Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0694 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0694 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0694 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0694 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0694 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0694 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0694 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0694 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 152 nM | In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line. | ChEMBL. | 12419378 |
ED50 (functional) | = 152 nM | In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line. | ChEMBL. | 12419378 |
ED50 (functional) | = 163 nM | In vitro cytotoxicity against A549 (human lung carcinoma) cell line. | ChEMBL. | 12419378 |
ED50 (functional) | = 163 nM | In vitro cytotoxicity against A549 (human lung carcinoma) cell line. | ChEMBL. | 12419378 |
ED50 (functional) | = 197 nM | In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line. | ChEMBL. | 12419378 |
ED50 (functional) | = 197 nM | In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line. | ChEMBL. | 12419378 |
Inhibition rate (functional) | % | Antitumor activity against Lewis lung carcinoma (LLC) cells transplanted s.c. into the auxiliary region of the BDF1 mice at a formulable dose of 0.06 mmol/kg/day; Not active | ChEMBL. | 12419378 |
Inhibition rate (functional) | 0 % | Antitumor activity against Lewis lung carcinoma (LLC) cells transplanted s.c. into the auxiliary region of the BDF1 mice at a formulable dose of 0.06 mmol/kg/day; Not active | ChEMBL. | 12419378 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.