Detailed information for compound 2012120

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 442.401 | Formula: C16H18N4O9S
  • H donors: 7 H acceptors: 8 LogP: -4.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@H]([C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc(=O)[nH]c1=O)NC(=O)[C@H](c1csc(c1)O)N
  • InChi: 1S/C16H18N4O9S/c17-8(5-3-7(22)30-4-5)13(25)19-9(15(26)27)12-10(23)11(24)14(29-12)20-2-1-6(21)18-16(20)28/h1-4,8-12,14,22-24H,17H2,(H,19,25)(H,26,27)(H,18,21,28)/t8-,9-,10-,11+,12+,14+/m0/s1
  • InChiKey: QSQNNIADTPWXHV-DYOQXNRMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RGC/RGC protein kinase 0.0595 0.1152 0.1152
Loa Loa (eye worm) glutamate receptor 1 0.131 0.2588 0.2588
Loa Loa (eye worm) hypothetical protein 0.0058 0.0074 0.0074
Loa Loa (eye worm) serotonin transporter b 0.0058 0.0074 0.0074
Brugia malayi regulator of G-protein signaling rgs-7 0.0082 0.0122 0.0149
Loa Loa (eye worm) hypothetical protein 0.0375 0.0711 0.0711
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0059 0.0458
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.0122
Brugia malayi cytochrome P450 0.0026 0.0009 0.0011
Schistosoma mansoni glutamate receptor kainate 0.1484 0.2937 0.3336
Onchocerca volvulus 0.0064 0.0086 0.0327
Brugia malayi hypothetical protein 0.0595 0.1152 0.1405
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0587 0.1136 0.1136
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0009 0.0023
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0086 0.5766
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0435 0.4395
Treponema pallidum glutamate transporter 0.0587 0.1136 0.9633
Leishmania major cathepsin L-like protease 0.0065 0.0087 0.0702
Schistosoma mansoni glutaminase 0.0268 0.0495 0.0563
Schistosoma mansoni loxhd1 0.0023 0.0003 0.0003
Trichomonas vaginalis rotamase, putative 0.0033 0.0022 0.0161
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0053 0.0062 0.0485
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0086 0.0811
Mycobacterium ulcerans aldehyde dehydrogenase 0.0193 0.0344 0.2866
Loa Loa (eye worm) hypothetical protein 0.0031 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0076 0.0603
Echinococcus multilocularis axis inhibition protein axin 0.0082 0.0122 0.0122
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0009 0.0009
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0238 0.0435 0.1631
Schistosoma mansoni glutamate receptor AMPA 0.0935 0.1834 0.2083
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0238 0.0435 0.3736
Echinococcus multilocularis bloom syndrome protein 0.0047 0.005 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0087 0.0702
Schistosoma mansoni lozenge 0.0057 0.007 0.008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0448 0.0856 0.0856
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0238 0.0435 0.3567
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0003 0.0003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0147 0.0526
Loa Loa (eye worm) hypothetical protein 0.0058 0.0074 0.0074
Loa Loa (eye worm) 6-phosphofructokinase 0.0238 0.0435 0.0435
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0002 0.0002
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0022 0.016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0037 0.085
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0021 0.0123
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0037 0.0046
Brugia malayi PXA domain containing protein 0.0082 0.0122 0.0149
Echinococcus granulosus intermediate filament protein 0.0032 0.002 0.002
Echinococcus multilocularis excitatory amino acid transporter 2 0.1325 0.2618 0.2618
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.039 0.1459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0035 0.0292
Entamoeba histolytica phosphofructokinase, putative 0.0238 0.0435 0.376
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0595 0.1152 0.4402
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0022 0.0505
Loa Loa (eye worm) hypothetical protein 0.0629 0.122 0.122
Loa Loa (eye worm) glutaminase 2 0.0268 0.0495 0.0495
Echinococcus granulosus neutral amino acid transporter A 0.1325 0.2618 0.2618
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0082 0.0122 0.0122
Brugia malayi Glutamate receptor 2 precursor 0.131 0.2588 0.3155
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0082 0.0122 0.0138
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0022 0.0136
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0587 0.1136 0.129
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0112 0.0918
Echinococcus multilocularis excitatory amino acid transporter 2 0.1325 0.2618 0.2618
Echinococcus granulosus excitatory amino acid transporter 3 0.1325 0.2618 0.2618
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0053 0.0062 0.0485
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0086 0.0086
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1325 0.2618 1
Schistosoma mansoni glutamate receptor AMPA 0.0935 0.1834 0.2083
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.2079 0.4133 0.4133
Echinococcus granulosus excitatory amino acid transporter 2 0.1325 0.2618 0.2618
Echinococcus granulosus regulator of G protein signaling 7 0.0082 0.0122 0.0122
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0079 0.0116 0.0956
Schistosoma mansoni rab6-interacting 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0451 0.0863 0.0863
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0037 0.2373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0147 0.0147
Brugia malayi 6-phosphofructokinase 0.0238 0.0435 0.053
Echinococcus granulosus neutral amino acid transporter 0.1325 0.2618 0.2618
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0037 0.0315
Mycobacterium tuberculosis Probable reductase 0.0216 0.039 0.1459
Loa Loa (eye worm) phosphofructokinase 0.0238 0.0435 0.0435
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0112 0.0136
Brugia malayi Guanylyl cyclase protein 23 0.0595 0.1152 0.1405
Echinococcus multilocularis pyruvate kinase 0.0033 0.0022 0.0022
Schistosoma mansoni 6-phosphofructokinase 0.0238 0.0435 0.0494
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.1 0.1965 0.1965
Loa Loa (eye worm) hypothetical protein 0.0032 0.002 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0037 0.0058
Schistosoma mansoni rotamase 0.0033 0.0022 0.0025
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0009 0.0023
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0003 0.0003
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0064 0.0086 0.0548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0086 0.0097
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0022 0.0136
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.0122
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0022 0.0161
Brugia malayi Doublecortin family protein 0.0023 0.0003 0.0004
Treponema pallidum sodium- and chloride- dependent transporter 0.0058 0.0074 0.0445
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0064 0.0086 0.0811
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Echinococcus granulosus neutral amino acid transporter A 0.1325 0.2618 0.2618
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0022 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Echinococcus multilocularis Regulator of G protein signaling 20 0.0082 0.0122 0.0122
Loa Loa (eye worm) intermediate filament protein 0.0032 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0035 0.0292
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0172 0.0172
Echinococcus multilocularis 6 phosphofructokinase 0.0238 0.0435 0.0435
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0086 0.0086
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0021 0.0123
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0595 0.1152 0.1152
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0082 0.0122 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0086 0.0097
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0112 0.0918
Onchocerca volvulus 0.051 0.0981 0.3746
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0022 0.0137
Toxoplasma gondii thioredoxin reductase 0.0095 0.0147 0.4095
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0022 0.039
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0082 0.0122 0.1038
Brugia malayi Regulator of G protein signaling domain containing protein 0.0082 0.0122 0.0149
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0009 0.0009
Schistosoma mansoni rab6-interacting 0.0023 0.0003 0.0003
Echinococcus multilocularis metabotropic glutamate receptor 5 0.5 1 1
Echinococcus multilocularis 0.0026 0.0009 0.0009
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0022 0.0085
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0041 0.0348
Entamoeba histolytica phosphofructokinase, putative 0.0238 0.0435 0.376
Toxoplasma gondii exonuclease III APE 0.004 0.0037 0.0837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0035 0.0292
Echinococcus multilocularis neutral amino acid transporter A 0.1325 0.2618 0.2618
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0147 0.1221
Entamoeba histolytica hypothetical protein 0.0082 0.0122 0.1038
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.005 0.0062
Trichomonas vaginalis glutaminase, putative 0.0268 0.0495 0.5017
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0087 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0134
Schistosoma mansoni polycystin 1-related 0.0023 0.0003 0.0003
Brugia malayi regulator of G-protein signaling egl-10 0.0082 0.0122 0.0149
Onchocerca volvulus 0.0032 0.002 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0025 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0047 0.0412
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0082 0.0122 0.0122
Echinococcus granulosus lamin 0.0032 0.002 0.002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0022 0.0137
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0065 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Echinococcus multilocularis glutamate receptor 2 0.131 0.2588 0.2588
Mycobacterium ulcerans 6-phosphofructokinase 0.0238 0.0435 0.3639
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0086 0.5766
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0022 0.0503
Echinococcus granulosus regulator of G protein signaling 7 0.0082 0.0122 0.0122
Brugia malayi glutathione reductase 0.0095 0.0147 0.0179
Brugia malayi hypothetical protein 0.0082 0.0122 0.0149
Loa Loa (eye worm) runx1 0.0057 0.007 0.007
Plasmodium falciparum pyruvate kinase 0.0033 0.0022 0.1349
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0087 0.0702
Echinococcus multilocularis pyruvate kinase 0.0033 0.0022 0.0022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0193 0.0344 0.0344
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0138
Echinococcus multilocularis nmda type glutamate receptor 0.0673 0.1308 0.1308
Schistosoma mansoni axis inhibition protein axin 0.0082 0.0122 0.0138
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1905 0.3783 0.3783
Brugia malayi phosphofructokinase 0.0238 0.0435 0.053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0062 0.0076
Brugia malayi hypothetical protein 0.0023 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Brugia malayi Excitatory amino acid transporter 0.1325 0.2618 0.3191
Echinococcus multilocularis nmda type glutamate receptor 0.1004 0.1974 0.1974
Loa Loa (eye worm) hypothetical protein 0.0595 0.1152 0.1152
Brugia malayi Cytochrome P450 family protein 0.0026 0.0009 0.0011
Leishmania major cytochrome p450-like protein 0.0026 0.0009 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0019 0.0127
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0005 0.0006
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1325 0.2618 1
Loa Loa (eye worm) glutamate receptor 2 0.0935 0.1834 0.1834
Brugia malayi metabotropic glutamate receptor type 2 0.2119 0.4213 0.5137
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.2079 0.4133 0.4133
Schistosoma mansoni hypothetical protein 0.0198 0.0355 0.0403
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.002 0.119
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0064 0.0086 0.2281
Brugia malayi Cytochrome P450 family protein 0.0107 0.0172 0.021
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0053 0.0062 0.0521
Echinococcus granulosus axis inhibition protein axin 0.0082 0.0122 0.0122
Echinococcus granulosus pyruvate kinase 0.0033 0.0022 0.0022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0005 0.0006
Treponema pallidum glutamate racemase 0.0608 0.1178 1
Schistosoma mansoni protein kinase 0.0595 0.1152 0.1309
Echinococcus granulosus pyruvate kinase 0.0033 0.0022 0.0022
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0021 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0064 0.0086 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0037 0.2397
Brugia malayi Cytochrome P450 family protein 0.0026 0.0009 0.0011
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0595 0.1152 0.1152
Leishmania major cathepsin L-like protease 0.0065 0.0087 0.0702
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0022 0.005
Schistosoma mansoni lipoxygenase 0.0065 0.0086 0.0098
Echinococcus granulosus Regulator of G protein signaling 20 0.0082 0.0122 0.0122
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0451 0.0862 0.0862
Echinococcus granulosus axis inhibition protein axin 0.0082 0.0122 0.0122
Mycobacterium ulcerans aldehyde dehydrogenase 0.0193 0.0344 0.2866
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0022 0.0112
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.1224 0.2415 0.2415
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0022 0.0085
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0022 0.0505
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0022 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0193 0.0344 0.0391
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.2079 0.4133 0.4133
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0193 0.0344 0.1285
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0037 0.0037
Loa Loa (eye worm) PXA domain-containing protein 0.0082 0.0122 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Echinococcus granulosus glutamate receptor 2 0.1455 0.2878 0.2878
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0989 0.1942 0.1942
Echinococcus multilocularis expressed protein 0.1602 0.3174 0.3174
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0053 0.0062 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0086 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0086 0.0811
Echinococcus multilocularis pyruvate kinase 0.0026 0.0008 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0022 0.0161
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0009 0.0023
Echinococcus granulosus glutamate NMDA receptor subunit 0.0989 0.1942 0.1942
Leishmania major cathepsin L-like protease 0.0065 0.0087 0.0702
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0022 0.0022
Schistosoma mansoni z-protein (S1r protein) 0.0082 0.0122 0.0138
Echinococcus multilocularis lamin 0.0032 0.002 0.002
Schistosoma mansoni lipoxygenase 0.0023 0.0003 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0435 0.4395
Leishmania major cytochrome p450-like protein 0.0026 0.0009 0.0023
Treponema pallidum glutamate/aspartate transporter 0.0587 0.1136 0.9633
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.005 0.0449
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.2079 0.4133 0.4133
Loa Loa (eye worm) cytochrome P450 0.0026 0.0009 0.0009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0238 0.0435 0.3639
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0022 0.0027
Echinococcus granulosus receptor type guanylyl cyclase 0.0595 0.1152 0.1152
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.0438 0.1645
Echinococcus multilocularis beta adrenergic receptor kinase 0.0082 0.0122 0.0122
Schistosoma mansoni metabotropic glutamate receptor 0.3476 0.6939 0.7881
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0037 0.0268
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0022 0.0112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0037 0.0268
Loa Loa (eye worm) hypothetical protein 0.0451 0.0863 0.0863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Leishmania major pyruvate kinase 0.0033 0.0022 0.0136
Onchocerca volvulus 0.0058 0.0074 0.0282
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0021 0.0344
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0022 0.0137
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0022 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0086 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0022 0.016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0022 0.0022
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0022 0.0027
Echinococcus multilocularis neutral amino acid transporter A 0.1325 0.2618 0.2618
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0134
Echinococcus multilocularis regulator of G protein signaling 7 0.0082 0.0122 0.0122
Echinococcus multilocularis RUN 0.0023 0.0003 0.0003
Echinococcus granulosus excitatory amino acid transporter 2 0.1325 0.2618 0.2618
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0086 0.0811
Echinococcus granulosus glutamate receptor 1 0.0375 0.0711 0.0711
Loa Loa (eye worm) glutamate receptor 0.4105 0.8202 0.8202
Echinococcus granulosus expressed protein 0.0033 0.0022 0.0022
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0629 0.122 0.1487
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.2079 0.4133 0.4133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0071
Schistosoma mansoni glutamate receptor NMDA 0.1607 0.3185 0.3617
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0022 0.1355
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1325 0.2618 0.2618
Brugia malayi Glutamate receptor 1 precursor 0.131 0.2588 0.3155
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0086 0.0244
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0064 0.0086 0.0725
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0086 0.0811
Echinococcus granulosus glutamate receptor subunit protein glur 0.0826 0.1616 0.1616
Brugia malayi glutaminase DH11.1 0.0268 0.0495 0.0604
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0138
Schistosoma mansoni pyruvate kinase 0.0033 0.0022 0.0025
Loa Loa (eye worm) glutamate receptor 0.1524 0.3018 0.3018
Echinococcus multilocularis metabotropic glutamate receptor 2 0.3476 0.6939 0.6939
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0022 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0022 0.0161
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0009 0.0023
Echinococcus granulosus glutamate receptor 2 0.1905 0.3783 0.3783
Schistosoma mansoni cytochrome P450 0.0026 0.0009 0.0011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0053 0.0062 0.1423
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0007 0.0037
Brugia malayi 6-phosphofructokinase 0.0238 0.0435 0.053
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0022 0.039
Loa Loa (eye worm) hypothetical protein 0.0595 0.1152 0.1152
Schistosoma mansoni tyrosine kinase 0.0595 0.1152 0.1309
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.002 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.039 0.1459
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0193 0.0344 0.2948
Mycobacterium ulcerans glutaminase 0.0268 0.0495 0.4157
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0009 0.0204
Echinococcus granulosus metabotropic glutamate receptor 2 0.3476 0.6939 0.6939
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0037 0.0268
Onchocerca volvulus 0.0023 0.0003 0.0011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.039 0.1459
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.0122
Echinococcus granulosus geminin 0.0198 0.0355 0.0355
Echinococcus granulosus Excitatory amino acid transporter 0.1325 0.2618 0.2618
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0003 0.0003
Echinococcus multilocularis glutamate receptor 2 0.1455 0.2878 0.2878
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0082 0.0122 0.1182
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0629 0.122 0.4659
Echinococcus multilocularis Protein lozenge 0.0057 0.007 0.007
Schistosoma mansoni pyruvate kinase 0.0033 0.0022 0.0025
Loa Loa (eye worm) solute carrier family 6 member 4 0.0058 0.0074 0.0074
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0022 0.1355
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0086 0.5766
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Loa Loa (eye worm) glutathione reductase 0.0095 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.1224 0.2415 0.2415
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.0041 0.0297
Brugia malayi Receptor family ligand binding region containing protein 0.1224 0.2415 0.2945
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1905 0.3783 0.3783
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0216 0.039 0.3255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0041 0.0348
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.0041 0.0297
Echinococcus multilocularis excitatory amino acid transporter 3 0.1325 0.2618 0.2618
Trichomonas vaginalis set domain proteins, putative 0.051 0.0981 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.007
Loa Loa (eye worm) RGS-3 protein 0.0082 0.0122 0.0122
Plasmodium falciparum thioredoxin reductase 0.0033 0.0022 0.1355
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0058 0.0074 0.009
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0039 0.2513
Schistosoma mansoni lamin 0.0032 0.002 0.0023
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0022 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0071
Schistosoma mansoni axis inhibition protein axin 0.0082 0.0122 0.0138
Echinococcus multilocularis Excitatory amino acid transporter 0.1325 0.2618 0.2618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0035 0.0292
Loa Loa (eye worm) hypothetical protein 0.0375 0.0711 0.0711
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0022 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0122 0.0138
Echinococcus granulosus lamin dm0 0.0032 0.002 0.002
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0476 0.0914 0.7709
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0138
Echinococcus granulosus regulator of G protein signaling 3 0.0082 0.0122 0.0122
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0031 0.0035
Loa Loa (eye worm) hypothetical protein 0.0595 0.1152 0.1152
Echinococcus granulosus atrial natriuretic peptide receptor 0.0595 0.1152 0.1152
Echinococcus granulosus glutamate receptor NMDA 0.0077 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.1182
Brugia malayi PXA domain containing protein 0.0082 0.0122 0.0149
Brugia malayi hypothetical protein 0.0451 0.0863 0.1052
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0022 0.0505
Schistosoma mansoni ap endonuclease 0.004 0.0037 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0062 0.0062
Chlamydia trachomatis glutamine binding protein 0.0476 0.0914 0.3434
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0022 0.0022
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0003 0.0003
Echinococcus multilocularis sodium channel protein 0.0079 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.0122
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0451 0.0862 0.0862
Brugia malayi Receptor family ligand binding region containing protein 0.0595 0.1152 0.1405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0041 0.0348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Echinococcus granulosus RUN 0.0023 0.0003 0.0003
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0079 0.0116 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0122 0.0138
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0022 0.1355
Echinococcus multilocularis expressed protein 0.0033 0.0022 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0087 0.0702
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0009 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0041 0.0348
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0147 0.0147
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0022 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.1182
Schistosoma mansoni hypothetical protein 0.0629 0.122 0.1385
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0009 0.0023
Echinococcus multilocularis geminin 0.0198 0.0355 0.0355
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0435 0.4395
Echinococcus granulosus bloom syndrome protein 0.0047 0.005 0.005
Mycobacterium ulcerans glutamate racemase 0.0608 0.1178 1
Chlamydia trachomatis neutral amino acid transporter 0.0587 0.1136 0.4291
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0595 0.1152 0.1405
Mycobacterium tuberculosis Probable glutamate racemase MurI 0.0608 0.1178 0.4482
Onchocerca volvulus 0.0023 0.0003 0.0011
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0003 0.0003
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0053 0.0062 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0019 0.0127
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.1 0.1965 0.1965
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0476 0.0914 0.7735
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0022 0.0505
Echinococcus granulosus sodium:dicarboxylate symporter 0.1325 0.2618 0.2618
Leishmania major cytochrome p450-like protein 0.0026 0.0009 0.0023
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.005 0.0449
Echinococcus granulosus glutamate receptor 4 0.0375 0.0711 0.0711
Toxoplasma gondii phosphofructokinase PFKII 0.0064 0.0086 0.2281
Echinococcus granulosus serotonin transporter 0.0058 0.0074 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.007
Brugia malayi Pre-SET motif family protein 0.0448 0.0856 0.1044
Leishmania major trypanothione reductase 0.0095 0.0147 0.1221
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0022 0.0085
Brugia malayi Metabotropic glutamate receptor precursor. 0.4105 0.8202 1
Echinococcus multilocularis serotonin transporter 0.0058 0.0074 0.0074
Echinococcus granulosus Excitatory amino acid transporter 0.1325 0.2618 0.2618
Trypanosoma brucei trypanothione reductase 0.0095 0.0147 0.3364
Onchocerca volvulus 0.0595 0.1152 0.4402
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.4405 0.8804 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.0438 0.1645
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.0438 0.3669
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0022 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0134
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0037 0.0304
Onchocerca volvulus 0.0595 0.1152 0.4402
Echinococcus multilocularis axis inhibition protein axin 0.0082 0.0122 0.0122
Echinococcus multilocularis Excitatory amino acid transporter 0.1325 0.2618 0.2618
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0022 0.0112
Echinococcus multilocularis regulator of G protein signaling 0.0082 0.0122 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.1182
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0112 0.0112
Brugia malayi Cytochrome P450 family protein 0.0026 0.0009 0.0011
Onchocerca volvulus 0.0451 0.0863 0.3297
Loa Loa (eye worm) 6-phosphofructokinase 0.0238 0.0435 0.0435
Schistosoma mansoni hypothetical protein 0.0198 0.0355 0.0403
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0022 0.0022
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0238 0.0435 1
Schistosoma mansoni metabotropic glutamate receptor 0.2119 0.4213 0.4785
Echinococcus multilocularis regulator of G protein signaling 3 0.0082 0.0122 0.0122
Loa Loa (eye worm) glutaminase 0.0268 0.0495 0.0495
Trypanosoma cruzi extracellular receptor, putative 0.0595 0.1152 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.0711 0.0711
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0587 0.1136 0.1136
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0082 0.0122 0.0122
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0112 0.0952
Schistosoma mansoni ap endonuclease 0.004 0.0037 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0062 0.0571
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0112 0.0112
Echinococcus multilocularis NMDA receptor 0.1 0.1965 0.1965
Echinococcus granulosus nmda type glutamate receptor 0.0673 0.1308 0.1308
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0122 0.0138
Loa Loa (eye worm) hypothetical protein 0.0037 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.1182
Chlamydia trachomatis glutamate symporter 0.1325 0.2618 1
Echinococcus multilocularis tyrosine kinase 0.0595 0.1152 0.1152
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0826 0.1616 0.1616
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0037 0.0315
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.002 0.002
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0053 0.0062 0.0062
Schistosoma mansoni intermediate filament proteins 0.0032 0.002 0.0023
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0035 0.0292
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0053 0.0062 0.0485
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0147 0.0147
Brugia malayi Pre-SET motif family protein 0.0064 0.0086 0.0104
Schistosoma mansoni 6-phosphofructokinase 0.0238 0.0435 0.0494
Echinococcus granulosus glutamate receptor ionotropic kainate 0.1 0.1965 0.1965
Plasmodium vivax glutathione reductase, putative 0.0095 0.0147 1
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0086 0.0811
Mycobacterium ulcerans hydantoin racemase 0.0239 0.0437 0.3655
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0007 0.0144
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.039 0.1459
Brugia malayi follicle stimulating hormone receptor 0.0243 0.0445 0.0542
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0003 0.0003
Loa Loa (eye worm) excitatory amino acid transporter 0.1325 0.2618 0.2618
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0086 0.5766
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.1182
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0046 0.0046
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0021 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0086 0.0811
Echinococcus granulosus expressed protein 0.1602 0.3174 0.3174
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0587 0.1136 0.129
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.0062 0.1423
Leishmania major extracellular receptor, putative 0.0595 0.1152 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0064 0.0086 1
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0122 0.0138
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0058 0.0074 0.0084
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.351 0.7006 0.8542
Plasmodium falciparum thioredoxin reductase 0.0095 0.0147 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.2079 0.4133 0.4133
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0022 0.0388
Onchocerca volvulus Poor gastrulation protein homolog 0.0629 0.122 0.4659
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0082 0.0122 0.0138
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0476 0.0914 0.7709
Onchocerca volvulus 0.0032 0.002 0.0076
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0009 0.0204
Brugia malayi hypothetical protein 0.0082 0.0122 0.0149
Loa Loa (eye worm) RGC/RGC protein kinase 0.0595 0.1152 0.1152
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0053 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Leishmania major pyruvate kinase 0.0033 0.0022 0.0136
Echinococcus granulosus 6 phosphofructokinase 0.0238 0.0435 0.0435
Trichomonas vaginalis phosphofructokinase, putative 0.0238 0.0435 0.4395
Brugia malayi hypothetical protein 0.0023 0.0003 0.0004
Echinococcus granulosus tyrosine kinase 0.0595 0.1152 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0035 0.0292
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0595 0.1152 0.1152
Schistosoma mansoni hypothetical protein 0.0451 0.0862 0.0979
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0595 0.1152 0.1309
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0009 0.0009
Plasmodium falciparum glutathione reductase 0.0095 0.0147 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0053 0.0062 0.0485
Toxoplasma gondii aldehyde dehydrogenase 0.0193 0.0344 1
Entamoeba histolytica phosphofructokinase, putative 0.0238 0.0435 0.376
Entamoeba histolytica hypothetical protein 0.0082 0.0122 0.1038
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0193 0.0344 0.0344
Schistosoma mansoni lamin 0.0032 0.002 0.0023
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0476 0.0914 0.3434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Echinococcus multilocularis glutamate receptor 2 0.1905 0.3783 0.3783
Plasmodium vivax SET domain protein, putative 0.0064 0.0086 0.5758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0062 0.0571
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0037 0.0037
Schistosoma mansoni sodium/chloride dependent transporter 0.0058 0.0074 0.0084
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0037 0.024
Entamoeba histolytica hypothetical protein 0.0595 0.1152 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0112 0.2565
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0112 0.0127
Giardia lamblia GTOR 0.0053 0.0062 0.63
Loa Loa (eye worm) hypothetical protein 0.0595 0.1152 0.1152
Loa Loa (eye worm) RecQ helicase 0.0047 0.005 0.005
Echinococcus multilocularis GPCR, family 3, C terminal 0.0629 0.122 0.122
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0007 0.014
Mycobacterium leprae PROBABLE GLUTAMATE RACEMASE MURI 0.0608 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.5 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0037 0.0108
Schistosoma mansoni ATP-binding cassette transporter 0.0935 0.1834 0.2083
Echinococcus multilocularis regulator of G protein signaling 7 0.0082 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0058 0.0074 0.0074
Echinococcus multilocularis glutamate receptor 4 0.0375 0.0711 0.0711
Loa Loa (eye worm) RGC/RGC protein kinase 0.0595 0.1152 0.1152
Loa Loa (eye worm) hypothetical protein 0.0595 0.1152 0.1152
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0065 0.0086 0.0086
Echinococcus granulosus GPCR family 3 C terminal 0.0629 0.122 0.122
Echinococcus granulosus beta-adrenergic receptor kinase 0.0082 0.0122 0.0122
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0019 0.0297
Echinococcus granulosus nmda type glutamate receptor 0.1004 0.1974 0.1974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0041 0.0348
Echinococcus multilocularis musashi 0.0032 0.002 0.002
Echinococcus multilocularis glutamate receptor NMDA 0.0077 0.0112 0.0112
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0022 0.1349
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0122 0.1182
Brugia malayi intermediate filament protein 0.0032 0.002 0.0024
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.0041 0.0927
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0086 0.0086
Echinococcus granulosus sodium channel protein 0.0079 0.0116 0.0116
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0037 0.0129
Schistosoma mansoni hypothetical protein 0.0026 0.0009 0.0011
Toxoplasma gondii 6-phosphofructokinase 0.0064 0.0086 0.2281
Brugia malayi Thioredoxin reductase 0.0095 0.0147 0.0179
Echinococcus granulosus regulator of G protein signaling 3 0.0082 0.0122 0.0122
Loa Loa (eye worm) norepinephrine transporter 0.0058 0.0074 0.0074
Trichomonas vaginalis rotamase, putative 0.0032 0.0021 0.0145
Schistosoma mansoni aldehyde dehydrogenase 0.0193 0.0344 0.0391
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0037 0.2397
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.0438 0.1645
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0022 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0087 0.1996
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1325 0.2618 1
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1325 0.2618 0.2973
Schistosoma mansoni glutamate receptor kainate 0.0935 0.1834 0.2083
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0082 0.0122 0.0149
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0021 0.0469
Plasmodium falciparum glutathione reductase 0.0033 0.0022 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0062 0.0571
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0147 1
Leishmania major ATP-dependent phosphofructokinase 0.0238 0.0435 0.3736
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0082 0.0122 0.0138
Echinococcus multilocularis lamin dm0 0.0032 0.002 0.002
Echinococcus multilocularis receptor type guanylyl cyclase 0.0595 0.1152 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.0213
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1476 0.2922 0.2922
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0112 0.0918
Brugia malayi Regulator of G protein signaling domain containing protein 0.0082 0.0122 0.0149
Mycobacterium ulcerans aldehyde dehydrogenase 0.0193 0.0344 0.2866
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0035 0.0772
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0081 0.0081
Schistosoma mansoni glutamate receptor NMDA 0.0989 0.1942 0.2206
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1325 0.2618 0.2618
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.1224 0.2415 0.2415
Echinococcus multilocularis neutral amino acid transporter A 0.1325 0.2618 0.2618
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0086 0.0097
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0476 0.0914 0.3467
Brugia malayi A-kinase anchor protein 10, precursor 0.0082 0.0122 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.039 0.1459
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0022 0.0137
Echinococcus multilocularis regulator of G protein signaling 3 0.0082 0.0122 0.0122
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0022 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0035 0.0292
Schistosoma mansoni glutamate receptor kainate 0.1484 0.2937 0.3336
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0086 0.2277
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0082 0.0122 0.0122
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0082 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0595 0.1152 0.1152
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0037 0.0037
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0022 0.0111

Activities

Activity type Activity value Assay description Source Reference
GMMIC (functional) > 2048 ug ml-1 Geometric mean minimum inhibitory concentration (GMMIC) for whole cell activity against Candida albicans ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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