Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.3055 | 0.4668 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.6652 | 0.647 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0515 | 0.0515 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0017 | 0.0515 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0017 | 0.0515 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.1679 | 0.1227 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0077 | 0.4627 | 0.3543 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.435 | 0.4043 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0017 | 0.0515 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.435 | 0.906 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.4627 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0017 | 0.0515 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.1679 | 0.1227 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0017 | 0.0515 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.4627 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.1679 | 0.1679 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.4627 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0077 | 0.4627 | 0.3543 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.6652 | 0.6652 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0515 | 0.0515 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.4627 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.435 | 0.435 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0077 | 0.4627 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.4627 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.6652 | 0.6652 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0077 | 0.4627 | 0.4335 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.6652 | 0.647 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0017 | 0.0515 | 0.0515 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1679 | 0.1679 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.2 | Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments | ChEMBL. | 12139452 |
Log Ki (binding) | = 8.2 | Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments | ChEMBL. | 12139452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.