Detailed information for compound 201357

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 507.558 | Formula: C26H25N3O6S
  • H donors: 2 H acceptors: 5 LogP: 2.67 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(=O)N[C@@H]1C(=O)N2[C@H]1S(=O)(=O)CC2)Cc1ccc2c(c1)cccc2)OCc1ccccc1
  • InChi: 1S/C26H25N3O6S/c30-23(28-22-24(31)29-12-13-36(33,34)25(22)29)21(27-26(32)35-16-17-6-2-1-3-7-17)15-18-10-11-19-8-4-5-9-20(19)14-18/h1-11,14,21-22,25H,12-13,15-16H2,(H,27,32)(H,28,30)/t21-,22+,25-/m0/s1
  • InChiKey: XJEBMYGPXQJVFF-FBLLAGFSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Rattus norvegicus Cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 295 aa 25.4 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Trypanosoma cruzi cysteine protease, putative Cathepsin L   334 aa 323 aa 30.3 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin L   334 aa 303 aa 23.4 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 337 aa 26.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin L   334 aa 359 aa 29.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 276 aa 26.8 %
Plasmodium vivax vivapain-1 Cathepsin L   334 aa 366 aa 28.4 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 317 aa 33.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin L   334 aa 296 aa 31.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 275 aa 29.1 %
Plasmodium berghei berghepain-1 Cathepsin L   334 aa 353 aa 29.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Cathepsin L   334 aa 290 aa 27.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 282 aa 26.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 372 aa 23.7 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 278 aa 26.6 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 270 aa 25.6 %
Plasmodium vivax unspecified product Cathepsin L   334 aa 366 aa 28.4 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 333 aa 28.8 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 36.4 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 298 aa 28.9 %
Onchocerca volvulus Cathepsin L   334 aa 300 aa 24.3 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin L   334 aa 323 aa 46.1 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 277 aa 26.0 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin L   334 aa 318 aa 48.4 %
Plasmodium knowlesi knowpain-1 Cathepsin L   334 aa 373 aa 27.6 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin L   334 aa 288 aa 26.7 %
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 271 aa 27.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 332 aa 23.5 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 273 aa 25.3 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 277 aa 26.0 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 279 aa 25.8 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 324 aa 34.6 %
Onchocerca volvulus Cathepsin L homolog Cathepsin L   334 aa 322 aa 41.6 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 303 aa 26.1 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin L   334 aa 277 aa 24.5 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 276 aa 25.4 %
Plasmodium yoelii cathepsin c precursor Cathepsin L   334 aa 292 aa 22.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 319 aa 25.7 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin L   334 aa 300 aa 41.0 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin L   334 aa 311 aa 36.0 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 325 aa 29.5 %
Giardia lamblia Dipeptidyl-peptidase I precursor Cathepsin L   334 aa 304 aa 28.3 %
Babesia bovis papain family cysteine protease containing protein Cathepsin L   334 aa 321 aa 32.7 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin L   334 aa 312 aa 42.0 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin L   334 aa 345 aa 35.4 %
Onchocerca volvulus Cathepsin L   334 aa 311 aa 40.8 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 309 aa 30.4 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin L   334 aa 294 aa 23.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 38.0 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 336 aa 25.9 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 273 aa 26.0 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 309 aa 26.5 %
Plasmodium vivax vivapain-3 Cathepsin L   334 aa 345 aa 30.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 279 aa 28.3 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 274 aa 48.5 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 23.4 %
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 273 aa 27.8 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.9 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 271 aa 26.9 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin L   334 aa 311 aa 35.0 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Onchocerca volvulus Cathepsin L   334 aa 325 aa 47.4 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin L   334 aa 316 aa 30.1 %
Neospora caninum hypothetical protein Cathepsin L   334 aa 299 aa 28.4 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 325 aa 38.1 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 347 aa 28.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 24.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 25.9 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin L   334 aa 360 aa 29.2 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 270 aa 25.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 28.6 %
Toxoplasma gondii cathepsin CPC1 Cathepsin L   334 aa 295 aa 28.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 341 aa 26.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 274 aa 48.2 %
Echinococcus granulosus cysteine protease Cathepsin L   334 aa 323 aa 44.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0314 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.2061 0.1469
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1129 0.1129
Giardia lamblia Cathepsin B precursor 0.007 0.1496 0.0801
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0694 0.0694
Brugia malayi Cathepsin L-like precursor 0.0086 0.2061 0.2061
Onchocerca volvulus Cathepsin L homolog 0.0086 0.2061 0.3271
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0314 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Brugia malayi Cathepsin L-like precursor 0.0086 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Plasmodium vivax protein kinase Crk2 0.0314 1 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1129 0.1129
Onchocerca volvulus 0.0059 0.1129 0.0936
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.537 0.537
Trichomonas vaginalis CMGC family protein kinase 0.0163 0.4747 0.4628
Trypanosoma cruzi CYC2-like cyclin, putative 0.0048 0.0755 0.0755
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0694 0.0694
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.537 0.537
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.1496 0.1496
Echinococcus multilocularis cyclin B 0.0048 0.0755 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0755 0.0755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Trichomonas vaginalis cyclin B, putative 0.0048 0.0755 0.0546
Trichomonas vaginalis cyclins, putative 0.0048 0.0755 0.0546
Trichomonas vaginalis cyclin B, putative 0.0048 0.0755 0.0546
Onchocerca volvulus Cathepsin L homolog 0.0086 0.2061 0.3271
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0694 0.0694
Echinococcus granulosus cyclin B 0.0048 0.0755 0.0066
Brugia malayi Cyclin, N-terminal domain containing protein 0.0048 0.0755 0.0755
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.1496 0.0862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.537 0.537
Echinococcus multilocularis cyclin dependent kinase 1 0.0314 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0163 0.4747 0.4747
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1129 0.0467
Brugia malayi Cathepsin L-like precursor 0.0059 0.1129 0.1129
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0163 0.4747 0.4747
Onchocerca volvulus 0.0086 0.2061 0.3271
Plasmodium vivax vivapain-2 0.0086 0.2061 0.2061
Giardia lamblia Cathepsin B precursor 0.007 0.1496 0.0801
Trypanosoma cruzi cyclin 6, putative 0.0048 0.0755 0.0755
Onchocerca volvulus 0.0163 0.4747 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.1496 0.1496
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2061 0.2061
Plasmodium vivax vivapain-2 0.0086 0.2061 0.2061
Echinococcus granulosus cyclin dependent kinase 0.0314 1 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0163 0.4747 0.4355
Trichomonas vaginalis cyclins, putative 0.0048 0.0755 0.0546
Onchocerca volvulus 0.0086 0.2061 0.3271
Echinococcus multilocularis protein kinase shaggy 0.0163 0.4747 0.4355
Loa Loa (eye worm) ctsf protein 0.0086 0.2061 0.2061
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.2061 0.1469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Echinococcus granulosus cathepsin l1 0.0059 0.1129 0.0467
Trypanosoma brucei protein kinase, putative 0.0163 0.4747 0.4355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Onchocerca volvulus 0.0086 0.2061 0.3271
Trichomonas vaginalis cyclins, putative 0.0048 0.0755 0.0546
Echinococcus granulosus cyclin dependent kinase 5 0.0314 1 1
Toxoplasma gondii cathepsin CPL 0.0086 0.2061 0.0664
Echinococcus multilocularis cathepsin b 0.0181 0.537 0.5025
Giardia lamblia Kinase, CMGC CDK 0.0314 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0314 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.2061 0.1881
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Echinococcus multilocularis cathepsin b 0.0181 0.537 0.5025
Giardia lamblia Cathepsin B precursor 0.007 0.1496 0.0801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Echinococcus multilocularis cyclin dependent kinase 1 0.0314 1 1
Entamoeba histolytica cyclin, putative 0.0048 0.0755 0.0066
Echinococcus granulosus cyclin dependent kinase 1 0.0314 1 1
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0314 1 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1129 0.1129
Brugia malayi Cathepsin L-like precursor 0.0086 0.2061 0.2061
Brugia malayi Cathepsin L-like precursor 0.0086 0.2061 0.2061
Trichomonas vaginalis cyclin B, putative 0.0048 0.0755 0.0546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.2061 0.1469
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0694 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0052
Giardia lamblia Kinase, CMGC GSK 0.0163 0.4747 0.4318
Brugia malayi Cathepsin L-like precursor 0.0086 0.2061 0.2061
Trichomonas vaginalis CMGC family protein kinase 0.0314 1 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0314 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Giardia lamblia Kinase, CMGC GSK 0.0163 0.4747 0.4318
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.2061 0.2061
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0694 0.0694
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0694 0.0694
Plasmodium vivax vivapain-1 0.0047 0.0694 0.0694
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0314 1 1
Echinococcus granulosus protein kinase shaggy 0.0163 0.4747 0.4355
Echinococcus granulosus cathepsin b 0.0181 0.537 0.5025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1129 0.0928
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Plasmodium falciparum glycogen synthase kinase 3 0.0163 0.4747 0.4355
Echinococcus granulosus cathepsin l1 0.0086 0.2061 0.1469
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0314 1 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0314 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Entamoeba histolytica protein kinase domain containing protein 0.0163 0.4747 0.4355
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.2061 0.1469
Entamoeba histolytica cell division protein kinase 2, putative 0.0314 1 1
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Brugia malayi Cathepsin L-like precursor 0.0059 0.1129 0.1129
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2061 0.2061
Loa Loa (eye worm) hypothetical protein 0.0048 0.0755 0.0755
Trichomonas vaginalis cyclins, putative 0.0048 0.0755 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0163 0.4747 0.4318
Loa Loa (eye worm) hypothetical protein 0.0181 0.537 0.537
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.2061 0.1469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.1496 0.1303
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2061 0.2061
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.537 0.537
Trypanosoma cruzi cyclin, putative 0.0048 0.0755 0.0755
Loa Loa (eye worm) hypothetical protein 0.0086 0.2061 0.2061
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.1496 0.0801
Onchocerca volvulus 0.0086 0.2061 0.3271
Brugia malayi intracellular kinase 0.0163 0.4747 0.4747
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Trypanosoma brucei mitotic cyclin 6 0.0048 0.0755 0.0066
Onchocerca volvulus 0.0086 0.2061 0.3271
Loa Loa (eye worm) fibroinase 0.0086 0.2061 0.2061
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0163 0.4747 0.4747
Brugia malayi Cathepsin L-like precursor 0.0086 0.2061 0.2061
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Trypanosoma brucei cdc2-related kinase 1 0.0314 1 1
Trichomonas vaginalis cyclin A, putative 0.0048 0.0755 0.0546
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.1129 0.1129
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0694 0.0694
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.537 0.537
Loa Loa (eye worm) hypothetical protein 0.0059 0.1129 0.1129
Entamoeba histolytica cysteine protease, putative 0.0086 0.2061 0.1469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Echinococcus granulosus cathepsin b 0.0181 0.537 0.5025
Schistosoma mansoni serine/threonine protein kinase 0.0314 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Echinococcus multilocularis cyclin dependent kinase 0.0314 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Trypanosoma cruzi cdc2-related kinase 3 0.0314 1 1
Echinococcus multilocularis cysteine protease 0.0086 0.2061 0.1469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0163 0.4747 0.3823
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.2061 0.2061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Onchocerca volvulus 0.0086 0.2061 0.3271
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0163 0.4747 0.4747
Trypanosoma cruzi cdc2-related kinase 3 0.0314 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0694 0.0483
Leishmania major cysteine peptidase A (CPA) 0.0086 0.2061 0.1412
Trichomonas vaginalis cyclin B, putative 0.0048 0.0755 0.0546
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0163 0.4747 0.4355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Plasmodium vivax unspecified product 0.0047 0.0694 0.0694
Trypanosoma cruzi cyclin, putative 0.0048 0.0755 0.0755
Trypanosoma cruzi cdc2-related kinase 1 0.0314 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0694 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.2061 0.1881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1129 0.0928
Giardia lamblia Kinase, CMGC CDK 0.0314 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0048 0.0755 0.0755
Trichomonas vaginalis CMGC family protein kinase 0.0314 1 1
Trypanosoma brucei cdc2-related kinase 3 0.0314 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.2061 0.2061
Plasmodium falciparum protein kinase 5 0.0314 1 1
Onchocerca volvulus Cathepsin F homolog 0.0086 0.2061 0.3271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0314 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0314 1 1
Schistosoma mansoni cyclin B 0.0048 0.0755 0.0755
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.2061 0.1469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.2061 0.1881
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.2061 0.1469
Plasmodium vivax vivapain-3 0.0047 0.0694 0.0694
Brugia malayi Protein kinase domain containing protein 0.0314 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0694 0.0694
Loa Loa (eye worm) cysteine protease 0.0086 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0694 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0314 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0314 1 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.983 0.983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Brugia malayi cathepsin L-like precursor 0.0059 0.1129 0.1129
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.2061 0.1469
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.1129 0.1129
Onchocerca volvulus 0.0086 0.2061 0.3271
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.2061 0.1469
Echinococcus multilocularis cysteine protease 0.0086 0.2061 0.1469
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.2061 0.1469
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.2061 0.1469
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0694 0.0694
Plasmodium vivax glycogen synthase kinase 3, putative 0.0163 0.4747 0.4747
Trichomonas vaginalis CMGC family protein kinase 0.0163 0.4747 0.4628
Entamoeba histolytica protein kinase, putative 0.0163 0.4747 0.4355
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.537 0.537
Leishmania major cathepsin L-like protease 0.0086 0.2061 0.1412
Loa Loa (eye worm) cathepsin B 0.007 0.1496 0.1496
Entamoeba histolytica protein kinase domain containing protein 0.0163 0.4747 0.4355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.2061 0.1469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.2061 0.1881
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.2061 0.2061

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.003 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.003 uM In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC ChEMBL. 12419374
IC50 (binding) = 0.003 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.003 uM In vitro Inhibitory activity of the compound was determined against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC ChEMBL. 12419374
IC50 (binding) = 0.39 uM Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.39 uM Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.4 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease ChEMBL. 12419374
IC50 (binding) = 0.4 uM Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine protease ChEMBL. 12419374

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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