Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 87 % | Antagonist activity at human androgen receptor expressed in CV1 cells assessed as inhibition of DHT-induced response | ChEMBL. | 17257838 |
IC50 (functional) | = 56 nM | Antagonist activity at human androgen receptor expressed in CV1 cells | ChEMBL. | 17257838 |
Ki (binding) | = 79 nM | Binding affinity to human androgen receptor expressed in CV1 cells | ChEMBL. | 17257838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.