Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 1000 nM | Agonist activity at GR by GRE activation assay | ChEMBL. | 17553679 |
EC50 (functional) | > 1000 nM | Agonist activity at GR by GRE activation assay relative to dexamethasone | ChEMBL. | 17553679 |
Efficacy (functional) | < 10 % | Agonist activity at GR by GRE activation assay relative to dexamethasone | ChEMBL. | 17553679 |
Efficacy (functional) | = 91 % | Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activation | ChEMBL. | 17553679 |
Efficacy (functional) | = 102 % | Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin response | ChEMBL. | 17553679 |
IC50 (functional) | = 2.3 nM | Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activation | ChEMBL. | 17553679 |
IC50 (functional) | = 12 nM | Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin response | ChEMBL. | 17553679 |
Ki (binding) | = 7.2 nM | Displacement of radiolabeled dexamethasone from glucocorticoid receptor | ChEMBL. | 17553679 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.