Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.211 | 0.4271 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0037 | 0.069 | 0.1028 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0175 | 0.0044 |
Echinococcus multilocularis | tumor protein p63 | 0.034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0175 | 0.0261 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0175 | 0.0044 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.069 | 0.0566 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0175 | 0.0261 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0175 | 0.0044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0175 | 0.0261 |
Onchocerca volvulus | 0.0083 | 0.211 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0175 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0175 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1082 | 0.1612 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.069 | 0.1028 |
Echinococcus granulosus | lamin | 0.0027 | 0.0387 | 0.0259 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0037 | 0.069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0372 | 0.0554 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0175 | 0.0044 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0175 | 0.0261 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0175 | 0.0044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.069 | 0.1206 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0175 | 0.0044 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0175 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1652 | 0.3282 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0387 | 0.0259 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0273 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0387 | 0.0259 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0387 | 0.0551 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0175 | 0.0093 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0.6714 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0175 | 0.0044 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0175 | 0.0261 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.069 | 0.0566 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0084 | 0.2136 | 0.2031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.069 | 1 |
Onchocerca volvulus | 0.0066 | 0.1581 | 0.7267 | |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0175 | 0.0044 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0175 | 0.0044 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0175 | 0.0261 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0175 | 0.0044 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0175 | 0.0261 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.069 | 1 |
Onchocerca volvulus | 0.0027 | 0.0387 | 0.1096 | |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0273 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0273 | 0.5 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0273 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.069 | 0.9995 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4765 | 1 |
Echinococcus multilocularis | jun protein | 0.0084 | 0.2136 | 0.2031 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0132 | 0.0196 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.3425 | 0.7108 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.069 | 0.0566 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.069 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0175 | 0.0093 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0175 | 0.0044 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.1082 | 0.2052 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0175 | 0.0093 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0273 | 0.252 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0175 | 0.0261 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0387 | 0.0577 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0273 | 0.2521 |
Echinococcus granulosus | geminin | 0.0169 | 0.4765 | 0.4695 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0175 | 0.0261 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.069 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.069 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Echinococcus granulosus | jun protein | 0.0084 | 0.2136 | 0.2031 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0387 | 0.0577 |
Brugia malayi | hypothetical protein | 0.0066 | 0.1581 | 0.2355 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.3425 | 0.3337 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0132 | 0.0196 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.211 | 0.2005 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2065 | 0.3076 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.069 | 0.0566 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0.069 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0175 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0273 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0175 | 0.0093 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.069 | 0.9995 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0175 | 0.0261 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.069 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | lamin | 0.0027 | 0.0387 | 0.0551 |
Onchocerca volvulus | 0.0027 | 0.0387 | 0.1096 | |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0273 | 0.2521 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0175 | 0.0093 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0387 | 0.0577 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0175 | 0.0093 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0175 | 0.0044 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.069 | 0.1028 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0273 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.4047 | 0.3967 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0175 | 0.0261 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0175 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Onchocerca volvulus | 0.005 | 0.1082 | 0.4688 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.4047 | 0.845 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.069 | 0.1028 |
Echinococcus multilocularis | geminin | 0.0169 | 0.4765 | 0.4695 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0273 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.069 | 0.1206 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0387 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0175 | 0.0261 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0273 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0387 | 0.0551 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0037 | 0.069 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0387 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0387 | 0.0577 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.4047 | 0.845 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.069 | 0.1028 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.069 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0387 | 0.0259 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.3425 | 0.3337 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0175 | 0.0044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0175 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.211 | 0.3143 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0175 | 0.0093 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0273 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0175 | 0.0044 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0175 | 0.0044 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.069 | 0.0566 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0175 | 0.0044 |
Trypanosoma brucei | cytochrome P450, putative | 0.0037 | 0.069 | 0.9995 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.1652 | 0.3282 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.211 | 0.3143 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0273 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0363 | 0.0541 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0084 | 0.2136 | 0.2031 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0175 | 0.0093 |
Brugia malayi | bZIP transcription factor family protein | 0.0084 | 0.2136 | 0.3182 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0175 | 0.0044 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.069 | 0.1028 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0387 | 0.0259 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0175 | 0.0261 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0175 | 0.0093 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0037 | 0.069 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0273 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0175 | 0.0261 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.069 | 0.0566 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0.6714 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.211 | 0.2005 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4765 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0037 | 0.069 | 0.9995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.