Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Oral activity expressed as percent inhibition in leukotriene mediated anaphylaxis assay in guinea pig; Not determined | ChEMBL. | 2157010 |
IC50 (functional) | = 20 nM | Inhibition of LTC4-induced contractions from guinea pig peripheral lung strips | ChEMBL. | 2157010 |
Inhibition (functional) | = 15 % | Oral activity expressed as percent inhibition in LTD4-induced wheal assay in guinea pig at 3 uM | ChEMBL. | 2157010 |
Ki (binding) | = 8.5 nM | Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM) | ChEMBL. | 2157010 |
Ki (binding) | = 8.5 nM | Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM) | ChEMBL. | 2157010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.