echinococcus multilocularis secreted frizzled protein 5 0.0019 0.0166 0.0136
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0048 0.0018
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0109 0.0079
Brugia malayi conserved hypotetical protein 0.0014 0.0109 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Echinococcus granulosus neuropeptide s receptor 0.0434 0.4596 0.458
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0278 0.0248
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0278 0.0245
Echinococcus granulosus secreted frizzled protein 5 0.0019 0.0166 0.0136
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0658 0.6985 1
Echinococcus multilocularis frizzled 0.0042 0.0411 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0109 0.0269
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0278 0.0248
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0122
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0312 0.0392
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0312 0.0282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0278 0.0248
Schistosoma mansoni frizzled-like receptor 0.0023 0.0204 0.0502
Schistosoma mansoni frizzled 0.0042 0.0411 0.1013
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0109 0.0093
Echinococcus multilocularis neuropeptide receptor A26 0.0434 0.4596 0.458
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0023 0.0204 0.0232
Schistosoma mansoni coup transcription factor 0.003 0.0278 0.0684
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0278 0.0684
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0127 0.0082
Schistosoma mansoni frizzled-like receptor 0.0042 0.0411 0.1013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0082
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0023 0.0204 0.016
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0278 0.0342
Echinococcus granulosus survival motor neuron protein 1 0.0222 0.233 0.2307
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0109 0.0093
Echinococcus granulosus GPCR family 2 0.0033 0.0312 0.0282
Brugia malayi hypothetical protein 0.0016 0.0127 0.0119
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0278 0.0236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0278 0.0236
Onchocerca volvulus 0.0027 0.0247 0.02
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0278 0.0342
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1075 0.1054
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0278 0.0248
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0278 0.0684
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.057 0.1403
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Schistosoma mansoni hypothetical protein 0.0033 0.0312 0.0768
Loa Loa (eye worm) hypothetical protein 0.0628 0.6666 0.6792
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0278 0.0684
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0042 0.0411 0.0373
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0278 0.0248
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0109 0.0269
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0278 0.0684
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0127 0.0119
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0504 0.5
Schistosoma mansoni hypothetical protein 0.0045 0.0442 0.1089
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Schistosoma mansoni secreted frizzled-related protein 0.0019 0.0166 0.0409
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0024 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0109 0.0063
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0109 0.0269
Schistosoma mansoni hypothetical protein 0.0023 0.0204 0.0502
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0642 0.6817 0.6946
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Brugia malayi hypothetical protein 0.0014 0.0109 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0278 0.0248
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0109 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0278 0.0342
Echinococcus granulosus frizzled 0.0042 0.0411 0.0382
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0082
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0042 0.0411 0.0539
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0109 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0278 0.0342
Brugia malayi ecdysteroid receptor 0.003 0.0278 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0278 0.0342
Echinococcus multilocularis frizzled 10 0.0042 0.0411 0.0382
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0278 0.0248
Schistosoma mansoni cpg binding protein 0.0027 0.0247 0.0608
Echinococcus multilocularis frizzled 4 0.0042 0.0411 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0278 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0278 0.0342
Echinococcus granulosus dnaJ subfamily B 0.0384 0.4061 0.4043
Echinococcus multilocularis GPCR, family 2 0.0033 0.0312 0.0282
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.003 0.0074
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0048 0.0018
Schistosoma mansoni zinc finger protein 0.0014 0.0109 0.0269
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0278 0.0342
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0127 0.0119
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0024 0.5
Brugia malayi nuclear hormone receptor 0.0642 0.6817 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0127 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0109 0.0269
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0109 0.0079
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0278 0.0248
Brugia malayi Fz domain containing protein 0.0019 0.0166 0.0177
Schistosoma mansoni survival motor neuron protein 0.0045 0.0442 0.1089
Echinococcus granulosus cpg binding protein 0.0029 0.0263 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0278 0.0236
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0127 0.0097
Echinococcus granulosus frizzled 4 0.0042 0.0411 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0312 0.0271
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0109 0.0093
Schistosoma mansoni wnt inhibitor frzb2 0.0019 0.0166 0.0409
Brugia malayi nuclear receptor NHR-88 0.003 0.0278 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0278 0.0236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0278 0.0684
Onchocerca volvulus 0.003 0.0278 0.0245
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.5
Loa Loa (eye worm) DR-78 0.0014 0.0109 0.0063
Onchocerca volvulus 0.0019 0.0166 0.0083
Schistosoma mansoni cpg binding protein 0.0029 0.0263 0.0648
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0312 0.0282
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0278 0.0248
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0109 0.0079
Echinococcus multilocularis secreted frizzled protein 0.0019 0.0166 0.0136
Brugia malayi hypothetical protein 0.0222 0.233 0.3373
Loa Loa (eye worm) hypothetical protein 0.0222 0.233 0.2342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0109 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0278 0.0248
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0109 0.0079
Trichomonas vaginalis helicase, putative 0.0006 0.0024 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Echinococcus multilocularis neuropeptide s receptor 0.0434 0.4596 0.458
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0109 0.0079
Brugia malayi steroid hormone receptor 0.003 0.0278 0.0342
Brugia malayi Fz domain containing protein 0.0019 0.0166 0.0177
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0278 0.0248
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0042 0.0411 0.0539
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0278 0.0342
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0278 0.0248
Schistosoma mansoni frizzled-like receptor 0.0042 0.0411 0.1013
Onchocerca volvulus 0.0045 0.0442 0.0484
Schistosoma mansoni hypothetical protein 0.0071 0.0722 0.1777
Schistosoma mansoni hypothetical protein 0.0023 0.0204 0.0502
Echinococcus multilocularis frizzled 5 0.0042 0.0411 0.0382
Brugia malayi nuclear receptor NHR-88 0.0014 0.0109 0.0093
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0109 0.0079
Echinococcus multilocularis dnaJ subfamily B 0.0384 0.4061 0.4043
Brugia malayi nuclear receptor RXR 0.0014 0.0109 0.0093
Brugia malayi nuclear hormone receptor 0.003 0.0278 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Schistosoma mansoni nuclear receptor 0.0014 0.0109 0.0269
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Schistosoma mansoni frizzled-like receptor 0.0023 0.0204 0.0502
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0312 0.0282
Brugia malayi hypothetical protein 0.0016 0.0127 0.0119
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0082
Loa Loa (eye worm) sfrp2 0.0019 0.0166 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Schistosoma mansoni cpg binding protein 0.0029 0.0263 0.0648
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1075 0.1518
Schistosoma mansoni nuclear receptor 0.0014 0.0109 0.0269
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0109 0.0269
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0278 0.0342
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0109 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1075 0.1518
Brugia malayi nuclear receptor RXR 0.0016 0.0127 0.0119
Schistosoma mansoni hypothetical protein 0.0033 0.0312 0.0768
Loa Loa (eye worm) hypothetical protein 0.0921 0.9792 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0278 0.0248
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0278 0.0684
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0109 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0762 0.8091 0.8085
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0278 0.0684
Schistosoma mansoni hypothetical protein 0.0033 0.0312 0.0768
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0109 0.0063
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0278 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0278 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Brugia malayi CXXC zinc finger family protein 0.0027 0.0247 0.0295
Echinococcus multilocularis smoothened 0.094 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0082
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Schistosoma mansoni nuclear hormone receptor 0.003 0.0278 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0278 0.0684
Loa Loa (eye worm) hypothetical protein 0.0105 0.1075 0.1054
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0109 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0278 0.0342
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0109 0.0079
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0312 0.0392
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0109 0.0079
Schistosoma mansoni thyroid hormone receptor 0.003 0.0278 0.0684
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0312 0.0271
Loa Loa (eye worm) hypothetical protein 0.0019 0.0166 0.0122
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0236
Echinococcus granulosus frizzled 0.0042 0.0411 0.0382
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0278 0.0248
Echinococcus multilocularis survival motor neuron protein 1 0.0222 0.233 0.2307
Echinococcus granulosus neuropeptide receptor A26 0.0434 0.4596 0.458

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 25 uM Inhibition of cell free transcription/translation by E. coli s30 bacterial extract. ChEMBL. 12139453
IC50 (functional) = 25 uM Inhibition of cell free transcription/translation by E. coli s30 bacterial extract. ChEMBL. 12139453
IC50 (functional) = 50 uM In vitro inhibition of translation in luciferase SP6 control plasmid ChEMBL. 12139453
MIC (functional) = 50 uM In vitro minimum inhibition concentration against E. coli D21f2, LPS mutant; Range is from 25-50. ChEMBL. 12139453
MIC (functional) = 50 uM In vitro minimum inhibition concentration against E. coli D21f2, LPS mutant; Range is from 25-50. ChEMBL. 12139453
MIC (functional) > 100 uM In vitro minimum inhibition concentration against E. coli K-12, wild type. ChEMBL. 12139453
MIC (functional) > 100 uM In vitro minimum inhibition concentration against E. coli KZM120, pump mutant. ChEMBL. 12139453
MIC (functional) > 100 uM In vitro minimum inhibition concentration against E. coli Ram195, pump mutant. ChEMBL. 12139453
MIC (functional) > 100 uM In vitro minimum inhibition concentration against E. coli K-12, wild type. ChEMBL. 12139453
MIC (functional) > 100 uM In vitro minimum inhibition concentration against E. coli KZM120, pump mutant. ChEMBL. 12139453
MIC (functional) > 100 uM In vitro minimum inhibition concentration against E. coli Ram195, pump mutant. ChEMBL. 12139453

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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