Detailed information for compound 201625

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.352 | Formula: C22H25Cl2N2O3-
  • H donors: 1 H acceptors: 2 LogP: 3.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=NOCCN1CCC[C@@H](C1)C(=O)O)c1ccccc1C.[Cl-]
  • InChi: 1S/C22H25ClN2O3.ClH/c1-16-6-2-3-10-20(16)21(17-7-4-9-19(23)14-17)24-28-13-12-25-11-5-8-18(15-25)22(26)27;/h2-4,6-7,9-10,14,18H,5,8,11-13,15H2,1H3,(H,26,27);1H/p-1/b24-21+;/t18-;/m0./s1
  • InChiKey: LJOAIPYQOSNKPC-QTMOBETQSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0196 0.0997 0.1822
Brugia malayi beta-lactamase family protein 0.0071 0.0242 0.0443
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.013 0.0542
Brugia malayi cathepsin L-like cysteine proteinase 0.0078 0.0286 0.0525
Plasmodium falciparum histone acetyltransferase GCN5 0.0121 0.0542 0.318
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0714 0.13
Echinococcus granulosus histone acetyltransferase KAT2B 0.0132 0.0608 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0309 0.1681 0.5216
Trichomonas vaginalis glutaminase, putative 0.0543 0.3096 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0595 0.0594
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0178 0.0887 0.1619
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0341 0.1875 1
Echinococcus multilocularis geminin 0.0813 0.4733 0.8725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0012 0.0006
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0078 0.0286 0.0501
Schistosoma mansoni hypothetical protein 0.014 0.0657 0.1194
Echinococcus multilocularis snurportin 1 0.0311 0.1695 0.3112
Onchocerca volvulus 0.0309 0.1681 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0012 0.001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.023 0.1203 0.2203
Brugia malayi Trypsin family protein 0.0054 0.014 0.0256
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0116 0.0511 0.0925
Plasmodium vivax vivapain-1 0.0172 0.0852 0.5035
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.013 0.0714
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0385 0.0384
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1259 0.2306
Onchocerca volvulus 0.0072 0.0247 0.1416
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0638 0.1691
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0286 0.1478
Onchocerca volvulus Huntingtin homolog 0.013 0.0595 0.3501
Trypanosoma cruzi cysteine peptidase, putative 0.0309 0.1681 0.3061
Toxoplasma gondii cathepsin CPL 0.0309 0.1681 0.8959
Loa Loa (eye worm) hypothetical protein 0.0054 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.006 0.0175 0.0173
Brugia malayi Cathepsin L-like precursor 0.0215 0.1116 0.2054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0172 0.0852 0.1554
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0286 0.0509
Giardia lamblia Cathepsin L precursor 0.0078 0.0286 0.1478
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0012 0.0018
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0054 0.0138 0.3076
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0132 0.0608 0.159
Brugia malayi jmjC domain containing protein 0.0043 0.0073 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0286 0.0501
Loa Loa (eye worm) hypothetical protein 0.0071 0.0242 0.024
Giardia lamblia Encystation-specific protease 0.0078 0.0286 0.1478
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0758 0.4401 0.8111
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.0377 0.0644
Brugia malayi Cathepsin L-like precursor 0.0309 0.1681 0.3097
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0123 0.0554 0.1005
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0242 0.0351
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.0566 0.1026
Plasmodium vivax serine-repeat antigen (SERA) 0.0078 0.0286 0.1649
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.0852 0.1568
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0078 0.0286 0.1649
Loa Loa (eye worm) hypothetical protein 0.0053 0.013 0.0128
Loa Loa (eye worm) hypothetical protein 0.0178 0.0887 0.0885
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0078 0.0286 0.1649
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0071 0.0239 0.1226
Mycobacterium tuberculosis Conserved protein 0.0071 0.0242 0.0607
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0075 0.0085
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0089 0.0144
Echinococcus granulosus lysine specific demethylase 5A 0.0162 0.0792 0.1444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0286 0.0501
Entamoeba histolytica cysteine proteinase, putative 0.0309 0.1681 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0385 0.0708
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0072
Entamoeba histolytica cysteine protease, putative 0.0078 0.0286 0.1702
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Loa Loa (eye worm) hypothetical protein 0.0093 0.0377 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0012 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.0852 0.4454
Brugia malayi jmjC domain containing protein 0.0162 0.0792 0.1458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0012 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Echinococcus granulosus muscleblind protein 0.0455 0.2565 0.4719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0154 0.0857
Schistosoma mansoni hypothetical protein 0.0054 0.014 0.024
Plasmodium vivax vivapain-3 0.0172 0.0852 0.5035
Echinococcus multilocularis jumonji domain containing 1A 0.0043 0.0073 0.0115
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0078 0.0286 0.1649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0012 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.013 0.0714
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0215 0.1116 0.3304
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0178 0.0887 0.2531
Echinococcus granulosus calpain A 0.0044 0.0075 0.012
Plasmodium vivax serine-repeat antigen (SERA) 0.0078 0.0286 0.1649
Plasmodium falciparum serine repeat antigen 9 0.0078 0.0286 0.1649
Echinococcus multilocularis tissue type plasminogen activator 0.0062 0.0184 0.032
Giardia lamblia Cathepsin B precursor 0.0078 0.0286 0.1478
Brugia malayi acetyltransferase, GNAT family protein 0.0448 0.2521 0.4646
Trypanosoma brucei antigen, putative 0.0044 0.0075 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0012 0.0018
Toxoplasma gondii kringle domain-containing protein 0.0062 0.0184 0.0929
Brugia malayi Cathepsin L-like cysteine proteinase 0.0215 0.1116 0.2054
Brugia malayi Calcitonin receptor-like protein seb-1 0.03 0.1625 0.2995
Onchocerca volvulus 0.0309 0.1681 1
Trypanosoma cruzi cysteine peptidase, putative 0.0309 0.1681 0.3061
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0012 0.0002
Schistosoma mansoni ferritin light chain 0.0054 0.0138 0.0235
Treponema pallidum ATP-dependent RNA helicase 0.0178 0.0887 1
Brugia malayi beta-lactamase 0.0071 0.0242 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.0852 0.2412
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0121 0.0543 0.0983
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0062 0.0184 0.1036
Schistosoma mansoni apoferritin-2 0.0054 0.0138 0.0235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0012 0.0002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0286 0.0285
Loa Loa (eye worm) cathepsin B 0.0341 0.1875 0.1874
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0078 0.0286 0.1702
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0078 0.0286 0.1478
Echinococcus granulosus geminin 0.0813 0.4733 0.8725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Brugia malayi calpain 7 0.0044 0.0075 0.0136
Toxoplasma gondii cathepsin CPC1 0.0078 0.0286 0.1478
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0997 0.2904
Onchocerca volvulus 0.0054 0.014 0.0777
Brugia malayi fibroinase precursor 0.0078 0.0286 0.0525
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0078 0.0286 0.0525
Brugia malayi Probable ClpP-like protease 0.0071 0.0239 0.0438
Plasmodium falciparum serine repeat antigen 7 0.0078 0.0286 0.1649
Giardia lamblia Histone acetyltransferase GCN5 0.0121 0.0542 0.2849
Brugia malayi glutaminase DH11.1 0.0543 0.3096 0.5708
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0078 0.0286 0.0285
Echinococcus granulosus cathepsin l1 0.0215 0.1116 0.2041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.045 0.2534 0.4671
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0178 0.0887 0.4699
Onchocerca volvulus 0.0054 0.014 0.0777
Loa Loa (eye worm) hypothetical protein 0.0149 0.0714 0.0713
Echinococcus multilocularis enteropeptidase 0.0054 0.014 0.024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0154 0.023
Loa Loa (eye worm) hypothetical protein 0.1684 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.0184 0.0182
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0071 0.0239 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0012 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0012 0.0002
Brugia malayi Cathepsin L-like precursor 0.0309 0.1681 0.3097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.014 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0178 0.0887 0.4644
Loa Loa (eye worm) hypothetical protein 0.0078 0.0286 0.0285
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0286 0.0509
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0178 0.0887 0.5245
Schistosoma mansoni cathepsin s 0.0093 0.0377 0.0677
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0178 0.0887 0.5275
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0054 0.0138 0.0187
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0215 0.0213
Loa Loa (eye worm) hypothetical protein 0.0078 0.0286 0.0285
Plasmodium falciparum eukaryotic initiation factor 4A 0.0178 0.0887 0.5245
Plasmodium falciparum serine repeat antigen 2 0.0078 0.0286 0.1649
Echinococcus granulosus phd:f box containing protein 0.0043 0.0073 0.0115
Loa Loa (eye worm) hypothetical protein 0.045 0.2534 0.2533
Loa Loa (eye worm) acetyltransferase 0.0448 0.2521 0.2519
Entamoeba histolytica cysteine proteinase, putative 0.0309 0.1681 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0286 0.0501
Schistosoma mansoni cathepsin S (C01 family) 0.0078 0.0286 0.0509
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.014 0.0657 0.1194
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0078 0.0286 0.1649
Schistosoma mansoni calpain C (C02 family) 0.0044 0.0075 0.012
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0012 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0078 0.0286 0.0501
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0242 0.0607
Onchocerca volvulus 0.0309 0.1681 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0073 0.0072
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0054 0.014 0.024
Trypanosoma cruzi cysteine protease, putative 0.0172 0.0852 0.1524
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0242 0.0393
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0012 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0385 0.0708
Mycobacterium tuberculosis Conserved protein 0.0071 0.0242 0.0607
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948
Onchocerca volvulus 0.0033 0.0012 0.0006
Schistosoma mansoni chromobox protein 0.0137 0.0638 0.116
Brugia malayi Muscleblind-like protein 0.0455 0.2565 0.4728
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0309 0.1681 0.3086
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0012 0.001
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.013 0.064
Trypanosoma cruzi cysteine proteinase, putative 0.0172 0.0852 0.1524
Trypanosoma brucei polo-like protein kinase 0.0196 0.0997 0.5242
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0242 0.0607
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0215 0.0377
Loa Loa (eye worm) hypothetical protein 0.013 0.0595 0.0594
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0398 0.088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.1182 0.2164
Trypanosoma cruzi polo-like protein kinase, putative 0.0196 0.0997 0.1793
Schistosoma mansoni hypothetical protein 0.0126 0.0576 0.1045
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Brugia malayi Kringle domain containing protein 0.0062 0.0184 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0997 0.2904
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.1182 0.2164
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0071 0.0239 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0172 0.0852 0.5035
Schistosoma mansoni hypothetical protein 0.0311 0.1695 0.3112
Echinococcus multilocularis cathepsin L 0.0172 0.0852 0.1554
Echinococcus multilocularis cathepsin b 0.0927 0.5424 1
Entamoeba histolytica hypothetical protein 0.014 0.0657 0.3907
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0012 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0852 0.5066
Schistosoma mansoni Mername-AA248 (C02 family) 0.0044 0.0075 0.012
Entamoeba histolytica cysteine protease, putative 0.0078 0.0286 0.1702
Plasmodium falciparum serine repeat antigen 5 0.0078 0.0286 0.1649
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0286 0.0501
Loa Loa (eye worm) hypothetical protein 0.0205 0.1051 0.105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.003 0.0103
Echinococcus multilocularis phd:f box containing protein 0.0043 0.0073 0.0115
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0242 0.0351
Echinococcus granulosus eukaryotic initiation factor 4A 0.0178 0.0887 0.1619
Brugia malayi RNA, U transporter 1 0.0083 0.0313 0.0575
Brugia malayi PHD-finger family protein 0.0033 0.0011 0.0017
Mycobacterium ulcerans lipase LipD 0.0071 0.0242 0.0351
Echinococcus granulosus cathepsin l cysteine peptidase 0.0309 0.1681 0.3086
Echinococcus granulosus peregrin 0.0044 0.0077 0.0123
Schistosoma mansoni ap endonuclease 0.0057 0.0154 0.0264
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0178 0.0887 0.3221
Loa Loa (eye worm) hypothetical protein 0.0215 0.1116 0.1114
Giardia lamblia Cathepsin B precursor 0.0341 0.1875 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0172 0.0852 0.1554
Loa Loa (eye worm) hypothetical protein 0.0071 0.0239 0.0238
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0286 0.1478
Echinococcus granulosus chromobox protein 1 0.0137 0.0638 0.116
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0012 0.0002
Entamoeba histolytica cysteine protease, putative 0.0078 0.0286 0.1702
Echinococcus granulosus cysteine protease 0.0172 0.0852 0.1554
Onchocerca volvulus 0.0149 0.0714 0.4214
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0927 0.5424 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0078 0.0286 0.0501
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0226 0.1182 0.2177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0215 0.1116 0.3304
Trypanosoma cruzi polo-like protein kinase, putative 0.0196 0.0997 0.1793
Loa Loa (eye worm) fibroinase 0.0309 0.1681 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0286 0.0501
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0196 0.0997 0.0996
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Loa Loa (eye worm) hypothetical protein 0.0095 0.0385 0.0384
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0071 0.0239 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0012 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0242 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0242 0.0351
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0154 0.0053
Giardia lamblia Cathepsin L precursor 0.0078 0.0286 0.1478
Toxoplasma gondii preprocathepsin c precursor, putative 0.0078 0.0286 0.1478
Loa Loa (eye worm) hypothetical protein 0.0078 0.0286 0.0285
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1259 0.2306
Echinococcus granulosus cathepsin b 0.0927 0.5424 1
Schistosoma mansoni calpain (C02 family) 0.0044 0.0075 0.012
Brugia malayi cathepsin Z-like cysteine proteinase 0.0078 0.0286 0.0525
Loa Loa (eye worm) glutaminase 0.0543 0.3096 0.3095
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0012 0.0018
Plasmodium falciparum cysteine proteinase falcipain 3 0.0309 0.1681 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0341 0.1875 0.3421
Plasmodium falciparum serine repeat antigen 4 0.0078 0.0286 0.1649
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0054 0.014 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0997 0.2904
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Plasmodium vivax calpain, putative 0.0044 0.0075 0.0388
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Echinococcus granulosus cathepsin L 0.0172 0.0852 0.1554
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0043 0.0073 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0286 0.0501
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0071 0.0239 0.1368
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0073 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0852 0.5066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0154 0.1553
Echinococcus granulosus jumonji domain containing 1A 0.0043 0.0073 0.0115
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0075 0.0247
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0242 0.0351
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0075 0.0085
Echinococcus multilocularis chromobox protein 1 0.0137 0.0638 0.116
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0078 0.0286 0.0509
Entamoeba histolytica cysteine protease, putative 0.0078 0.0286 0.1702
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0448 0.2521 0.4637
Toxoplasma gondii exonuclease III APE 0.0057 0.0154 0.0767
Onchocerca volvulus 0.0078 0.0286 0.1649
Brugia malayi cathepsin L-like precursor 0.0215 0.1116 0.2054
Echinococcus multilocularis cathepsin L 0.0078 0.0286 0.0509
Echinococcus multilocularis calpain family protein 1, d 0.0085 0.0327 0.0584
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0714 0.13
Brugia malayi hypothetical protein 0.014 0.0657 0.1208
Echinococcus granulosus ferritin 0.0054 0.0138 0.0235
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.003 0.0115
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0078 0.0286 0.0285
Giardia lamblia Cysteine protease 0.0078 0.0286 0.1478
Loa Loa (eye worm) hypothetical protein 0.0071 0.0242 0.024
Brugia malayi Papain family cysteine protease containing protein 0.0309 0.1681 0.3097
Brugia malayi jmjC domain containing protein 0.0043 0.0073 0.0132
Trypanosoma cruzi cruzipain precursor, putative 0.0093 0.0377 0.0644
Giardia lamblia Cathepsin L-like protease 0.0078 0.0286 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0286 0.0501
Loa Loa (eye worm) hypothetical protein 0.0071 0.0242 0.024
Onchocerca volvulus 0.0054 0.014 0.0777
Loa Loa (eye worm) hypothetical protein 0.0054 0.014 0.0139
Echinococcus granulosus glycoprotein Antigen 5 0.0054 0.014 0.024
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0075 0.0085
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0071 0.0239 0.1226
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.003 0.0028
Brugia malayi RNA binding protein 0.0067 0.0215 0.0393
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0044 0.0075 0.0085
Schistosoma mansoni ferritin 0.0054 0.0138 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0398 0.088
Schistosoma mansoni cathepsin C 0.0078 0.0286 0.0509
Echinococcus multilocularis GPCR, family 2 0.0095 0.0385 0.0692
Echinococcus multilocularis calpain 7 (C02 family) 0.0044 0.0075 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0275 0.0463
Echinococcus granulosus enteropeptidase 0.0054 0.014 0.024
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0242 0.0607
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0242 0.0607
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0012 0.0002
Onchocerca volvulus 0.0309 0.1681 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Plasmodium vivax unspecified product 0.0093 0.0377 0.2194
Onchocerca volvulus 0.0071 0.0242 0.1384
Brugia malayi calpain family protein 1 0.0116 0.0511 0.094
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0215 0.0393
Loa Loa (eye worm) hypothetical protein 0.0455 0.2565 0.2564
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0215 0.0377
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.0566 0.1026
Schistosoma mansoni hypothetical protein 0.0095 0.0385 0.0692
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0078 0.0286 0.1649
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0075 0.0085
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0154 0.0914
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Trypanosoma cruzi cysteine peptidase, putative 0.0309 0.1681 0.3061
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0132 0.0608 0.3578
Entamoeba histolytica cysteine proteinase, putative 0.0215 0.1116 0.6636
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0247
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0439 0.2466 0.2464
Brugia malayi nuclear receptor NHR-88 0.0033 0.0012 0.0018
Entamoeba histolytica cysteine protease, putative 0.0078 0.0286 0.1702
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0154 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.1182 0.2164
Brugia malayi Cathepsin L-like precursor 0.0093 0.0377 0.0693
Schistosoma mansoni hypothetical protein 0.0049 0.0107 0.0178
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Echinococcus granulosus dnaJ subfamily C 6 0.0126 0.0576 0.1045
Loa Loa (eye worm) hypothetical protein 0.0071 0.0242 0.024
Brugia malayi TAR-binding protein 0.0067 0.0215 0.0393
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948
Entamoeba histolytica acetyltransferase, GNAT family 0.0121 0.0542 0.3223
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0093 0.0377 0.0376
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0012 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0286 0.0509
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0071 0.0239 0.0422
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0242 0.0443
Loa Loa (eye worm) hypothetical protein 0.0054 0.014 0.0139
Giardia lamblia Cysteine protease 0.0078 0.0286 0.1478
Schistosoma mansoni hypothetical protein 0.0813 0.4733 0.8725
Schistosoma mansoni cathepsin B (C01 family) 0.0078 0.0286 0.0509
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0012 0.0006
Brugia malayi Augmenter of liver regeneration 0.0036 0.003 0.0052
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0054 0.014 0.024
Schistosoma mansoni calpain-7 (C02 family) 0.0044 0.0075 0.012
Mycobacterium tuberculosis Conserved protein 0.0071 0.0242 0.0607
Loa Loa (eye worm) hypothetical protein 0.0455 0.2565 0.2564
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Echinococcus granulosus tar DNA binding protein 0.0067 0.0215 0.0377
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0012 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0245 0.1294 0.2372
Plasmodium falciparum serine repeat antigen 6 0.0078 0.0286 0.1649
Schistosoma mansoni hypothetical protein 0.0095 0.0385 0.0692
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Schistosoma mansoni ferritin 0.0054 0.0138 0.0235
Echinococcus granulosus lysine specific demethylase 6a 0.0043 0.0073 0.0115
Giardia lamblia Cathepsin L precursor 0.0078 0.0286 0.1478
Entamoeba histolytica cysteine proteinase 2 0.0172 0.0852 0.5066
Giardia lamblia Cathepsin B precursor 0.0078 0.0286 0.1478
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Echinococcus multilocularis ferritin 0.0054 0.0138 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0309 0.1681 0.5216
Echinococcus granulosus transmembrane protease serine 3 0.0054 0.014 0.024
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0012 0.0002
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Entamoeba histolytica cysteine protease, putative 0.0078 0.0286 0.1702
Schistosoma mansoni jumonji/arid domain-containing protein 0.0162 0.0792 0.1444
Echinococcus multilocularis peregrin 0.0044 0.0077 0.0123
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0927 0.5424 1
Brugia malayi Cathepsin L-like precursor 0.0309 0.1681 0.3097
Loa Loa (eye worm) hypothetical protein 0.0071 0.0242 0.024
Echinococcus granulosus histone acetyltransferase KAT2B 0.0435 0.2445 0.4496
Onchocerca volvulus 0.0054 0.014 0.0777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Brugia malayi cathepsin B-like cysteine proteinase 0.0927 0.5424 1
Brugia malayi nuclear hormone receptor 0.0033 0.0012 0.0018
Echinococcus multilocularis hypothetical protein 0.0044 0.0075 0.012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0154 0.0671
Loa Loa (eye worm) hypothetical protein 0.0123 0.0554 0.0553
Brugia malayi chromobox protein homolog 3 0.0077 0.0275 0.0504
Onchocerca volvulus 0.0309 0.1681 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0012 0.0002
Echinococcus granulosus tissue type plasminogen activator 0.0062 0.0184 0.032
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.0852 0.1568
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0012 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0075 0.0247
Echinococcus multilocularis expressed protein 0.0054 0.0138 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0341 0.1875 0.5872
Onchocerca volvulus 0.0062 0.0184 0.1036
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0178 0.0887 0.1589
Echinococcus granulosus calpain 7 C02 family 0.0044 0.0075 0.012
Schistosoma mansoni jumonji domain containing protein 0.0208 0.1069 0.1956
Mycobacterium ulcerans hypothetical protein 0.0071 0.0242 0.0351
Giardia lamblia Cathepsin L precursor 0.0078 0.0286 0.1478
Brugia malayi Trypsin family protein 0.0149 0.0714 0.1315
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.0073 0.008
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0078 0.0286 0.0509
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0043 0.0073 0.0115
Loa Loa (eye worm) hypothetical protein 0.0033 0.0011 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0085
Loa Loa (eye worm) cysteine protease 0.0309 0.1681 0.168
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0078 0.0286 0.1649
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.014 0.024
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0178 0.0887 0.2531
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0286 0.0501
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0997 0.2904
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0154 0.0264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0242 0.0427
Echinococcus multilocularis JmjC domain containing protein 4 0.0043 0.0073 0.0115
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0852 0.5066
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948
Brugia malayi jmjC domain containing protein 0.0043 0.0073 0.0132
Loa Loa (eye worm) DnaJ domain-containing protein 0.0126 0.0576 0.0575
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0043 0.0073 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0012 0.0018
Giardia lamblia Cysteine protease 0.0078 0.0286 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Loa Loa (eye worm) hypothetical protein 0.0071 0.0242 0.024
Brugia malayi eukaryotic initiation factor 4A 0.0178 0.0887 0.1633
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0927 0.5424 1
Brugia malayi jmjC domain containing protein 0.0043 0.0073 0.0132
Schistosoma mansoni survival motor neuron protein 0.0049 0.0107 0.0178
Leishmania major eukaryotic initiation factor 4a, putative 0.0178 0.0887 0.4644
Giardia lamblia Cathepsin L-like protease 0.0078 0.0286 0.1478
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0184 0.0285
Schistosoma mansoni peptidase Clp (S14 family) 0.0071 0.0239 0.0422
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0927 0.5424 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.035 0.0349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Trichomonas vaginalis protein kinase inhibitor, putative 0.0126 0.0576 0.1481
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0242 0.0351
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0078 0.0286 0.0509
Loa Loa (eye worm) hypothetical protein 0.0927 0.5424 0.5423
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0215 0.0377
Giardia lamblia Cathepsin L precursor 0.0078 0.0286 0.1478
Trichomonas vaginalis bromodomain-containing protein, putative 0.0132 0.0608 0.159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Trypanosoma cruzi cysteine peptidase, putative 0.0309 0.1681 0.3061
Entamoeba histolytica hypothetical protein 0.014 0.0657 0.3907
Entamoeba histolytica cysteine protease, putative 0.0309 0.1681 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0309 0.1681 0.168
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.031 0.1793
Leishmania major hypothetical protein, conserved 0.0053 0.013 0.0542
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0107 0.0194
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0554 0.1005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0286 0.0285
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0078 0.0286 0.1649
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0012 0.0002
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Loa Loa (eye worm) hypothetical protein 0.0093 0.0377 0.0376
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0554 0.1005
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0078 0.0286 0.1649
Echinococcus multilocularis cathepsin L cysteine protease 0.0309 0.1681 0.3086
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0078 0.0286 0.1649
Trypanosoma cruzi cysteine proteinase, putative 0.0172 0.0852 0.1524
Echinococcus multilocularis glycoprotein Antigen 5 0.0054 0.014 0.024
Giardia lamblia Cathepsin B precursor 0.0341 0.1875 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0154 0.0857
Onchocerca volvulus Cathepsin F homolog 0.0309 0.1681 1
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0012 0.0002
Schistosoma mansoni hypothetical protein 0.0205 0.1051 0.1923
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0385 0.0692
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0054 0.0138 0.0187
Schistosoma mansoni calpain-7 (C02 family) 0.0044 0.0075 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0997 0.2904
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0154 0.0053
Plasmodium falciparum serine repeat antigen 3 0.0078 0.0286 0.1649
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.1182 0.2164
Schistosoma mansoni jumonji domain containing protein 0.0043 0.0073 0.0115
Schistosoma mansoni hypothetical protein 0.0095 0.0385 0.0692
Echinococcus granulosus cathepsin b 0.0927 0.5424 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0012 0.0018
Brugia malayi Bromodomain containing protein 0.0044 0.0077 0.0139
Giardia lamblia Hypothetical protein 0.0078 0.0286 0.1478
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0071 0.0239 0.1352
Brugia malayi cathepsin F-like cysteine proteinase 0.0078 0.0286 0.0525
Loa Loa (eye worm) hypothetical protein 0.0215 0.1116 0.1114
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0071 0.0239 0.5
Mycobacterium ulcerans glutaminase 0.0543 0.3096 1
Echinococcus granulosus calpain 0.0044 0.0075 0.012
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0223 0.0221
Loa Loa (eye worm) hypothetical protein 0.0062 0.0184 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0012 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.1182 0.2164
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0178 0.0887 0.1619
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0247
Schistosoma mansoni phosphatidylserine receptor 0.0043 0.0073 0.0115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0012 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0012 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0012 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0242 0.0351
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0071 0.0239 0.0342
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0309 0.1681 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0121 0.0543 0.0983
Echinococcus granulosus cathepsin L cysteine proteinase 0.0309 0.1681 0.3086
Schistosoma mansoni ferritin light chain 0.0054 0.0138 0.0235
Echinococcus multilocularis chromobox protein 1 0.0137 0.0638 0.116
Loa Loa (eye worm) calpain family protein 1 0.0085 0.0327 0.0325
Onchocerca volvulus 0.0054 0.014 0.0777
Loa Loa (eye worm) hypothetical protein 0.0215 0.1116 0.1114
Entamoeba histolytica hypothetical protein 0.014 0.0657 0.3907
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0242 0.024
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.0852 0.1524
Brugia malayi Probable ATP-dependent helicase DHX35 0.0439 0.2466 0.4544
Plasmodium vivax vivapain-2 0.0309 0.1681 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.014 0.024
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0123 0.0554 0.1005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0154 0.021
Loa Loa (eye worm) hypothetical protein 0.0102 0.0432 0.043
Entamoeba histolytica serine/threonine protein kinase, putative 0.0196 0.0997 0.5932
Echinococcus granulosus peptidase Clp S14 family 0.0046 0.0092 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0286 0.0501
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.0073 0.008
Echinococcus granulosus JmjC domain containing protein 4 0.0043 0.0073 0.0115
Loa Loa (eye worm) hypothetical protein 0.0085 0.0327 0.0325
Mycobacterium leprae Probable lipase LipE 0.0071 0.0242 1
Loa Loa (eye worm) calpain 0.0044 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0149 0.0714 0.0713
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.003 0.0103
Echinococcus multilocularis cysteine protease 0.0309 0.1681 0.3086
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0071 0.0239 0.1368
Onchocerca volvulus 0.0071 0.0242 0.1384
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0012 0.0002
Echinococcus granulosus snurportin 1 0.0311 0.1695 0.3112
Toxoplasma gondii ABC1 family protein 0.0071 0.0242 0.124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.0852 0.2412
Brugia malayi Protein kinase domain containing protein 0.0062 0.0184 0.0336
Schistosoma mansoni ferritin 0.0054 0.0138 0.0235
Loa Loa (eye worm) hypothetical protein 0.0309 0.1681 0.168
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0075 0.0247
Schistosoma mansoni hypothetical protein 0.0054 0.014 0.024
Schistosoma mansoni ap endonuclease 0.0057 0.0154 0.0264
Brugia malayi DnaJ domain containing protein 0.0126 0.0576 0.106
Loa Loa (eye worm) hypothetical protein 0.0239 0.1259 0.1257
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0078 0.0286 0.1702
Brugia malayi Heterochromatin protein 1 0.0137 0.0638 0.1174
Leishmania major eukaryotic initiation factor 4a, putative 0.0178 0.0887 0.4644
Schistosoma mansoni jumonji/arid domain-containing protein 0.0162 0.0792 0.1444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0286 0.0501
Echinococcus multilocularis calpain A 0.0121 0.0543 0.0983
Toxoplasma gondii cathepsin B 0.0341 0.1875 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0078 0.0286 0.1649
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.003 0.0115
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0078 0.0286 0.0509
Loa Loa (eye worm) hypothetical protein 0.0123 0.0554 0.0553
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0196 0.0997 0.1822
Plasmodium vivax RNA helicase-1, putative 0.0178 0.0887 0.5245
Entamoeba histolytica hypothetical protein 0.014 0.0657 0.3907
Echinococcus multilocularis lysine specific demethylase 5A 0.0162 0.0792 0.1444
Schistosoma mansoni coup transcription factor 0.0033 0.0012 0.0002
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.003 0.0035
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0247
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.014 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0012 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0997 0.1822
Mycobacterium ulcerans hypothetical protein 0.0054 0.014 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.013 0.0186
Echinococcus granulosus cathepsin L 0.0078 0.0286 0.0509
Giardia lamblia Hypothetical protein 0.0078 0.0286 0.1478
Echinococcus multilocularis peptidase Clp (S14 family) 0.0046 0.0092 0.015
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0054 0.014 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0275 0.0463
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0286 0.0509
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0172 0.0852 0.1524
Trichomonas vaginalis chromobox protein, putative 0.0082 0.031 0.0582
Echinococcus multilocularis cathepsin L cysteine protease 0.0309 0.1681 0.3086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0012 0.0018
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0309 0.1681 0.3086
Trichomonas vaginalis esterase, putative 0.0071 0.0242 0.0351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.013 0.0714
Loa Loa (eye worm) hypothetical protein 0.0116 0.0511 0.051
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0132 0.0608 0.3205
Onchocerca volvulus 0.0215 0.1116 0.6615
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0178 0.0887 0.1619
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0215 0.1116 0.2013
Echinococcus multilocularis cathepsin b 0.0927 0.5424 1
Echinococcus granulosus calpain A 0.0121 0.0543 0.0983
Loa Loa (eye worm) beta-lactamase 0.0071 0.0242 0.024
Echinococcus granulosus cathepsin L cysteine protease 0.0172 0.0852 0.1554
Loa Loa (eye worm) hypothetical protein 0.0054 0.014 0.0139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0012 0.0002
Onchocerca volvulus 0.0071 0.0242 0.1384
Echinococcus multilocularis dnaJ subfamily C 6 0.0126 0.0576 0.1045
Echinococcus multilocularis Mastin 0.0054 0.014 0.024
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0286 0.0525
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0071 0.0239 0.9829
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0012 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0162 0.0792 0.0791
Echinococcus granulosus expressed protein 0.0054 0.0138 0.0235
Trypanosoma cruzi major cysteine proteinase, putative 0.0078 0.0286 0.0475
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948
Loa Loa (eye worm) hypothetical protein 0.0054 0.014 0.0139
Schistosoma mansoni apoferritin-2 0.0054 0.0138 0.0235
Entamoeba histolytica hypothetical protein 0.0078 0.0286 0.1702
Loa Loa (eye worm) RNA binding protein 0.0067 0.0215 0.0213
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948
Plasmodium vivax unspecified product 0.0078 0.0286 0.1649
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0226 0.1182 0.1181
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0309 0.1681 0.168
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0078 0.0286 0.1649
Loa Loa (eye worm) DEAH box polypeptide 35 0.0439 0.2466 0.2464
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0012 0.0002
Plasmodium vivax vivapain-2 0.0309 0.1681 1
Toxoplasma gondii cathepsin CPC2 0.0078 0.0286 0.1478
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Onchocerca volvulus 0.0049 0.0107 0.0576
Brugia malayi Trypsin-like protease protein 5 0.0054 0.014 0.0256
Giardia lamblia Cathepsin B precursor 0.0078 0.0286 0.1478
Brugia malayi Cathepsin L-like precursor 0.0309 0.1681 0.3097
Echinococcus multilocularis muscleblind protein 1 0.0455 0.2565 0.4719
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.1182 0.2164
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.013 0.0186
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0242 0.0427
Schistosoma mansoni cathepsin F (C01 family) 0.0215 0.1116 0.2041
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0927 0.5424 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0012 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0242 0.1384
Loa Loa (eye worm) hypothetical protein 0.0078 0.0286 0.0285
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.023 0.1203 0.2203
Leishmania major hypothetical protein, conserved 0.0071 0.0242 0.1149
Brugia malayi jmjC domain containing protein 0.023 0.1203 0.2216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Onchocerca volvulus 0.006 0.0175 0.0983
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0286 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0012 0.0018
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.014 0.024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0012 0.0002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0043 0.0073 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0215 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.014 0.0006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0154 0.0671
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0242 0.0393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Giardia lamblia Cathepsin B precursor 0.0078 0.0286 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0078 0.0286 0.0501
Giardia lamblia Cysteine protease 0.0078 0.0286 0.1478
Onchocerca volvulus Cathepsin L homolog 0.0309 0.1681 1
Brugia malayi hypothetical protein 0.0053 0.013 0.0237
Plasmodium falciparum cysteine repeat modular protein 1 0.0062 0.0184 0.1036
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0242 0.1149
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.1695 0.1694
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0242 0.0607
Schistosoma mansoni hypothetical protein 0.0062 0.0184 0.032
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0078 0.0286 0.1649
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0997 0.2904
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0044 0.0075 0.0247
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0078 0.0286 0.1649
Brugia malayi steroid hormone receptor 0.0033 0.0012 0.0018
Schistosoma mansoni kinase 0.01 0.0414 0.0745
Schistosoma mansoni transcription factor LCR-F1 0.014 0.0657 0.1194
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0275 0.1583
Schistosoma mansoni chromobox protein 0.0137 0.0638 0.116
Giardia lamblia Cathepsin B precursor 0.0341 0.1875 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0043 0.0073 0.0374
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0012 0.0002
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.003 0.0035
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0012 0.0018
Schistosoma mansoni protein phosphatase 2C 0.0043 0.0073 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0012 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.1051 0.1936
Plasmodium falciparum serine repeat antigen 1 0.0078 0.0286 0.1649
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.1182 0.2164
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0286 0.0525
Schistosoma mansoni hypothetical protein 0.0095 0.0385 0.0692
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0012 0.0002
Giardia lamblia Kinase, PLK 0.0196 0.0997 0.5291
Brugia malayi serine/threonine-protein kinase plk-2 0.0196 0.0997 0.1836
Brugia malayi Trypsin family protein 0.0054 0.014 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0012 0.0018
Echinococcus granulosus calpain 5 0.0044 0.0075 0.012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0172 0.0852 0.1554
Loa Loa (eye worm) hypothetical protein 0.0078 0.0286 0.0285
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0154 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0286 0.0501
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0196 0.0997 0.5242
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0075 0.0247
Schistosoma mansoni ferritin 0.0054 0.0138 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0012 0.001
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0085
Giardia lamblia Cathepsin B precursor 0.0078 0.0286 0.1478
Leishmania major cysteine peptidase A (CPA) 0.0309 0.1681 0.8948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Loa Loa (eye worm) calpain family protein 1 0.0116 0.0511 0.051
Loa Loa (eye worm) ctsf protein 0.0309 0.1681 0.168
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0073 0.0072
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0178 0.0887 0.1619
Loa Loa (eye worm) trypsin family protein 0.0054 0.014 0.0139
Brugia malayi calpain family protein 1 0.0116 0.0511 0.094
Brugia malayi Cathepsin L-like precursor 0.0215 0.1116 0.2054
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0638 0.1691
Entamoeba histolytica cysteine proteinase 1, putative 0.0172 0.0852 0.5066
Plasmodium falciparum serine repeat antigen 8 0.0078 0.0286 0.1649
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0012 0.001
Echinococcus granulosus chromobox protein 1 0.0137 0.0638 0.116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0309 0.1681 0.5216
Brugia malayi cathepsin Z-like cysteine proteinase 0.0078 0.0286 0.0525
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0215 0.0213
Echinococcus multilocularis calpain 0.0044 0.0075 0.012
Loa Loa (eye worm) heterochromatin protein 1 0.0137 0.0638 0.0637
Loa Loa (eye worm) glutaminase 2 0.0543 0.3096 0.3095
Brugia malayi hypothetical protein 0.013 0.0595 0.1095
Loa Loa (eye worm) hypothetical protein 0.0043 0.0073 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0154 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0286 0.0501
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0071 0.0239 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0012 0.0002
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0089 0.0144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0275 0.0273
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0043 0.0073 0.0335
Brugia malayi cathepsin F-like cysteine proteinase 0.0093 0.0377 0.0693
Brugia malayi hypothetical protein 0.0054 0.014 0.0256
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0286 0.1649
Echinococcus multilocularis lysine specific demethylase 6a 0.0043 0.0073 0.0115
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0054 0.014 0.024
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0178 0.0887 0.4699
Brugia malayi Trypsin family protein 0.0054 0.014 0.0256
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0121 0.0543 0.0983
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0178 0.0887 0.1619
Onchocerca volvulus Huntingtin homolog 0.013 0.0595 0.3501
Schistosoma mansoni glutaminase 0.0543 0.3096 0.57
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0154 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0012 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0286 0.0509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Onchocerca volvulus 0.0095 0.0386 0.2245
Brugia malayi Cathepsin L-like precursor 0.0309 0.1681 0.3097
Brugia malayi hypothetical protein 0.0239 0.1259 0.2318
Plasmodium vivax unspecified product 0.0172 0.0852 0.5035
Schistosoma mansoni lipoxygenase 0.0087 0.0339 0.0607
Brugia malayi beta-lactamase family protein 0.0071 0.0242 0.0443
Trypanosoma brucei cysteine peptidase C (CPC) 0.0341 0.1875 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0286 0.0501
Schistosoma mansoni cathepsin F (C01 family) 0.0309 0.1681 0.3086
Echinococcus granulosus Mastin 0.0054 0.014 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0286 0.1478
Echinococcus multilocularis transmembrane protease serine 3 0.0054 0.014 0.024
Schistosoma mansoni lipoxygenase 0.0125 0.0566 0.1026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0242 0.0351
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0154 0.0264
Onchocerca volvulus 0.0309 0.1681 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.014 0.0657 0.1194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0178 0.0887 0.2531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Brugia malayi hypothetical protein 0.0034 0.0017 0.0029
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0093 0.0377 0.0693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.0852 0.4454
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0132 0.0608 0.3205
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0385 0.0692
Trypanosoma cruzi major cysteine proteinase, putative 0.0078 0.0286 0.0475
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0242 0.0607
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0852 0.5066
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0215 0.0377
Trichomonas vaginalis chromobox protein, putative 0.0082 0.031 0.0582
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0012 0.001
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0215 0.0377
Schistosoma mansoni hypothetical protein 0.0813 0.4733 0.8725
Onchocerca volvulus Cathepsin L homolog 0.0309 0.1681 1
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0997 0.2904
Schistosoma mansoni cathepsin F (C01 family) 0.0309 0.1681 0.3086
Leishmania major hypothetical protein, conserved 0.0043 0.0073 0.0235
Echinococcus multilocularis muscleblind protein 0.0455 0.2565 0.4719
Brugia malayi Cathepsin L-like precursor 0.0309 0.1681 0.3097
Giardia lamblia Cathepsin L precursor 0.0078 0.0286 0.1478
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.256 1
Schistosoma mansoni phd/f-box containing protein 0.0043 0.0073 0.0115
Plasmodium vivax JmjC domain containing protein 0.0043 0.0073 0.0374
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0012 0.0002
Trypanosoma cruzi cruzipain precursor, putative 0.0309 0.1681 0.3061
Entamoeba histolytica cysteine protease, putative 0.0172 0.0852 0.5066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0341 0.1875 0.3444
Brugia malayi cathepsin L precursor 0.0078 0.0286 0.0525
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0178 0.0887 0.1589
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0554 0.1005
Onchocerca volvulus Serine\/threonine kinase homolog 0.0196 0.0997 0.5906
Brugia malayi ecdysteroid receptor 0.0033 0.0012 0.0018
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0093 0.0377 0.0376
Echinococcus multilocularis cysteine protease 0.0309 0.1681 0.3086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0309 0.1681 0.8948
Echinococcus granulosus cathepsin l1 0.0309 0.1681 0.3086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0242 0.0427
Onchocerca volvulus 0.0309 0.1681 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0242 0.0427
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0012 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0309 0.1681 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0286 0.0501
Loa Loa (eye worm) hypothetical protein 0.0072 0.0247 0.0246
Mycobacterium ulcerans beta-lactamase 0.0071 0.0242 0.0351
Echinococcus granulosus GPCR family 2 0.0095 0.0385 0.0692
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0242 0.0607
Echinococcus multilocularis calpain 5 0.0044 0.0075 0.012
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0121 0.0543 0.0983
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0286 0.0525
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0448 0.2521 0.4637
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0245 0.1294 0.2372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0309 0.1681 0.5216
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0012 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.03 0.1625 0.1624
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0154 0.0767
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0075 0.0085
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.014 0.024
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0154 0.0152
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.014 0.024
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0012 0.0018
Leishmania major hypothetical protein, conserved 0.0062 0.0184 0.0834
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.014 0.024
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0043 0.0073 0.0235
Leishmania major cathepsin L-like protease 0.0309 0.1681 0.8948

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 4.8 mg kg-1 Dose that protected 50% of the mice against seizures induced by intraperitoneally administered DMCM (15 mg/Kg) 30 min after intraperitoneal administration ChEMBL. 10479278
Ki (binding) = 93 nM In vitro inhibition of [3H]-GABA uptake at the Sodium- and chloride-dependent GABA transporter 1 (GAT-1) uptake site in rat brain synaptosomes ChEMBL. 10479278

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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