Detailed information for compound 2017413

Basic information

Technical information
  • TDR Targets ID: 2017413
  • Name: ZINC00754233
  • MW: 352.384 | Formula: C20H20N2O4
  • H donors: 3 H acceptors: 2 LogP: 0.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)[C@H]1N[C@@H](Cc2c1[nH]c1c2cccc1)C(=O)O
  • InChi: 1S/C20H20N2O4/c1-25-16-8-7-11(9-17(16)26-2)18-19-13(10-15(22-18)20(23)24)12-5-3-4-6-14(12)21-19/h3-9,15,18,21-22H,10H2,1-2H3,(H,23,24)/t15-,18+/m0/s1
  • InChiKey: JLKKXFLIQLNLAN-MAUKXSAKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R,3S)-1-(3,4-dimethoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[5,4-b]indole-3-carboxylic acid
  • (1R,3S)-1-(3,4-dimethoxyphenyl)-2,3,4,9-tetrahydro-1H-$b-carboline-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Brugia malayi ecdysteroid receptor 0.0182 0.5163 0.5163
Schistosoma mansoni retinoic acid receptor RXR 0.0182 0.5163 0.5163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0415 0.0896
Brugia malayi nuclear receptor NHR-88 0.0086 0.2034 0.2034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0182 0.5163 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.2034 0.394
Loa Loa (eye worm) hypothetical protein 0.0096 0.2369 0.2369
Echinococcus multilocularis peregrin 0.0035 0.0388 0.0751
Schistosoma mansoni zinc finger protein 0.0086 0.2034 0.2034
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0023 0.0005 0.001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.036 0.0697
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0163 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0182 0.5163 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0182 0.5163 1
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0163 0.2352
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0182 0.5163 0.5163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0182 0.5163 0.5163
Brugia malayi photoreceptor-specific nuclear receptor 0.0182 0.5163 0.5163
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Onchocerca volvulus 0.0036 0.0415 0.0034
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.285 0.285
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0415 0.0804
Onchocerca volvulus 0.0182 0.5163 0.5841
Mycobacterium ulcerans glutaminase 0.033 1 1
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0388 0.0388
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0182 0.5163 1
Brugia malayi nuclear receptor NHR-88 0.0182 0.5163 0.5163
Loa Loa (eye worm) inositol-1 0.0045 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Brugia malayi Nuclear hormone receptor-like 1 0.0182 0.5163 0.5163
Brugia malayi jmjC domain containing protein 0.0115 0.2999 0.2999
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0005 0.0005
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0086 0.2034 0.2034
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.2369 0.2369
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0388 0.0751
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0086 0.2034 0.394
Brugia malayi Bromodomain containing protein 0.0035 0.0388 0.0388
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0096 0.2369 0.2369
Brugia malayi nuclear receptor RXR 0.0086 0.2034 0.2034
Brugia malayi jmjC domain containing protein 0.0043 0.0629 0.0629
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0694 0.0694
Plasmodium vivax SET domain protein, putative 0.0036 0.0415 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.2594 0.2594
Brugia malayi Pre-SET motif family protein 0.0251 0.7432 0.7432
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.2034 0.394
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0182 0.5163 0.5163
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0005 0.001
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0034 0.036 0.036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0096 0.2369 0.4589
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0182 0.5163 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0182 0.5163 0.5163
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.036 0.036
Onchocerca volvulus Bile acid receptor homolog 0.0182 0.5163 0.5841
Brugia malayi orphan nuclear receptor NR2E1 0.0086 0.2034 0.2034
Brugia malayi Cyclic-nucleotide gated cation channel 0.0023 0.0005 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0182 0.5163 0.5841
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0096 0.2369 0.2369
Echinococcus multilocularis FTZ F1 alpha 0.0182 0.5163 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.006 0.1208 0.1208
Loa Loa (eye worm) steroid hormone receptor 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Loa Loa (eye worm) DR-78 0.0086 0.2034 0.2034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0388 0.0388
Schistosoma mansoni RAR-like nuclear receptor 0.0182 0.5163 0.5163
Loa Loa (eye worm) glutaminase 0.033 1 1
Onchocerca volvulus 0.0086 0.2034 0.2014
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0182 0.5163 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0182 0.5163 0.5163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0415 0.0415
Brugia malayi Pre-SET motif family protein 0.0036 0.0415 0.0415
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0182 0.5163 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0629 0.0629
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0629 0.0629
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.161 0.161
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0005 0.0005
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0005 0.001
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0119 0.3105 0.3105
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0005 0.0005
Giardia lamblia PHD finger protein 15 0.0035 0.0388 1
Echinococcus granulosus ecdysone induced protein 78C 0.0182 0.5163 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0086 0.2034 0.2034
Brugia malayi nuclear receptor RXR 0.0096 0.2369 0.2369
Brugia malayi Cytochrome P450 family protein 0.0028 0.0163 0.0163
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0415 0.0804
Echinococcus multilocularis ecdysone induced protein 78C 0.0182 0.5163 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0163 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0182 0.5163 0.5163
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.2034 0.2014
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0182 0.5163 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0163 0.0163
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0086 0.2034 0.394
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.036 0.0697
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Plasmodium falciparum phd finger protein, putative 0.0035 0.0388 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0182 0.5163 0.5163
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0086 0.2034 0.2034
Brugia malayi hypothetical protein 0.0086 0.2034 0.2034
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0005 0.0005
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0542 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0086 0.2034 0.394
Brugia malayi nuclear hormone receptor 0.0086 0.2034 0.2034
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0096 0.2369 0.2369
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0182 0.5163 0.5163
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2999 0.5808
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0694 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0182 0.5163 0.5163
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7432 0.7432
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0182 0.5163 0.5163
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0388 0.0388
Brugia malayi conserved hypotetical protein 0.0086 0.2034 0.2034
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0119 0.3105 0.6013
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0005 0.0005
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0023 0.0005 0.001
Schistosoma mansoni coup transcription factor 0.0182 0.5163 0.5163
Onchocerca volvulus 0.0086 0.2034 0.2014
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0415 0.0804
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Echinococcus granulosus peregrin 0.0035 0.0388 0.0751
Schistosoma mansoni nuclear hormone receptor 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.285 0.285
Brugia malayi PHD-finger family protein 0.0035 0.0388 0.0388
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.2034 0.394
Schistosoma mansoni thyroid hormone receptor 0.0182 0.5163 0.5163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0694 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0096 0.2369 0.2369
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.2034 0.394
Brugia malayi nuclear hormone receptor family member nhr-6 0.0086 0.2034 0.2034
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0005 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0182 0.5163 1
Schistosoma mansoni nuclear receptor 0.0086 0.2034 0.2034
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0415 0.0415
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0182 0.5163 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8564 0.8564
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0182 0.5163 0.5163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0415 0.0415
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0023 0.0005 0.001
Schistosoma mansoni nuclear receptor nhr-48 0.0086 0.2034 0.2034
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0119 0.3105 0.6013
Brugia malayi hypothetical protein 0.0096 0.2369 0.2369
Loa Loa (eye worm) hypothetical protein 0.0096 0.2369 0.2369
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.0034 0.036 0.036
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0005 0.001
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0086 0.2034 0.2034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0182 0.5163 0.5163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0182 0.5163 0.5163
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0694 0.0694
Brugia malayi ecdysone receptor 0.0086 0.2034 0.2034
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0023 0.0005 0.001
Schistosoma mansoni nuclear receptor 0.0086 0.2034 0.2034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0182 0.5163 0.5163
Brugia malayi Inositol-1 0.0045 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0182 0.5163 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0182 0.5163 0.5163
Schistosoma mansoni hypothetical protein 0.0035 0.0388 0.0388
Trichomonas vaginalis glutaminase, putative 0.033 1 1
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0163 0.2352
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2999 0.5808
Brugia malayi hypothetical protein 0.0096 0.2369 0.2369
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0182 0.5163 1
Brugia malayi nuclear hormone receptor 0.0182 0.5163 0.5163
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0023 0.0005 0.001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0119 0.3105 0.3105
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0694 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0182 0.5163 0.5841
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0837 0.1622
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0694 0.1344
Schistosoma mansoni glutaminase 0.033 1 1
Brugia malayi tailless protein 0.0086 0.2034 0.2034
Loa Loa (eye worm) cytochrome P450 family protein 0.0103 0.2613 0.2613
Brugia malayi nuclear receptor NHR-67 0.0086 0.2034 0.2034
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0694 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0694 0.1344
Schistosoma mansoni inositol monophosphatase 0.0045 0.0694 0.0694
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0182 0.5163 0.5163
Loa Loa (eye worm) nuclear receptor NHR-67 0.0086 0.2034 0.2034
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Brugia malayi hypothetical protein 0.0086 0.2034 0.2034
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.346 0.346
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0182 0.5163 0.5163
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.346 0.346
Brugia malayi steroid hormone receptor 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.2034 0.2014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0372 0.0721
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0096 0.2369 0.4589
Leishmania major cytochrome p450-like protein 0.0028 0.0163 0.2352
Brugia malayi Nuclear hormone receptor E75 0.0086 0.2034 0.2034
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.2034 0.394
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0096 0.2369 0.2369
Brugia malayi Cytochrome P450 family protein 0.0103 0.2613 0.2613
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Echinococcus granulosus voltage gated potassium channel 0.0034 0.036 0.0697
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0182 0.5163 0.5163
Onchocerca volvulus 0.0286 0.8564 1
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0629 0.1219
Schistosoma mansoni nuclear hormone receptor 0.0086 0.2034 0.2034
Echinococcus granulosus FTZ F1 alpha 0.0182 0.5163 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0629 0.1219
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0086 0.2034 0.394
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0542 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0182 0.5163 0.5163
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0182 0.5163 0.5163
Loa Loa (eye worm) hypothetical protein 0.0182 0.5163 0.5163
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.036 0.036
Brugia malayi Steroid receptor seven-up type 2 0.0182 0.5163 0.5163
Schistosoma mansoni nuclear hormone receptor 0.0086 0.2034 0.2034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0182 0.5163 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0005 0.001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0086 0.2034 0.2034
Brugia malayi glutaminase DH11.1 0.033 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0005 0.001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0415 0.0415
Echinococcus multilocularis nuclear receptor nhr 48 0.0086 0.2034 0.394
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0005 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.2369 0.2369
Schistosoma mansoni inositol monophosphatase 0.0045 0.0694 0.0694
Brugia malayi Nuclear hormone receptor E75 0.0086 0.2034 0.2034
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0163 0.2352
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0388 0.0751
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0629 0.0629
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0182 0.5163 0.5163
Brugia malayi nuclear hormone receptor family member odr-7 0.0086 0.2034 0.2034
Loa Loa (eye worm) hypothetical protein 0.0096 0.2369 0.2369
Loa Loa (eye worm) nuclear hormone receptor 0.0086 0.2034 0.2034
Schistosoma mansoni thyroid hormone receptor 0.0182 0.5163 0.5163
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0182 0.5163 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0182 0.5163 0.5163
Echinococcus granulosus nuclear receptor nhr 48 0.0086 0.2034 0.394
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0837 0.1622
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2226 0.2226
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0182 0.5163 0.5163
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0694 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.2034 0.394
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0694 0.0694
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0694 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0005 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0182 0.5163 0.5163
Echinococcus multilocularis voltage gated potassium channel 0.0034 0.036 0.0697

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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