Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.3 uM | Agonist activity at Gal4-tagged LXRbeta (unknown origin) expressed in CHOK1 cells after 24 hrs by luciferase reporter gene assay | ChEMBL. | 25677664 |
EC50 (binding) | = 1.5 uM | Agonist activity at Gal4-tagged LXRalpha (unknown origin) expressed in CHOK1 cells after 24 hrs by luciferase reporter gene assay | ChEMBL. | 25677664 |
Efficacy (binding) | = 5 % | Agonist activity at Gal4-tagged LXRalpha (unknown origin) expressed in CHOK1 cells assessed as maximal efficacy at 10 uM after 24 hrs by luciferase reporter gene assay relative to T0901317 luminescence intensity | ChEMBL. | 25677664 |
Efficacy (binding) | = 14 % | Agonist activity at Gal4-tagged LXRbeta (unknown origin) expressed in CHOK1 cells assessed as maximal efficacy at 10 uM after 24 hrs by luciferase reporter gene assay relative to T0901317 luminescence intensity | ChEMBL. | 25677664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.