Detailed information for compound 201242

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.5 | Formula: C22H23N3O5S
  • H donors: 2 H acceptors: 4 LogP: 2.14 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](C(=O)N[C@@H]1C(=O)N2[C@H]1[S+]([O-])CC2)Cc1ccccc1)OCc1ccccc1
  • InChi: 1S/C22H23N3O5S/c26-19(24-18-20(27)25-11-12-31(29)21(18)25)17(13-15-7-3-1-4-8-15)23-22(28)30-14-16-9-5-2-6-10-16/h1-10,17-18,21H,11-14H2,(H,23,28)(H,24,26)/t17-,18+,21-,31?/m0/s1
  • InChiKey: GESCBNXAUSHCBH-KJEPARCNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 372 aa 23.7 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin L   334 aa 318 aa 48.4 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 278 aa 26.6 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin L   334 aa 360 aa 29.2 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin L   334 aa 288 aa 26.7 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 336 aa 25.9 %
Plasmodium berghei berghepain-1 Cathepsin L   334 aa 353 aa 29.7 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 325 aa 38.1 %
Onchocerca volvulus Cathepsin L homolog Cathepsin L   334 aa 322 aa 41.6 %
Plasmodium yoelii cathepsin c precursor Cathepsin L   334 aa 292 aa 22.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 276 aa 26.8 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 309 aa 26.5 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 36.4 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.2 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 325 aa 29.5 %
Plasmodium vivax unspecified product Cathepsin L   334 aa 366 aa 28.4 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 324 aa 34.6 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin L   334 aa 300 aa 41.0 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 276 aa 25.4 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 282 aa 26.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin L   334 aa 303 aa 23.4 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Trypanosoma cruzi cysteine protease, putative Cathepsin L   334 aa 323 aa 30.3 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 275 aa 29.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin L   334 aa 359 aa 29.8 %
Giardia lamblia Dipeptidyl-peptidase I precursor Cathepsin L   334 aa 304 aa 28.3 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 271 aa 26.9 %
Plasmodium vivax vivapain-3 Cathepsin L   334 aa 345 aa 30.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 295 aa 25.4 %
Echinococcus granulosus cysteine protease Cathepsin L   334 aa 323 aa 44.3 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 298 aa 28.9 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin L   334 aa 311 aa 35.0 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 270 aa 25.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin L   334 aa 296 aa 31.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 23.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 319 aa 25.7 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 317 aa 33.8 %
Babesia bovis papain family cysteine protease containing protein Cathepsin L   334 aa 321 aa 32.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin L   334 aa 277 aa 24.5 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 273 aa 26.0 %
Onchocerca volvulus Cathepsin L   334 aa 325 aa 47.4 %
Onchocerca volvulus Cathepsin L   334 aa 311 aa 40.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 332 aa 23.5 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 273 aa 25.3 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin L   334 aa 312 aa 42.0 %
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Cathepsin L   334 aa 290 aa 27.6 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 274 aa 48.5 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin L   334 aa 345 aa 35.4 %
Toxoplasma gondii cathepsin CPC1 Cathepsin L   334 aa 295 aa 28.1 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 270 aa 25.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 274 aa 48.2 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 279 aa 28.3 %
Plasmodium knowlesi knowpain-1 Cathepsin L   334 aa 373 aa 27.6 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin L   334 aa 316 aa 30.1 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 277 aa 26.0 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 279 aa 25.8 %
Neospora caninum hypothetical protein Cathepsin L   334 aa 299 aa 28.4 %
Onchocerca volvulus Cathepsin L   334 aa 300 aa 24.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 277 aa 26.0 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 38.0 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 309 aa 30.4 %
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 271 aa 27.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 303 aa 26.1 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin L   334 aa 323 aa 46.1 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 337 aa 26.1 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 347 aa 28.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 24.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 28.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 25.9 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.9 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin L   334 aa 311 aa 36.0 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 333 aa 28.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 341 aa 26.7 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin L   334 aa 294 aa 23.8 %
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 273 aa 27.8 %
Plasmodium vivax vivapain-1 Cathepsin L   334 aa 366 aa 28.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cysteine peptidase A (CPA) 0.0086 0.2924 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.093 0.093
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.2924 0.2198
Echinococcus multilocularis cysteine protease 0.0086 0.2924 0.2924
Plasmodium vivax vivapain-2 0.0086 0.2924 1
Brugia malayi Cathepsin L-like precursor 0.0059 0.093 0.093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.2924 0.2924
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.1716 0.1716
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Toxoplasma gondii cathepsin CPL 0.0086 0.2924 1
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.093 0.093
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Onchocerca volvulus Cathepsin L homolog 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.2924 0.2924
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.2924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.2924 0.2924
Onchocerca volvulus 0.0086 0.2924 1
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.093 0.3182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.093 0.3182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2924 0.2924
Loa Loa (eye worm) cathepsin B 0.007 0.1716 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Onchocerca volvulus 0.0086 0.2924 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.2924 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.2924 0.2924
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.2924 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Onchocerca volvulus Cathepsin F homolog 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.2924 0.2924
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2924 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Loa Loa (eye worm) fibroinase 0.0086 0.2924 0.2198
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.2924 0.2924
Echinococcus granulosus cathepsin l1 0.0086 0.2924 0.2924
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.2924 0.2924
Echinococcus granulosus cathepsin l1 0.0059 0.093 0.093
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2924 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.2924 0.2924
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Echinococcus multilocularis cysteine protease 0.0086 0.2924 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.093 0.093
Onchocerca volvulus 0.0086 0.2924 1
Giardia lamblia Cathepsin B precursor 0.007 0.1716 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.2924 1
Loa Loa (eye worm) cysteine protease 0.0086 0.2924 0.2198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.2924 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.2924 0.2198
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.1716 0.5868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.2924 0.2924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Plasmodium vivax vivapain-2 0.0086 0.2924 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Onchocerca volvulus 0.0086 0.2924 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2924 0.2924
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.2924 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.2924 0.2924
Giardia lamblia Cathepsin B precursor 0.007 0.1716 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2924 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0181 1 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.2924 0.2924
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.2924 0.2198
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.2924 0.2924
Echinococcus multilocularis cathepsin b 0.0181 1 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.2924 0.2924
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Brugia malayi cathepsin L-like precursor 0.0059 0.093 0.093
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.1716 0.5868
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.2924 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.093 0.3182
Onchocerca volvulus 0.0086 0.2924 1
Onchocerca volvulus 0.0086 0.2924 1
Loa Loa (eye worm) ctsf protein 0.0086 0.2924 0.2198
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.1716 0.1716
Leishmania major cathepsin L-like protease 0.0086 0.2924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2924 1
Onchocerca volvulus 0.0086 0.2924 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.2924 0.2924
Giardia lamblia Cathepsin B precursor 0.007 0.1716 0.5
Onchocerca volvulus Cathepsin L homolog 0.0086 0.2924 1
Echinococcus multilocularis cathepsin b 0.0181 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2924 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.2924 0.2924

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.035 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.035 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.068 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.068 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.07 uM In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC ChEMBL. 12419374
IC50 (binding) = 0.07 uM In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC ChEMBL. 12419374
IC50 (binding) = 16.4 uM Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine protease ChEMBL. 12419374
IC50 (binding) = 16.4 uM Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine protease ChEMBL. 12419374

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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