Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1113 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0865 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 2 | 0.0536 | 0.3546 | 0.3546 |
Brugia malayi | Serotonin receptor | 0.104 | 0.9181 | 0.9181 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0219 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0536 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0865 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0865 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0865 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0865 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0536 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0865 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0536 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0536 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1113 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1113 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0865 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1113 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0865 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0865 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0536 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0865 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0536 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0536 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0219 | 0 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0865 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1113 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0536 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain | 0.1113 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.1113 | 1 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0536 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1113 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1113 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0865 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.1113 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1113 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0865 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0865 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0536 | 0.3546 | 0.3546 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0536 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0536 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1113 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0865 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1113 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 40 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 40 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose | ChEMBL. | 1404226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.